EKS-DRM-00191

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00191

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	355.5	2.8E-106	213	494	282

Status

Reviewed

Ensembl Protein

FBpp0084549

UniProt Accession

Q05652; B8A3X2; Q8T005; Q9VB57;

Protein Name

Serine/threonine-protein kinase pelle

Protein Synonyms/Alias

Gene Name

pll

Gene Synonyms/Alias

pll; CG5974;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0010441	FBpp0084549	FBtr0085179

Organism

Drosophila melanogaster

Functional Description

Plays an essential role in the Tl receptor signalingpathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.

Protein Length

501

Protein Sequence
(FASTA)

MSGVQTAEAE AQAQNQANGN RTRSRSHLDN TMAIRLLPLP VRAQLCAHLD ALDVWQQLAT 60

AVKLYPDQVE QISSQKQRGR SASNEFLNIW GGQYNHTVQT LFALFKKLKL HNAMRLIKDY 120

VSEDLHKYIP RSVPTISELR AAPDSSAKVN NGPPFPSSSG VSNSNNNRTS TTATEEIPSL 180

ESLGNIHIST VQRAAESLLE IDYAELENAT DGWSPDNRLG QGGFGDVYRG KWKQLDVAIK 240

VMNYRSPNID QKMVELQQSY NELKYLNSIR HDNILALYGY SIKGGKPCLV YQLMKGGSLE 300

ARLRAHKAQN PLPALTWQQR FSISLGTARG IYFLHTARGT PLIHGDIKPA NILLDQCLQP 360

KIGDFGLVRE GPKSLDAVVE VNKVFGTKIY LPPEFRNFRQ LSTGVDVYSF GIVLLEVFTG 420

RQVTDRVPEN ETKKNLLDYV KQQWRQNRME LLEKHLAAPM GKELDMCMCA IEAGLHCTAL 480

DPQDRPSMNA VLKRFEPFVT D 501

Nucleotide Sequence
(FASTA)

ATGAGTGGCG TCCAGACCGC CGAAGCCGAG GCGCAGGCCC AAAACCAAGC GAATGGCAAC 60

AGGACCAGGT CGCGTTCCCA CTTGGACAAC ACAATGGCCA TCCGACTGCT GCCGTTGCCC 120

GTGCGAGCCC AGCTATGTGC CCACTTGGAT GCCCTAGACG TATGGCAACA GCTGGCCACG 180

GCCGTAAAAC TCTATCCCGA CCAGGTGGAG CAGATAAGCA GCCAGAAGCA GCGTGGCCGC 240

TCAGCCTCCA ATGAGTTCCT CAACATTTGG GGCGGTCAGT ACAATCACAC GGTGCAAACA 300

TTGTTTGCTT TGTTCAAAAA ATTGAAGCTT CATAACGCCA TGCGTCTGAT CAAAGATTAC 360

GTTAGCGAGG ATCTGCACAA GTACATACCG AGGAGCGTGC CCACCATCAG CGAGCTGCGC 420

GCTGCTCCCG ATTCCAGTGC CAAAGTAAAC AACGGCCCGC CGTTTCCCTC CTCCTCGGGC 480

GTCAGCAACT CAAACAACAA TCGCACCAGC ACAACGGCAA CGGAGGAGAT ACCCAGCCTG 540

GAGTCCCTGG GCAATATACA CATTAGCACC GTACAGCGGG CAGCCGAATC CTTGCTGGAG 600

ATCGATTATG CGGAGCTAGA AAACGCCACG GACGGCTGGA GTCCGGATAA TCGACTGGGA 660

CAGGGCGGAT TCGGAGACGT GTACCGCGGC AAATGGAAGC AACTGGACGT GGCCATCAAG 720

GTGATGAACT ACCGCAGTCC CAACATCGAC CAGAAAATGG TGGAGCTGCA GCAGAGCTAC 780

AACGAACTCA AGTATTTAAA CAGCATCCGG CACGACAATA TCCTGGCCCT CTACGGATAC 840

AGCATCAAAG GTGGTAAGCC GTGCCTCGTC TACCAGCTGA TGAAGGGCGG CTCCCTGGAG 900

GCTCGTTTAC GAGCGCATAA GGCACAAAAC CCACTACCAG CACTCACCTG GCAGCAGCGG 960

TTTAGCATCA GCCTCGGCAC GGCTAGAGGC ATCTACTTTC TGCACACGGC GCGAGGCACA 1020

CCGCTGATTC ATGGAGATAT TAAGCCGGCC AACATCCTGC TGGACCAATG TCTGCAGCCA 1080

AAAATCGGAG ACTTCGGTCT GGTGCGCGAG GGTCCCAAGT CCTTGGACGC TGTGGTGGAA 1140

GTGAATAAAG TTTTCGGCAC TAAGATCTAC CTGCCACCGG AGTTCCGCAA CTTCAGACAA 1200

CTCAGCACGG GCGTGGACGT CTACAGCTTC GGCATTGTGC TGTTGGAGGT GTTCACGGGT 1260

CGTCAGGTGA CGGATCGCGT GCCGGAAAAC GAGACGAAGA AGAATTTGCT GGACTACGTT 1320

AAGCAGCAGT GGCGGCAAAA CCGGATGGAG CTGCTAGAGA AGCACTTAGC AGCACCGATG 1380

GGCAAGGAGC TGGACATGTG CATGTGCGCC ATCGAGGCGG GCTTGCACTG TACTGCCCTG 1440

GATCCGCAGG ATCGCCCATC CATGAACGCG GTGCTCAAGC GTTTCGAACC GTTTGTTACC 1500

GACTAG 1506

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklk...eeadlslkelkqsfltElkvlarfrH  57

         +s dnr+g+Ggfg+vyrg++k+++va+k+++    ++d+++ el+qs+ +Elk+l+++rH

Q: 213   WSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNyrsPNIDQKMVELQQSY-NELKYLNSIRH  271

         789***************************988889************.9**********

S: 58    dnilellgysaeseklcLvYqymknGsLedrLqcqkgsepLs...WpqRlsillGtarai  114

         dnil+l+gys++++k+cLvYq+mk+GsLe+rL+++k+++pL+   W+qR+si+lGtar+i

Q: 272   DNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPaltWQQRFSISLGTARGI  331

         ****************************************99999***************

S: 115   efLHeasp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtl  173

         +fLH+a++ +lihgdik+aNiLLD++l+pK+gDfgl+r   e +k+ ++v++++kv+gt+

Q: 332   YFLHTARGtPLIHGDIKPANILLDQCLQPKIGDFGLVR---EGPKSLDAVVEVNKVFGTK  388

         *******99*****************************...9******************

S: 174   aYlpeefirvgqltvkvDvySfGiVllEvltGlra...vdedrktkyLkdllkeeieeek  230

         +Ylp+ef++++ql++ vDvySfGiVllEv+tG+++   v e++++k+L+d++k+++++++

Q: 389   IYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVtdrVPENETKKNLLDYVKQQWRQNR  448

         ***********************************99999********************

S: 231   veilekfldkkagkleeellealielalaclaekakkrPtmsqvlel  277

         +e+lek+l++ +gk e ++++++ie++l+c+a + + rP+m+ vl++

Q: 449   MELLEKHLAAPMGK-ELDMCMCAIEAGLHCTALDPQDRPSMNAVLKR  494

         **************.****************************9986

Domain Sequence
(FASTA)

WSPDNRLGQG GFGDVYRGKW KQLDVAIKVM NYRSPNIDQK MVELQQSYNE LKYLNSIRHD 60

NILALYGYSI KGGKPCLVYQ LMKGGSLEAR LRAHKAQNPL PALTWQQRFS ISLGTARGIY 120

FLHTARGTPL IHGDIKPANI LLDQCLQPKI GDFGLVREGP KSLDAVVEVN KVFGTKIYLP 180

PEFRNFRQLS TGVDVYSFGI VLLEVFTGRQ VTDRVPENET KKNLLDYVKQ QWRQNRMELL 240

EKHLAAPMGK ELDMCMCAIE AGLHCTALDP QDRPSMNAVL KR 282

Keyword

3D-structure; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0019732	; P:antifungal humoral response
GO:0006915	; P:apoptotic process
GO:0048262	; P:determination of dorsal/ventral asymmetry
GO:0035172	; P:hemocyte proliferation
GO:0030097	; P:hemopoiesis
GO:0045087	; P:innate immune response
GO:0030162	; P:regulation of proteolysis
GO:0008063	; P:Toll signaling pathway
GO:0007352	; P:zygotic specification of dorsal/ventral axis

KEGG

dme:Dmel_CG5974

;

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00005

; DEATH; 1.

Prosites

PS50017	; DEATH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013