EKS-DRM-00154
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00154
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20353.01.3E-10532296265
StatusUnreviewed
Ensembl ProteinFBpp0089311
UniProt AccessionQ9W002;
Protein Name
Protein Synonyms/Alias Misshapen, isoform A;
Gene Namemsn
Gene Synonyms/Alias msn; Dmel_CG16973;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0010909FBpp0305556FBtr0333364
FBgn0010909FBpp0089311FBtr0072958
FBgn0010909FBpp0089312FBtr0072959
FBgn0010909FBpp0305557FBtr0333365
FBgn0010909FBpp0305554FBtr0333362
FBgn0010909FBpp0305555FBtr0333363
FBgn0010909FBpp0089310FBtr0072957
FBgn0010909FBpp0072830FBtr0072956
OrganismDrosophila melanogaster
Functional Description
Protein Length1102
Protein Sequence
(FASTA)
MAHQQQQQLA PSVNCSLDDI DLTALKDPAG IFELIEVVGN GTYGQVYKGR HTKTGQLAAI 60
KVMDVTEDEE EEIKLEINVL KKYSNHRNIA TYYGAFIKKS PPGKDDQLWL VMEYCGAGSV 120
TDLVKSTKGQ SLKEEWIAYI CREILRGLSY LHSNKVIHRD IKGQNVLLTD NAEVKLVDFG 180
VSAQLDRTIG RRNTFIGTPY WMAPEVIACD ENPDATYDNR SDLWSLGITA LEMAESQPPL 240
CDLHPMRALF LIPRNSPPRL KSKKWSKKFH GFIDTVLVKD YHQRPYTENL LKHGFIKDQP 300
TDRQVRIQLK DHIDRCKKRK QEKEREDYRY SGSDNDDDEP QLAGEHSSIV QAPGGDTLRR 360
NFQQIQEGRL AAEQQQQHHL MAQAQAQAAA AHAAAQAQAQ LQQQQQQAAA AAAAAAHAAQ 420
QAQQAAQQAQ AQQPQANRQP KPPSRQQVEE PGPPARPPQR LIVVPDPPHA NRPLPPTPKC 480
GEPAGQTPQQ QQRNSQNNFK PSLPPRRPED HLDVLAAQLS ELGVVFSQQP QPQTAAGGQG 540
SQQQAQPEAP PRNNRQSSGL SSSGGSASGG GGSSKPAAAL PQQSNNHLGQ PVNPLDPLDS 600
SDSDSEPDEP NDRARNDGTL LASDPPKPLP GLGPVSEDAN TTTPLSHGSG GPPNRPLPPT 660
PDDDDQAGDR TLIMKRNRGG GGGGGGGGGG GGSSGVGADG TGLGTPGTRT SSVLPDLLSQ 720
ASPATPPRHD KSSSEEKQRS FLTFGFGAGG SGPSRRESHV NVNVTPTSHE AANDTPEIRK 780
YKKRFNSEIL CAALWGVNLL IGTENGLMLL DRSGQGKVYQ LISRRRFQQM EVLEGQNILV 840
TISGKKNRVR VYYLSWLKSK ILRTDGLSDQ VERRNGWINV GDLQGAVHFK IVKYERIKFL 900
VIALKDSIEI YAWAPKPYHK FMAFKNFGEL EHRPLLVDLT IEDQSRLKVI YGSAEGFHAV 960
DLDSAEVYDI YLPKHTQGAI IPHCIVALPN SNGMQLLLCY DNEGVYVNTV GRVSKNIVLQ 1020
WGEMPTSVAY IGTGQIMGWG NKAIEIRSVE SGHLDGVFMH KKAQRLKFLC ERNDKVFFSS 1080
AKGASSCQIY FMTLNKPGMA NW 1102
Nucleotide Sequence
(FASTA)
ATGGCGCACC AGCAGCAACA ACAACTGGCT CCATCGGTCA ACTGTTCACT GGACGATATC 60
GATCTGACGG CCCTAAAAGA TCCAGCTGGC ATCTTTGAGC TCATCGAAGT TGTGGGCAAT 120
GGCACCTACG GTCAGGTCTA CAAGGGCCGT CACACGAAGA CTGGTCAATT GGCTGCCATA 180
AAGGTGATGG ACGTCACCGA GGACGAAGAG GAGGAGATCA AGCTGGAGAT CAATGTGCTA 240
AAGAAATACT CGAATCACCG CAACATCGCC ACCTACTACG GAGCCTTCAT CAAGAAGTCG 300
CCACCTGGGA AGGACGATCA GCTCTGGCTG GTGATGGAGT ACTGTGGTGC TGGATCGGTA 360
ACGGATCTGG TCAAGTCCAC CAAGGGTCAG AGCCTGAAGG AGGAGTGGAT CGCCTACATC 420
TGCCGCGAGA TTCTGCGGGG CCTGAGCTAC CTGCACTCGA ACAAAGTCAT CCATCGCGAC 480
ATCAAGGGGC AGAATGTGCT CCTCACCGAC AACGCCGAGG TGAAGCTGGT GGACTTTGGT 540
GTCTCCGCCC AGCTGGATCG CACGATAGGA CGGCGCAACA CATTCATCGG TACTCCCTAC 600
TGGATGGCCC CCGAGGTCAT TGCCTGCGAC GAGAATCCCG ACGCCACGTA CGACAATCGC 660
TCCGATCTGT GGTCGCTGGG CATCACCGCT CTGGAGATGG CTGAGTCACA GCCCCCGCTC 720
TGCGATCTGC ATCCGATGCG CGCCCTCTTC CTGATTCCGC GCAACTCGCC ACCCAGGCTC 780
AAATCGAAGA AGTGGTCCAA GAAGTTTCAC GGCTTTATTG ACACGGTGCT AGTTAAGGAC 840
TATCACCAGC GGCCTTACAC CGAGAACCTG CTGAAGCACG GCTTCATCAA GGACCAGCCC 900
ACAGATCGCC AGGTGCGCAT CCAGCTGAAG GACCACATCG ATCGCTGCAA GAAGCGCAAG 960
CAGGAGAAGG AGCGCGAGGA CTATCGCTAC TCGGGCTCCG ACAACGACGA CGACGAACCA 1020
CAGCTGGCCG GTGAGCACAG CTCCATTGTC CAGGCACCAG GCGGCGATAC GTTGCGCCGC 1080
AACTTCCAGC AGATCCAGGA AGGTCGCCTG GCCGCCGAGC AGCAGCAGCA GCATCACCTG 1140
ATGGCCCAGG CGCAGGCTCA GGCGGCTGCC GCTCATGCCG CTGCCCAGGC CCAGGCGCAA 1200
CTCCAGCAGC AGCAACAGCA GGCTGCGGCG GCGGCAGCAG CGGCGGCCCA TGCAGCACAA 1260
CAGGCTCAGC AGGCCGCACA GCAGGCGCAG GCCCAGCAGC CACAGGCCAA TCGGCAGCCA 1320
AAACCGCCAT CGCGCCAGCA GGTTGAGGAG CCGGGTCCGC CAGCACGTCC GCCACAGCGC 1380
CTGATCGTGG TGCCGGATCC GCCGCACGCC AATCGGCCAT TGCCACCGAC GCCCAAGTGC 1440
GGCGAGCCGG CGGGACAGAC GCCGCAGCAA CAGCAGCGCA ATTCGCAGAA TAACTTCAAG 1500
CCATCGTTAC CACCAAGGAG ACCTGAGGAT CATTTGGATG TGTTAGCAGC ACAATTAAGT 1560
GAATTGGGCG TGGTCTTCTC CCAACAGCCA CAGCCGCAGA CGGCCGCCGG TGGTCAGGGA 1620
TCCCAGCAGC AGGCGCAGCC GGAGGCGCCG CCTCGCAACA ATCGCCAGTC GAGCGGTCTG 1680
TCCTCCTCCG GCGGATCGGC ATCCGGAGGC GGCGGTTCGT CGAAGCCCGC AGCCGCTCTG 1740
CCGCAGCAGT CGAACAATCA TTTGGGCCAG CCGGTGAATC CGCTGGATCC CTTGGACAGC 1800
AGCGATTCGG ACAGCGAGCC GGATGAGCCC AACGATCGGG CTAGGAACGA TGGAACTCTA 1860
TTGGCCAGTG ATCCGCCCAA GCCACTGCCC GGCTTGGGAC CCGTCTCCGA GGACGCCAAC 1920
ACGACAACGC CCTTGAGTCA CGGCAGCGGT GGACCGCCCA ACCGCCCACT GCCGCCCACG 1980
CCCGACGACG ACGATCAGGC TGGCGATCGG ACTTTGATCA TGAAGCGCAA TCGAGGAGGA 2040
GGCGGTGGCG GCGGCGGCGG CGGAGGAGGC GGTGGCAGCA GCGGCGTGGG CGCCGATGGC 2100
ACTGGACTGG GAACTCCTGG GACAAGGACC AGCAGCGTCC TGCCGGATCT ACTCAGCCAG 2160
GCATCGCCGG CAACGCCACC ACGCCATGAT AAATCATCCA GTGAGGAGAA GCAGCGCAGT 2220
TTCCTGACCT TTGGCTTCGG CGCCGGCGGC TCTGGTCCTT CGCGCCGGGA ATCGCACGTC 2280
AATGTCAATG TAACGCCCAC CTCCCACGAG GCGGCCAACG ATACGCCCGA GATCCGTAAG 2340
TATAAGAAGC GCTTCAATTC GGAAATCCTG TGCGCAGCGC TATGGGGCGT CAACCTGCTG 2400
ATTGGAACGG AGAATGGCTT AATGCTGCTA GATCGATCCG GTCAGGGCAA GGTCTACCAG 2460
CTCATCTCGC GACGCCGTTT CCAGCAAATG GAGGTGCTAG AGGGCCAGAA CATATTGGTC 2520
ACCATATCCG GCAAGAAGAA CCGAGTGCGC GTCTACTACT TGTCCTGGCT AAAGTCGAAG 2580
ATCTTGCGCA CCGACGGACT CTCCGATCAA GTGGAGCGTC GGAACGGTTG GATCAACGTG 2640
GGTGATCTGC AAGGTGCTGT ACATTTTAAG ATTGTCAAAT ACGAGAGGAT TAAGTTCCTA 2700
GTGATTGCAT TAAAAGACTC TATTGAAATT TATGCATGGG CTCCCAAACC ATATCACAAA 2760
TTTATGGCAT TTAAGAATTT TGGTGAACTG GAACATCGCC CGCTTTTGGT CGATCTCACC 2820
ATTGAGGATC AGTCGAGACT GAAGGTGATC TATGGCTCCG CCGAGGGTTT CCATGCGGTT 2880
GATTTAGATT CAGCTGAAGT ATACGATATC TATCTTCCCA AGCATACTCA GGGTGCAATC 2940
ATTCCGCATT GTATTGTGGC GCTTCCCAAC TCAAATGGCA TGCAACTGCT GCTGTGCTAC 3000
GACAATGAGG GCGTCTATGT GAACACTGTG GGCCGCGTTT CCAAGAACAT TGTACTGCAG 3060
TGGGGCGAGA TGCCCACCTC GGTGGCCTAC ATCGGCACTG GACAAATCAT GGGCTGGGGC 3120
AATAAAGCAA TAGAGATACG TTCCGTTGAG AGCGGCCATT TGGATGGTGT GTTCATGCAC 3180
AAAAAGGCGC AGCGCTTGAA ATTCCTTTGC GAGCGAAACG ACAAAGTATT CTTCAGCAGT 3240
GCCAAAGGTG CTTCATCGTG TCAAATCTAC TTTATGACGC TCAACAAGCC GGGCATGGCC 3300
AATTGGTAA 3309
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee++ ei+vlkk+++ +ni 
Q: 32    FELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTE-DEEEEIKLEINVLKKYSNhRNIA  90
         899********************************8.999************9766****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvmey+ +Gs++dlvk+++ ++lkEe+iayi+re+l++L+y
Q: 91    TYYGAFIKksppgkDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSY  150
         *************99*********************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lHs+kviHrdik++n+Llt+++eVkL+dfgv+aql++t  +r+t++gtpywmAPEvia++
Q: 151   LHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACD  210
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd+++D+wslGIta+e+ae +pP++dl+p++al++i++n+pp+lksk k+sk+f
Q: 211   enpDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSK-KWSKKF  269
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
         + f++++l k++++Rp +++llkh F+
Q: 270   HGFIDTVLVKDYHQRPYTENLLKHGFI  296
         *************************97
Domain Sequence
(FASTA)
FELIEVVGNG TYGQVYKGRH TKTGQLAAIK VMDVTEDEEE EIKLEINVLK KYSNHRNIAT 60
YYGAFIKKSP PGKDDQLWLV MEYCGAGSVT DLVKSTKGQS LKEEWIAYIC REILRGLSYL 120
HSNKVIHRDI KGQNVLLTDN AEVKLVDFGV SAQLDRTIGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDNRS DLWSLGITAL EMAESQPPLC DLHPMRALFL IPRNSPPRLK SKKWSKKFHG 240
FIDTVLVKDY HQRPYTENLL KHGFI 265
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00288
EKS-ANC-00322
EKS-BOT-00336
EKS-CAE-00258
EKS-CAJ-00314
EKS-CAF-00339
EKS-CAP-00343
EKS-CII-00177
EKS-CIS-00079
EKS-DAR-00667
EKS-DIO-00042
EKS-EQC-00300
EKS-FEC-00295
EKS-GAG-00280
EKS-GAA-00383
EKS-GOG-00305
EKS-HOS-00315
EKS-ICT-00307
EKS-LAC-00328
EKS-LOA-00329
EKS-MAM-00312
EKS-MEG-00264
EKS-MOD-00311
EKS-MUM-00343
EKS-MUP-00324
EKS-MYL-00320
EKS-NOL-00284
EKS-OCP-00056
EKS-ORN-00402
EKS-ORA-00286
EKS-ORC-00294
EKS-ORL-00382
EKS-OTG-00318
EKS-PAT-00292
EKS-PES-00292
EKS-PEM-00170
EKS-POA-00300
EKS-PTV-00077
EKS-RAN-00346
EKS-SAH-00303
EKS-SUS-00288
EKS-TAG-00340
EKS-TAR-00407
EKS-TAS-00031
EKS-TEN-00431
EKS-TUT-00074
EKS-XET-00401
EKS-XIM-00416
Gene Ontology
GO:0005938; C:cell cortex
GO:0005524; F:ATP binding
GO:0042656; F:JUN kinase kinase kinase kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0007411; P:axon guidance
GO:0007391; P:dorsal closure
GO:0001736; P:establishment of planar polarity
GO:0046529; P:imaginal disc fusion, thorax closure
GO:0007476; P:imaginal disc-derived wing morphogenesis
GO:0046580; P:negative regulation of Ras protein signal transduction
GO:0007097; P:nuclear migration
GO:0048477; P:oogenesis
GO:0001748; P:optic lobe placode development
GO:0008594; P:photoreceptor cell morphogenesis
GO:0016476; P:regulation of embryonic cell shape
GO:0009611; P:response to wounding
KEGG
dme:Dmel_CG16973;
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013