EPS-DRM-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DRM-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	542.4	3.5E-163	207	516	310

Status

Unreviewed

Ensembl Protein

FBpp0081606

UniProt Accession

Q9VH81; Q26244;

Protein Name

Protein Synonyms/Alias

GH12714p; Protein phosphatase 5; Protein phosphatase D3, isoform A; Protein phosphatase D3, isoform B;

Gene Name

PpD3

Gene Synonyms/Alias

PpD3; PPP5; CG8402, Dmel_CG8402;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0005777	FBpp0081607	FBtr0082129
FBgn0005777	FBpp0081606	FBtr0082128
FBgn0005777	FBpp0304082	FBtr0331693

Organism

Drosophila melanogaster

Functional Description

Protein Length

520

Protein Sequence
(FASTA)

MSSSELEVQK AADCQQEAKV PASVEITGSK QPEEDTNART KAELDFAAAE QYKNQGNEML 60

KTKEFSKAID MYTKAIELHP NSAIYYANRS LAHLRQESFG FALQDGVSAV KADPAYLKGY 120

YRRAAAHMSL GKFKQALCDF EFVAKCRPND KDAKLKFTEC NKIVKMRAFE RAIAVDKPEK 180

TLSEMYSDME NITIEDDYKG PQLEDGKVTL KFMKELMEHY KAQKRLHRKF AYKILCEIDT 240

YMRAQPSLVD ITVPDEEKFT ICGDIHGQFY DLMNIFEING LPSEKNPYLF NGDFVDRGSF 300

SVECIFTLFG FKLLYPNHFF LARGNHESIN MNQMYGFTGE VTAKYTSAMA DIFTQVFNWL 360

PLCHCINQKI LVMHGGLFST EDVTLDHIRR IERNCQPPEE GLMCELLWSD PQQWMGLGQS 420

KRGVGIQFGP DVTEKFCKDN NLDYIIRSHE VKDMGYEVAH NGKCITVFSA PNYCDTMGNM 480

GAFITITGNN LKPNYKSFEA VPHPDVKPMA YANSLMNWLA 520

Nucleotide Sequence
(FASTA)

ATGTCTTCGT CCGAACTGGA AGTACAGAAG GCTGCTGATT GTCAGCAGGA GGCGAAGGTG 60

CCGGCAAGCG TGGAGATTAC GGGGTCCAAG CAGCCGGAGG AGGACACAAA TGCCCGTACG 120

AAGGCGGAAC TCGATTTTGC CGCGGCGGAG CAGTACAAAA ATCAGGGAAA TGAAATGCTC 180

AAAACCAAGG AGTTCTCCAA AGCCATCGAC ATGTACACCA AAGCCATAGA ACTGCACCCC 240

AACAGCGCGA TATATTACGC CAACCGATCC TTGGCGCACT TGCGCCAGGA GAGCTTTGGT 300

TTCGCACTAC AGGATGGTGT TTCGGCGGTA AAGGCGGATC CTGCCTACCT TAAGGGTTAC 360

TATCGCCGGG CAGCGGCTCA CATGTCTCTG GGGAAGTTCA AGCAAGCCCT TTGTGACTTT 420

GAATTCGTAG CCAAGTGCCG GCCGAACGAC AAAGACGCCA AGCTTAAGTT TACCGAGTGC 480

AACAAAATTG TCAAAATGCG CGCCTTCGAA CGGGCCATTG CTGTGGATAA GCCCGAGAAG 540

ACGCTCTCAG AGATGTACAG CGACATGGAA AACATAACTA TTGAGGATGA CTACAAGGGT 600

CCGCAGCTGG AAGACGGCAA GGTGACTCTA AAGTTCATGA AGGAATTGAT GGAGCATTAC 660

AAGGCACAGA AGCGATTGCA CCGCAAATTT GCCTACAAAA TACTCTGCGA GATCGACACG 720

TATATGCGAG CTCAGCCCTC GCTGGTGGAT ATCACTGTGC CGGATGAGGA GAAGTTCACG 780

ATTTGTGGCG ACATTCACGG TCAATTCTAC GACTTGATGA ACATATTCGA GATCAATGGT 840

CTGCCCTCTG AAAAGAATCC CTACCTGTTC AACGGCGATT TCGTTGACAG GGGTTCCTTC 900

TCTGTGGAGT GTATATTTAC GCTGTTTGGT TTCAAGCTGT TGTATCCTAA TCACTTCTTC 960

TTGGCGCGCG GCAACCATGA AAGCATTAAC ATGAACCAAA TGTATGGATT CACTGGCGAG 1020

GTGACAGCGA AGTACACCAG CGCCATGGCT GACATATTCA CGCAAGTTTT CAACTGGCTG 1080

CCGTTGTGCC ACTGCATCAA CCAAAAGATC CTGGTCATGC ACGGCGGGCT CTTCTCCACG 1140

GAAGACGTGA CTCTGGACCA TATAAGACGC ATCGAACGAA ATTGCCAGCC GCCCGAGGAA 1200

GGTCTTATGT GCGAGTTGCT GTGGTCCGAT CCTCAGCAGT GGATGGGTCT CGGTCAGTCG 1260

AAGCGAGGCG TGGGCATCCA GTTTGGTCCG GATGTTACCG AGAAATTCTG CAAAGACAAC 1320

AACCTGGACT ACATCATTCG AAGCCACGAG GTTAAGGATA TGGGCTATGA AGTGGCTCAC 1380

AACGGTAAAT GCATAACAGT CTTCTCTGCT CCGAACTATT GTGATACTAT GGGCAACATG 1440

GGCGCATTTA TTACCATTAC GGGTAACAAT TTGAAACCAA ATTACAAATC ATTCGAGGCT 1500

GTGCCACATC CCGACGTCAA GCCCATGGCC TATGCCAACA GCCTAATGAA CTGGCTGGCG 1560

TAG 1563

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+ +f+k+l++++k +k+l+rk a++il +    +  +  +++ ++ +++k+t+cGd+h

Q: 207   KVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIH  266

         7999*************************99988888888********************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gqfydl+nife+nGlpseknpylfnGdfvdrGsfsve+i+tlfg+kllyP+hffl+rGnh

Q: 267   GQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNH  326

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         es nmn++yGf+gev+akyt++++++f++vf+wlPl+++in+k+lvmhGGlfs+++vtld

Q: 327   ESINMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLD  386

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         +ir+iern+qPPeeG++cellWsdPq+++G+g+skrGvg+qfGpdvt++f+++n+ldyii

Q: 387   HIRRIERNCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYII  446

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevk  g+ev+++gk++tvfsapnycd++gn++++i + +++l++ +++feav+hpdv

Q: 447   RSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPHPDV  506

         ************************************************************

S: 302   kpmaysngll  311

         kpmay+n+l+

Q: 507   KPMAYANSLM  516

         *******987

Domain Sequence
(FASTA)

KVTLKFMKEL MEHYKAQKRL HRKFAYKILC EIDTYMRAQP SLVDITVPDE EKFTICGDIH 60

GQFYDLMNIF EINGLPSEKN PYLFNGDFVD RGSFSVECIF TLFGFKLLYP NHFFLARGNH 120

ESINMNQMYG FTGEVTAKYT SAMADIFTQV FNWLPLCHCI NQKILVMHGG LFSTEDVTLD 180

HIRRIERNCQ PPEEGLMCEL LWSDPQQWMG LGQSKRGVGI QFGPDVTEKF CKDNNLDYII 240

RSHEVKDMGY EVAHNGKCIT VFSAPNYCDT MGNMGAFITI TGNNLKPNYK SFEAVPHPDV 300

KPMAYANSLM 310

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000278	; P:mitotic cell cycle
GO:0006470	; P:protein dephosphorylation

KEGG

dme:Dmel_CG8402

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS50005	; TPR; 2.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013