EKS-DRM-00118

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00118

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	353.4	1.0E-105	197	456	260

Status

Reviewed

Ensembl Protein

FBpp0073579

UniProt Accession

Q23977; O18411; Q8SZ04; Q8SZZ1; Q9I7S3;

Protein Name

Dual specificity mitogen-activated protein kinase kinase hemipterous

Protein Synonyms/Alias

MAPKK;

Gene Name

hep

Gene Synonyms/Alias

hep; hem, MKK7; CG4353;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0010303	FBpp0073578	FBtr0073747
FBgn0010303	FBpp0073579	FBtr0073748
FBgn0010303	FBpp0303423	FBtr0330397
FBgn0010303	FBpp0303422	FBtr0330396

Organism

Drosophila melanogaster

Functional Description

Required for the epithelial cell sheet movement calleddorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis.

Protein Length

492

Protein Sequence
(FASTA)

MSTIEFETIG SRLQSLEAKL QAQNESHDQI VLSGARGPVV SGSVPSARVP PLATSASAAT 60

SATHAPSLGA GSVSGSGISI AQRPAPPVPH ATPFGSASAS SSSSSASAFA SAAPATGTFG 120

GTYTPPTTRV SRATPTLPML SSGPGGGLNR TRPVILPLPT PPHPPVSETD MKLKIIMEQT 180

GKLNINGRQY PTDINDLKHL GDLGNGTSGN VVKMMHLSSN TIIAVKQMRR TGNAEENKRI 240

LMDLDVVLKS HDCKYIVKCL GCFVRDPDVW ICMELMSMCF DKLLKLSKKP VPEQILGKVT 300

VATVNALSYL KDKHGVIHRD VKPSNILIDE RGNIKLCDFG ISGRLVDSKA NTRSAGCAAY 360

MAPERIDPKK PKYDIRADVW SLGITLVELA TARSPYEGCN TDFEVLTKVL DSEPPCLPYG 420

EGYNFSQQFR DFVIKCLTKN HQDRPKYPEL LAQPFIRIYE SAKVDVPNWF QSIKDNRLRA 480

NGDPTLQRLP NS 492

Nucleotide Sequence
(FASTA)

ATGTCCACCA TTGAGTTCGA AACGATCGGC AGTCGGCTGC AATCCTTGGA GGCAAAGCTC 60

CAGGCGCAGA ATGAGTCCCA CGACCAGATC GTCCTCTCCG GTGCGCGCGG CCCTGTCGTT 120

TCCGGTTCCG TTCCATCTGC CCGCGTCCCG CCCCTGGCGA CATCCGCATC CGCAGCCACA 180

TCCGCCACCC ACGCACCTTC CTTGGGCGCA GGTTCCGTTT CCGGATCGGG TATCAGCATA 240

GCCCAGCGTC CAGCACCTCC AGTTCCTCAT GCGACGCCCT TCGGCAGCGC CAGCGCCTCG 300

TCATCATCCT CATCCGCATC CGCATTTGCA TCCGCAGCAC CGGCGACGGG CACCTTCGGT 360

GGAACATACA CCCCGCCGAC AACTAGAGTG TCGCGAGCCA CGCCCACACT GCCCATGCTT 420

TCTAGTGGTC CCGGTGGTGG ACTGAATCGT ACGCGGCCGG TGATACTTCC GCTGCCCACG 480

CCGCCACATC CTCCAGTTTC GGAAACGGAC ATGAAGCTGA AGATCATCAT GGAGCAGACC 540

GGCAAGCTGA ACATCAACGG GCGGCAGTAT CCGACGGACA TCAATGACCT CAAGCACCTG 600

GGCGACCTGG GCAATGGGAC TAGCGGCAAT GTGGTGAAGA TGATGCACCT GTCCAGCAAC 660

ACGATCATCG CCGTGAAGCA GATGCGACGC ACTGGCAACG CGGAGGAGAA CAAACGCATC 720

CTGATGGATC TGGATGTTGT GCTCAAATCG CACGACTGCA AGTACATTGT CAAGTGCCTT 780

GGCTGCTTCG TTCGCGATCC GGATGTGTGG ATCTGCATGG AGCTGATGTC CATGTGCTTT 840

GACAAGCTGC TCAAGCTGTC CAAGAAGCCG GTGCCGGAAC AGATCCTGGG CAAGGTCACA 900

GTGGCGACGG TCAACGCATT GTCCTACTTG AAGGACAAGC ACGGAGTCAT CCATCGAGAT 960

GTGAAGCCCT CGAACATTCT GATCGATGAG CGCGGGAACA TCAAGCTCTG TGATTTCGGG 1020

ATCAGCGGAC GCCTGGTGGA CTCCAAGGCC AACACTCGAT CCGCCGGCTG TGCAGCTTAT 1080

ATGGCGCCGG AGCGCATCGA CCCCAAGAAA CCAAAGTACG ACATTCGCGC AGATGTGTGG 1140

TCACTGGGCA TAACGCTGGT GGAGCTGGCC ACAGCGCGAT CCCCGTACGA GGGATGCAAC 1200

ACGGACTTCG AGGTGCTCAC CAAGGTGCTT GACTCGGAGC CGCCGTGTTT GCCATACGGC 1260

GAGGGTTACA ACTTTAGTCA GCAGTTCCGC GATTTCGTCA TCAAGTGCCT CACAAAGAAC 1320

CATCAGGATC GACCCAAGTA TCCGGAGCTT TTGGCCCAGC CCTTCATCCG GATTTATGAA 1380

TCAGCCAAAG TAGATGTGCC CAATTGGTTT CAGAGCATCA AGGATAACCG ACTGCGCGCC 1440

AATGGCGATC CAACGCTCCA GAGGTTACCT AATTCCTAA 1479

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l++lG+G++g+V k++h +s++i+avK++r++ + ee+k+il++l+v+ ks++++yi

Q: 197   LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYI  256

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         vk+ G+fv++ dv+icmelm+ +++dk+lk    +kk +pe++lgk++va+v+al+ylk+

Q: 257   VKCLGCFVRDPDVWICMELMS-MCFDKLLKL---SKKPVPEQILGKVTVATVNALSYLKD  312

         *********************.*******97...599***********************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg.kkk  178

         k+ +iHRDvKPsNiL++++G++KlCDFG+sg+lvds A+++ +G+++YmaPEri++ k+k

Q: 313   KHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRsAGCAAYMAPERIDPkKPK  372

         ********************************************************899*

S: 179   YsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseefqef  235

         Y++++dvWslG+tlvelat+r pye +++++e+l++++++epp lp     +fs++f++f

Q: 373   YDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGegyNFSQQFRDF  432

         **********************************************998999********

S: 236   vskClkkdekeRpklkellkhafi  259

         v kCl+k++++Rpk+ ell+++fi

Q: 433   VIKCLTKNHQDRPKYPELLAQPFI  456

         **********************97

Domain Sequence
(FASTA)

LKHLGDLGNG TSGNVVKMMH LSSNTIIAVK QMRRTGNAEE NKRILMDLDV VLKSHDCKYI 60

VKCLGCFVRD PDVWICMELM SMCFDKLLKL SKKPVPEQIL GKVTVATVNA LSYLKDKHGV 120

IHRDVKPSNI LIDERGNIKL CDFGISGRLV DSKANTRSAG CAAYMAPERI DPKKPKYDIR 180

ADVWSLGITL VELATARSPY EGCNTDFEVL TKVLDSEPPC LPYGEGYNFS QQFRDFVIKC 240

LTKNHQDRPK YPELLAQPFI 260

Keyword

Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0005078	; F:MAP-kinase scaffold activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0051017	; P:actin filament bundle assembly
GO:0048675	; P:axon extension
GO:0034769	; P:basement membrane disassembly
GO:0007298	; P:border follicle cell migration
GO:0033500	; P:carbohydrate homeostasis
GO:0071243	; P:cellular response to arsenic-containing substance
GO:0071276	; P:cellular response to cadmium ion
GO:0030381	; P:chorion-containing eggshell pattern formation
GO:0008340	; P:determination of adult lifespan
GO:0046843	; P:dorsal appendage formation
GO:0007395	; P:dorsal closure, spreading of leading edge cells
GO:0001736	; P:establishment of planar polarity
GO:0046847	; P:filopodium assembly
GO:0007561	; P:imaginal disc eversion
GO:0046529	; P:imaginal disc fusion, thorax closure
GO:0030032	; P:lamellipodium assembly
GO:0035006	; P:melanization defense response
GO:0046844	; P:micropyle formation
GO:0046330	; P:positive regulation of JNK cascade
GO:0045610	; P:regulation of hemocyte differentiation
GO:0009408	; P:response to heat
GO:0070328	; P:triglyceride homeostasis
GO:0042060	; P:wound healing

KEGG

dme:Dmel_CG4353

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013