EKS-DRM-00064
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00064
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt483.61.9E-145185442258
StatusReviewed
Ensembl ProteinFBpp0082680
UniProt AccessionQ8INB9; Q0KI65; Q24293; Q24469; Q24470; Q7JN11; Q8T9A5; Q9VEY7;
Protein NameRAC serine/threonine-protein kinase
Protein Synonyms/Alias DAkt; DRAC-PK; Dakt1; Akt; Protein kinase B; PKB;
Gene NameAkt1
Gene Synonyms/Alias Akt1; CG4006;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0010379FBpp0082682FBtr0083228
FBgn0010379FBpp0082680FBtr0083226
FBgn0010379FBpp0082681FBtr0083227
OrganismDrosophila melanogaster
Functional DescriptionSerine/threonine kinase involved in variousdevelopmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex. Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth.
Protein Length530
Protein Sequence
(FASTA)
MSINTTFDLS SPSVTSGHAL TEQTQVVKEG WLMKRGEHIK NWRQRYFVLH SDGRLMGYRS 60
KPADSASTPS DFLLNNFTVR GCQIMTVDRP KPFTFIIRGL QWTTVIERTF AVESELERQQ 120
WTEAIRNVSS RLIDVGEVAM TPSEQTDMTD VDMATIAEDE LSEQFSVQGT TCNSSGVKKV 180
TLENFEFLKV LGKGTFGKVI LCREKATAKL YAIKILKKEV IIQKDEVAHT LTESRVLKST 240
NHPFLISLKY SFQTNDRLCF VMQYVNGGEL FWHLSHERIF TEDRTRFYGA EIISALGYLH 300
SQGIIYRDLK LENLLLDKDG HIKVADFGLC KEDITYGRTT KTFCGTPEYL APEVLDDNDY 360
GQAVDWWGTG VVMYEMICGR LPFYNRDHDV LFTLILVEEV KFPRNITDEA KNLLAGLLAK 420
DPKKRLGGGK DDVKEIQAHP FFASINWTDL VLKKIPPPFK PQVTSDTDTR YFDKEFTGES 480
VELTPPDPTG PLGSIAEEPL FPQFSYQGDM ASTLGTSSHI STSTSLASMQ 530
Nucleotide Sequence
(FASTA)
ATGTCAATAA ACACAACTTT CGACCTCAGC TCGCCCAGCG TTACATCGGG TCATGCGCTT 60
ACGGAACAGA CTCAGGTCGT AAAGGAGGGG TGGCTGATGA AGAGGGGCGA GCACATAAAG 120
AACTGGCGCC AGCGCTACTT CGTGCTCCAC TCCGATGGAA GACTGATGGG TTACCGCAGC 180
AAGCCGGCAG ATAGTGCCAG CACGCCATCG GACTTCCTGC TCAACAACTT TACGGTGCGC 240
GGCTGCCAGA TCATGACCGT CGATCGGCCC AAGCCATTCA CCTTCATCAT CCGCGGCCTG 300
CAATGGACCA CGGTAATCGA AAGGACATTT GCCGTCGAAT CAGAATTAGA GCGCCAGCAG 360
TGGACGGAGG CCATTCGCAA CGTATCCAGC CGGCTCATAG ATGTGGGTGA GGTGGCTATG 420
ACGCCATCTG AACAGACAGA CATGACAGAC GTGGACATGG CCACCATTGC CGAGGACGAG 480
CTTTCCGAGC AGTTCTCCGT ACAGGGAACG ACTTGTAATA GCAGCGGCGT TAAGAAAGTG 540
ACTTTGGAGA ATTTTGAGTT CCTCAAGGTG CTCGGCAAGG GCACCTTTGG TAAGGTTATT 600
TTGTGTCGCG AGAAGGCTAC CGCCAAGCTG TACGCGATCA AAATTCTTAA AAAGGAAGTT 660
ATTATCCAAA AGGACGAGGT GGCCCATACC CTGACCGAGA GTCGTGTGCT CAAGTCCACA 720
AATCATCCGT TCCTCATTTC ACTCAAATAT TCGTTTCAAA CCAACGACCG CCTGTGTTTT 780
GTGATGCAGT ACGTGAACGG TGGCGAGCTC TTTTGGCATT TAAGCCACGA ACGCATATTT 840
ACTGAGGATC GAACACGTTT CTATGGGGCA GAGATCATTT CTGCTCTGGG CTATCTGCAT 900
TCACAGGGCA TAATTTATCG CGACTTAAAG CTGGAAAATC TTTTGCTGGA CAAAGATGGT 960
CACATAAAGG TCGCAGACTT CGGTCTGTGC AAGGAGGACA TCACCTACGG CCGCACAACG 1020
AAAACCTTCT GCGGTACACC GGAATACCTA GCTCCGGAAG TATTAGATGA CAATGATTAT 1080
GGCCAAGCGG TGGACTGGTG GGGCACTGGC GTGGTCATGT ACGAGATGAT CTGTGGTCGT 1140
CTTCCGTTTT ACAATCGTGA TCATGATGTG CTCTTTACAT TGATTTTGGT GGAGGAGGTA 1200
AAATTCCCGC GTAATATCAC AGATGAGGCG AAAAATCTGT TAGCAGGCCT TCTAGCTAAG 1260
GATCCCAAAA AGCGTTTGGG AGGTGGAAAG GATGATGTCA AGGAGATACA AGCACATCCA 1320
TTCTTTGCGA GTATTAACTG GACAGATCTA GTGTTGAAAA AAATACCGCC GCCTTTCAAG 1380
CCTCAGGTGA CATCCGATAC GGATACAAGG TACTTCGACA AGGAGTTTAC GGGAGAGAGT 1440
GTGGAGTTGA CGCCGCCGGA TCCCACTGGC CCGTTGGGCT CCATAGCCGA AGAGCCGCTT 1500
TTCCCGCAGT TCAGCTACCA AGGAGACATG GCCTCCACGT TGGGCACCTC GTCGCACATT 1560
AGTACTTCCA CAAGTCTCGC ATCGATGCAA TAG 1593
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         f++lk+lGkGtfGkvil+rekat+klya+kilkkevi++kdevahtlte+rvlk+t+hpf
Q: 185   FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPF  244
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120
         l++lkysfqt+++lc+v++yvnGGelf+hls+er+f+edr+rfygaei+sal+ylhs+ +
Q: 245   LISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGI  304
         ************************************************************
S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180
         +yrdlklenllldkdGhik++dfGlcke+i++g++tktfcGtpeylapevl+d+dyg+av
Q: 305   IYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAV  364
         ************************************************************
S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240
         dwwg+Gvv+yem+cGrlpfyn+dh+ lf+lil+ee+kfpr++++eak+ll+Gll+kdpkk
Q: 365   DWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKK  424
         ************************************************************
S: 241   rlGggkddakeireheff  258
         rlGggkdd+kei++h+ff
Q: 425   RLGGGKDDVKEIQAHPFF  442
         *****************9
Domain Sequence
(FASTA)
FEFLKVLGKG TFGKVILCRE KATAKLYAIK ILKKEVIIQK DEVAHTLTES RVLKSTNHPF 60
LISLKYSFQT NDRLCFVMQY VNGGELFWHL SHERIFTEDR TRFYGAEIIS ALGYLHSQGI 120
IYRDLKLENL LLDKDGHIKV ADFGLCKEDI TYGRTTKTFC GTPEYLAPEV LDDNDYGQAV 180
DWWGTGVVMY EMICGRLPFY NRDHDVLFTL ILVEEVKFPR NITDEAKNLL AGLLAKDPKK 240
RLGGGKDDVK EIQAHPFF 258
KeywordAlternative initiation; Apoptosis; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Developmental protein; Growth regulation; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00131
EKS-ANC-00134
EKS-BOT-00139
EKS-CAE-00113
EKS-CAJ-00143
EKS-CAF-00145
EKS-CAP-00139
EKS-CII-00086
EKS-CIS-00177
EKS-DAR-00421
EKS-DAN-00010
EKS-DIO-00075
EKS-ECT-00022
EKS-EQC-00136
EKS-FEC-00130
EKS-GAM-00069
EKS-GAG-00117
EKS-GAA-00163
EKS-GOG-00139
EKS-HOS-00144
EKS-ICT-00132
EKS-LAC-00148
EKS-LOA-00138
EKS-MAM-00137
EKS-MAE-00052
EKS-MEG-00107
EKS-MIM-00067
EKS-MOD-00138
EKS-MUM-00142
EKS-MUP-00142
EKS-MYL-00149
EKS-NOL-00133
EKS-OCP-00093
EKS-ORN-00170
EKS-ORA-00118
EKS-ORC-00132
EKS-ORL-00162
EKS-OTG-00145
EKS-PAT-00129
EKS-PES-00124
EKS-PEM-00075
EKS-POA-00134
EKS-PRC-00020
EKS-PTV-00129
EKS-RAN-00135
EKS-SAH-00133
EKS-SUS-00122
EKS-TAG-00167
EKS-TAR-00179
EKS-TAS-00054
EKS-TEN-00174
EKS-TUB-00017
EKS-TUT-00134
EKS-VIP-00069
EKS-XET-00128
EKS-XIM-00167
Gene Ontology
GO:0009986; C:cell surface
GO:0005829; C:cytosol
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0035091; F:phosphatidylinositol binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006915; P:apoptotic process
GO:0008362; P:chitin-based embryonic cuticle biosynthetic process
GO:0007623; P:circadian rhythm
GO:0031104; P:dendrite regeneration
GO:0007427; P:epithelial cell migration, open tracheal system
GO:0008286; P:insulin receptor signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0019915; P:lipid storage
GO:0060292; P:long term synaptic depression
GO:0043066; P:negative regulation of apoptotic process
GO:0048680; P:positive regulation of axon regeneration
GO:0030307; P:positive regulation of cell growth
GO:0045793; P:positive regulation of cell size
GO:0040018; P:positive regulation of multicellular organism growth
GO:0046622; P:positive regulation of organ growth
GO:0008360; P:regulation of cell shape
GO:0050773; P:regulation of dendrite development
GO:0035206; P:regulation of hemocyte proliferation
GO:0042306; P:regulation of protein import into nucleus
GO:0006979; P:response to oxidative stress
KEGG
dme:Dmel_CG4006;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013