EKS-DRM-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	288.0	1.0E-85	893	1148	256

Status

Reviewed

Ensembl Protein

FBpp0073313

UniProt Accession

Q24592; Q712V3; Q8SZI9; Q9VYZ7;

Protein Name

Tyrosine-protein kinase hopscotch

Protein Synonyms/Alias

Gene Name

hop

Gene Synonyms/Alias

hop; HD-160; CG1594;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0004864	FBpp0073313	FBtr0073457

Organism

Drosophila melanogaster

Functional Description

Tyrosine kinase of the non-receptor type, phosphorylatesthe marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner.

Protein Length

1177

Protein Sequence
(FASTA)

MALANGGEDR MDDSSSGRTS LADSASLTNS SLRSGTSSQS IHTNDGTIRV FNFTTGEFER 60

FHPNMLCEEI CNTMCRQLGI APIAQLLYGI REHSTSRRPS PLVRLDLTWC LPGERLNCQL 120

VYCFRMRFRV PELDSQLELI DGRSHKFLYR QMRYDMRTEQ IPEIRYPEHK DKSTGLAVMD 180

MLIDDQEQSE DQQAMRSIEK LYKLYLPPSL WRAHSFFVGS KIREVFRSLK ANSLSVERLK 240

WHYVHQVSHL APTYMTEQFT CTVQYLPNEE VARGSGPIGT SLAHSTSTLA SSGSTNTLST 300

LTTNTNSVAL GGSGKKAKRR STSGGIDVYV RVFPHDSLEP GLKVARVTSE ATLKWILVGA 360

VEGIFMISKI NDTSVRLEIV GLPKGYEMQF QTEKEMKSFI SYLGIYIRLS SKWMQDLCHS 420

YRTPSLEELS SLHCHGPIGG AYSLMKLHEN GDKCGSYIVR ECDREYNIYY IDINTKIMAK 480

KTDQERCKTE TFRIVRKDSQ WKLSYNNGEH VLNSLHEVAH IIQADSPDRY RIPASKYDKP 540

PLLLLLLPKN LKAKKTDLQL SEAELQRRNP QIFNPRTDLQ WYPDSISLSD DGMMFTMRGD 600

WIQQSPVKDV SVTMKMLKSD GNFMEFFRLA QTWSLIQSPQ FLKLYGLTLA DPYTMVMEYS 660

RYGPLNKFLH SMPNVTLHCL LDLMHGLVRG MHYLEDNKII HNYIRCSNLY VTKYDPNSYV 720

LDAKISDPGY PRPYRESDSP WIPVKYYRNL QAAKTDQFAQ LWAFATTIYE IFSRCKEDLS 780

TLRQEQLLRQ KNLDGNILKM LDQDICPAPI FETIMDGWSD DETKRFSHHD IFSRLNTIKA 840

EILPNYMPPP EIATNGTGDE TVIDRSDIPF LPFPRSNMLM VIPLTSECRV IYNMENMIGR 900

GHYGTVYKGH LEFNDKDQPR EQVAIKMLNT MQVSTDFHRE IGIMRTLSHP NIVKFKYWAE 960

KSHCIIMEYL QSGSFDIYLR FTAPNLNNPR LVSFALDIAN GMKYLSDMGL IHRDLAARNI 1020

LVDHNGDGDC VKISDFGLAQ FANSDGYYYA KSKRDIPIRW YSPEAISTCR FSSYSDVWSY 1080

GVTLFEMFSR GEEPNLVPIQ TSQEDFLNRL QSGERLNRPA SCPDFIYDLM QLCWHATPRS 1140

RPSFATIVDI ITREVATKVT HPTDGHQSPP NQPTDAE 1177

Nucleotide Sequence
(FASTA)

ATGGCCCTGG CCAACGGGGG AGAGGATAGA ATGGACGACA GCAGCAGCGG ACGCACTTCG 60

CTGGCGGACA GCGCCAGCCT GACGAACTCC TCGCTGCGCA GCGGCACCTC CTCGCAGAGC 120

ATCCACACCA ACGATGGCAC AATCCGTGTG TTCAACTTCA CCACCGGCGA ATTTGAGCGT 180

TTCCATCCCA ACATGCTGTG CGAGGAGATC TGCAATACGA TGTGCCGCCA GCTGGGCATT 240

GCACCAATTG CCCAGCTGCT CTACGGAATA CGGGAGCACT CGACATCGCG ACGTCCCTCG 300

CCGCTGGTGC GTTTGGATCT GACGTGGTGC CTGCCCGGCG AGCGACTCAA CTGCCAGCTG 360

GTCTATTGCT TTCGGATGCG TTTCCGTGTG CCCGAATTGG ATAGCCAGCT GGAGTTGATC 420

GATGGACGGA GCCACAAGTT CCTCTACCGC CAAATGCGCT ACGATATGCG GACCGAGCAA 480

ATCCCGGAGA TTCGCTATCC GGAGCACAAG GACAAATCAA CGGGACTGGC CGTGATGGAT 540

ATGCTAATCG ACGATCAGGA ACAGTCGGAG GATCAGCAGG CGATGCGCTC CATCGAGAAG 600

CTTTACAAAC TGTATTTGCC ACCGAGCTTG TGGCGCGCCC ACAGCTTCTT TGTGGGCTCC 660

AAGATACGTG AGGTTTTCCG CAGTCTAAAA GCGAATTCGC TGAGTGTGGA GCGTTTGAAG 720

TGGCACTATG TGCATCAGGT ATCCCATTTG GCGCCCACCT ATATGACCGA ACAGTTCACC 780

TGCACCGTTC AGTATCTGCC CAACGAGGAG GTGGCCCGCG GTAGCGGACC CATCGGCACC 840

AGTCTGGCCC ACTCGACGTC GACGCTGGCC AGTTCTGGAT CGACCAACAC TCTGTCCACG 900

CTCACCACCA ACACCAATTC CGTTGCACTC GGCGGCAGTG GCAAGAAGGC CAAACGACGT 960

TCCACCAGCG GTGGAATCGA TGTCTATGTG CGAGTCTTTC CACACGATTC CCTGGAGCCT 1020

GGACTCAAGG TGGCCAGGGT CACCTCCGAG GCCACACTCA AGTGGATCCT TGTTGGCGCC 1080

GTGGAAGGAA TTTTTATGAT CTCCAAAATC AACGACACCT CTGTGCGGCT GGAAATCGTT 1140

GGTCTGCCCA AGGGCTACGA GATGCAGTTT CAGACGGAGA AGGAGATGAA GTCCTTCATC 1200

TCCTACCTGG GTATCTACAT CAGATTGTCG AGCAAATGGA TGCAGGATCT GTGCCATTCG 1260

TACCGCACGC CCTCCCTGGA GGAGCTGAGC TCCCTCCACT GCCATGGTCC AATCGGCGGT 1320

GCCTACTCGC TGATGAAGCT GCACGAGAAC GGTGACAAGT GCGGCAGCTA TATTGTGCGT 1380

GAATGCGATC GAGAATACAA CATATACTAC ATCGATATCA ACACCAAAAT CATGGCCAAG 1440

AAAACCGATC AGGAACGCTG CAAGACGGAG ACATTTAGGA TCGTGCGCAA GGACTCGCAA 1500

TGGAAGCTAA GCTACAACAA CGGCGAGCAT GTACTAAACT CACTGCACGA AGTGGCGCAC 1560

ATCATTCAAG CGGATAGTCC CGATCGCTAT CGCATACCCG CCTCCAAATA TGACAAGCCG 1620

CCGCTGCTGC TACTGCTGCT GCCAAAGAAC CTCAAGGCCA AAAAGACTGA CCTCCAGCTG 1680

AGCGAGGCGG AGCTGCAGCG CCGCAATCCG CAGATCTTCA ATCCCCGAAC GGATCTGCAG 1740

TGGTATCCAG ATTCGATATC GCTTAGCGAC GATGGCATGA TGTTTACGAT GCGCGGCGAT 1800

TGGATCCAAC AGAGTCCCGT CAAGGATGTG TCCGTGACGA TGAAAATGCT AAAGAGCGAT 1860

GGCAATTTCA TGGAGTTCTT TCGCTTGGCA CAGACCTGGA GCCTCATCCA GTCGCCGCAG 1920

TTCCTCAAGC TGTACGGCCT AACGCTCGCC GATCCGTACA CAATGGTCAT GGAGTATTCG 1980

CGGTATGGTC CGCTCAATAA GTTCCTGCAC TCGATGCCCA ATGTAACACT GCATTGTCTA 2040

CTGGATCTGA TGCATGGATT GGTGCGCGGC ATGCACTATT TGGAGGACAA CAAGATTATC 2100

CACAATTACA TACGATGCAG TAATCTGTAC GTGACCAAGT ACGATCCGAA TTCGTACGTG 2160

CTAGACGCGA AAATTAGCGA TCCCGGCTAT CCGCGTCCCT ACCGAGAATC CGACTCGCCA 2220

TGGATACCTG TTAAGTATTA TCGCAATTTG CAAGCAGCCA AAACGGATCA GTTTGCCCAG 2280

CTGTGGGCCT TCGCTACCAC CATATACGAG ATCTTCTCGC GCTGCAAGGA AGATCTGAGC 2340

ACACTGCGCC AGGAGCAGCT ACTCAGGCAG AAAAATCTCG ATGGCAACAT ACTCAAGATG 2400

CTCGATCAGG ACATCTGTCC GGCGCCGATA TTCGAGACAA TCATGGATGG ATGGTCCGAT 2460

GATGAGACCA AGCGCTTCAG TCACCACGAC ATTTTCTCGC GTCTCAACAC GATCAAGGCG 2520

GAAATTCTGC CCAATTATAT GCCGCCACCC GAGATCGCAA CGAATGGAAC TGGAGACGAG 2580

ACCGTGATCG ATAGAAGCGA CATACCCTTT CTACCCTTTC CGCGTTCGAA TATGTTGATG 2640

GTCATACCGC TGACCAGCGA ATGTCGAGTG ATCTACAACA TGGAGAACAT GATCGGGCGC 2700

GGTCATTATG GCACTGTCTA CAAGGGTCAT CTGGAGTTCA ACGACAAGGA TCAGCCGCGC 2760

GAGCAGGTTG CCATCAAGAT GCTGAACACC ATGCAGGTGT CGACCGATTT TCATCGCGAG 2820

ATCGGCATCA TGCGCACCCT CAGTCATCCG AACATAGTCA AGTTCAAGTA TTGGGCTGAG 2880

AAGTCGCACT GCATCATTAT GGAATATCTG CAATCTGGTT CCTTCGACAT TTACCTGCGT 2940

TTCACGGCAC CCAATCTCAA TAATCCACGG CTCGTCAGCT TCGCTTTAGA TATTGCAAAT 3000

GGCATGAAAT ACTTGTCCGA CATGGGACTC ATCCACCGCG ACCTGGCCGC CCGCAACATT 3060

TTGGTGGACC ACAACGGCGA TGGTGACTGC GTCAAAATCT CAGACTTCGG CCTGGCGCAA 3120

TTCGCCAATT CCGATGGATA TTACTATGCG AAAAGCAAGC GTGATATTCC CATTAGATGG 3180

TACTCTCCGG AGGCCATCTC CACCTGCAGA TTCTCATCGT ATTCGGATGT TTGGAGCTAT 3240

GGCGTGACGC TCTTCGAAAT GTTTTCGCGC GGCGAGGAGC CCAATTTGGT GCCGATCCAG 3300

ACATCGCAGG AGGATTTCCT CAATCGCCTT CAGAGCGGCG AACGCTTAAA TCGTCCGGCC 3360

AGTTGTCCCG ATTTCATTTA CGACCTGATG CAGCTGTGCT GGCATGCCAC GCCCCGTTCG 3420

CGACCCAGTT TCGCGACCAT TGTGGACATC ATCACAAGGG AGGTGGCCAC CAAGGTGACG 3480

CACCCGACAG ATGGACACCA GTCGCCGCCG AATCAGCCGA CGGATGCCGA GTGA 3534

Domain Profile

S: 2     kqiesLgkgtftkvfevred.aegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         ++++++g+g++++v++++++ +++d+ +e+va+k+L+  ++++s+df+re+ i+++lsh+

Q: 893   NMENMIGRGHYGTVYKGHLEfNDKDQPREQVAIKMLN--TMQVSTDFHREIGIMRTLSHP  950

         67899***************9****************..*********************

S: 61    hivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLedk  120

         +ivk+k  ++ae++++++mey++sGs+diyLr ++++l+ ++l+++a ++a++m+YL+d+

Q: 951   NIVKFK--YWAEKSHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDM  1008

         ******..****************************************************

S: 121   klvhrdvaarnvLveresnegtppfvklsdpglakavnqdeYylvreerdsripwlapec  180

          l+hrd+aarn+Lv+++++   + +vk+sd+gla+++n+d Yy+++++rd +i w++pe+

Q: 1009  GLIHRDLAARNILVDHNGD---GDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEA  1065

         *******************...**************************************

S: 181   lseaknlstasdvWsFgvtlyelltcskgesp....lrseslerklelleekerlpkpk.  235

         +s+++ +s++sdvWs+gvtl+e+  +s+ge+p    +++++ + +l+ l+++erl++p

Q: 1066  ISTCR-FSSYSDVWSYGVTLFEM--FSRGEEPnlvpIQTSQED-FLNRLQSGERLNRPAs  1121

         *****.*****************..889998888879998888.****************

S: 236   cpaelaelmtnclsyepsqrpsFrail  262

         cp+ +++lm+ c++++p++rpsF +i+

Q: 1122  CPDFIYDLMQLCWHATPRSRPSFATIV  1148

         ************************996

Domain Sequence
(FASTA)

NMENMIGRGH YGTVYKGHLE FNDKDQPREQ VAIKMLNTMQ VSTDFHREIG IMRTLSHPNI 60

VKFKYWAEKS HCIIMEYLQS GSFDIYLRFT APNLNNPRLV SFALDIANGM KYLSDMGLIH 120

RDLAARNILV DHNGDGDCVK ISDFGLAQFA NSDGYYYAKS KRDIPIRWYS PEAISTCRFS 180

SYSDVWSYGV TLFEMFSRGE EPNLVPIQTS QEDFLNRLQS GERLNRPASC PDFIYDLMQL 240

CWHATPRSRP SFATIV 256

Keyword

ATP-binding; Complete proteome; Developmental protein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; SH2 domain; Transcription; Transcription regulation; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0012505	; C:endomembrane system
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0003383	; P:apical constriction
GO:0007298	; P:border follicle cell migration
GO:0006968	; P:cellular defense response
GO:0001751	; P:compound eye photoreceptor cell differentiation
GO:0000910	; P:cytokinesis
GO:0051607	; P:defense response to virus
GO:0035010	; P:encapsulation of foreign target
GO:0045317	; P:equator specification
GO:0007455	; P:eye-antennal disc morphogenesis
GO:0042078	; P:germ-line stem cell division
GO:0035172	; P:hemocyte proliferation
GO:0007442	; P:hindgut morphogenesis
GO:0006959	; P:humoral immune response
GO:0007480	; P:imaginal disc-derived leg morphogenesis
GO:0007476	; P:imaginal disc-derived wing morphogenesis
GO:0035171	; P:lamellocyte differentiation
GO:0045475	; P:locomotor rhythm
GO:0007616	; P:long-term memory
GO:0060031	; P:mediolateral intercalation
GO:0016318	; P:ommatidial rotation
GO:0007424	; P:open tracheal system development
GO:0030713	; P:ovarian follicle cell stalk formation
GO:0007365	; P:periodic partitioning
GO:0007538	; P:primary sex determination
GO:0016476	; P:regulation of embryonic cell shape
GO:0045610	; P:regulation of hemocyte differentiation
GO:0035206	; P:regulation of hemocyte proliferation
GO:0046425	; P:regulation of JAK-STAT cascade
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0048103	; P:somatic stem cell division
GO:0007262	; P:STAT protein import into nucleus
GO:0019827	; P:stem cell maintenance
GO:0006351	; P:transcription, DNA-dependent
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

dme:Dmel_CG1594

;

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS00660	; FERM_1; FALSE_NEG.
PS00661	; FERM_2; FALSE_NEG.
PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; FALSE_NEG.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013