| Tag | Content |
|---|
| EKPD ID | EKS-DRM-00074 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/NDR | 494.5 | 1.3E-148 | 93 | 390 | 298 |
|
| Status | Reviewed |
| Ensembl Protein | FBpp0074691 |
| UniProt Accession | Q9NBK5; Q24464; Q9NGW6; Q9VW46; |
| Protein Name | Serine/threonine-protein kinase tricorner |
| Protein Synonyms/Alias | NDR protein kinase; Serine/threonine-protein kinase 38-like; |
| Gene Name | trc |
| Gene Synonyms/Alias | trc; CG8637; |
| Ensembl Information | |
| Organism | Drosophila melanogaster |
| Functional Description | Has an important role, with fry, in controlling cellstructure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. |
| Protein Length | 459 |
Protein Sequence
(FASTA) | | MMSSRTQDAD GASIRFSDHT LDKATKAKVT LENYYSNLVT QYGERKQRLA KLEAQLKDES 60 | | LSEAQRQEKR LQHAQKETEY LRLKRLRLGV EDFEALKVIG RGAFGEVRLV QKKDTGHVYA 120 | | MKVLRKADML EKEQVAHVRA ERDVLVEADH QWVVKMYYSF QDPVNLYLIM EFLPGGDMMT 180 | | LLMKKDTLSE EGTQFYISET ALAIDSIHKL GFIHRDIKPD NLLLDARGHL KLSDFGLCTG 240 | | LKKSHRTDFY RDLSQAKPSD FIGTCASPMD SKRRAESWKR NRRALAYSTV GTPDYIAPEV 300 | | FLQTGYGPAC DWWSLGVIMY EMLMGYPPFC SDNPQDTYRK VMNWRETLIF PPEIPISEEA 360 | | KETIINFCCE ADRRLGSQRG LEDLKSVPFF RGVDWEHIRE RPAAIPVEVR SIDDTSNFDE 420 | | FPDVSLEIPS APIPQGGEIA KDWVFINYTY KRFEVRNLE 459 |
|
Nucleotide Sequence
(FASTA) | | ATGATGAGCA GCAGAACGCA GGACGCGGAC GGTGCCTCGA TCAGATTCAG CGACCACACA 60 | | CTGGACAAGG CCACCAAGGC CAAGGTGACG TTGGAGAACT ACTACAGCAA CCTGGTGACG 120 | | CAGTATGGCG AGCGAAAGCA GCGCCTCGCA AAGCTGGAGG CTCAGCTGAA GGACGAGAGC 180 | | TTGTCGGAGG CGCAGCGCCA GGAGAAGCGT CTGCAGCATG CCCAGAAGGA GACGGAGTAT 240 | | CTCCGGCTGA AGCGATTGCG CCTCGGTGTG GAGGACTTTG AGGCCCTCAA AGTCATCGGA 300 | | CGCGGCGCGT TCGGTGAAGT GCGTTTGGTG CAGAAAAAGG ACACGGGACA TGTGTACGCC 360 | | ATGAAGGTGC TGCGCAAAGC GGACATGCTG GAAAAGGAGC AGGTGGCACA CGTACGAGCC 420 | | GAGCGCGATG TCCTGGTCGA GGCCGATCAT CAGTGGGTGG TGAAGATGTA CTACAGTTTC 480 | | CAGGATCCCG TCAATTTATA TTTGATAATG GAGTTCTTGC CTGGTGGTGA TATGATGACG 540 | | CTTTTGATGA AGAAGGACAC GCTATCCGAG GAGGGCACAC AGTTCTATAT CAGTGAGACG 600 | | GCATTGGCGA TCGATTCTAT TCACAAACTC GGTTTCATAC ACAGGGATAT CAAGCCCGAT 660 | | AACTTGCTGC TGGACGCGCG AGGGCATCTG AAGCTCTCCG ACTTCGGACT GTGCACTGGC 720 | | TTAAAGAAGT CGCATCGAAC AGACTTTTAT CGGGACTTGT CGCAGGCGAA ACCATCCGAT 780 | | TTTATAGGCA CGTGCGCCAG TCCGATGGAC TCCAAGCGAC GTGCCGAGTC GTGGAAGCGA 840 | | AATCGACGCG CCCTCGCCTA CAGCACCGTG GGAACGCCGG ACTATATTGC ACCCGAAGTA 900 | | TTTCTGCAGA CTGGCTACGG ACCCGCCTGC GACTGGTGGT CCCTGGGAGT CATCATGTAC 960 | | GAAATGCTGA TGGGCTATCC TCCATTCTGC TCGGACAATC CCCAGGACAC CTACCGCAAG 1020 | | GTGATGAACT GGCGCGAGAC GCTGATATTT CCCCCAGAGA TCCCCATATC GGAGGAGGCC 1080 | | AAGGAGACGA TCATCAACTT CTGCTGCGAG GCCGATCGCC GGCTGGGTTC CCAGCGCGGT 1140 | | CTGGAGGATC TGAAGTCCGT GCCGTTCTTC CGGGGAGTTG ACTGGGAGCA CATACGTGAG 1200 | | CGTCCCGCGG CCATACCCGT TGAGGTGCGC TCAATCGACG ATACGTCCAA CTTCGACGAG 1260 | | TTTCCCGATG TGTCGCTGGA GATACCATCG GCGCCCATAC CGCAGGGCGG TGAGATTGCG 1320 | | AAGGACTGGG TCTTTATCAA CTACACGTAC AAACGATTCG AGGTGCGAAA TTTGGAGTGA 1380 |
|
| Domain Profile | S: 1 feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew 60 | fe+lkvig+GafGevrlv+kkdt++vya+k+lrk+d+l+k+qvahv+aerd+l+ead++w | Q: 93 FEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQW 152 | 899********************************************************* |
| S: 61 vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf 120 | vvk+yysfqd nlyl+me+lPGGd+mtll+kk++l+ee ++fyi+e++la++s+hklGf | Q: 153 VVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGF 212 | ************************************************************ |
| S: 121 ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler 180 | ihrd+kPdnll+da+Gh+kl+dfGlctGlkk+hr+++y++l++ak++d+ + ++++++++ | Q: 213 IHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDF-IGTCASPMDS 271 | *************************************************.8999999999 |
| S: 181 rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla 236 | +++ k+nrr+lays+vGtpdyiapev++++gy +cdwWslGvi+yeml+GypPf++ | Q: 272 KRRaeswKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCS 331 | 99889******************************************************* |
| S: 237 etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkk.Gvdeikkhpff 294 | ++pq+ty+kv+nw+etl fp+e+++seeak++i +++++a++rlg++ G++++k++pff | Q: 332 DNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQrGLEDLKSVPFF 390 | *********************************************999**********9 |
|
Domain Sequence
(FASTA) | | FEALKVIGRG AFGEVRLVQK KDTGHVYAMK VLRKADMLEK EQVAHVRAER DVLVEADHQW 60 | | VVKMYYSFQD PVNLYLIMEF LPGGDMMTLL MKKDTLSEEG TQFYISETAL AIDSIHKLGF 120 | | IHRDIKPDNL LLDARGHLKL SDFGLCTGLK KSHRTDFYRD LSQAKPSDFI GTCASPMDSK 180 | | RRAESWKRNR RALAYSTVGT PDYIAPEVFL QTGYGPACDW WSLGVIMYEM LMGYPPFCSD 240 | | NPQDTYRKVM NWRETLIFPP EIPISEEAKE TIINFCCEAD RRLGSQRGLE DLKSVPFF 298 |
|
| Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |