EKS-DRM-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.82.5E-130248500253
StatusReviewed
Ensembl ProteinFBpp0085320
UniProt AccessionQ9V9J3; O18369; Q0E9P0; Q26297; Q94879;
Protein NameTyrosine-protein kinase Src42A
Protein Synonyms/Alias Tyrosine-protein kinase Src41; Dsrc41;
Gene NameSrc42A
Gene Synonyms/Alias Src42A; Src41, TK5; CG7873;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0004603FBpp0085320FBtr0085967
FBgn0004603FBpp0085321FBtr0085968
OrganismDrosophila melanogaster
Functional DescriptionEssential for correct eye morphogenesis (ommatidial R7neuron formation), this requires the Ras1/MAPK signal transduction pathway. May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia.
Protein Length517
Protein Sequence
(FASTA)
MGNCLTTQKG EPDKPADRIK LDDPPTIGVG VGVPQIPMPS HAGQPPEQIR PVPQIPESET 60
AGANAKIFVA LYDYDARTDE DLSFRKGEHL EILNDTQGDW WLARSKKTRS EGYIPSNYVA 120
KLKSIEAEPW YFRKIKRIEA EKKLLLPENE HGAFLIRDSE SRHNDYSLSV RDGDTVKHYR 180
IRQLDEGGFF IARRTTFRTL QELVEHYSKD SDGLCVNLCK PCVQIEKPVT EGLSHRTRDQ 240
WEIDRTSLKF VRKLGSGQFG DVWEGLWNNT TPVAIKTLKS GTMDPKDFLA EAQIMKKLRH 300
TKLIQLYAVC TVEEPIYIIT ELMKHGSLLE YLQAIAGKGR SLKMQTLIDM AAQIAAGMAY 360
LESQNYIHRD LAARNVLVGD GNIVKIADFG LARLIKEDEY EARVGARFPI KWTAPEAANY 420
SKFSIKSDVW SFGILLTELV TYGRIPYPGM TNAEVLTQVE HGYRMPQPPN CEPRLYEIML 480
ECWHKDPMRR PTFETLQWKL EDFYTSDQSD YKEAQAY 517
Nucleotide Sequence
(FASTA)
ATGGGTAACT GCCTCACCAC ACAGAAGGGC GAACCCGACA AGCCCGCAGA TCGAATCAAG 60
CTGGACGACC CGCCCACCAT CGGAGTCGGA GTGGGCGTGC CACAAATCCC CATGCCCTCA 120
CACGCCGGAC AGCCACCGGA GCAGATACGT CCGGTTCCCC AGATCCCGGA GAGCGAAACG 180
GCAGGTGCCA ACGCCAAGAT TTTTGTCGCC CTCTACGACT ACGACGCCCG CACCGACGAG 240
GATTTGAGCT TCCGCAAGGG AGAGCACTTG GAGATACTGA ATGACACGCA GGGTGACTGG 300
TGGCTGGCGC GGAGCAAGAA GACACGTTCG GAAGGCTACA TTCCATCCAA TTATGTGGCC 360
AAGTTGAAAT CAATCGAAGC AGAACCCTGG TACTTCCGCA AAATCAAACG CATTGAGGCT 420
GAGAAAAAAC TTCTACTGCC AGAGAACGAG CACGGTGCAT TTTTAATTCG CGATTCCGAA 480
AGCCGTCACA ACGACTACTC GCTATCAGTG CGCGATGGCG ATACGGTTAA GCATTATCGC 540
ATCAGACAAT TGGACGAAGG CGGCTTCTTC ATCGCCAGGC GCACGACATT CAGAACCCTT 600
CAGGAGCTGG TGGAACACTA TTCGAAGGAC TCTGATGGCC TATGCGTCAA CCTCTGCAAG 660
CCGTGTGTCC AGATCGAGAA GCCTGTAACT GAGGGGCTTT CGCACCGCAC TCGCGATCAG 720
TGGGAGATCG ACAGAACGTC TTTGAAATTC GTGCGCAAAC TGGGCTCCGG ACAGTTTGGC 780
GATGTCTGGG AGGGATTGTG GAACAACACA ACACCTGTGG CAATTAAAAC TCTGAAATCT 840
GGTACAATGG ACCCCAAGGA TTTCTTAGCG GAAGCCCAGA TCATGAAGAA ACTGCGCCAC 900
ACCAAGCTTA TACAGTTGTA CGCTGTCTGC ACTGTTGAGG AGCCTATCTA TATTATCACA 960
GAGTTAATGA AGCACGGTTC ACTGTTGGAA TATCTCCAAG CCATTGCAGG CAAGGGTCGT 1020
AGCCTTAAAA TGCAAACTCT GATTGATATG GCAGCGCAAA TAGCTGCTGG CATGGCTTAC 1080
TTGGAGTCCC AGAATTATAT TCATAGGGAT TTAGCGGCGC GCAATGTACT GGTAGGCGAT 1140
GGAAACATCG TCAAAATCGC CGACTTTGGT TTAGCTAGGC TCATCAAGGA GGACGAATAC 1200
GAGGCGCGGG TAGGCGCCAG ATTTCCCATA AAATGGACCG CTCCAGAGGC TGCTAACTAC 1260
AGCAAATTCT CAATAAAATC GGATGTTTGG AGCTTTGGCA TTCTTCTCAC AGAACTGGTC 1320
ACCTACGGAC GCATACCATA TCCAGGCATG ACCAACGCTG AGGTGCTAAC GCAAGTGGAG 1380
CACGGCTATC GAATGCCGCA ACCTCCCAAC TGCGAGCCGC GCCTGTATGA GATTATGCTG 1440
GAATGTTGGC ACAAGGACCC CATGCGCAGA CCCACGTTTG AGACGCTACA ATGGAAACTG 1500
GAAGACTTCT ATACATCTGA TCAGAGCGAC TACAAAGAGG CGCAGGCCTA CTGA 1554
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lk+v+klG+GqfG+vw+g+w+++++va+ktlk+gt++p++fl+eaqi+kklrh+kl++ly
Q: 248   LKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLY  307
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflk..eeegkklklpklvdlaaqvaeGmayleeknli  118
         av++ eePiyi+telm++Gsll++l+    +g++lk+++l+d+aaq+a+Gmayle++n+i
Q: 308   AVCTVEEPIYIITELMKHGSLLEYLQaiAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYI  367
         **************************44467889**************************
S: 119   hrdlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiks  178
         hrdlaarnvlvg+ ++vk+adfGlarli++dey+a+ ga++PikWtaPea++++kf+iks
Q: 368   HRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKS  427
         ************************************************************
S: 179   dvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdp  238
         dvWsfGillte+vt+G++PypGmtn+evl+qve+gyr+p+p +c+ +lye++lecw+kdp
Q: 428   DVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDP  487
         ************************************************************
S: 239   eerPtfetlqevl  251
          +rPtfetlq++l
Q: 488   MRRPTFETLQWKL  500
         **********986
Domain Sequence
(FASTA)
LKFVRKLGSG QFGDVWEGLW NNTTPVAIKT LKSGTMDPKD FLAEAQIMKK LRHTKLIQLY 60
AVCTVEEPIY IITELMKHGS LLEYLQAIAG KGRSLKMQTL IDMAAQIAAG MAYLESQNYI 120
HRDLAARNVL VGDGNIVKIA DFGLARLIKE DEYEARVGAR FPIKWTAPEA ANYSKFSIKS 180
DVWSFGILLT ELVTYGRIPY PGMTNAEVLT QVEHGYRMPQ PPNCEPRLYE IMLECWHKDP 240
MRRPTFETLQ WKL 253
KeywordATP-binding; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00339
EKS-ANC-00361
EKS-BOT-00373
EKS-CAE-00300
EKS-CAJ-00369
EKS-CAF-00374
EKS-CAP-00398
EKS-CHH-00039
EKS-CII-00205
EKS-CIS-00121
EKS-DAR-00746
EKS-DAN-00035
EKS-DIO-00056
EKS-EQC-00362
EKS-ERE-00054
EKS-FEC-00360
EKS-GAM-00219
EKS-GAG-00315
EKS-GAA-00454
EKS-GOG-00362
EKS-HOS-00371
EKS-ICT-00346
EKS-LAC-00387
EKS-LOA-00374
EKS-MAM-00371
EKS-MAE-00042
EKS-MEG-00305
EKS-MIM-00048
EKS-MOD-00354
EKS-MUM-00405
EKS-MUP-00367
EKS-MYL-00364
EKS-NOL-00340
EKS-OCP-00073
EKS-ORN-00481
EKS-ORA-00320
EKS-ORC-00343
EKS-ORL-00432
EKS-OTG-00376
EKS-PAT-00351
EKS-PES-00330
EKS-PEM-00197
EKS-POA-00362
EKS-PRC-00071
EKS-PTV-00093
EKS-RAN-00387
EKS-SAH-00343
EKS-SOA-00006
EKS-SUS-00326
EKS-TAG-00444
EKS-TAR-00477
EKS-TAS-00041
EKS-TEN-00468
EKS-TUB-00053
EKS-TUT-00100
EKS-VIP-00051
EKS-XET-00486
EKS-XIM-00460
Gene Ontology
GO:0005912; C:adherens junction
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0051017; P:actin filament bundle assembly
GO:0034332; P:adherens junction organization
GO:0043277; P:apoptotic cell clearance
GO:0048749; P:compound eye development
GO:0007395; P:dorsal closure, spreading of leading edge cells
GO:0090136; P:epithelial cell-cell adhesion
GO:0046529; P:imaginal disc fusion, thorax closure
GO:0007476; P:imaginal disc-derived wing morphogenesis
GO:0007254; P:JNK cascade
GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007424; P:open tracheal system development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0007435; P:salivary gland morphogenesis
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0006099; P:tricarboxylic acid cycle
KEGG
dme:Dmel_CG7873;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013