EKS-DRM-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	290.7	2.0E-86	2181	2468	288

Status

Reviewed

Ensembl Protein

FBpp0074047

UniProt Accession

Q9VXG8; Q24135;

Protein Name

Serine/threonine-protein kinase ATR

Protein Synonyms/Alias

Ataxia telangiectasia and Rad3-related protein homolog; ATR homolog; dATR; Meiotic protein 41;

Gene Name

mei-41

Gene Synonyms/Alias

mei-41; CG4252;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0004367	FBpp0074047	FBtr0074271

Organism

Drosophila melanogaster

Functional Description

Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. Essential for the DNA damage checkpoint in larval imaginal disks and neuroblasts and for the DNA replication checkpoint in the embryo. Has also an essential role during early nuclear divisions in embryos, where it is required to delay mitosis in response to incomplete DNA replication. Also plays an important role during meiosis, where it may monitor double-strand- break repair during meiotic crossing over, to regulate the progression of prophase I, and to enforce metaphase I delay observed at the end of oogenesis.

Protein Length

2517

Protein Sequence
(FASTA)

MSTQRKDMWK LLYNHVNRNV SNFSGVYSVI EDILCQEPSL ISCSLVRELH NKFQDTFLLW 60

LLNKLAKCLS ESPDSSECIN LQRKILSSCC SNHPKLFERL VLAYVEAIEE THLQLSSLDL 120

GQLSNERKPA ITVRIFRCDV ECLQEFDPHC AIEDIKVPLE QADMYAKSLL EVLQHAHHIG 180

YATHGDIFSG SLHQALLILK ECDMDTKLAS LNYCHNVLRS QSASSWITNP DVGHYAQLTL 240

EATAIMWSAV AKWLDMGCMT RQELKRLNIT TKLLLEVLHM RARPAHHLGY LLLNEILSLP 300

TAIELDDGLL ETLSSYIQGQ LEHSVVPLEQ LVHLQQLMLS HWHCHPTHLV PILALMGLKQ 360

TEMRSGVVQV LTQSLVEILK KEEVLSKDWQ KLIAILRGFK QLEKLILSQS QHKIAEHEGH 420

IDSSVLAMLP LQCEIIKVAD TNWNNLSMQL VELESKCSAD RRHIHLEICS LLMQITFIRH 480

FLKTQTQHQL LAILQRHLKL SYLCAIRLET PSSVHTQMQS FYAQQYMRLF QSEETQEIFC 540

SNLPQLYISG FIKPEQLMKA LPTINNRSGR AQVIRLLLCS QPGKLSVFKV KDRIELYCPK 600

CRPLPKKLPG IYLGKCKQQL PCPDFSSTNL EMIANDLLFY PDFECIAQHL DLLCFEPNVI 660

LGLLRETEAL QKVSVKVIGQ LVSAMRVRSP EFLEQLANLV LAAIKAMLAK PLTEQNVLQQ 720

RSMLNVLTAI AHMEDNEIWL FHWFKMTFFF LVHTRSLVAQ EAVLAATEMC ASQGLQTIHL 780

WNWYKRDALD LTVRLALNVY LLDGVRFTRS LRALTKMLGF TCVQEFTCKY HRLLTAMVLP 840

HCIVNPLCKG VLVLIAKQMQ KHIGTLFSIS FLRIYTHVFL TEEPELANSC IELVVSCTQS 900

SLQQLMNADV KQTVAELLIY FNRNPTFVMR SFQSLLQLSI GSLEELSSQT ANAEFANFIA 960

ERFLGVITYF ESCLSEPSFE KPLKEETLYS LGQIMRFVGS QHVTQFRFKI IAMLSFVHTL 1020

QEPRLQRICL KIWHIFLHVV NVQELGPSLG RIVATLQPLL ADNESVKQVN DLYEFIILRN 1080

ASMLGTFITD LYFLDRMENV SPSIQKCIRR HTAHLDLKGL AEEENQSPPL VDQLRFLQKH 1140

ITDECLQVRV YALQHLGDLF GRRRPKLNST ILSELPLEPM LEQIVNVLMA GCQHDDSQLQ 1200

MASAKCLGEL GAIDASYLPS NYNFASPQHL PLNILSDDFA VLALTSLCRG YQFQQNTKHV 1260

DSFSLAIQET LAICGISPKE QKKVQLWQSL PARMRQLMEP MLHSCYTCVH RPSTCLQQPL 1320

FGSHYSHNYY EEWAFLWASR LIDYLPSSGR RHLLSSYKPC IKRDSNMLST FYPYILLHAL 1380

LECTTEQRNH IQEEFMAVLQ ANEESSSSVR GRQELGAIKE NAFKQFESRK YAAGIKPLAS 1440

TLVSDRKEDS SRVPRLAGKL CAELLDFLQR WLREWQRIHG RSTGGKPPET IDSNYRKIHE 1500

FLNLIPKLLV SRASYNCGEY ARALSYLESY LEEGEDKSQR LLEQFTFLVE VYGSLRDPDS 1560

VEGAVQVRSY DMSVTQDILV NRLVERQQDM ITSYEQLLSS TDQMQPDHVR AMIDAYLRDT 1620

PKTAQLIADG LWQRLSDRYS DQCFAECKSE LLWRLGSYDE MEELQSNWPA QCSQGCLKLR 1680

RPLTTRIEFD SLLDGMRESV LEELRSCSAV QQHSYANAYD AVLKLHLVHE LHCSQELVEK 1740

LEQDRDEDNQ EKLMKNYFDD WQYRLQIVQP QVRIQESIYS FRRNILAELQ RRLTDRNHLL 1800

PHLKTELARI WLNSAQINRN AGQLQRAQLY ILKAAEYQPS GLFIERAKLL WQKGDQVMAM 1860

NYLEEQLSIM RSGCQGNVKQ LAAEQRHLFF RGKYLQAVYS AESMHLCADA VLKYFQEAIA 1920

VHRQSESCHV QMAQFLEKIL EARQGGKSEP TGEQDDMLIN VMVNYAKSLR YGSEHVYQSM 1980

PRLISLWLDT TESSTNTEQV KKMNDLLTNC CTALPTAVFY TVYSQMLSRL CHPVNDVFTV 2040

LRNVIIKLVE AYPQQSLWML LPHFKSAKAH RIKRCKLVLT DSRLQNSTFQ KLLQDFNSLT 2100

ERLMDLTNKE VTLDRTYKLS DLDTRLSKLC KQPEFSQILL PFEKYMQPTL PLNSDSNSSE 2160

GSHLPANQST VNWFPYQQIY ISGFQESVLI LRSAAKPKKL TIRCSDGKDY DVLVKPKDDL 2220

RRDARLMEFN GLVKRYLHQD APARQRRLHI RTYAVLPFNE ECGLVEWLPN LASYRSICMN 2280

LYAQRRLVMS TRQLQSLAVP LHESIERKRE VFTKQLVPAH PPVFQEWLRQ RFATPHSWYE 2340

ARNTYIRTVA VMSMVGYILG LGDRHGENIL FAEGNGDAVH VDFNCLFNQG ELLPYPEVVP 2400

FRLTHNMIVA MGPLGVEGSF RKCCEITLRL LKQESKTLMS ILRPFVYDVG AQTRKGAATA 2460

KITKDVQRIA DRLQGHVKRQ QANSIPLSTE GQVNFLINEA TKVDNLASMY IGWGAFL 2517

Nucleotide Sequence
(FASTA)

ATGTCGACAC AACGGAAGGA TATGTGGAAG TTGCTTTACA ACCACGTAAA CCGGAACGTA 60

AGCAACTTTT CCGGCGTGTA CAGCGTTATA GAAGACATAT TGTGCCAGGA GCCGAGTCTG 120

ATAAGCTGTT CGTTGGTGCG GGAGCTGCAC AACAAATTCC AGGACACATT CCTACTCTGG 180

CTGCTCAACA AGCTGGCCAA GTGCCTTAGT GAATCTCCAG ATAGCAGCGA GTGCATCAAT 240

CTTCAAAGGA AAATACTGAG CTCCTGCTGT TCCAATCATC CTAAGCTTTT TGAACGCCTT 300

GTACTGGCCT ATGTGGAAGC CATTGAGGAG ACGCACCTTC AGCTAAGTTC CCTGGACCTC 360

GGCCAATTGA GTAATGAGCG AAAACCCGCC ATAACTGTAA GAATATTCCG ATGCGATGTG 420

GAATGCCTGC AGGAGTTCGA TCCGCACTGC GCTATCGAGG ACATCAAGGT GCCCCTTGAG 480

CAAGCCGACA TGTATGCCAA GAGCCTGCTG GAGGTCCTCC AGCATGCCCA TCACATTGGA 540

TACGCCACGC ACGGCGACAT CTTCTCGGGC AGCCTTCATC AGGCTCTGCT AATCCTCAAG 600

GAGTGCGACA TGGACACAAA ACTGGCCAGC TTGAATTACT GTCACAATGT CCTACGATCA 660

CAGTCGGCCA GCAGCTGGAT AACAAATCCG GACGTTGGAC ATTATGCGCA ATTAACGTTG 720

GAGGCGACGG CAATCATGTG GTCGGCAGTA GCCAAGTGGC TGGACATGGG ATGTATGACG 780

CGCCAGGAGC TAAAACGGCT CAATATAACA ACAAAGCTAC TGCTAGAAGT TCTGCATATG 840

CGTGCACGTC CAGCCCACCA TCTTGGCTAC CTGCTTTTGA ACGAGATCCT TAGTTTGCCG 900

ACAGCCATTG AATTGGACGA TGGACTGCTG GAGACCCTAA GTTCCTATAT TCAAGGCCAG 960

CTAGAGCATT CGGTTGTACC ATTGGAGCAA CTGGTGCACT TGCAGCAGCT TATGTTAAGC 1020

CATTGGCACT GCCACCCCAC ACATTTGGTG CCCATATTGG CGCTAATGGG CTTGAAACAG 1080

ACTGAGATGC GCTCAGGAGT GGTCCAAGTG CTTACCCAAA GTCTCGTTGA AATCTTGAAG 1140

AAGGAAGAAG TATTGTCGAA GGATTGGCAG AAACTGATTG CTATTTTACG AGGCTTCAAG 1200

CAGCTGGAGA AACTAATTCT GTCACAGAGT CAGCATAAAA TAGCTGAGCA CGAAGGTCAC 1260

ATCGATTCCT CAGTTCTGGC CATGTTACCG CTGCAGTGTG AAATCATAAA GGTTGCGGAT 1320

ACCAATTGGA ATAACCTTTC AATGCAGCTG GTTGAGCTGG AATCAAAGTG TTCCGCAGAC 1380

CGAAGACACA TACACTTGGA AATCTGCTCC CTTTTGATGC AAATCACCTT CATCCGGCAC 1440

TTTTTAAAGA CTCAAACGCA ACACCAGCTG CTGGCCATTC TTCAGCGACA TTTGAAGCTG 1500

TCCTACCTTT GCGCCATTCG CTTGGAGACA CCTTCTAGTG TTCATACCCA AATGCAAAGC 1560

TTCTATGCCC AGCAGTACAT GAGGCTATTT CAATCCGAGG AGACACAGGA GATATTCTGT 1620

AGCAACCTTC CGCAGTTGTA CATATCGGGT TTCATAAAGC CGGAGCAACT GATGAAAGCT 1680

CTGCCCACCA TTAACAATCG TAGTGGCCGC GCTCAAGTTA TACGCCTATT GCTCTGCTCC 1740

CAGCCAGGTA AATTGAGTGT CTTTAAAGTC AAAGATCGCA TTGAGCTATA CTGCCCGAAA 1800

TGCAGGCCAC TGCCAAAGAA ACTGCCAGGT ATTTACCTCG GAAAATGCAA GCAACAGCTG 1860

CCATGTCCAG ACTTTTCAAG CACCAACCTC GAAATGATAG CAAATGATTT ATTGTTTTAT 1920

CCCGATTTTG AATGTATTGC CCAGCATCTG GACCTTCTGT GCTTTGAACC CAATGTGATT 1980

CTTGGCCTGC TAAGAGAAAC GGAGGCACTG CAAAAGGTTA GCGTTAAGGT TATCGGCCAG 2040

CTGGTCTCTG CGATGCGTGT GCGTTCGCCA GAATTCTTGG AGCAATTAGC CAATCTTGTT 2100

CTAGCTGCTA TAAAAGCAAT GCTAGCAAAG CCACTGACAG AGCAAAATGT GCTGCAGCAA 2160

AGAAGTATGC TCAACGTACT GACCGCCATT GCGCACATGG AGGATAATGA AATCTGGCTC 2220

TTTCACTGGT TCAAAATGAC ATTCTTCTTT CTGGTGCACA CTCGCTCACT GGTGGCGCAA 2280

GAAGCTGTGC TGGCGGCCAC CGAGATGTGT GCCAGCCAGG GTCTGCAGAC GATTCATCTG 2340

TGGAACTGGT ACAAGCGAGA TGCTCTCGAC CTCACCGTTC GCCTGGCTTT GAACGTTTAT 2400

CTTTTGGATG GCGTACGCTT CACCCGATCC CTCCGAGCGC TTACGAAAAT GTTGGGATTC 2460

ACGTGCGTTC AGGAGTTCAC CTGCAAGTAT CATCGCCTTC TGACTGCCAT GGTCCTGCCG 2520

CATTGCATCG TGAATCCGCT TTGCAAGGGA GTTTTGGTAT TGATAGCCAA ACAAATGCAG 2580

AAACACATTG GCACCTTGTT CTCCATCTCG TTCCTGCGGA TCTACACACA CGTCTTCCTG 2640

ACCGAGGAAC CGGAGTTGGC CAATAGTTGC ATCGAGCTGG TGGTCAGTTG CACCCAGTCC 2700

AGCCTGCAAC AGCTAATGAA TGCGGATGTC AAGCAAACGG TGGCCGAGTT GCTTATATAT 2760

TTCAACCGAA ACCCCACATT CGTGATGCGA TCCTTTCAAA GCCTCTTGCA GTTATCAATC 2820

GGTTCCTTGG AGGAGTTGTC AAGTCAAACG GCGAATGCAG AGTTTGCGAA TTTCATTGCT 2880

GAGCGTTTCC TCGGTGTGAT CACCTACTTC GAGAGCTGCC TAAGTGAACC GTCTTTTGAG 2940

AAGCCATTGA AGGAGGAGAC TTTGTACAGT TTGGGCCAGA TTATGCGATT TGTGGGCTCC 3000

CAGCATGTCA CCCAGTTTCG CTTCAAAATC ATTGCCATGC TGAGTTTCGT TCACACATTG 3060

CAGGAGCCTC GTCTCCAGCG AATTTGCCTA AAGATTTGGC ACATATTTCT GCATGTTGTA 3120

AATGTGCAGG AGCTGGGACC CTCTCTGGGA AGAATCGTGG CCACCTTGCA GCCTCTGCTG 3180

GCGGACAACG AGAGCGTTAA GCAGGTCAAT GATCTGTACG AGTTCATAAT TCTACGCAAC 3240

GCCTCCATGC TGGGCACCTT TATAACAGAT CTGTACTTTC TAGATCGCAT GGAGAATGTT 3300

TCGCCTTCGA TTCAAAAATG CATCAGAAGG CATACAGCCC ATCTGGACCT TAAGGGATTG 3360

GCGGAGGAGG AGAATCAATC GCCACCATTG GTCGACCAGT TGCGTTTCCT GCAAAAGCAC 3420

ATAACCGATG AATGTCTCCA GGTACGCGTC TATGCCCTCC AACATCTTGG CGATCTGTTC 3480

GGCAGGCGAC GACCCAAGCT AAACAGTACG ATTCTCAGTG AACTACCTCT GGAGCCAATG 3540

CTGGAGCAGA TCGTGAATGT CCTAATGGCC GGATGTCAGC ACGATGACAG CCAACTGCAA 3600

ATGGCATCGG CCAAGTGTCT CGGAGAACTG GGAGCCATCG ATGCAAGTTA CCTGCCCTCG 3660

AACTATAATT TTGCCAGTCC ACAGCATTTG CCGCTCAACA TTTTATCAGA TGATTTTGCG 3720

GTTCTGGCGC TGACTTCGCT GTGCCGTGGC TATCAGTTCC AACAGAATAC AAAGCACGTG 3780

GATAGCTTTT CGCTGGCCAT TCAGGAGACG CTAGCCATTT GTGGCATCTC GCCCAAGGAG 3840

CAGAAGAAGG TTCAGCTGTG GCAATCGCTG CCAGCACGAA TGCGTCAGCT GATGGAACCG 3900

ATGCTTCATT CCTGTTACAC CTGTGTCCAT CGACCCAGCA CTTGTCTACA GCAGCCGCTC 3960

TTTGGGAGCC ACTACTCTCA CAACTATTAT GAGGAATGGG CCTTTCTTTG GGCAAGTCGA 4020

TTGATTGACT ACCTCCCATC CTCGGGAAGG CGCCATCTGC TCAGCTCCTA CAAGCCGTGC 4080

ATCAAGCGGG ATAGTAACAT GCTCAGCACA TTCTATCCGT ATATTCTGTT ACACGCACTG 4140

CTTGAATGCA CGACGGAGCA GAGGAATCAC ATCCAGGAGG AGTTCATGGC AGTTCTGCAA 4200

GCCAACGAGG AAAGCTCGAG CTCAGTCAGG GGCCGCCAGG AGCTTGGAGC CATTAAGGAA 4260

AATGCCTTCA AGCAATTCGA GTCTAGAAAG TATGCCGCTG GTATCAAGCC ACTGGCGAGC 4320

ACTTTGGTTT CGGATCGTAA GGAAGATTCG AGCCGTGTTC CTCGCCTGGC TGGCAAGCTG 4380

TGCGCCGAAC TCTTGGATTT CCTGCAGCGC TGGCTAAGGG AATGGCAGAG AATTCATGGC 4440

CGGAGCACCG GCGGAAAGCC ACCCGAGACG ATAGATTCTA ACTATCGAAA GATCCATGAG 4500

TTTCTCAATC TGATACCCAA GCTATTGGTA TCACGAGCCA GCTACAATTG CGGCGAATAT 4560

GCTCGTGCGC TTAGCTACCT GGAGAGCTAT CTGGAGGAGG GCGAGGACAA ATCGCAGAGG 4620

TTGTTGGAGC AATTCACATT CCTCGTTGAA GTGTACGGCT CACTCAGGGA CCCCGATTCT 4680

GTGGAGGGAG CCGTGCAGGT TCGCAGCTAC GACATGAGTG TGACGCAAGA CATTCTCGTC 4740

AATCGACTGG TGGAGCGGCA GCAGGACATG ATCACCTCGT ACGAACAGCT GCTCTCCAGC 4800

ACGGACCAGA TGCAGCCGGA TCACGTACGC GCCATGATCG ATGCATATTT GAGGGACACC 4860

CCGAAGACAG CTCAGCTAAT CGCCGACGGT CTTTGGCAGC GACTGTCCGA TCGGTATTCC 4920

GATCAGTGCT TCGCCGAGTG CAAGTCAGAG TTACTCTGGC GCCTGGGTAG CTATGATGAG 4980

ATGGAGGAGC TGCAGTCCAA TTGGCCAGCT CAGTGTTCGC AAGGCTGTCT AAAGCTGCGT 5040

AGGCCACTAA CCACGCGTAT CGAATTCGAC TCGTTGCTGG ACGGGATGCG CGAATCGGTG 5100

CTGGAGGAGC TGCGTAGCTG CTCGGCAGTA CAGCAGCACT CGTATGCCAA TGCGTACGAT 5160

GCTGTGTTGA AACTTCACTT GGTGCATGAA CTGCACTGCA GCCAGGAGCT TGTGGAGAAG 5220

CTCGAACAGG ATCGGGATGA GGACAATCAG GAGAAGCTAA TGAAGAATTA CTTCGACGAC 5280

TGGCAGTATC GCTTGCAGAT TGTACAACCG CAGGTTCGCA TCCAGGAGTC TATATACAGC 5340

TTTCGGCGTA ATATACTGGC TGAGCTTCAA CGCCGCCTGA CAGATCGTAA CCATTTGCTG 5400

CCCCATCTCA AGACGGAGCT GGCCAGAATC TGGCTAAATA GTGCGCAAAT CAATCGCAAT 5460

GCCGGTCAAC TTCAGCGTGC GCAGCTTTAT ATACTCAAGG CGGCGGAATA TCAGCCGTCG 5520

GGGCTCTTCA TCGAGCGCGC TAAGCTTCTG TGGCAAAAGG GTGATCAGGT GATGGCCATG 5580

AACTATCTGG AGGAGCAGCT ATCGATCATG CGATCGGGTT GCCAGGGCAA TGTGAAGCAG 5640

CTTGCAGCGG AGCAACGACA TCTCTTCTTT CGCGGAAAGT ACTTGCAGGC CGTATATAGT 5700

GCCGAGTCCA TGCACCTGTG CGCGGATGCA GTACTGAAGT ATTTTCAAGA GGCCATCGCT 5760

GTGCATCGCC AATCGGAGAG CTGCCACGTA CAGATGGCGC AATTTTTGGA GAAGATACTC 5820

GAAGCCAGGC AGGGCGGCAA GTCGGAGCCC ACTGGCGAGC AGGACGATAT GCTGATCAAT 5880

GTGATGGTCA ACTATGCCAA GTCCCTGCGC TATGGCAGCG AGCATGTGTA TCAGTCCATG 5940

CCTCGACTGA TCAGCCTCTG GCTGGACACC ACCGAGAGTT CCACAAACAC CGAGCAGGTG 6000

AAGAAGATGA ACGATTTGCT GACAAACTGC TGCACCGCAC TGCCGACGGC GGTGTTCTAT 6060

ACGGTGTACT CTCAGATGCT GAGTCGCCTC TGTCACCCCG TGAACGATGT GTTCACTGTT 6120

CTCCGTAATG TGATAATCAA ACTGGTGGAG GCATATCCGC AACAGTCGCT GTGGATGCTC 6180

TTGCCGCATT TCAAGTCGGC CAAGGCGCAC AGGATTAAGC GCTGCAAGTT GGTGCTCACC 6240

GACAGCCGCC TGCAGAATTC CACATTCCAA AAGCTCCTGC AAGACTTTAA TTCGCTCACA 6300

GAGCGTCTCA TGGATCTCAC CAACAAGGAG GTGACACTGG ATCGCACGTA TAAGTTGAGT 6360

GATCTGGACA CTCGCCTCTC TAAGCTATGC AAACAGCCAG AATTTTCGCA AATACTTCTT 6420

CCCTTTGAGA AGTACATGCA GCCAACGCTG CCACTAAATT CCGACTCCAA TTCAAGTGAG 6480

GGATCGCATC TTCCGGCAAA CCAATCGACC GTCAACTGGT TTCCCTACCA GCAGATCTAC 6540

ATCAGTGGCT TCCAGGAGTC AGTGCTAATC CTGCGCTCGG CAGCAAAGCC CAAGAAGCTG 6600

ACCATTCGCT GTAGCGATGG CAAGGACTAC GATGTTCTGG TGAAGCCCAA GGATGATTTG 6660

CGTCGAGATG CTCGCCTGAT GGAGTTCAAT GGTCTGGTCA AGCGATATCT GCATCAGGAT 6720

GCACCGGCCA GGCAGCGGCG CCTTCACATC CGTACATATG CCGTGCTGCC GTTTAACGAG 6780

GAGTGCGGCC TGGTCGAGTG GCTGCCCAAT CTGGCGTCGT ACCGAAGTAT CTGTATGAAC 6840

CTGTACGCTC AGCGAAGGCT GGTGATGTCC ACCCGACAGC TGCAGAGTCT GGCTGTGCCT 6900

CTGCACGAAT CGATAGAGCG CAAGCGAGAG GTCTTCACCA AGCAGCTGGT ACCTGCCCAT 6960

CCGCCGGTCT TTCAGGAGTG GCTGCGCCAA CGCTTCGCCA CTCCGCACAG TTGGTACGAG 7020

GCGAGAAATA CGTATATTCG TACCGTGGCC GTTATGTCCA TGGTGGGATA TATCCTCGGC 7080

CTGGGCGATC GCCACGGCGA GAACATCCTG TTCGCCGAGG GCAACGGCGA CGCTGTCCAC 7140

GTGGACTTCA ATTGCCTGTT CAATCAGGGC GAGCTGCTTC CCTATCCGGA GGTGGTGCCC 7200

TTCCGTCTCA CACATAACAT GATCGTTGCC ATGGGTCCGC TGGGCGTCGA GGGCAGCTTT 7260

CGCAAGTGCT GCGAGATTAC GCTGCGTCTG CTGAAGCAGG AGTCCAAGAC CCTGATGTCC 7320

ATTCTGCGTC CCTTTGTCTA CGATGTGGGG GCACAGACGC GTAAAGGCGC CGCCACGGCC 7380

AAAATAACAA AGGATGTGCA GCGCATCGCC GATCGCCTGC AAGGACACGT TAAACGACAG 7440

CAGGCGAACA GCATTCCGCT TTCGACCGAA GGACAGGTGA ACTTCCTCAT CAATGAGGCC 7500

ACCAAGGTGG ACAACCTGGC GTCCATGTAC ATTGGCTGGG GAGCGTTTCT TTGA 7554

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i gf+e+v il s  kpkkl++r sdgk y  Lvk+k+Dlr+d+r++++++lv  +L++d

Q: 2181  ISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQD  2240

         789*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +  ++r+L+irty+V p ++++gl+ew++n +s + +  +l++++   ++      + +l

Q: 2241  APARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMS------TRQL  2294

         *****************************************999999998......3333

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         +   a   + +   ++ evf + l + +p+ +++++l + f +p +w+e r+ y r +Av

Q: 2295  QSL-AVPLHESIERKR-EVFTKQLVPAHPP-VFQEWLRQRFATPHSWYEARNTYIRTVAV  2351

         333.333333334444.8***********8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+++  g  vh+df++ f++++  l+ pe vPFRLT+n++ a

Q: 2352  MSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGEL-LPYPEVVPFRLTHNMIVA  2410

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeela  298

         +g++gveG fr++ce +lr+l+++ ++l++iL  f+yd   + +k  +t k+t+ +

Q: 2411  MGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVGAQTRKGAATAKITKDVQR  2468

         **************************************88888875555555555444

Domain Sequence
(FASTA)

ISGFQESVLI LRSAAKPKKL TIRCSDGKDY DVLVKPKDDL RRDARLMEFN GLVKRYLHQD 60

APARQRRLHI RTYAVLPFNE ECGLVEWLPN LASYRSICMN LYAQRRLVMS TRQLQSLAVP 120

LHESIERKRE VFTKQLVPAH PPVFQEWLRQ RFATPHSWYE ARNTYIRTVA VMSMVGYILG 180

LGDRHGENIL FAEGNGDAVH VDFNCLFNQG ELLPYPEVVP FRLTHNMIVA MGPLGVEGSF 240

RKCCEITLRL LKQESKTLMS ILRPFVYDVG AQTRKGAATA KITKDVQR 288

Keyword

ATP-binding; Complete proteome; Developmental protein; DNA damage; DNA repair; DNA-binding; Kinase; Manganese; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007015	; P:actin filament organization
GO:0007349	; P:cellularization
GO:0030261	; P:chromosome condensation
GO:0045002	; P:double-strand break repair via single-strand annealing
GO:0045003	; P:double-strand break repair via synthesis-dependent strand annealing
GO:0001700	; P:embryonic development via the syncytial blastoderm
GO:0016321	; P:female meiosis chromosome segregation
GO:0007444	; P:imaginal disc development
GO:0007133	; P:meiotic anaphase I
GO:0000706	; P:meiotic DNA double-strand break processing
GO:0033314	; P:mitotic cell cycle DNA replication checkpoint
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0048477	; P:oogenesis
GO:0007131	; P:reciprocal meiotic recombination
GO:0008360	; P:regulation of cell shape
GO:0007088	; P:regulation of mitosis
GO:0007348	; P:regulation of syncytial blastoderm mitotic cell cycle
GO:0009314	; P:response to radiation
GO:0000723	; P:telomere maintenance

KEGG

dme:Dmel_CG4252

;

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013