EKS-DRM-00102

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00102

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	388.3	2.1E-116	112	363	252

Status

Unreviewed

Ensembl Protein

FBpp0083130

UniProt Accession

Q9Y1A8;

Protein Name

Protein Synonyms/Alias

Serine/threonine protein kinase;

Gene Name

cdi

Gene Synonyms/Alias

cdi; CG6027;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0004876	FBpp0083130	FBtr0083716
FBgn0004876	FBpp0293864	FBtr0305321

Organism

Drosophila melanogaster

Functional Description

Protein Length

1213

Protein Sequence
(FASTA)

MSLNQHSGPG PPSEICGLSV DQVDSSAASP FIWPSTAGMC TTATTVTTST NGDATAEAPV 60

KHQPLHNGGW IGNGLPPAPV TRTISSDRLV TGSSCRALRT AVSALYSVDD FVKEKIGSGF 120

FSEVYKVTHR TTGQVMVLKM NQLRANRPNM LREVQLLNKL SHANILSFMG VCVQEGQLHA 180

LTEYINGGSL EQLLANKEVV LSATQKIRLA LGIARGMSYV HDAGIFHRDL TSKNVLIRNL 240

ANDQYEAVVG DFGLAAKIPV KSRKSRLETV GSPYWVSPEC LKGQWYDQTS DVFSFGIIQC 300

EIIARIEADP DMMPRTASFG LDYLAFVELC PMDTPPVFLR LAFYCCLYDA KSRPTFHDAT 360

KKLTLLLEKY EHESSAGASP LSSLELINCS PGGSDSENVT LTPRASVPTV ATICTAPAGT 420

LTPRHLQEVD EDGFRFPSKK SASAALPGTP NGSAGSSGFD DHILKSRVRR ATQKLEAEIL 480

LHRRSLSENI IHFPMHTSPS DKARCHQMQR QRSSTHSPTP PRQLSSVQLP ATSIPDPPPL 540

PKPVPAVLTL RKVGDPQYKP TSEKDHNGSK PNPFEALAQL RGVKKILDAN PKTYAAGVGD 600

LFSSCFEMLA PFFKELAAMQ SKAGAQGGGT STEETSTGNK ASAATPSEPK SLPVSPHMTR 660

KYSAIELRLP QRISNAAPPA VTSAPPPSIA LPTDEDDCDD CNSEGEDPDG GGNCADAESS 720

SDDSAVRPST VPTARKYRAN SLYAHPLFRG SNGTSMKSTS TGEFESPTLL KASASTITLT 780

ASVGATNSCE DLTESARKSK EQASSGATAA VQALPTPMSG CSTRLVETPV SVSSCTDLEL 840

DELKNTCDLN ELKNSCEQLP LKTNLTRRDS IESGFFSCFN EESDAAITNN SFGRQLNGIG 900

SLGFGCGGGG NSSNCCYEKL KTQLMLDACV SADSEINDKL ASLCRCCYYA TSTSNAAVTA 960

AAAAAQQQQQ SHLLNDTSST SSSVLLIDND PAVIGGNTSS STALDSMDDL DADIVASRRT 1020

HQRRYTCHHA LLSGNGSESQ MAATASLINR LALDSEIHTL LQRSPFATNQ LLYCKNRTSS 1080

IYTDSSDDIS SLAGSDSLLW DDRSFTALPS TRSAQIAKIV EYFERKRQDS SPPSVHHRNG 1140

NGTVAAAVAA SALGSNYLSY ESRRYSDFKR HLNADGLCFD LDKKPAQQRM MVCEGAVKSK 1200

LPIFDKKKQQ QGG 1213

Nucleotide Sequence
(FASTA)

ATGAGCCTGA ATCAGCACAG TGGACCCGGC CCGCCGTCGG AGATCTGCGG ATTATCGGTG 60

GACCAGGTGG ACTCATCGGC CGCCTCCCCT TTCATCTGGC CGAGCACAGC GGGTATGTGC 120

ACCACCGCCA CCACCGTCAC AACATCGACC AATGGAGACG CCACCGCGGA AGCACCAGTG 180

AAACATCAGC CGCTCCACAA CGGCGGCTGG ATCGGAAATG GTCTTCCGCC GGCGCCCGTG 240

ACGCGGACCA TATCATCGGA TCGCCTGGTC ACCGGCAGCT CGTGTCGGGC GCTGCGCACT 300

GCCGTCTCAG CATTATACTC CGTGGATGAC TTCGTCAAGG AGAAAATTGG ATCGGGATTC 360

TTCTCGGAGG TTTACAAGGT CACACATCGT ACAACCGGCC AGGTGATGGT GCTCAAGATG 420

AATCAGTTGC GGGCCAATCG ACCGAATATG CTGCGGGAGG TGCAGCTGTT GAATAAACTT 480

TCGCATGCGA ATATATTGAG CTTCATGGGC GTTTGCGTGC AGGAGGGCCA ACTGCACGCC 540

CTGACCGAGT ACATCAACGG CGGCTCCCTG GAGCAGCTGC TGGCCAACAA GGAGGTGGTG 600

CTCAGCGCCA CGCAGAAGAT AAGACTGGCG CTGGGTATAG CGCGCGGCAT GTCCTACGTT 660

CACGACGCGG GCATCTTTCA CAGGGATCTG ACGAGCAAGA ATGTACTTAT TCGCAATCTG 720

GCCAACGATC AGTACGAAGC TGTAGTGGGT GACTTTGGTC TAGCCGCAAA GATACCAGTC 780

AAATCCAGAA AATCACGCCT TGAGACAGTC GGCTCACCGT ATTGGGTCAG TCCGGAGTGC 840

CTGAAGGGCC AGTGGTACGA TCAGACAAGC GATGTCTTCT CCTTTGGCAT CATTCAATGC 900

GAGATCATAG CCCGCATCGA AGCGGACCCG GATATGATGC CGCGCACGGC GTCGTTTGGA 960

CTGGACTACC TGGCATTTGT AGAATTGTGT CCGATGGACA CTCCTCCTGT GTTTTTACGT 1020

CTGGCCTTCT ACTGCTGTCT GTACGATGCC AAGAGCCGAC CCACGTTCCA CGATGCCACC 1080

AAAAAGTTGA CTTTGCTGCT GGAGAAATAC GAGCACGAGT CGTCGGCCGG AGCAAGTCCA 1140

CTCAGTTCCC TGGAGTTGAT CAACTGCTCA CCAGGAGGCA GCGATTCGGA GAACGTAACG 1200

TTGACACCCC GAGCATCAGT ACCCACGGTG GCCACTATTT GTACTGCTCC TGCTGGCACT 1260

TTAACACCGC GCCATCTACA GGAAGTGGAC GAGGACGGCT TCCGATTTCC AAGTAAAAAG 1320

TCTGCTTCGG CTGCGCTTCC GGGCACGCCA AATGGATCTG CTGGAAGCAG TGGCTTTGAT 1380

GATCATATAC TGAAGTCTAG AGTGCGACGG GCTACTCAGA AGTTGGAGGC CGAGATCTTG 1440

TTGCACCGGC GTTCGCTAAG CGAGAACATC ATCCACTTCC CCATGCACAC GTCGCCAAGT 1500

GACAAGGCGC GGTGTCATCA GATGCAGCGA CAGCGCTCCT CAACACACTC ACCAACGCCC 1560

CCAAGGCAGC TTTCCTCGGT TCAGTTGCCC GCCACGTCTA TTCCAGATCC CCCACCGCTT 1620

CCCAAGCCCG TTCCAGCGGT ACTCACACTG CGCAAAGTGG GCGATCCACA GTACAAGCCG 1680

ACATCTGAAA AGGATCACAA CGGCTCTAAA CCCAATCCGT TTGAAGCGCT GGCGCAACTG 1740

CGTGGTGTCA AGAAAATCCT GGACGCCAAT CCGAAAACCT ATGCAGCAGG GGTGGGAGAT 1800

CTATTCAGCT CATGCTTCGA GATGCTAGCG CCGTTCTTCA AAGAACTGGC CGCAATGCAG 1860

AGCAAAGCGG GGGCTCAGGG CGGAGGAACG AGTACGGAGG AAACATCAAC GGGTAACAAG 1920

GCTTCGGCAG CAACGCCCAG TGAACCAAAG AGCCTGCCAG TGTCGCCGCA TATGACGCGC 1980

AAATACAGCG CCATCGAGCT TCGACTTCCT CAGCGAATCA GCAATGCTGC TCCTCCAGCA 2040

GTTACCAGTG CTCCACCACC ATCAATAGCA TTGCCAACCG ATGAGGATGA CTGCGATGAT 2100

TGCAATTCGG AAGGTGAGGA TCCCGATGGC GGTGGCAACT GTGCAGATGC GGAATCAAGC 2160

AGCGATGACA GCGCCGTGCG TCCGTCCACT GTGCCAACCG CTCGAAAATA CCGCGCGAAT 2220

TCCTTGTATG CGCATCCGCT TTTTCGCGGC TCCAATGGCA CCAGCATGAA AAGTACCAGT 2280

ACTGGTGAAT TCGAGAGTCC AACTCTACTG AAGGCCAGCG CATCTACAAT CACGTTGACT 2340

GCGTCAGTGG GTGCGACCAA TTCGTGTGAG GATCTGACTG AAAGCGCCAG AAAATCAAAA 2400

GAGCAAGCGA GTAGCGGTGC AACAGCGGCG GTGCAGGCTT TGCCCACTCC CATGTCTGGC 2460

TGCTCCACCA GGTTGGTGGA AACCCCGGTG TCCGTTTCAT CCTGCACTGA TCTTGAGCTC 2520

GACGAACTGA AAAACACCTG CGATCTGAAC GAATTGAAGA ACTCGTGTGA GCAGCTTCCC 2580

TTGAAGACAA ACCTAACGAG GCGGGACTCT ATAGAAAGTG GCTTCTTCTC GTGCTTTAAC 2640

GAAGAGTCCG ATGCGGCGAT AACCAACAAC AGTTTCGGAC GGCAGCTGAA CGGGATTGGA 2700

TCGTTGGGGT TTGGTTGCGG CGGCGGGGGC AACAGTAGCA ACTGCTGCTA TGAGAAATTG 2760

AAGACGCAGC TTATGCTCGA TGCATGCGTC AGCGCAGATA GTGAAATCAA CGATAAACTG 2820

GCGAGTTTGT GTCGCTGCTG CTACTACGCC ACCTCGACAT CGAATGCCGC CGTAACTGCA 2880

GCCGCTGCTG CGGCCCAGCA ACAACAGCAG AGCCACTTGC TCAACGATAC GTCCTCGACC 2940

TCATCGTCGG TGCTGCTGAT CGACAATGAT CCCGCTGTGA TCGGTGGAAA TACCTCATCA 3000

TCCACAGCGT TGGACTCGAT GGATGACTTG GACGCGGACA TTGTGGCATC GCGGCGCACA 3060

CACCAGCGAC GATACACTTG CCACCATGCG TTGCTCAGCG GGAATGGCAG CGAATCCCAA 3120

ATGGCGGCTA CGGCGAGCCT GATCAATCGT CTGGCTTTAG ACTCGGAGAT ACATACTCTG 3180

CTTCAGCGTA GTCCTTTTGC AACGAATCAA CTATTGTACT GTAAGAACCG CACCTCGTCC 3240

ATATACACGG ATAGCTCCGA TGATATAAGT AGCTTGGCCG GCTCTGACTC CCTGCTCTGG 3300

GACGACCGCT CCTTCACGGC ACTGCCCAGT ACAAGATCCG CACAGATTGC CAAGATAGTG 3360

GAGTATTTTG AGCGAAAGCG ACAGGACTCC TCGCCGCCTT CGGTGCACCA TCGCAATGGG 3420

AACGGGACGG TAGCAGCTGC TGTGGCTGCC TCTGCCCTGG GTTCCAACTA CCTTTCGTAC 3480

GAGTCGCGTC GCTATTCGGA CTTCAAGCGG CACCTGAACG CGGATGGCCT GTGCTTCGAT 3540

CTGGACAAGA AGCCGGCGCA GCAAAGGATG ATGGTGTGCG AGGGTGCGGT CAAGTCGAAG 3600

CTTCCCATAT TCGATAAAAA GAAGCAACAG CAAGGCGGCT AG 3642

Domain Profile

S: 3     vgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfi  62

         v+ek+G+Gffsev+kvthr++G+vmvlk  ++++++nr n+l+ev+ll+kl+h+n+l+f+

Q: 112   VKEKIGSGFFSEVYKVTHRTTGQVMVLK--MNQLRANRPNMLREVQLLNKLSHANILSFM  169

         68**************************..******************************

S: 63    GvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiihrd  121

         Gv+v++++lh+lteyi+gG+l++ll++ke  l++tq++rla +ia+G+sy+h++gi+hrd

Q: 170   GVCVQEGQLHALTEYINGGSLEQLLANKEVvLSATQKIRLALGIARGMSYVHDAGIFHRD  229

         *****************************99*****************************

S: 122   lnsknclvre....dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywm  177

         l+skn+l+r+    ++++vv+dfGla          +k+++   k+rk+rl++vGsPyw+

Q: 230   LTSKNVLIRNlandQYEAVVGDFGLA----------AKIPV---KSRKSRLETVGSPYWV  276

         *********999999***********..........89998...789*************

S: 178   aPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcP  237

         +Pe+lkg++yd+++dvfsfGi++ceiiar+eadPd++Prt++fgld+ af+e l+++d+P

Q: 277   SPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAFVE-LCPMDTP  335

         ****************************************************.*******

S: 238   eaflklavvccdldpesrpsfeelekkl  265

         + fl+la++cc +d++srp+f++ +kkl

Q: 336   PVFLRLAFYCCLYDAKSRPTFHDATKKL  363

         ***********************99986

Domain Sequence
(FASTA)

VKEKIGSGFF SEVYKVTHRT TGQVMVLKMN QLRANRPNML REVQLLNKLS HANILSFMGV 60

CVQEGQLHAL TEYINGGSLE QLLANKEVVL SATQKIRLAL GIARGMSYVH DAGIFHRDLT 120

SKNVLIRNLA NDQYEAVVGD FGLAAKIPVK SRKSRLETVG SPYWVSPECL KGQWYDQTSD 180

VFSFGIIQCE IIARIEADPD MMPRTASFGL DYLAFVELCP MDTPPVFLRL AFYCCLYDAK 240

SRPTFHDATK KL 252

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0001700	; P:embryonic development via the syncytial blastoderm

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013