EKS-DRM-00087
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00087
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC420.14.8E-126371629259
StatusReviewed
Ensembl ProteinFBpp0086196
UniProt AccessionP13677; Q9V7V5;
Protein NameProtein kinase C, eye isozyme
Protein Synonyms/Alias Eye-PKC; Inactivation no after-potential C protein; Protein INAC; Photoreceptor-specific PKC; dPKC53E(EY);
Gene NameinaC
Gene Synonyms/Alias inaC; PKC2; CG6518;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0004784FBpp0086196FBtr0087047
OrganismDrosophila melanogaster
Functional DescriptionThis is a calcium-activated, phospholipid-dependent,serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD.
Protein Length700
Protein Sequence
(FASTA)
MAAAAVATPG ATVLPPSVPS AAPGAKAPAA GAGKGPGNLL EITGEANIVN YMKNRLRKGA 60
MKRKGLEMVN GHRFGVRFFK NPTYCGHCKD FIWGFGKQGF QCEECRFNIH QKCCKFVVFK 120
CPGKDTDFDA DCAKVKHGWI STTYTTPTFC DECGLLLHGV AHQGVKCENC NLNVHHACQE 180
TVPPMCGADI SEVRGKLLLY VELKGNNLKV DIKEAANLIP MDTNGFSDPY IAVQMHPDRS 240
GRTKKKTKTI QKNLNPVFNE TFTFELQPQD RDKRLLIEVW DWDRTSRNDF MGSFSFSLEE 300
LQKEPVDGWY KFLSQVEGEH YNIPCVDAFN DIARLRDEVR HDRRPNEKRR MDNKDMPHNM 360
SKRDMIRAAD FNFVKVIGKG SFGKVLLAER RGTDELYAVK VLRKDVIIQT DDMELPMNEK 420
KILALSGRPP FLVSMHSCFQ TMDRLFFVME YCKGGDLMYH MQQYGRFKES VAIFYAVEVA 480
IALFFLHERD IIYRDLKLDN ILLDGEGHVK LVDFGLSKEG VTERQTTRTF CGTPNYMAPE 540
IVSYDPYSIA ADWWSFGVLL FEFMAGQAPF EGDDETTVFR NIKDKKAVFP KHFSVEAMDI 600
ITSFLTKKPN NRLGAGRYAR QEITTHPFFR NVDWDKAEAC EMEPPIKPMI KHRKDISNFD 660
DAFTKEKTDL TPTDKLFMMN LDQNDFIGFS FMNPEFITII 700
Nucleotide Sequence
(FASTA)
ATGGCTGCGG CTGCTGTTGC CACACCGGGG GCCACTGTGC TCCCTCCCTC GGTGCCCAGT 60
GCCGCTCCAG GGGCCAAGGC TCCAGCGGCT GGAGCTGGCA AAGGTCCAGG AAATCTACTG 120
GAGATCACTG GCGAAGCAAA TATCGTCAAC TATATGAAGA ATCGTCTAAG GAAGGGTGCG 180
ATGAAGCGAA AGGGTCTCGA AATGGTCAAT GGTCATCGTT TCGGAGTTAG ATTCTTTAAG 240
AATCCAACCT ACTGCGGTCA TTGCAAGGAT TTCATCTGGG GCTTTGGCAA GCAAGGTTTT 300
CAGTGCGAGG AATGCCGCTT CAACATTCAC CAGAAGTGCT GTAAATTTGT GGTGTTCAAA 360
TGTCCTGGCA AGGACACGGA CTTCGATGCC GACTGCGCTA AGGTGAAGCA CGGCTGGATT 420
TCCACCACCT ACACCACACC GACATTCTGC GACGAGTGCG GACTGCTGCT CCATGGAGTC 480
GCCCATCAGG GCGTCAAGTG CGAGAATTGC AACCTAAATG TGCATCACGC CTGCCAGGAG 540
ACAGTGCCAC CGATGTGTGG TGCGGACATC AGCGAGGTGA GGGGTAAACT ACTGCTATAC 600
GTCGAGCTTA AGGGCAATAA CTTGAAAGTT GATATTAAGG AGGCAGCTAA CCTCATTCCC 660
ATGGATACCA ACGGGTTTAG CGATCCCTAT ATTGCAGTGC AAATGCATCC GGACCGTTCG 720
GGGCGCACCA AAAAGAAGAC CAAGACCATT CAGAAAAACC TCAATCCAGT GTTCAACGAG 780
ACTTTTACTT TTGAGTTGCA GCCGCAGGAC CGTGACAAGC GTTTGCTCAT CGAGGTTTGG 840
GATTGGGATC GAACTTCTCG CAATGATTTC ATGGGATCGT TCTCGTTCAG CCTGGAGGAA 900
CTGCAAAAGG AGCCAGTTGA TGGCTGGTAT AAGTTTCTGT CGCAAGTGGA GGGTGAACAT 960
TATAACATAC CCTGTGTGGA TGCCTTTAAT GATATAGCTC GCTTAAGGGA TGAAGTTAGG 1020
CACGATCGTC GTCCGAATGA AAAGCGTCGC ATGGACAACA AGGATATGCC GCATAATATG 1080
AGCAAACGCG ATATGATTCG AGCTGCTGAT TTCAACTTTG TTAAAGTTAT TGGCAAGGGA 1140
TCCTTTGGCA AAGTCCTGCT GGCCGAGCGT CGTGGCACGG ATGAGCTGTA TGCCGTGAAG 1200
GTCCTGCGAA AGGATGTCAT TATCCAAACG GACGATATGG AGCTGCCAAT GAATGAGAAG 1260
AAAATTCTAG CCCTATCCGG ACGTCCTCCT TTCCTCGTCT CCATGCACTC ATGTTTCCAG 1320
ACTATGGACC GATTATTCTT CGTAATGGAG TACTGTAAGG GTGGAGATCT TATGTACCAT 1380
ATGCAGCAGT ATGGAAGGTT CAAGGAGTCT GTGGCTATTT TTTACGCTGT GGAAGTGGCT 1440
ATTGCTCTGT TTTTCCTCCA CGAGCGTGAT ATTATCTATA GAGATCTAAA GCTGGACAAC 1500
ATTTTGCTGG ATGGTGAGGG GCATGTAAAG CTGGTCGACT TTGGATTGAG CAAAGAGGGC 1560
GTTACCGAGC GGCAGACCAC ACGAACCTTT TGTGGTACTC CAAATTATAT GGCTCCCGAA 1620
ATTGTTAGCT ACGATCCGTA TTCCATCGCC GCTGATTGGT GGTCTTTTGG TGTATTGCTT 1680
TTCGAATTCA TGGCAGGTCA GGCTCCATTC GAAGGAGATG ATGAAACTAC TGTCTTTAGG 1740
AACATAAAGG ACAAGAAGGC GGTGTTTCCA AAGCATTTCA GCGTGGAGGC CATGGATATA 1800
ATAACGAGCT TCCTGACCAA AAAGCCCAAC AATAGATTGG GTGCAGGCCG CTATGCCAGA 1860
CAGGAGATTA CCACGCATCC TTTCTTCCGG AATGTGGACT GGGATAAGGC AGAGGCATGC 1920
GAAATGGAGC CACCTATTAA GCCAATGATT AAACATCGCA AGGATATAAG CAACTTTGAT 1980
GATGCCTTTA CCAAGGAGAA GACGGACTTA ACTCCAACGG ACAAGCTTTT TATGATGAAT 2040
TTGGACCAGA ACGATTTTAT CGGATTTTCT TTCATGAATC CCGAGTTTAT AACCATCATT 2100
TAA 2103
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kv+GkGsfgkvllae+++tdelya+kvl+kdv++q+dd+el + ek++lal+ ++p
Q: 371   FNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPP  430
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv+++scfqt+drlffv+ey++GGdlm+h+q+++++ke+ a fya+e+++al+flhe++
Q: 431   FLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERD  490
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldn+lld eGh+kl+dfGl+ke+++e++tt+tfcGtP+y+aPei+++++y+ +
Q: 491   IIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIA  550
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
          dww++Gvll+e++agq+Pfeg+de ++f++i++k++++Pk++s+ea++i++++ltk+p+
Q: 551   ADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPN  610
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         +rlG+ + ++++i++h+ff
Q: 611   NRLGAGRYARQEITTHPFF  629
         ******************9
Domain Sequence
(FASTA)
FNFVKVIGKG SFGKVLLAER RGTDELYAVK VLRKDVIIQT DDMELPMNEK KILALSGRPP 60
FLVSMHSCFQ TMDRLFFVME YCKGGDLMYH MQQYGRFKES VAIFYAVEVA IALFFLHERD 120
IIYRDLKLDN ILLDGEGHVK LVDFGLSKEG VTERQTTRTF CGTPNYMAPE IVSYDPYSIA 180
ADWWSFGVLL FEFMAGQAPF EGDDETTVFR NIKDKKAVFP KHFSVEAMDI ITSFLTKKPN 240
NRLGAGRYAR QEITTHPFF 259
KeywordATP-binding; Calcium; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Sensory transduction; Serine/threonine-protein kinase; Transferase; Vision; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0016027; C:inaD signaling complex
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0016062; P:adaptation of rhodopsin mediated signaling
GO:0019722; P:calcium-mediated signaling
GO:0006928; P:cellular component movement
GO:0016059; P:deactivation of rhodopsin mediated signaling
GO:0050962; P:detection of light stimulus involved in sensory perception
GO:0008585; P:female gonad development
GO:0006911; P:phagocytosis, engulfment
GO:0030845; P:phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0045471; P:response to ethanol
GO:0007601; P:visual perception
KEGG
dme:Dmel_CG6518;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013