EKS-DRM-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	405.0	2.1E-121	4	287	284

Status

Reviewed

Ensembl Protein

FBpp0079641

UniProt Accession

P23572; A0ANT1; Q86FT5; Q86FT6; Q86FT7; Q86FT8; Q86FT9; Q9TX68; Q9TX69; Q9TX70; Q9TX71; Q9TX72; Q9TX73; Q9TX74; Q9VKX5;

Protein Name

Cyclin-dependent kinase 1

Protein Synonyms/Alias

CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase;

Gene Name

cdc2

Gene Synonyms/Alias

cdc2; cdk1; CG5363;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0004106	FBpp0079641	FBtr0080051

Organism

Drosophila melanogaster

Functional Description

Plays a key role in the control of the eukaryotic cellcycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Protein Length

297

Protein Sequence
(FASTA)

MEDFEKIEKI GEGTYGVVYK GRNRLTGQIV AMKKIRLESD DEGVPSTAIR EISLLKELKH 60

ENIVCLEDVL MEENRIYLIF EFLSMDLKKY MDSLPVDKHM ESELVRSYLY QITSAILFCH 120

RRRVLHRDLK PQNLLIDKSG LIKVADFGLG RSFGIPVRIY THEIVTLWYR APEVLLGSPR 180

YSCPVDIWSI GCIFAEMATR KPLFQGDSEI DQLFRMFRIL KTPTEDIWPG VTSLPDYKNT 240

FPCWSTNQLT NQLKNLDANG IDLIQKMLIY DPVHRISAKD ILEHPYFNGF QSGLVRN 297

Nucleotide Sequence
(FASTA)

ATGGAGGATT TTGAGAAAAT TGAGAAGATT GGCGAGGGCA CATATGGCGT GGTGTATAAG 60

GGTCGCAACC GCCTGACGGG CCAAATTGTG GCAATGAAGA AAATCCGCTT GGAGTCCGAC 120

GACGAAGGCG TTCCATCAAC CGCGATCAGA GAAATTTCGT TGCTTAAGGA GTTGAAACAT 180

GAAAACATTG TCTGTTTGGA GGATGTTTTG ATGGAGGAGA ACCGCATATA CTTGATCTTT 240

GAATTCCTAT CGATGGACCT CAAGAAATAC ATGGATTCGC TGCCAGTTGA TAAGCACATG 300

GAGAGTGAAT TGGTCCGTAG CTATTTGTAC CAAATAACTA GCGCCATTCT TTTCTGCCAT 360

CGTCGGCGAG TACTTCACCG TGATCTTAAG CCGCAGAACT TACTAATCGA CAAGAGTGGC 420

CTCATAAAAG TCGCCGACTT TGGACTTGGC CGATCCTTTG GCATTCCGGT GCGCATTTAT 480

ACGCACGAGA TTGTTACCTT GTGGTACAGA GCGCCGGAGG TGCTACTGGG TTCACCCCGG 540

TATTCCTGTC CCGTCGATAT CTGGTCCATT GGATGCATAT TCGCGGAGAT GGCAACGAGA 600

AAGCCGCTAT TCCAGGGTGA CTCGGAAATT GACCAGTTGT TTAGAATGTT TAGAATTCTG 660

AAAACACCTA CCGAAGACAT TTGGCCGGGC GTTACTTCGC TACCCGACTA TAAGAACACG 720

TTCCCCTGCT GGTCCACGAA CCAATTGACC AATCAGTTAA AGAATCTCGA TGCGAATGGT 780

ATTGATCTCA TACAAAAGAT GTTAATCTAC GATCCAGTTC ATCGCATTTC CGCCAAGGAC 840

ATTTTGGAGC ATCCCTATTT CAATGGTTTT CAATCGGGCT TAGTTCGAAA TTAA 894

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ek+ekigeGtyg+vyk++++ tg++vA+Kkirle+++egvp+ta+rEisllkelkh+ni

Q: 4     FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v L +v++ +++++yL+fefl++dLkk++++ + + ++++e v+s+l+q+ +++ ++H++

Q: 64    VCLEDVLM-EENRIYLIFEFLSMDLKKYMDSLPVDkHMESELVRSYLYQITSAILFCHRR  122

         ********.99********************998779***********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+k+g +k+aDfGl r+f+ p++ yt+e+vTlwYraPe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

           vDiWs+gci+ae++trkplfqg+seidql+r+f++l tp+e++wp+v++lp+yk++fp

Q: 183   CPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          +++++l++++k+l+ +++dl++k+l +dp +Risak++l+h+yf

Q: 243   CWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

FEKIEKIGEG TYGVVYKGRN RLTGQIVAMK KIRLESDDEG VPSTAIREIS LLKELKHENI 60

VCLEDVLMEE NRIYLIFEFL SMDLKKYMDS LPVDKHMESE LVRSYLYQIT SAILFCHRRR 120

VLHRDLKPQN LLIDKSGLIK VADFGLGRSF GIPVRIYTHE IVTLWYRAPE VLLGSPRYSC 180

PVDIWSIGCI FAEMATRKPL FQGDSEIDQL FRMFRILKTP TEDIWPGVTS LPDYKNTFPC 240

WSTNQLTNQL KNLDANGIDL IQKMLIYDPV HRISAKDILE HPYF 284

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005875	; C:microtubule associated complex
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0055059	; P:asymmetric neuroblast division
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0048142	; P:germarium-derived cystoblast division
GO:0007141	; P:male meiosis I
GO:0008315	; P:meiotic G2/MI transition
GO:0007067	; P:mitosis
GO:0032880	; P:regulation of protein localization
GO:0006974	; P:response to DNA damage stimulus
GO:0007284	; P:spermatogonial cell division

KEGG

dme:Dmel_CG5363

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013