EPS-DRM-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DRM-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	428.8	3.8E-129	150	350	201

Status

Reviewed

Ensembl Protein

FBpp0074069

UniProt Accession

Q27889; Q26248; Q9VXF2;

Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit 2

Protein Synonyms/Alias

Calmodulin-dependent calcineurin A2 subunit;

Gene Name

Pp2B-14D

Gene Synonyms/Alias

Pp2B-14D; CG9842;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0011826	FBpp0074069	FBtr0074294
FBgn0011826	FBpp0301546	FBtr0309793
FBgn0011826	FBpp0294044	FBtr0305593

Organism

Drosophila melanogaster

Functional Description

Calcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Protein Length

570

Protein Sequence
(FASTA)

MSSNNQSSSV AQAATSARTV SAGSAEATDA NSTASNNNNN SSSTAAAGNN SDNSSPTTGT 60

GTGASTGKLH GGHTAVNTKE RVVDSVPFPP SHKLTLAEVF DQRTGKPNHE LLKQHFILEG 120

RIEEAPALKI IQDGAALLRQ EKTMIDIEAP VTVCGDIHGQ FYDLMKLFEV GGSPASTKYL 180

FLGDYVDRGY FSIECVLYLW SLKITYPQTL FLLRGNHECR HLTEYFTFKQ ECKIKYSERV 240

YDACMDAFDC LPLAALMNQQ FLCVHGGLSP EIHELEDIRR LDRFKEPPAF GPMCDLLWSD 300

PLEDFGNEKN SDFYTHNSVR GCSYFYSYAA CCDFLQNNNL LSIIRAHEAQ DAGYRMYRKS 360

QTTGFPSLIT IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL 420

PFVGEKVTEM LVNVLNICSD DELMTEESEE PLSDDEAALR KEVIRNKIRA IGKMARVFSV 480

LREESESVLQ LKGLTPTGAL PLGALSGGKQ SLKNAMQGFS PNHKITSFAE AKGLDAVNER 540

MPPRRDQPPT PSEDPNQHSQ QGGKNGAGHG 570

Nucleotide Sequence
(FASTA)

ATGTCTTCGA ATAACCAGAG CAGCAGCGTT GCCCAGGCGG CAACAAGTGC CCGCACCGTC 60

AGTGCCGGAT CGGCGGAAGC CACAGATGCC AATAGTACCG CCTCGAACAA CAACAATAAT 120

AGCAGCAGTA CCGCTGCAGC GGGCAACAAC AGCGACAACA GCAGTCCCAC CACTGGAACG 180

GGCACAGGAG CGAGCACTGG AAAGCTGCAC GGCGGCCACA CGGCAGTAAA CACCAAGGAA 240

CGGGTGGTGG ACAGCGTTCC CTTCCCGCCC AGCCACAAGC TGACCTTGGC GGAGGTGTTC 300

GACCAACGCA CCGGCAAGCC CAACCATGAG CTGCTCAAGC AGCACTTCAT TCTTGAGGGC 360

AGAATCGAGG AGGCGCCCGC CCTGAAAATC ATCCAGGACG GAGCCGCCCT GCTGCGTCAG 420

GAGAAGACGA TGATCGATAT TGAGGCGCCG GTGACGGTGT GCGGTGATAT CCACGGCCAG 480

TTCTACGACC TGATGAAGCT GTTCGAAGTG GGCGGCTCGC CCGCGAGCAC CAAGTATCTG 540

TTCCTGGGCG ACTACGTCGA TCGGGGCTAC TTCAGCATCG AGTGCGTCCT GTATTTGTGG 600

TCGCTAAAGA TCACCTATCC GCAGACGCTG TTCCTGCTGC GCGGCAACCA CGAGTGCCGG 660

CACTTAACCG AGTACTTCAC CTTCAAGCAG GAGTGCAAGA TCAAGTACTC GGAGCGCGTG 720

TACGACGCCT GCATGGACGC ATTCGACTGC CTGCCGCTGG CGGCGCTAAT GAACCAGCAG 780

TTCCTCTGCG TGCACGGCGG TCTGTCGCCG GAGATACACG AGCTGGAGGA CATCCGGCGG 840

CTCGACCGCT TCAAGGAGCC GCCCGCCTTT GGCCCCATGT GCGACCTGCT GTGGTCCGAT 900

CCCCTGGAGG ACTTTGGCAA CGAGAAGAAC TCGGACTTCT ACACGCACAA CTCCGTGCGC 960

GGATGCTCGT ACTTCTACAG CTACGCCGCC TGCTGCGACT TCCTGCAGAA CAACAACCTG 1020

CTGTCGATCA TCCGGGCGCA CGAGGCGCAG GACGCCGGCT ACCGCATGTA CCGCAAAAGC 1080

CAGACCACCG GCTTCCCCTC GCTGATCACC ATCTTCTCGG CGCCCAACTA TCTCGACGTG 1140

TACAACAACA AGGCGGCGGT GCTGAAGTAC GAGAACAACG TGATGAACAT CCGGCAATTC 1200

AACTGCTCGC CGCACCCGTA CTGGCTGCCC AACTTCATGG ACGTGTTCAC CTGGTCGCTA 1260

CCCTTCGTGG GCGAGAAGGT CACCGAGATG TTGGTGAACG TGCTGAACAT CTGCTCCGAC 1320

GACGAGCTCA TGACCGAGGA GAGCGAGGAG CCGCTCTCCG ACGACGAGGC GGCGCTGCGC 1380

AAGGAGGTGA TACGCAACAA GATCCGTGCC ATTGGCAAGA TGGCGCGCGT CTTCTCCGTG 1440

CTGCGCGAGG AGTCCGAGTC GGTGCTGCAG CTGAAGGGCC TGACGCCCAC GGGCGCCCTG 1500

CCCCTCGGCG CCCTCTCCGG CGGCAAGCAG TCGCTCAAGA ACGCCATGCA GGGCTTCTCG 1560

CCCAACCACA AGATTACCTC GTTCGCGGAG GCCAAGGGCC TGGATGCCGT CAACGAACGG 1620

ATGCCGCCGC GGCGGGATCA GCCGCCCACG CCCAGCGAGG ATCCGAATCA GCACAGTCAG 1680

CAGGGCGGCA AAAATGGGGC TGGACATGGG TAA 1713

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         pvtvcgdihgqf+dl+klfevggspa+t+ylflgdyvdrgyfsiecvlyl++lki+yp+t

Q: 150   PVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQT  209

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe+kikyservydac++afd+lplaal+nqqflcvhggls

Q: 210   LFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLS  269

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe+++l+dir+ldrfkeppa+g+mcdllwsdpledfgnek++++++hnsvrgcsyfysy+

Q: 270   PEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYA  329

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         a+c+flq+nnllsiiraheaq

Q: 330   ACCDFLQNNNLLSIIRAHEAQ  350

         ********************8

Domain Sequence
(FASTA)

PVTVCGDIHG QFYDLMKLFE VGGSPASTKY LFLGDYVDRG YFSIECVLYL WSLKITYPQT 60

LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYDACMDAFD CLPLAALMNQ QFLCVHGGLS 120

PEIHELEDIR RLDRFKEPPA FGPMCDLLWS DPLEDFGNEK NSDFYTHNSV RGCSYFYSYA 180

ACCDFLQNNN LLSIIRAHEA Q 201

Keyword

Calcium; Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005516	; F:calmodulin binding
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0009790	; P:embryo development
GO:0007143	; P:female meiosis
GO:0006470	; P:protein dephosphorylation
GO:0030431	; P:sleep
GO:0035220	; P:wing disc development

KEGG

dme:Dmel_CG9842

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013