EKS-DRM-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	477.1	1.7E-143	416	688	273

Status

Reviewed

Ensembl Protein

FBpp0082970

UniProt Accession

Q07407; A4V320; O18371; Q26294; Q9VED5;

Protein Name

Fibroblast growth factor receptor homolog 1

Protein Synonyms/Alias

DmHD-38; Protein heartless; Tyrosine kinase 1; dTk1;

Gene Name

htl

Gene Synonyms/Alias

htl; FR1, Tk1; CG7223;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0010389	FBpp0082972	FBtr0083550
FBgn0010389	FBpp0082971	FBtr0083549
FBgn0010389	FBpp0082970	FBtr0083548

Organism

Drosophila melanogaster

Functional Description

May be required for patterning of muscle precursorcells. May be essential for generation of mesodermal and endodermal layers, invaginations of various types of cells and CNS formation.

Protein Length

729

Protein Sequence
(FASTA)

MAAAWSWRAS HSTITMTSGS LVVLFLLLSI WQPAVQVEGR RQMANSQEMI KDHLGARSQN 60

KTPAITNNAN QSSTSSADLD DGAADDDDNK ADLPVNVSSK PYWRNPKKMS FLQTRPSGSL 120

LTLNCHALGN PEPNITWYRN GTVDWTRGYG SLKRNRWTLT MEDLVPGDCG NYTCKVCNSL 180

GCIRHDTQVI VSDRVNHKPI LMTGPLNLTL VVNSTGSMHC KYLSDLTSKK AWIFVPCHGM 240

TNCSNNRSII AEDKDQLDFV NVRMEQEGWY TCVESNSLGQ SNSTAYLRVV RSLHVLEAGV 300

ASGSLHSTSF VYIFVFGGLI FIFMTTLFVF YAIRKMKHEK VLKQRIETVH QWTKKVIIFK 360

PEGGGDSSGS MDTMIMPVVR IQKQRTTVLQ NGNEPAPFNE YEFPLDSNWE LPRSHLVLGA 420

TLGEGAFGRV VMAEVNNAIV AVKMVKEGHT DDDIASLVRE MEVMKIIGRH INIINLLGCC 480

SQNGPLYVIV EYAPHGNLKD FLYKNRPFGR DQDRDSSQPP PSPPAHVITE KDLIKFAHQI 540

ARGMDYLASR RCIHRDLAAR NVLVSDDYVL KIADFGLARD IQSTDYYRKN TNGRLPIKWM 600

APESLQEKFY DSKSDVWSYG ILLWEIMTYG QQPYPTIMSA EELYTYLMSG QRMEKPAKCS 660

MNIYILMRQC WHFNADDRPP FTEIVEYMDK LLQTKEDYLD VDIANLDTPP STSDEEEDET 720

DNLQKWCNY 729

Nucleotide Sequence
(FASTA)

ATGGCTGCCG CCTGGAGTTG GCGAGCCAGT CACTCAACGA TCACAATGAC AAGCGGATCG 60

CTGGTAGTGC TCTTCCTGTT GCTTTCGATT TGGCAGCCAG CCGTGCAGGT TGAAGGACGA 120

CGCCAAATGG CCAATAGCCA GGAGATGATC AAGGATCATT TGGGAGCCAG GAGTCAAAAC 180

AAGACACCAG CCATCACGAA CAATGCTAAT CAATCGAGCA CATCCAGTGC GGATTTGGAT 240

GATGGCGCCG CAGATGATGA TGATAACAAG GCCGATTTGC CGGTGAATGT CAGTTCGAAA 300

CCCTACTGGC GTAATCCCAA AAAGATGAGT TTTCTGCAGA CGCGACCCTC GGGCTCACTG 360

CTCACCCTCA ATTGCCATGC CCTGGGCAAT CCTGAGCCCA ATATCACATG GTATCGCAAT 420

GGCACCGTCG ACTGGACGCG CGGCTATGGG AGCCTGAAGC GGAATCGATG GACCCTGACG 480

ATGGAGGATC TGGTGCCGGG CGATTGTGGC AACTACACCT GCAAGGTGTG CAATTCATTG 540

GGTTGCATTC GTCACGACAC CCAGGTGATT GTAAGCGATC GAGTTAATCA CAAACCGATC 600

CTGATGACCG GTCCATTGAA TCTCACACTG GTGGTCAATT CCACAGGCAG CATGCACTGC 660

AAATATCTAT CGGACTTGAC CAGCAAGAAG GCGTGGATCT TTGTGCCCTG CCATGGCATG 720

ACCAACTGCT CCAACAATCG ATCCATCATT GCCGAGGATA AGGATCAGTT GGACTTCGTG 780

AACGTTAGGA TGGAGCAGGA GGGCTGGTAC ACGTGCGTCG AAAGCAACAG CCTGGGTCAA 840

TCCAATAGCA CTGCATATCT GCGAGTGGTG CGAAGTCTTC ACGTCTTGGA AGCCGGAGTT 900

GCCAGTGGTT CACTTCACTC GACCAGCTTC GTGTATATCT TCGTCTTTGG CGGACTTATT 960

TTCATCTTTA TGACCACCCT GTTTGTGTTC TATGCCATCC GAAAGATGAA ACATGAAAAG 1020

GTGTTGAAAC AACGCATCGA AACCGTTCAC CAGTGGACCA AGAAAGTGAT CATCTTCAAG 1080

CCCGAAGGTG GCGGAGACTC CAGTGGTTCC ATGGACACCA TGATTATGCC GGTGGTTAGG 1140

ATACAGAAAC AGCGCACCAC TGTTCTTCAG AATGGCAACG AGCCGGCTCC ATTCAATGAA 1200

TATGAATTTC CACTGGACTC GAACTGGGAA CTGCCCAGAA GTCATTTGGT ACTGGGTGCC 1260

ACTTTGGGAG AAGGTGCTTT CGGACGAGTG GTCATGGCGG AGGTCAATAA TGCCATTGTC 1320

GCCGTGAAAA TGGTGAAGGA AGGACACACG GATGATGACA TTGCCAGCTT GGTGCGGGAA 1380

ATGGAAGTGA TGAAGATCAT TGGGCGACAT ATCAATATTA TTAACTTACT TGGTTGCTGC 1440

AGTCAAAATG GTCCGCTCTA TGTGATTGTC GAGTATGCGC CACACGGAAA TCTCAAGGAC 1500

TTCCTCTATA AAAATCGACC CTTCGGAAGG GATCAGGATA GGGACAGCTC GCAACCGCCG 1560

CCATCGCCAC CAGCTCATGT GATAACCGAA AAGGATCTGA TCAAATTTGC CCACCAAATT 1620

GCCAGAGGAA TGGACTATTT GGCCTCGCGG CGATGCATCC ATCGAGATTT GGCAGCCAGG 1680

AATGTGCTCG TCAGCGATGA TTATGTGCTG AAGATTGCTG ATTTTGGACT GGCGAGGGAC 1740

ATTCAAAGCA CGGATTACTA TCGGAAGAAC ACAAATGGCA GGCTACCCAT CAAATGGATG 1800

GCACCGGAGT CGCTGCAGGA GAAATTCTAT GATTCCAAGA GCGATGTCTG GTCATATGGC 1860

ATCCTGCTGT GGGAGATCAT GACCTATGGG CAGCAACCAT ATCCAACTAT CATGTCCGCT 1920

GAGGAGCTGT ACACCTATCT CATGTCCGGT CAGCGGATGG AGAAACCAGC GAAATGCTCC 1980

ATGAACATCT ACATTCTGAT GCGACAATGT TGGCATTTCA ACGCCGACGA TCGGCCACCT 2040

TTTACGGAAA TTGTTGAGTA TATGGACAAG CTGCTCCAGA CGAAGGAGGA CTACCTCGAT 2100

GTGGATATCG CCAATCTGGA TACACCGCCC TCGACTAGCG ACGAGGAGGA AGATGAAACG 2160

GACAACCTGC AGAAGTGGTG TAATTATTAA 2190

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlg++lGeGafG+vv+ae+         ++++vavkm+ke +td+d+a+lv+emev+k+

Q: 416   LVLGATLGEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKI  466

         79*****************9.........889****************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeask....dkskasee  116

         iG+h+niinllG+c+q+Gplyviveya++Gnl++fl+++rp g+++++     +++ +++

Q: 467   IGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRdssqPPPSPPAH  526

         *******************************************99998333345566788

S: 117   qltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidy  176

          +tekdl++fa+q+arGm+ylas++cihrdlaarnvlv++d+vlkiadfGlard++++dy

Q: 527   VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDY  586

         ************************************************************

S: 177   ykkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgi.aveelfkl  235

         y+k+tnGrlp+kwmape+l++++y+s+sdvws+G+llwei+t+G++pyp+i ++eel+++

Q: 587   YRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTImSAEELYTY  646

         ***************************************************99*******

S: 236   lkeGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         l++G+rmekpakc++++y+lmr+cwh++a++rp+f+++ve++

Q: 647   LMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM  688

         ****************************************86

Domain Sequence
(FASTA)

LVLGATLGEG AFGRVVMAEV NNAIVAVKMV KEGHTDDDIA SLVREMEVMK IIGRHINIIN 60

LLGCCSQNGP LYVIVEYAPH GNLKDFLYKN RPFGRDQDRD SSQPPPSPPA HVITEKDLIK 120

FAHQIARGMD YLASRRCIHR DLAARNVLVS DDYVLKIADF GLARDIQSTD YYRKNTNGRL 180

PIKWMAPESL QEKFYDSKSD VWSYGILLWE IMTYGQQPYP TIMSAEELYT YLMSGQRMEK 240

PAKCSMNIYI LMRQCWHFNA DDRPPFTEIV EYM 273

Keyword

ATP-binding; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0010002	; P:cardioblast differentiation
GO:0007493	; P:endodermal cell fate determination
GO:0048013	; P:ephrin receptor signaling pathway
GO:0010001	; P:glial cell differentiation
GO:0008347	; P:glial cell migration
GO:0007506	; P:gonadal mesoderm development
GO:0007523	; P:larval visceral muscle development
GO:0048542	; P:lymph gland development
GO:0007500	; P:mesodermal cell fate determination
GO:0008078	; P:mesodermal cell migration
GO:0048747	; P:muscle fiber development
GO:0061320	; P:pericardial nephrocyte differentiation
GO:0007280	; P:pole cell migration
GO:0008284	; P:positive regulation of cell proliferation
GO:0008360	; P:regulation of cell shape
GO:0007431	; P:salivary gland development
GO:0007525	; P:somatic muscle development
GO:0007419	; P:ventral cord development

KEGG

dme:Dmel_CG7223

;

InterPros

IPR020766	; Fibroblast_GF_rcpt-like.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013