EPS-DRM-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DRM-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	571.6	4.8E-172	47	353	307

Status

Reviewed

Ensembl Protein

FBpp0074601

UniProt Accession

P40421; A4V255; Q5U1D3; Q9VWA4;

Protein Name

Serine/threonine-protein phosphatase rdgC

Protein Synonyms/Alias

Retinal degeneration C protein;

Gene Name

rdgC

Gene Synonyms/Alias

rdgC; CG6571;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0004366	FBpp0305009	FBtr0332773
FBgn0004366	FBpp0074602	FBtr0074833
FBgn0004366	FBpp0074601	FBtr0074832

Organism

Drosophila melanogaster

Functional Description

Phosphatase required to prevent light-induced retinaldegeneration.

Protein Length

603

Protein Sequence
(FASTA)

MPQAAGRKNQ YQGSAHVSVL DDKDDLVEEF GDIVNAKIEL PIRKNHIDLL IDVFRKKRGN 60

RLHPKYVALI LREAAKSLKQ LPNISPVSTA VSQQVTVCGD LHGKLDDLLV VLHKNGLPSS 120

SNPYVFNGDF VDRGKRGLEV LLLLLSLYLA FPNAVFLNRG NHEDSVMNAR YGFIREVESK 180

YPRNHKRILA FIDEVYRWLP LGSVLNSRVL IVHGGFSDST SLDLIKSIDR GKYVSILRPP 240

LTDGEPLDKT EWQQIFDIMW SDPQATMGCV PNTLRGAGVW FGPDVTDNFL QRHRLSYVIR 300

SHECKPNGHE FMHDNKIITI FSASNYYAIG SNKGAYIRLN NQLMPHFVQY ISAASQTKRL 360

SFKQRMGIVE SSALKELAVR MRDHRDELED EFRKYDPKDS GYISISHWCK VMENVTKLGL 420

PWRLLRDKLA PGTDSQKVNY NRTLDLLDTD VILEAEADGM SVMDALYANK ASLVAIFNII 480

DADNSGEITL DEFETAIDLL VAHMPGAYSK AEMLEKCRMM DLNGDGKVDL NEFLEAFRLS 540

DLHRKEQQDE NIRRRSTGRP SVAKTATDPV TLLADKISKN TLVVEHDIDP TDCESKVIDP 600

KKS 603

Nucleotide Sequence
(FASTA)

ATGCCCCAGG CGGCGGGCAG GAAGAATCAG TACCAAGGAT CCGCCCATGT TTCCGTCTTG 60

GATGATAAGG ACGATCTCGT CGAAGAGTTT GGGGACATTG TGAATGCCAA AATTGAGTTG 120

CCAATACGAA AAAATCATAT CGATCTATTG ATTGACGTCT TCCGCAAGAA ACGGGGCAAC 180

CGATTGCATC CCAAGTATGT GGCCCTGATT CTACGCGAAG CTGCCAAATC GCTAAAGCAG 240

CTGCCCAATA TTTCTCCGGT GTCCACGGCG GTTTCCCAAC AAGTTACGGT TTGCGGGGAT 300

CTACATGGAA AATTGGACGA TCTTCTTGTG GTGCTGCATA AGAACGGTCT TCCCTCATCT 360

TCCAATCCCT ACGTGTTCAA TGGAGACTTC GTGGACAGGG GCAAGCGTGG CTTGGAGGTC 420

CTGCTCCTGC TGCTCTCCCT TTACTTGGCT TTTCCCAACG CAGTTTTCCT CAACCGCGGA 480

AACCACGAGG ATAGTGTTAT GAATGCGCGA TATGGATTTA TCCGGGAGGT GGAAAGCAAG 540

TATCCCCGGA ATCACAAGCG AATCCTGGCC TTCATCGACG AGGTCTACCG ATGGCTTCCC 600

CTGGGCTCCG TTCTCAATAG TAGAGTCCTA ATCGTGCATG GAGGCTTCTC GGACAGCACA 660

AGCCTGGATC TAATAAAGAG TATCGATAGG GGAAAGTACG TGTCCATTTT GCGACCGCCA 720

CTTACGGATG GCGAACCACT GGACAAAACC GAGTGGCAGC AGATCTTCGA CATAATGTGG 780

AGTGACCCGC AGGCCACCAT GGGATGTGTT CCGAACACTT TGCGAGGAGC TGGCGTGTGG 840

TTTGGACCGG ATGTGACTGA CAACTTTCTG CAAAGACATC GACTCAGCTA CGTCATTCGA 900

TCGCACGAAT GCAAGCCCAA TGGCCATGAG TTTATGCATG ACAACAAGAT AATTACAATA 960

TTTTCGGCCT CGAACTACTA TGCCATTGGA TCCAACAAGG GCGCCTACAT CCGGCTTAAC 1020

AACCAGCTGA TGCCCCATTT CGTTCAGTAC ATATCGGCGG CATCGCAGAC CAAGCGATTA 1080

TCCTTCAAAC AGCGAATGGG CATCGTGGAG AGTTCGGCAC TCAAGGAGTT GGCGGTGCGT 1140

ATGCGCGACC ATCGGGACGA GTTGGAGGAC GAGTTCCGGA AGTATGATCC CAAGGATAGC 1200

GGCTATATAT CCATATCGCA CTGGTGCAAG GTAATGGAGA ACGTGACCAA GTTGGGGCTG 1260

CCCTGGAGAC TCCTACGCGA TAAACTGGCA CCAGGCACGG ATAGTCAAAA GGTTAACTAT 1320

AATAGGACGT TGGATCTGCT GGACACGGAT GTTATTCTCG AAGCTGAGGC TGATGGCATG 1380

TCAGTAATGG ATGCTTTGTA TGCCAACAAA GCCAGCCTAG TTGCCATTTT TAATATAATT 1440

GATGCCGATA ATTCAGGCGA AATTACCCTA GATGAGTTCG AAACTGCGAT TGACTTGCTG 1500

GTGGCCCATA TGCCGGGTGC CTATTCCAAG GCGGAAATGC TGGAGAAGTG CAGAATGATG 1560

GACCTCAACG GAGATGGCAA AGTGGACTTG AACGAATTCC TGGAAGCGTT CAGGCTGAGT 1620

GATCTGCATA GAAAGGAGCA GCAGGACGAA AACATCAGGA GGCGTTCGAC TGGCAGACCT 1680

TCCGTGGCTA AAACAGCCAC AGATCCTGTC ACCCTCCTGG CCGACAAGAT CTCAAAGAAC 1740

ACGCTGGTTG TGGAACACGA CATCGATCCC ACGGACTGTG AGTCCAAAGT AATCGATCCT 1800

AAGAAGTCCT AA 1812

Domain Profile

S: 1     idlllevfkkkr..ilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGkld  58

         idll++vf+kkr  +lh+kyv+++l+ea+k+lkqlpnis+vstavs++vtv+GdlhGkld

Q: 47    IDLLIDVFRKKRgnRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLD  106

         8**********999**********************************************

S: 59    dlllvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkv  118

         dll+vl+knGlPs++npyvfnGdfvdrGkrglevll+llsl+l+fPnav+lnrGnhed+v

Q: 107   DLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSV  166

         ************************************************************

S: 119   mnaryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllk  178

         mnaryGf++ev+sky+r++kril++++evy+wlPlgs+++srvl+vhGG+s+stsldl+k

Q: 167   MNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIK  226

         ************************************************************

S: 179   sverkkrksvllpPeessrdlgrldtdgepreslteteweqiidilwsdPratnGlvPnt  238

         s++r+k++s+l+pP+          tdgep   l++tew+qi+di+wsdP+at+G+vPnt

Q: 227   SIDRGKYVSILRPPL----------TDGEP---LDKTEWQQIFDIMWSDPQATMGCVPNT  273

         ***************..........9****...***************************

S: 239   lrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtifsasnyyeegsnk  298

         lrGaGv+fGPdvt++fl++++l++virsheckp+g+e++hd+k++tifsasnyy++gsnk

Q: 274   LRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNK  333

         ************************************************************

S: 299   gayiklnsqltprfvqyiva  318

         gayi+ln+ql+p+fvqyi+a

Q: 334   GAYIRLNNQLMPHFVQYISA  353

         ******************98

Domain Sequence
(FASTA)

IDLLIDVFRK KRGNRLHPKY VALILREAAK SLKQLPNISP VSTAVSQQVT VCGDLHGKLD 60

DLLVVLHKNG LPSSSNPYVF NGDFVDRGKR GLEVLLLLLS LYLAFPNAVF LNRGNHEDSV 120

MNARYGFIRE VESKYPRNHK RILAFIDEVY RWLPLGSVLN SRVLIVHGGF SDSTSLDLIK 180

SIDRGKYVSI LRPPLTDGEP LDKTEWQQIF DIMWSDPQAT MGCVPNTLRG AGVWFGPDVT 240

DNFLQRHRLS YVIRSHECKP NGHEFMHDNK IITIFSASNY YAIGSNKGAY IRLNNQLMPH 300

FVQYISA 307

Keyword

Alternative splicing; Calcium; Complete proteome; Hydrolase; Iron; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Repeat; Sensory transduction; Vision.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0004723	; F:calcium-dependent protein serine/threonine phosphatase activity
GO:0005516	; F:calmodulin binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0019722	; P:calcium-mediated signaling
GO:0016059	; P:deactivation of rhodopsin mediated signaling
GO:0050906	; P:detection of stimulus involved in sensory perception
GO:0007602	; P:phototransduction
GO:0006470	; P:protein dephosphorylation
GO:0043052	; P:thermotaxis
GO:0007601	; P:visual perception

KEGG

dme:Dmel_CG6571

;

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013