EKS-DRM-00096
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00096
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ror482.16.7E-145410675266
StatusReviewed
Ensembl ProteinFBpp0079568
UniProt AccessionQ24488;
Protein NameTyrosine-protein kinase transmembrane receptor Ror
Protein Synonyms/Alias dRor;
Gene NameRor
Gene Synonyms/Alias Ror; CG4926;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0010407FBpp0079568FBtr0079978
OrganismDrosophila melanogaster
Functional DescriptionTyrosine-protein kinase receptor that functions duringearly stages of neuronal development.
Protein Length685
Protein Sequence
(FASTA)
MNKYSAFIVC ISLVLLFTKK DVGSHNVDSR IYGFQQSSGI CHIYNGTICR DVLSNAHVFV 60
SPNLTMNDLE ERLKAAYGVI KESKDMNANC RMYALPSLCF SSMPICRTPE RTNLLYFANV 120
ATNAKQLKNV SIRRKRTKSK DIKNISIFKK KSTIYEDVFS TDISSKYPPT RESENLKRIC 180
REECELLENE LCQKEYAIAK RHPVIGMVGV EDCQKLPQHK DCLSLGITIE VDKTENCYWE 240
DGSTYRGVAN VSASGKPCLR WSWLMKEISD FPELIGQNYC RNPGSVENSP WCFVDSSRER 300
IIELCDIPKC ADKIWIAIVG TTAAIILIFI IIFAIILFKR RTIMHYGMRN IHNINTPSAD 360
KNIYGNSQLN NAQDAGRGNL GNLSDHVALN SKLIERNTLL RINHFTLQDV EFLEELGEGA 420
FGKVYKGQLL QPNKTTITVA IKALKENASV KTQQDFKREI ELISDLKHQN IVCILGVVLN 480
KEPYCMLFEY MANGDLHEFL ISNSPTEGKS LSQLEFLQIA LQISEGMQYL SAHHYVHRDL 540
AARNCLVNEG LVVKISDFGL SRDIYSSDYY RVQSKSLLPV RWMPSESILY GKFTTESDVW 600
SFGVVLWEIY SYGMQPYYGF SNQEVINLIR SRQLLSAPEN CPTAVYSLMI ECWHEQSVKR 660
PTFTDISNRL KTWHEGHFKA SNPEM 685
Nucleotide Sequence
(FASTA)
ATGAACAAAT ACTCGGCATT TATAGTCTGC ATTTCGCTCG TGCTTTTATT TACAAAAAAG 60
GATGTGGGGA GCCATAATGT GGACTCAAGA ATATATGGTT TCCAGCAATC ATCAGGTATT 120
TGCCATATTT ACAATGGCAC CATTTGTCGC GATGTCTTGA GCAATGCCCA TGTTTTCGTA 180
TCCCCCAATC TCACCATGAA CGATTTGGAG GAGCGATTAA AGGCAGCTTA TGGAGTAATC 240
AAGGAATCCA AGGATATGAA CGCAAATTGC CGCATGTACG CTTTGCCCAG CTTGTGTTTC 300
AGTTCAATGC CAATTTGCCG GACTCCAGAG CGCACGAATC TCTTGTACTT CGCCAACGTG 360
GCCACAAATG CCAAGCAACT GAAGAACGTC AGCATTCGAC GGAAGAGAAC CAAGTCCAAG 420
GACATTAAGA ACATAAGCAT ATTCAAGAAG AAGTCCACCA TCTACGAGGA TGTGTTCAGC 480
ACAGACATAT CGAGTAAATA CCCACCAACC AGAGAGTCTG AGAACCTAAA ACGCATTTGC 540
CGCGAAGAGT GCGAACTTCT GGAGAACGAG CTGTGCCAGA AGGAATATGC CATTGCCAAG 600
CGACATCCCG TCATCGGGAT GGTGGGTGTG GAGGATTGCC AAAAGTTGCC GCAGCACAAG 660
GACTGCCTAT CCTTGGGCAT CACCATCGAG GTGGATAAGA CGGAGAATTG TTACTGGGAG 720
GATGGATCGA CATATAGAGG AGTGGCCAAC GTCTCCGCAT CCGGAAAGCC ATGTTTGCGA 780
TGGTCATGGC TGATGAAGGA AATCTCCGAT TTCCCTGAAC TCATCGGTCA GAATTATTGC 840
AGAAATCCTG GAAGCGTTGA AAATAGTCCT TGGTGTTTTG TGGACTCCTC ACGTGAACGC 900
ATAATCGAAC TTTGTGATAT TCCAAAATGT GCGGACAAAA TATGGATTGC CATTGTCGGA 960
ACGACTGCAG CCATTATTCT AATATTCATA ATTATATTTG CGATAATACT TTTCAAAAGG 1020
AGAACAATCA TGCACTATGG AATGAGGAAT ATTCATAATA TCAACACACC CAGCGCCGAT 1080
AAAAATATCT ACGGAAATTC GCAGCTTAAT AACGCACAAG ATGCTGGCAG GGGAAATCTG 1140
GGAAATCTAT CCGATCACGT TGCTTTGAAC TCCAAACTTA TCGAAAGAAA TACTCTGCTG 1200
AGGATAAACC ATTTTACGCT GCAGGATGTT GAGTTTCTGG AGGAGCTGGG CGAAGGAGCT 1260
TTTGGAAAAG TCTACAAGGG ACAGCTCCTG CAGCCGAACA AAACCACCAT AACAGTTGCC 1320
ATCAAGGCGT TGAAGGAAAA CGCCTCGGTG AAAACGCAGC AGGACTTTAA GCGCGAAATC 1380
GAACTAATCT CGGATCTAAA GCATCAGAAT ATAGTGTGCA TATTGGGCGT AGTGCTCAAT 1440
AAGGAGCCCT ACTGCATGCT GTTCGAGTAC ATGGCCAATG GTGATCTGCA CGAATTCCTA 1500
ATCTCAAACT CACCCACCGA AGGCAAGTCG CTGTCGCAGT TGGAATTCCT GCAAATAGCT 1560
CTACAAATCA GCGAAGGAAT GCAGTATCTG TCGGCCCATC ATTACGTACA TCGCGACTTG 1620
GCAGCTCGGA ATTGCCTGGT AAACGAGGGT CTGGTTGTGA AGATATCCGA TTTTGGACTA 1680
TCCAGAGACA TTTACAGCTC AGATTATTAT CGAGTTCAGT CAAAGTCGCT ATTGCCTGTA 1740
AGGTGGATGC CCTCGGAATC GATATTGTAT GGAAAGTTTA CGACCGAGAG CGATGTTTGG 1800
TCCTTTGGAG TCGTTCTTTG GGAAATATAC AGCTATGGAA TGCAGCCATA CTACGGTTTT 1860
AGCAATCAGG AAGTAATCAA TCTCATCCGT TCACGGCAAC TGCTCTCCGC TCCGGAAAAC 1920
TGTCCCACTG CTGTCTACTC GCTAATGATC GAGTGCTGGC ATGAGCAGTC AGTAAAACGT 1980
CCAACATTCA CAGATATTTC GAACCGTCTC AAAACTTGGC ACGAGGGCCA CTTTAAGGCC 2040
AGTAATCCAG AAATGTAA 2058
Domain Profile
S: 1     vrfleelGegafGkvykGhlfapekektqavaiktlkdkaeakereefkqeielvaelkh  60
         v+fleelGegafGkvykG+l++p+k +t++vaik+lk++a++k++++fk+eiel+++lkh
Q: 410   VEFLEELGEGAFGKVYKGQLLQPNK-TTITVAIKALKENASVKTQQDFKREIELISDLKH  468
         79***********************.9*********************************
S: 61    pnivcllGvvtkdqpllmlfeylshGdlheflivrsphsdvgssdedrtvkssleeadfl  120
         +nivc+lGvv++++p++mlfey+++Gdlhefli++sp           t+++sl++ +fl
Q: 469   QNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSP-----------TEGKSLSQLEFL  517
         *************************************...........899*********
S: 121   hiaiqiaaGmeylsshsfvhkdlaarnvlvgdkltvkisdlGlsreiysadyykllsksl  180
         +ia+qi++Gm+yls+h++vh+dlaarn+lv++ l+vkisd+Glsr+iys+dyy+++sksl
Q: 518   QIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSL  577
         ************************************************************
S: 181   lpirwmskeailyGkfsedsdiwsfGvvlweifsfGlqpyeGfsnqevielvrkrqllec  240
         lp+rwm++e+ilyGkf+++sd+wsfGvvlwei+s+G+qpy+Gfsnqevi+l+r+rqll++
Q: 578   LPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSA  637
         ************************************************************
S: 241   pedcpaavyslmiecwneipsrrprfkdirsrlrswen  278
         pe+cp+avyslmiecw+e++++rp+f+di++rl++w++
Q: 638   PENCPTAVYSLMIECWHEQSVKRPTFTDISNRLKTWHE  675
         ************************************74
Domain Sequence
(FASTA)
VEFLEELGEG AFGKVYKGQL LQPNKTTITV AIKALKENAS VKTQQDFKRE IELISDLKHQ 60
NIVCILGVVL NKEPYCMLFE YMANGDLHEF LISNSPTEGK SLSQLEFLQI ALQISEGMQY 120
LSAHHYVHRD LAARNCLVNE GLVVKISDFG LSRDIYSSDY YRVQSKSLLP VRWMPSESIL 180
YGKFTTESDV WSFGVVLWEI YSYGMQPYYG FSNQEVINLI RSRQLLSAPE NCPTAVYSLM 240
IECWHEQSVK RPTFTDISNR LKTWHE 266
KeywordATP-binding; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Kinase; Kringle; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00176
EKS-ANC-00180
EKS-BOT-00186
EKS-CAE-00176
EKS-CAJ-00193
EKS-CAF-00193
EKS-CAP-00212
EKS-CII-00120
EKS-CIS-00218
EKS-DAR-00486
EKS-DAN-00030
EKS-DIO-00096
EKS-ECT-00004
EKS-EQC-00182
EKS-FEC-00175
EKS-GAG-00160
EKS-GAA-00229
EKS-GOG-00184
EKS-HOS-00193
EKS-ICT-00180
EKS-LAC-00196
EKS-LOA-00184
EKS-MAM-00188
EKS-MEG-00143
EKS-MIM-00063
EKS-MOD-00184
EKS-MUM-00190
EKS-MUP-00188
EKS-MYL-00192
EKS-NOL-00177
EKS-OCP-00087
EKS-ORN-00238
EKS-ORA-00164
EKS-ORC-00170
EKS-ORL-00223
EKS-OTG-00193
EKS-PAT-00178
EKS-PES-00163
EKS-PEM-00224
EKS-POA-00181
EKS-PTV-00164
EKS-RAN-00182
EKS-SAH-00179
EKS-SOA-00046
EKS-SUS-00161
EKS-TAG-00212
EKS-TAR-00243
EKS-TEN-00238
EKS-TUB-00046
EKS-TUT-00167
EKS-XET-00217
EKS-XIM-00233
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007417; P:central nervous system development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
dme:Dmel_CG4926;
InterPros
IPR020067; Frizzled_dom.
IPR011009; Kinase-like_dom.
IPR000001; Kringle.
IPR013806; Kringle-like.
IPR018056; Kringle_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00051; Kringle; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00130; KR; 1.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013