EPS-DRM-00077
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-DRM-00077
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPP/PP2B417.21.4E-125124324201
StatusReviewed
Ensembl ProteinFBpp0293125
UniProt AccessionP48456; Q8MQN3; Q9TY69; Q9VA20;
Protein NameSerine/threonine-protein phosphatase 2B catalytic subunit 1
Protein Synonyms/Alias Calmodulin-dependent calcineurin A1 subunit;
Gene NameCanA1
Gene Synonyms/Alias CanA1; CNA1, PpD14; CG1455;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0010015FBpp0085094FBtr0085732
FBgn0010015FBpp0293125FBtr0304583
FBgn0010015FBpp0293124FBtr0304582
OrganismDrosophila melanogaster
Functional DescriptionCalcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Protein Length462
Protein Sequence
(FASTA)
MSATSTRSSV TRKSSLSKSS SSDKSAKSSS NSSKSPTAAS GNKQKMQYTK TRERMVDDVP 60
LPPTHKLTMS EVYDDPKTGK PNFDALRQHF LLEGRIEEAV ALRIITEGAA LLREEKNMID 120
VEAPITVCGD IHGQFFDLVK LFEVGGPPAT TRYLFLGDYV DRGYFSIECV LYLWSLKITY 180
PTTLSLLRGN HECRHLTEYF TFKQECIIKY SESIYDACME AFDCLPLAAL LNQQFLCIHG 240
GLSPEIFTLD DIKTLNRFRE PPAYGPMCDL LWSDPLEDFG NEKTNEFFSH NSVRGCSYFF 300
SYSACCEFLQ KNNLLSIVRA HEAQDAGYRM YRKNQVTGFP SLITIFSAPN YLDVYNNKAA 360
VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK VTEMLVNILN ICSDDELVAG 420
PDDELEEELR KKIVLVPANA SNNNNNNNTP SKPGRNPRAC SS 462
Nucleotide Sequence
(FASTA)
ATGTCGGCGA CCTCCACGCG AAGTTCGGTG ACGAGGAAAT CATCGCTATC AAAAAGTTCT 60
AGTTCAGACA AATCGGCAAA GTCCTCGTCG AATTCCTCGA AATCTCCGAC AGCCGCCAGT 120
GGAAACAAAC AGAAAATGCA GTACACAAAA ACCAGGGAGC GCATGGTCGA TGATGTTCCA 180
CTTCCGCCCA CCCACAAGCT GACCATGTCG GAGGTATACG ACGATCCGAA GACCGGAAAA 240
CCCAACTTCG ACGCCCTGCG CCAGCACTTT CTGCTGGAGG GGCGGATCGA GGAGGCGGTG 300
GCCCTGAGGA TCATCACCGA AGGAGCCGCC CTGCTGCGCG AGGAGAAGAA CATGATCGAC 360
GTGGAGGCAC CCATTACCGT GTGCGGTGAC ATCCACGGGC AGTTCTTCGA TCTCGTAAAG 420
CTCTTCGAAG TGGGCGGCCC GCCGGCCACC ACTAGGTACC TTTTTCTAGG CGACTACGTG 480
GACAGGGGAT ACTTCAGTAT TGAGTGCGTT CTCTACCTGT GGTCCCTGAA AATAACCTAC 540
CCCACCACGC TTTCCCTGCT GCGAGGAAAT CACGAGTGCA GGCATCTCAC AGAGTACTTT 600
ACCTTCAAGC AGGAATGCAT CATCAAGTAT TCGGAAAGTA TTTACGACGC CTGCATGGAA 660
GCGTTCGACT GCCTGCCCCT CGCCGCCCTC CTCAACCAGC AGTTCCTCTG TATTCACGGC 720
GGTCTGTCGC CCGAGATTTT CACACTCGAC GACATCAAGA CGCTGAATCG CTTCAGGGAA 780
CCACCGGCCT ACGGGCCCAT GTGCGACCTG CTCTGGTCCG ATCCTCTGGA GGACTTTGGC 840
AACGAGAAGA CCAACGAGTT CTTCTCGCAC AACTCGGTGC GCGGGTGCTC CTACTTCTTC 900
AGCTACTCGG CCTGCTGTGA GTTTCTGCAG AAGAACAACC TGCTGTCGAT AGTCAGGGCG 960
CACGAGGCGC AGGATGCGGG GTATCGCATG TATCGGAAGA ACCAGGTTAC GGGCTTCCCC 1020
TCGCTGATCA CCATATTCTC CGCCCCCAAT TATCTGGATG TTTACAATAA CAAGGCAGCT 1080
GTGCTCAAGT ACGAGAACAA CGTGATGAAT ATCCGCCAGT TCAACTGCTC GCCACATCCC 1140
TACTGGCTAC CCAACTTCAT GGACGTCTTC ACATGGTCGC TGCCCTTCGT GGGCGAAAAG 1200
GTAACCGAGA TGCTAGTCAA CATCCTGAAC ATTTGCTCAG ACGATGAACT GGTGGCCGGA 1260
CCCGATGACG AGCTCGAGGA AGAGCTACGC AAGAAAATTG TGCTCGTGCC GGCGAACGCG 1320
AGCAATAATA ACAATAACAA TAATACGCCC AGTAAGCCAG GGAGGAATCC GAGAGCGTGC 1380
TCCAGCTGA 1389
Domain Profile
S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60
         p+tvcgdihgqffdl+klfevgg pa+trylflgdyvdrgyfsiecvlyl++lki+yp+t
Q: 124   PITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTT  183
         9***********************************************************
S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120
         l llrgnhecrhlteyftfkqe++ikyse++ydac+eafd+lplaallnqqflc+hggls
Q: 184   LSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLS  243
         ************************************************************
S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180
         pe+ tlddi++l+rf+eppayg+mcdllwsdpledfgnek++e+f+hnsvrgcsyf+sy+
Q: 244   PEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYS  303
         ************************************************************
S: 181   avceflqennllsiiraheaq  201
         a+ceflq+nnllsi+raheaq
Q: 304   ACCEFLQKNNLLSIVRAHEAQ  324
         ********************8
Domain Sequence
(FASTA)
PITVCGDIHG QFFDLVKLFE VGGPPATTRY LFLGDYVDRG YFSIECVLYL WSLKITYPTT 60
LSLLRGNHEC RHLTEYFTFK QECIIKYSES IYDACMEAFD CLPLAALLNQ QFLCIHGGLS 120
PEIFTLDDIK TLNRFREPPA YGPMCDLLWS DPLEDFGNEK TNEFFSHNSV RGCSYFFSYS 180
ACCEFLQKNN LLSIVRAHEA Q 201
KeywordCalmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005955; C:calcineurin complex
GO:0008021; C:synaptic vesicle
GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity
GO:0046872; F:metal ion binding
GO:0072375; P:medium-term memory
GO:0007269; P:neurotransmitter secretion
GO:0006470; P:protein dephosphorylation
GO:0030431; P:sleep
GO:0016192; P:vesicle-mediated transport
KEGG
dme:Dmel_CG1455;
InterPros
IPR004843; Metallo_PEstase_dom.
IPR006186; Ser/Thr-sp_prot-phosphatase.
Pfam
PF00149; Metallophos; 1.
SMARTs
SM00156; PP2Ac; 1.
Prosites
PS00125; SER_THR_PHOSPHATASE; 1.
Prints
PR00114; STPHPHTASE.
Created Date20-Feb-2013