EKS-DRM-00071
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00071
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR490.71.3E-147712995284
StatusReviewed
Ensembl ProteinFBpp0075520
UniProt AccessionQ09147; A4V1Y3; Q712V2; Q9VUC8;
Protein NameFibroblast growth factor receptor homolog 2
Protein Synonyms/Alias Protein breathless; Tyrosine kinase 2; dTk2; Tyrosine kinase receptor HD-311; dFGF-R1;
Gene Namebtl
Gene Synonyms/Alias btl; FR2, HD-311, Tk2; CG32134;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0005592FBpp0100143FBtr0100676
FBgn0005592FBpp0075520FBtr0075778
OrganismDrosophila melanogaster
Functional DescriptionMay be required for patterning of muscle precursorcells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues.
Protein Length1052
Protein Sequence
(FASTA)
MAKVPITLVM IIAIVSAAAD LGCDYGHHRC YIDVTVENSP RQRHLLSDMD ITLQCVRPMA 60
KWFYEDKFQL RATLLRLERA QSGNSGNYGC LDSQNRWYNI SLVVGHKEPV GNDIASFVKL 120
EDAPALPESD LFFQPLNESR SLKLLQPLPK TVQRTAGGLF QLNCSPMDPD AKGVNISWLH 180
NDTQILGGRG RIKLKRWSLT VGQLQPEDAG SYHCELCVEQ DCQRSNPTQL EVISRKHTVP 240
MLKPGYPRNT SIALGDNVSI ECLLEDSALE PKITWLHKGN ADNIDDLLQR LREQSQLPVD 300
VTRLITRMDE PQVLRLGNVL MEDGGWYICI AENQVGRTVA ASYVDLYSPS DTTTVRTTTT 360
TTVASPIPTA STGEDNDDDV ENPAAEASGG VGPPVFRKEL KRLQHSLSGN TVNLACPVYG 420
KANITWTKDK KPLNRELGVY VQKNWTLRFV EATSEDSGLY NCKVCNAWGC IQFDFSVQIN 480
DRTRSAPIIV VPQNQTVKVN GSLVMKCTVY SDLHPTVSWK RVVLKNASLD GLKSVEIQNL 540
NFTVTNDSVV LTLRNVTFDQ EGWYTCLASS GLGRSNSSVY LRVVSPLPPL EIYALLHAHP 600
LGFTLAAITI VALFLLGSAF ITFMLRRLRR EKLLKLRIET VHQWTKKVII YRPGGEEGSG 660
CSSGDLQMPV IRIEKQRTTV STTGTGGTDP AQGFNEYEFP LDSNWEIPRQ QLSLGSILGE 720
GAFGRVVMAE AEGLPRSPQL AETIVAVKMV KEEHTDTDMA SLVREMEVMK MIGKHINIIN 780
LLGCCSQGGP LWVIVEYAPH GNLKDFLKQN RPGAPQRRSD SDGYLDDKPL ISTQHLGEKE 840
LTKFAFQIAR GMEYLASRRC IHRDLAARNV LVSDGYVMKI ADFGLARDIQ DTEYYRKNTN 900
GRLPIKWMAP ESLQEKKYDS QSDVWSYGVL LWEIMTYGDQ PYPHILSAEE LYSYLITGQR 960
MEKPAKCSLN IYVVMRQCWH FESCARPTFA ELVESFDGIL QQASSNPNDA YLDLSMPMLE 1020
TPPSSGDEDD GSDTETFRET SPLRYQYTYK FN 1052
Nucleotide Sequence
(FASTA)
ATGGCAAAAG TGCCGATCAC GCTGGTGATG ATCATTGCGA TCGTCTCTGC CGCTGCGGAC 60
CTGGGATGCG ATTATGGCCA TCATCGTTGC TACATCGATG TGACTGTGGA AAACAGTCCC 120
CGCCAGCGCC ATCTGCTCTC CGACATGGAC ATCACGCTGC AGTGCGTCCG ACCCATGGCC 180
AAATGGTTCT ATGAGGATAA GTTTCAACTG AGGGCTACCC TTTTGCGACT TGAACGAGCA 240
CAGTCCGGAA ATTCTGGAAA CTACGGCTGC CTGGATAGTC AGAACAGATG GTACAATATT 300
TCCCTTGTTG TTGGCCATAA GGAACCAGTT GGCAATGATA TCGCCAGCTT TGTCAAGTTG 360
GAAGATGCAC CGGCCCTCCC GGAGTCAGAT CTCTTTTTTC AGCCCCTGAA TGAGAGTCGA 420
TCCCTGAAGT TGCTGCAACC CCTACCCAAA ACCGTACAAC GGACCGCAGG TGGCCTTTTT 480
CAGTTGAACT GCAGTCCCAT GGATCCGGAT GCAAAGGGTG TTAATATATC CTGGCTGCAC 540
AATGATACTC AAATCCTTGG TGGACGTGGA CGCATTAAGC TTAAAAGGTG GTCATTAACA 600
GTGGGGCAAC TGCAGCCGGA GGATGCTGGA AGCTATCACT GTGAGCTGTG CGTGGAACAG 660
GACTGCCAAA GGAGTAATCC GACCCAATTG GAGGTGATAA GCAGAAAGCA CACGGTGCCC 720
ATGCTAAAGC CCGGATATCC CCGCAATACC AGCATTGCCC TCGGGGACAA TGTGAGCATT 780
GAATGCCTAC TTGAGGACTC TGCCCTGGAG CCGAAGATCA CGTGGCTACA TAAGGGGAAT 840
GCGGACAACA TCGATGACCT CTTGCAGCGT TTAAGAGAGC AGTCCCAGCT ACCTGTGGAT 900
GTTACCCGAT TGATTACCCG AATGGATGAA CCGCAGGTAC TTCGTCTTGG AAATGTCCTG 960
ATGGAGGATG GCGGATGGTA CATATGCATA GCCGAGAACC AGGTTGGACG CACTGTGGCC 1020
GCCTCCTATG TGGATCTTTA CAGTCCCTCA GATACTACCA CAGTTCGCAC GACCACTACT 1080
ACCACCGTGG CCAGCCCAAT ACCCACTGCA TCCACCGGAG AGGACAACGA TGACGACGTG 1140
GAAAATCCAG CAGCGGAAGC ATCAGGCGGC GTTGGTCCAC CTGTGTTCAG AAAAGAGCTG 1200
AAACGATTAC AGCACTCATT ATCGGGAAAT ACTGTCAATC TAGCCTGTCC AGTGTACGGC 1260
AAAGCGAACA TCACCTGGAC GAAGGACAAG AAGCCGCTAA ACCGTGAACT CGGCGTCTAT 1320
GTGCAAAAGA ACTGGACACT CCGCTTCGTG GAGGCCACCA GCGAGGATTC TGGACTATAC 1380
AACTGTAAGG TGTGCAATGC GTGGGGCTGC ATCCAGTTTG ACTTCAGTGT CCAAATAAAC 1440
GATCGCACGA GATCCGCACC AATAATCGTG GTGCCGCAAA ATCAGACGGT GAAAGTCAAT 1500
GGCAGCTTGG TGATGAAGTG CACCGTCTAC TCTGATCTGC ATCCAACAGT CAGCTGGAAA 1560
AGGGTTGTCC TCAAGAATGC CTCCTTGGAC GGCCTTAAGT CTGTGGAAAT CCAGAATCTC 1620
AACTTCACCG TGACGAATGA CTCCGTAGTT TTAACGCTTC GTAATGTGAC CTTTGACCAG 1680
GAGGGCTGGT ACACCTGTTT GGCCTCAAGT GGTCTGGGAA GGAGTAACTC CAGTGTGTAC 1740
CTTAGGGTAG TGAGTCCTCT GCCACCTTTG GAGATCTACG CCCTGCTGCA CGCCCATCCT 1800
CTCGGATTCA CCTTGGCCGC TATTACGATA GTGGCTTTGT TCCTTTTGGG CAGTGCTTTC 1860
ATAACGTTCA TGCTGCGTCG GCTGAGGAGG GAGAAGCTCC TGAAGCTCCG CATCGAAACG 1920
GTTCATCAGT GGACTAAAAA GGTGATCATA TACCGACCGG GTGGAGAAGA AGGAAGTGGC 1980
TGCAGCTCCG GCGATCTTCA GATGCCAGTG ATAAGGATCG AGAAGCAGAG AACAACCGTT 2040
TCCACAACGG GAACTGGCGG TACTGATCCC GCCCAGGGCT TTAATGAGTA TGAGTTCCCG 2100
CTGGACTCAA ACTGGGAGAT TCCCAGGCAG CAGCTTAGCT TGGGCTCCAT TTTGGGTGAG 2160
GGCGCCTTTG GACGCGTAGT GATGGCGGAG GCGGAGGGGC TTCCCAGGAG TCCACAACTG 2220
GCCGAAACCA TCGTGGCCGT CAAGATGGTC AAGGAGGAGC ACACGGATAC GGACATGGCC 2280
AGTTTGGTGC GTGAAATGGA GGTGATGAAA ATGATTGGCA AGCACATAAA CATCATCAAT 2340
CTGCTAGGCT GCTGCAGCCA GGGCGGTCCT CTGTGGGTGA TCGTGGAGTA TGCTCCACAC 2400
GGAAACCTCA AGGACTTCCT CAAGCAGAAT CGACCTGGTG CTCCACAGCG ACGGAGTGAC 2460
AGTGATGGCT ATCTAGATGA CAAGCCACTG ATTTCCACTC AACATCTTGG CGAAAAGGAG 2520
CTCACCAAGT TTGCATTTCA AATCGCTCGA GGAATGGAGT ACCTTGCTTC AAGACGGTGC 2580
ATTCATCGCG ATCTGGCTGC CCGTAATGTC CTTGTAAGCG ATGGATACGT TATGAAGATC 2640
GCCGATTTTG GTCTGGCGAG GGATATCCAA GATACGGAGT ACTACCGAAA AAATACCAAT 2700
GGACGGTTGC CCATTAAGTG GATGGCGCCC GAGTCGCTGC AGGAGAAGAA GTACGACTCA 2760
CAGAGCGACG TCTGGAGCTA TGGTGTTCTG CTGTGGGAGA TCATGACCTA CGGGGATCAA 2820
CCATACCCGC ACATACTGTC TGCCGAGGAG CTCTACAGCT ACCTGATTAC GGGTCAGCGC 2880
ATGGAGAAAC CGGCCAAGTG CTCCCTGAAC ATCTACGTGG TAATGCGACA GTGCTGGCAC 2940
TTTGAGTCCT GTGCACGACC CACGTTCGCG GAGCTGGTAG AGAGTTTCGA TGGGATCCTG 3000
CAGCAGGCTA GTAGCAATCC AAACGATGCC TATCTGGACC TTTCGATGCC GATGCTGGAG 3060
ACGCCGCCCT CATCGGGGGA TGAGGATGAT GGCTCCGACA CCGAAACATT CCGGGAAACG 3120
TCCCCGCTTA GATATCAGTA CACCTATAAG TTTAATTAG 3159
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lg++lGeGafG+vv+aea gl+++ + +e++vavkm+ke++td+d+a+lv+emev+k+
Q: 712   LSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKM  771
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeask.......dkska  113
         iGkh+niinllG+c+q+Gpl+viveya++Gnl++fl+++rp + ++++       dk+ +
Q: 772   IGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSdsdgyldDKPLI  831
         *******************************************999998999999999**
S: 114   seeqltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvhe  173
         s+++l+ek+l++fa+q+arGmeylas++cihrdlaarnvlv++++v+kiadfGlard+++
Q: 832   STQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQD  891
         ************************************************************
S: 174   idyykkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgi.aveel  232
         ++yy+k+tnGrlp+kwmape+l+++ y+sqsdvws+Gvllwei+t+G++pyp+i ++eel
Q: 892   TEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHIlSAEEL  951
         ******************************************************9*****
S: 233   fkllkeGhrmekpakctkelyvlmrecwhakaserptfkqlved  276
         +++l +G+rmekpakc+ ++yv+mr+cwh+++++rptf++lve+
Q: 952   YSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVES  995
         ******************************************97
Domain Sequence
(FASTA)
LSLGSILGEG AFGRVVMAEA EGLPRSPQLA ETIVAVKMVK EEHTDTDMAS LVREMEVMKM 60
IGKHINIINL LGCCSQGGPL WVIVEYAPHG NLKDFLKQNR PGAPQRRSDS DGYLDDKPLI 120
STQHLGEKEL TKFAFQIARG MEYLASRRCI HRDLAARNVL VSDGYVMKIA DFGLARDIQD 180
TEYYRKNTNG RLPIKWMAPE SLQEKKYDSQ SDVWSYGVLL WEIMTYGDQP YPHILSAEEL 240
YSYLITGQRM EKPAKCSLNI YVVMRQCWHF ESCARPTFAE LVES 284
KeywordATP-binding; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAF-00154
EKS-CII-00090
EKS-DAR-00432
EKS-EQC-00145
EKS-GAM-00078
EKS-GAG-00125
EKS-GOG-00147
EKS-HOS-00152
EKS-MOD-00147
EKS-MUP-00151
EKS-NOL-00141
EKS-ORC-00138
EKS-OTG-00152
EKS-PAT-00137
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-XET-00137
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0000187; P:activation of MAPK activity
GO:0007298; P:border follicle cell migration
GO:0048013; P:ephrin receptor signaling pathway
GO:0007427; P:epithelial cell migration, open tracheal system
GO:0035153; P:epithelial cell type specification, open tracheal system
GO:0046847; P:filopodium assembly
GO:0035215; P:genital disc development
GO:0008347; P:glial cell migration
GO:0030517; P:negative regulation of axon extension
GO:0007428; P:primary branching, open tracheal system
GO:0007435; P:salivary gland morphogenesis
GO:0007429; P:secondary branching, open tracheal system
GO:0007430; P:terminal branching, open tracheal system
GO:0060439; P:trachea morphogenesis
GO:0007426; P:tracheal outgrowth, open tracheal system
KEGG
dme:Dmel_CG32134;
InterPros
IPR020766; Fibroblast_GF_rcpt-like.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013