EKS-DRM-00141

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00141

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	446.7	4.6E-134	297	584	288

Status

Unreviewed

Ensembl Protein

FBpp0289826

UniProt Accession

A1Z7L8;

Protein Name

Protein Synonyms/Alias

Baboon, isoform B;

Gene Name

babo

Gene Synonyms/Alias

babo; Dmel_CG8224;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0011300	FBpp0087740	FBtr0088659
FBgn0011300	FBpp0087739	FBtr0088658
FBgn0011300	FBpp0289826	FBtr0300599

Organism

Drosophila melanogaster

Functional Description

Protein Length

595

Protein Sequence
(FASTA)

MLSALRLIFL GALLGASVCA SPIEFVMDTS LNGSRSDPAT ATHPGKWPPT TKAPALRAPA 60

GTAGHAYQSP SSSLAADNRS HDNNNASAVS MLLPQDGDAS GAVAPAVTPQ LPIYIAQPSA 120

KKPENKIKCH CDTCKESNNI CETDGFCFTS VEKNSDGSII FSYRCITDQL PPEDPTSCKL 180

NSEAGSSQCC AEDFCNTREN YSGVLPDYVP HRLTSWEFVA IILGATLFIC FTGTSTWYYC 240

QRRKRMASGR TFAKEDSAYD PILNGNTTIH DIIEMTTSGS GSAGLPLLVQ RSIARQVQLC 300

HVIGKGRFGE VWRGRWRGEN VAVKIFSSRE ECSWFREAEI YQTVMLRHEN ILGFIAADNK 360

DNGTWTQLWL VTDYHENGSL FDYLTTHPVD TNTMLNMSLS IATGLAHLHM DIVGTRGKPA 420

IAHRDLKSKN ILVKSNLSCA IGDLGLAVRH VEKNDSVDIP STHRVGTKRY MAPEVLDESM 480

NDQHFDSYKR ADVYAFGLIL WEIARRCNMG MIYDEYQLPY YDVVQPDPSI EEMKKVVCIE 540

KCRPNIPNRW HASDVLHNMA KVMKECWYPN PVARLTALRI KKTLASISVE DKVKN 595

Nucleotide Sequence
(FASTA)

ATGTTATCTG CGCTCCGGCT AATCTTCCTG GGCGCTCTGC TCGGCGCCTC TGTTTGCGCC 60

TCCCCCATTG AGTTCGTAAT GGACACCAGC CTAAATGGCT CTCGATCTGA TCCTGCGACT 120

GCAACCCACC CTGGCAAATG GCCACCGACG ACCAAAGCGC CGGCGCTCAG GGCTCCAGCT 180

GGAACAGCTG GACATGCTTA TCAGTCGCCA TCGTCGTCGC TGGCCGCTGA TAACAGAAGC 240

CACGACAACA ACAACGCTAG CGCCGTGTCC ATGCTGCTGC CGCAAGACGG CGACGCATCT 300

GGAGCTGTGG CCCCTGCTGT TACTCCCCAG CTGCCCATCT ACATTGCTCA GCCTAGCGCG 360

AAAAAGCCAG AAAACAAGAT AAAATGCCAC TGTGACACGT GCAAGGAATC GAACAATATA 420

TGTGAAACGG ACGGCTTTTG TTTCACGTCC GTGGAGAAGA ACTCTGATGG GAGCATCATC 480

TTCAGCTACA GATGCATAAC AGACCAGTTG CCACCTGAAG ATCCTACCTC GTGCAAGTTA 540

AATTCGGAAG CGGGCTCTTC TCAGTGCTGC GCCGAAGATT TTTGCAATAC GCGTGAGAAT 600

TACAGTGGTG TCCTACCAGA TTATGTGCCA CACCGACTGA CCAGCTGGGA GTTTGTGGCT 660

ATCATCCTAG GGGCCACCCT CTTCATTTGC TTCACGGGCA CCAGTACGTG GTATTATTGC 720

CAGCGTCGCA AGCGAATGGC TAGCGGAAGG ACGTTTGCCA AGGAGGATTC GGCGTACGAT 780

CCTATTTTGA ATGGTAATAC AACCATACAC GACATCATTG AGATGACCAC CTCTGGTTCG 840

GGTTCGGCTG GTCTTCCGCT GCTGGTGCAG CGTTCCATTG CCCGACAGGT GCAGCTGTGC 900

CACGTTATCG GAAAGGGACG TTTCGGCGAG GTCTGGCGTG GACGCTGGCG AGGCGAAAAC 960

GTGGCGGTCA AGATCTTCTC TAGTCGCGAG GAGTGTTCCT GGTTCCGTGA GGCGGAAATC 1020

TATCAGACTG TTATGCTCCG CCACGAGAAC ATTTTGGGAT TCATAGCTGC AGACAACAAG 1080

GACAATGGAA CTTGGACACA GTTGTGGCTC GTAACAGACT ACCATGAAAA CGGATCGCTC 1140

TTTGACTACC TAACCACGCA CCCAGTGGAC ACCAACACCA TGCTGAACAT GTCGCTGAGT 1200

ATTGCCACTG GACTGGCGCA TCTGCATATG GACATTGTGG GCACTCGCGG CAAGCCCGCC 1260

ATCGCCCATC GTGATCTCAA ATCCAAAAAC ATACTGGTCA AATCAAATCT AAGCTGTGCT 1320

ATTGGAGATT TGGGTCTGGC CGTGCGCCAT GTGGAGAAGA ATGACTCTGT GGACATACCT 1380

TCCACTCATC GCGTGGGTAC CAAGCGCTAT ATGGCGCCCG AGGTGCTGGA CGAGAGTATG 1440

AATGATCAGC ATTTTGACTC GTACAAGCGG GCGGATGTGT ACGCCTTTGG ACTGATTCTC 1500

TGGGAGATTG CGCGTCGCTG CAACATGGGC ATGATATACG ATGAGTATCA ATTGCCGTAT 1560

TACGATGTCG TGCAACCTGA TCCCAGCATT GAGGAGATGA AGAAGGTGGT TTGCATCGAG 1620

AAGTGCCGGC CAAACATTCC AAACCGCTGG CACGCCTCCG ATGTGCTCCA CAACATGGCC 1680

AAGGTGATGA AGGAGTGCTG GTATCCCAAT CCTGTGGCCC GATTGACAGC GCTTCGCATC 1740

AAAAAGACAC TTGCTAGCAT CAGTGTGGAG GACAAGGTCA AGAACTGA 1788

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+++igkGr+geVw++++rge+vAvKifs+++e sw+rE+eiyqtv+lrhenil+fia

Q: 297   VQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIA  356

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lvt+yhe+gsL+dyL+++ +d++++l++ ls+a+GlahLH++ivgt+

Q: 357   ADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTR  416

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvk++l+c+i+DlGLa+++ e+++++d+ ++++vGtkRYmaPE

Q: 417   G--KPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPE  474

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n ++f+++kraDvY++gL+lWE+a+Rc++ + + +ey+lp+++vv+ dPs+eem

Q: 475   VLDESMNDQHFDSYKRADVYAFGLILWEIARRCNM-GMIYDEYQLPYYDVVQPDPSIEEM  533

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+ +k+rP+ip++w+++++l++++k+++ecW+ +p aRltalr+kk+l

Q: 534   KKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTL  584

         *************************************************97

Domain Sequence
(FASTA)

VQLCHVIGKG RFGEVWRGRW RGENVAVKIF SSREECSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVTDYHE NGSLFDYLTT HPVDTNTMLN MSLSIATGLA HLHMDIVGTR 120

GKPAIAHRDL KSKNILVKSN LSCAIGDLGL AVRHVEKNDS VDIPSTHRVG TKRYMAPEVL 180

DESMNDQHFD SYKRADVYAF GLILWEIARR CNMGMIYDEY QLPYYDVVQP DPSIEEMKKV 240

VCIEKCRPNI PNRWHASDVL HNMAKVMKEC WYPNPVARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0048185	; F:activin binding
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004703	; F:G-protein coupled receptor kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0007411	; P:axon guidance
GO:0048813	; P:dendrite morphogenesis
GO:0007455	; P:eye-antennal disc morphogenesis
GO:0007476	; P:imaginal disc-derived wing morphogenesis
GO:0016319	; P:mushroom body development
GO:0007405	; P:neuroblast proliferation
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0040018	; P:positive regulation of multicellular organism growth
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0007346	; P:regulation of mitotic cell cycle
GO:0009411	; P:response to UV
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

dme:Dmel_CG8224

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013