EKS-DRM-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	356.4	1.3E-106	184	468	285

Status

Unreviewed

Ensembl Protein

FBpp0110222

UniProt Accession

C9QP46;

Protein Name

Protein Synonyms/Alias

GH02721p;

Gene Name

Eip63E-RE

Gene Synonyms/Alias

Eip63E-RE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0005640	FBpp0110224	FBtr0110924
FBgn0005640	FBpp0072990	FBtr0073131
FBgn0005640	FBpp0110225	FBtr0110925
FBgn0005640	FBpp0072991	FBtr0073132
FBgn0005640	FBpp0072992	FBtr0073133
FBgn0005640	FBpp0072993	FBtr0073134
FBgn0005640	FBpp0072994	FBtr0073135
FBgn0005640	FBpp0110220	FBtr0110920
FBgn0005640	FBpp0110221	FBtr0110921
FBgn0005640	FBpp0110222	FBtr0110922
FBgn0005640	FBpp0303101	FBtr0330068
FBgn0005640	FBpp0110223	FBtr0110923
FBgn0005640	FBpp0291754	FBtr0302598
FBgn0005640	FBpp0291160	FBtr0301948

Organism

Drosophila melanogaster

Functional Description

Protein Length

501

Protein Sequence
(FASTA)

MREKKGGALQ KLKKRLSHSF GRLTISREDG DESTHHHHHH HHHRGGHGGH HNHGNKVPYN 60

GYNSEEYLDR LEPNGNIPAD KTNCRYGAQE SAKNDNNKPQ DWRSTDSTDH HDRVQRQLSV 120

SSDSKLLDED IREEMKYHSH VVMRPKKPPR PKSEVFLNKQ ETHPRRKRFS AFGGDSPFGK 180

QEAYVKLEPL GEGSYATVYK GFSKLTYQRV ALKEIRLQEE EGAPFTAIRE ASLLKELKHS 240

NIVTLHDIVH TRETLTFVFE YVNTDLSQYM EKHPGGLDHR NVRLFLFQLL RGLSYCHKRR 300

VLHRDVKPQN LLISDCGELK LADFGLARAK SVPSHTYSHE VVTLWYRPPD VLLGSTEYST 360

SLDMWGVGCI FVEMVTGMPT FPGIRDTYDQ LDKIFKLLGT PTEDTWPGVT HFPGYKPHKL 420

GFYRPRKLGH NFPRLYDIIE GETIANGFLQ LNPEQRLGAD DALQHPYFAQ LPKKLYELPD 480

ETSIFTVEGV QLYTEPNRQN K 501

Nucleotide Sequence
(FASTA)

ATGCGCGAGA AAAAGGGAGG AGCCCTTCAG AAGCTCAAGA AGAGACTTTC GCACAGCTTC 60

GGCAGATTAA CAATTTCCCG CGAAGATGGC GACGAGTCGA CGCACCACCA TCACCACCAC 120

CATCATCATC GCGGTGGACA TGGCGGGCAC CACAACCACG GTAACAAAGT TCCATACAAC 180

GGCTACAATT CGGAGGAATA CTTGGACCGA CTCGAACCGA ATGGCAATAT ACCCGCTGAC 240

AAGACAAATT GCAGATATGG AGCACAAGAG TCTGCGAAAA ATGATAATAA CAAACCACAA 300

GACTGGCGCA GCACGGACAG CACCGACCAC CACGATCGCG TCCAGAGACA GCTTTCCGTG 360

TCCTCCGACA GCAAGTTGCT CGACGAGGAC ATTCGCGAGG AGATGAAGTA CCATTCGCAC 420

GTGGTCATGC GTCCCAAGAA GCCGCCCAGA CCCAAATCCG AGGTCTTTCT GAACAAACAG 480

GAAACGCATC CGCGCCGGAA ACGATTCAGT GCATTTGGTG GCGACTCCCC ATTTGGCAAG 540

CAGGAGGCCT ATGTTAAACT CGAGCCGCTG GGCGAAGGCT CCTATGCGAC GGTCTACAAA 600

GGATTTAGCA AATTAACCTA CCAGCGGGTG GCGCTGAAGG AGATTCGCCT GCAGGAGGAG 660

GAGGGAGCAC CCTTCACCGC GATTCGCGAG GCCTCGCTGC TGAAAGAACT GAAACACAGC 720

AACATCGTCA CGCTGCACGA CATTGTCCAC ACGCGCGAGA CGCTGACCTT TGTCTTTGAA 780

TATGTGAATA CGGATCTGTC GCAATACATG GAGAAGCATC CGGGCGGCCT GGATCATCGC 840

AACGTGCGCC TGTTCCTCTT CCAGCTGCTC CGTGGACTCT CCTACTGCCA CAAGCGGCGT 900

GTCCTCCATC GGGATGTCAA GCCGCAGAAC CTGCTTATTA GCGACTGCGG CGAACTGAAG 960

TTGGCCGATT TCGGACTGGC CAGGGCCAAG AGCGTGCCCA GCCACACCTA CTCCCACGAG 1020

GTGGTCACGT TATGGTACCG CCCTCCAGAT GTCCTGCTGG GCAGCACGGA GTACTCGACC 1080

TCGCTGGACA TGTGGGGCGT GGGCTGCATC TTCGTGGAGA TGGTGACCGG GATGCCGACG 1140

TTTCCGGGCA TACGTGATAC CTACGATCAG CTGGACAAGA TATTCAAATT GCTGGGCACG 1200

CCCACCGAGG ACACGTGGCC GGGAGTCACC CACTTTCCCG GCTACAAGCC ACACAAGCTG 1260

GGTTTCTATC GACCACGGAA ACTGGGTCAC AACTTCCCAC GGCTATACGA CATCATCGAG 1320

GGCGAGACGA TAGCTAACGG CTTCCTGCAA CTGAATCCGG AGCAGCGTTT GGGCGCCGAT 1380

GATGCACTGC AGCATCCGTA CTTTGCGCAG TTGCCAAAGA AACTCTACGA ATTGCCAGAC 1440

GAAACCTCAA TTTTCACCGT GGAAGGCGTG CAGCTTTACA CGGAGCCAAA TCGACAGAAT 1500

AAATGA 1506

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kle +geG+y++vyk+ +k t + vAlK+irl++e eg p+ta+rE sllkelkh+ni

Q: 184   YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEE-EGAPFTAIREASLLKELKHSNI  242

         78999*****************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++v+ ++++l++vfe++++dL+++++k++  +l++++v+ +l+qll+gl+y+H+++

Q: 243   VTLHDIVH-TRETLTFVFEYVNTDLSQYMEKHPG-GLDHRNVRLFLFQLLRGLSYCHKRR  300

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRD+KpqNlLis+ g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 301   VLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYST  360

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

         ++D+W+vgci++e++t  p f+g ++  dql++ifkllgtp+e++wp+v+++p yk +++

Q: 361   SLDMWGVGCIFVEMVTGMPTFPGIRDtYDQLDKIFKLLGTPTEDTWPGVTHFPGYKpHKL  420

         ***********************88758****************************8899

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

           ++++kl +++++l    ++ ++ + +l+l+p++R+ a++alqh+yf

Q: 421   GFYRPRKLGHNFPRLYdiIEGETIANGFLQLNPEQRLGADDALQHPYF  468

         99999********99944469**************************9

Domain Sequence
(FASTA)

YVKLEPLGEG SYATVYKGFS KLTYQRVALK EIRLQEEEGA PFTAIREASL LKELKHSNIV 60

TLHDIVHTRE TLTFVFEYVN TDLSQYMEKH PGGLDHRNVR LFLFQLLRGL SYCHKRRVLH 120

RDVKPQNLLI SDCGELKLAD FGLARAKSVP SHTYSHEVVT LWYRPPDVLL GSTEYSTSLD 180

MWGVGCIFVE MVTGMPTFPG IRDTYDQLDK IFKLLGTPTE DTWPGVTHFP GYKPHKLGFY 240

RPRKLGHNFP RLYDIIEGET IANGFLQLNP EQRLGADDAL QHPYF 285

Keyword

ATP-binding; Nucleotide-binding.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR018506	; Cyt_B5_heme-BS.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00191	; CYTOCHROME_B5_1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013