EKS-DRM-00003

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00003

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	492.9	2.6E-148	1371	1650	280

Status

Reviewed

Ensembl Protein

FBpp0083519

UniProt Accession

P09208; B7Z0N6; Q24023; Q24089; Q9VD94;

Protein Name

Insulin-like receptor subunit beta 2

Protein Synonyms/Alias

dIR; dInr; dIRH;

Gene Name

InR

Gene Synonyms/Alias

InR; dinr, Dir-a, Inr-a; CG18402;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0013984	FBpp0288671	FBtr0290232
FBgn0013984	FBpp0288670	FBtr0290231
FBgn0013984	FBpp0288669	FBtr0290230
FBgn0013984	FBpp0083519	FBtr0084121

Organism

Drosophila melanogaster

Functional Description

Has a ligand-stimulated tyrosine-protein kinaseactivity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell- autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination.

Protein Length

2144

Protein Sequence
(FASTA)

MFNMPRGVTK SKSKRGKIKM ENDMAAAATT TACTLGHICV LCRQEMLLDT CCCRQAVEAV 60

DSPASSEEAY SSSNSSSCQA SSEISAEEVW FLSHDDIVLC RRPKFDEVET TGKKRDVKCS 120

GHQCSNECDD GSTKNNRQQR ENFNIFSNCH NILRTLQSLL LLMFNCGIFN KRRRRQHQQQ 180

HHHHYQHHHQ QHHQQHHQRQ QANVSYTKFL LLLQTLAAAT TRLSLSPKNY KQQQQLQHNQ 240

QLPRATPQQK QQEKDRHKCF HYKHNYSYSP GISLLLFILL ANTLAIQAVV LPAHQQHLLH 300

NDIADGLDKT ALSVSGTQSR WTRSESNPTM RLSQNVKPCK SMDIRNMVSH FNQLENCTVI 360

EGFLLIDLIN DASPLNRSFP KLTEVTDYII IYRVTGLHSL SKIFPNLSVI RGNKLFDGYA 420

LVVYSNFDLM DLGLHKLRSI TRGGVRIEKN HKLCYDRTID WLEILAENET QLVVLTENGK 480

EKECRLSKCP GEIRIEEGHD TTAIEGELNA SCQLHNNRRL CWNSKLCQTK CPEKCRNNCI 540

DEHTCCSQDC LGGCVIDKNG NESCISCRNV SFNNICMDSC PKGYYQFDSR CVTANECITL 600

TKFETNSVYS GIPYNGQCIT HCPTGYQKSE NKRMCEPCPG GKCDKECSSG LIDSLERARE 660

FHGCTIITGT EPLTISIKRE SGAHVMDELK YGLAAVHKIQ SSLMVHLTYG LKSLKFFQSL 720

TEISGDPPMD ADKYALYVLD NRDLDELWGP NQTVFIRKGG VFFHFNPKLC VSTINQLLPM 780

LASKPKFFEK SDVGADSNGN RGSCGTAVLN VTLQSVGANS AMLNVTTKVE IGEPQKPSNA 840

TIVFKDPRAF IGFVFYHMID PYGNSTKSSD DPCDDRWKVS SPEKSGVMVL SNLIPYTNYS 900

YYVRTMAISS ELTNAESDVK NFRTNPGRPS KVTEVVATAI SDSKINVTWS YLDKPYGVLT 960

RYFIKAKLIN RPTRNNNRDY CTEPLVKAME NDLPATTPTK KISDPLAGDC KCVEGSKKTS 1020

SQEYDDRKVQ AGMEFENALQ NFIFVPNIRK SKNGSSDKSD GAEGAALDSN AIPNGGATNP 1080

SRRRRDVALE PELDDVEGSV LLRHVRSITD DTDAFFEKDD ENTYKDEEDL SSNKQFYEVF 1140

AKELPPNQTH FVFEKLRHFT RYAIFVVACR EEIPSEKLRD TSFKKSLCSD YDTVFQTTKR 1200

KKFADIVMDL KVDLEHANNT ESPVRVRWTP PVDPNGEIVT YEVAYKLQKP DQVEEKKCIP 1260

AADFNQTAGY LIKLNEGLYS FRVRANSIAG YGDFTEVEHI KVEPPPSYAK VFFWLLGIGL 1320

AFLIVSLFGY VCYLHKRKVP SNDLHMNTEV NPFYASMQYI PDDWEVLREN IIQLAPLGQG 1380

SFGMVYEGIL KSFPPNGVDR ECAIKTVNEN ATDRERTNFL SEASVMKEFD TYHVVRLLGV 1440

CSRGQPALVV MELMKKGDLK SYLRAHRPEE RDEAMMTYLN RIGVTGNVQP PTYGRIYQMA 1500

IEIADGMAYL AAKKFVHRDL AARNCMVADD LTVKIGDFGM TRDIYETDYY RKGTKGLLPV 1560

RWMPPESLRD GVYSSASDVF SFGVVLWEMA TLAAQPYQGL SNEQVLRYVI DGGVMERPEN 1620

CPDFLHKLMQ RCWHHRSSAR PSFLDIIAYL EPQCPNSQFK EVSFYHSEAG LQHREKERKE 1680

RNQLDAFAAV PLDQDLQDRE QQEDATTPLR MGDYQQNSSL DQPPESPIAM VDDQGSHLPF 1740

SLPSGFIASS TPDGQTVMAT AFQNIPAAQG DISATYVVPD ADALDGDRGY EIYDPSPKCA 1800

ELPTSRSGST GGGKLSGEQH LLPRKGRQPT IMSSSMPDDV IGGSSLQPST ASAGSSNASS 1860

HTGRPSLKKT VADSVRNKAN FINRHLFNHK RTGSNASHKS NASNAPSTSS NTNLTSHPVA 1920

MGNLGTIESG GSGSAGSYTG TPRFYTPSAT PGGGSGMAIS DNPNYRLLDE SIASEQATIL 1980

TTSSPNPNYE MMHPPTSLVS TNPNYMPMNE TPVQMAGVTI SHNPNYQPMQ APLNARQSQS 2040

SSDEDNEQEE DDEDEDDDVD DEHVEHIKME RMPLSRPRQR ALPSKTQPPR SRSVSQTRKS 2100

PTNPNSGIGA TGAGNRSNLL KENWLRPAST PRPPPPNGFI GREA 2144

Nucleotide Sequence
(FASTA)

ATGTTCAATA TGCCACGGGG AGTGACAAAA AGTAAATCCA AGCGTGGGAA AATTAAGATG 60

GAAAACGATA TGGCAGCAGC AGCAACAACA ACAGCCTGCA CGCTTGGACA CATTTGTGTT 120

TTGTGCCGGC AAGAAATGTT GCTGGATACA TGTTGCTGCC GGCAAGCAGT AGAAGCAGTT 180

GACAGCCCCG CAAGCAGTGA AGAAGCGTAT AGCAGTAGCA ACAGCAGCAG CTGTCAAGCA 240

AGCAGTGAAA TCAGTGCGGA GGAGGTCTGG TTTCTCAGTC ATGATGATAT CGTACTGTGC 300

CGCAGACCAA AATTTGACGA AGTGGAGACG ACGGGTAAAA AGAGGGACGT TAAATGCAGC 360

GGGCATCAGT GCAGCAATGA ATGCGACGAT GGCAGCACGA AAAACAATCG ACAACAGCGC 420

GAAAACTTCA ATATCTTTAG CAACTGTCAC AATATTTTGC GAACATTGCA ATCGCTGCTG 480

CTGCTCATGT TCAATTGCGG CATTTTCAAC AAGCGACGCA GGCGGCAGCA TCAGCAGCAG 540

CATCATCATC ATTATCAGCA TCATCATCAG CAGCATCATC AGCAGCATCA TCAGCGGCAG 600

CAAGCCAATG TTAGTTACAC AAAATTCCTA TTGCTGCTAC AAACACTGGC AGCAGCAACC 660

ACAAGACTGA GTTTAAGCCC TAAAAACTAC AAACAACAAC AACAACTACA GCATAACCAA 720

CAGCTGCCAC GTGCCACACC GCAACAAAAG CAACAAGAGA AAGATAGGCA TAAGTGCTTT 780

CACTACAAGC ACAATTACTC TTACTCGCCT GGCATTAGCC TTCTACTCTT TATCCTACTG 840

GCCAACACAT TGGCCATCCA AGCGGTCGTG TTGCCAGCAC ATCAGCAGCA CCTGCTGCAC 900

AATGATATAG CCGATGGACT GGATAAAACA GCGCTTTCGG TGTCGGGGAC GCAATCGCGA 960

TGGACAAGGA GCGAATCAAA CCCAACAATG CGACTGTCAC AAAATGTAAA ACCTTGCAAA 1020

TCCATGGACA TCAGGAACAT GGTGTCGCAC TTCAATCAGC TGGAGAACTG CACGGTCATC 1080

GAGGGCTTCC TGCTGATCGA TTTGATAAAC GACGCCAGCC CTCTGAACAG AAGCTTTCCA 1140

AAACTGACCG AGGTCACAGA TTATATCATA ATCTACCGTG TGACTGGATT GCACTCGCTG 1200

TCAAAGATCT TTCCCAATCT GAGCGTCATT AGGGGAAACA AGCTGTTCGA CGGATATGCC 1260

TTGGTCGTCT ACTCGAATTT CGACCTCATG GATTTGGGAC TTCACAAGCT ACGATCCATA 1320

ACCAGAGGCG GTGTGCGGAT TGAGAAGAAT CATAAGCTGT GCTATGATAG GACCATCGAT 1380

TGGCTGGAAA TTCTGGCGGA AAACGAAACC CAACTGGTGG TGCTGACAGA GAACGGCAAG 1440

GAGAAGGAGT GCAGGCTTTC CAAGTGCCCG GGGGAGATCA GAATTGAGGA GGGGCACGAT 1500

ACCACGGCTA TTGAGGGAGA GCTTAATGCC AGTTGTCAGC TGCACAATAA TAGGCGCCTG 1560

TGCTGGAACA GCAAACTCTG CCAGACGAAA TGCCCTGAAA AGTGCAGAAA TAACTGCATC 1620

GATGAGCACA CCTGCTGCAG CCAGGATTGT TTGGGTGGAT GCGTGATCGA TAAGAATGGG 1680

AATGAGAGCT GCATCTCCTG TCGAAATGTG TCTTTCAACA ACATCTGTAT GGACTCCTGT 1740

CCGAAAGGCT ATTATCAGTT CGACAGCCGC TGCGTAACGG CGAACGAGTG CATCACACTG 1800

ACAAAGTTTG AAACGAACAG TGTGTATTCC GGTATTCCAT ACAACGGACA ATGTATCACC 1860

CACTGTCCAA CGGGGTACCA GAAGTCAGAG AACAAGCGCA TGTGCGAACC TTGTCCGGGC 1920

GGCAAGTGTG ACAAGGAGTG CTCCTCCGGT CTTATCGACA GTTTGGAGCG TGCTCGGGAG 1980

TTCCACGGCT GCACCATTAT AACCGGAACC GAGCCCCTTA CCATCAGCAT TAAACGTGAA 2040

AGCGGCGCTC ACGTCATGGA TGAATTAAAA TATGGCCTGG CTGCCGTCCA TAAAATTCAG 2100

TCGTCCCTAA TGGTTCATTT GACCTACGGA TTGAAGTCCT TGAAATTCTT TCAATCCCTA 2160

ACTGAAATTA GCGGCGATCC GCCGATGGAC GCGGATAAAT ATGCTTTGTA TGTGCTTGAT 2220

AATCGCGATC TAGATGAGCT CTGGGGACCC AACCAAACGG TGTTCATTAG GAAGGGCGGC 2280

GTCTTCTTTC ATTTCAACCC AAAACTATGT GTGTCCACCA TTAACCAGTT GCTGCCCATG 2340

CTGGCCTCCA AGCCAAAGTT TTTTGAAAAG TCAGATGTGG GCGCAGACTC GAATGGAAAC 2400

CGCGGATCAT GTGGAACAGC CGTTCTCAAT GTCACATTAC AATCAGTGGG AGCAAACTCC 2460

GCTATGCTGA ACGTCACGAC AAAAGTTGAA ATAGGAGAGC CCCAAAAGCC GAGCAATGCT 2520

ACAATTGTTT TTAAGGATCC GCGCGCCTTC ATCGGTTTCG TGTTTTATCA TATGATCGAT 2580

CCGTACGGGA ACTCAACTAA AAGCAGTGAC GATCCATGCG ATGATCGCTG GAAGGTTAGC 2640

TCTCCGGAAA AGAGCGGGGT CATGGTATTA AGCAATTTGA TTCCGTACAC TAACTACTCC 2700

TACTACGTTC GGACCATGGC TATATCCTCG GAATTGACAA ACGCGGAGAG CGACGTGAAG 2760

AACTTTAGGA CGAATCCCGG ACGACCGTCA AAGGTTACGG AGGTGGTAGC AACCGCCATT 2820

TCAGATTCGA AAATTAACGT AACATGGAGC TACCTAGATA AGCCTTATGG CGTGCTAACG 2880

CGCTATTTTA TAAAAGCCAA ACTTATAAAT CGGCCTACTC GAAACAATAA CCGGGATTAC 2940

TGTACTGAAC CTCTCGTCAA GGCCATGGAA AATGACCTGC CAGCCACAAC GCCTACCAAG 3000

AAAATATCAG ATCCTTTAGC AGGCGACTGT AAGTGCGTGG AGGGTTCGAA GAAGACTAGC 3060

AGTCAGGAAT ACGATGATCG TAAAGTTCAA GCGGGCATGG AGTTTGAGAA CGCGTTGCAA 3120

AACTTTATAT TTGTTCCAAA CATTCGGAAA AGCAAGAATG GATCGTCTGA CAAATCAGAC 3180

GGAGCGGAAG GTGCAGCTCT CGATTCTAAT GCTATTCCAA ATGGAGGAGC TACTAACCCT 3240

TCACGTAGAA GGAGAGACGT TGCGCTCGAG CCAGAGCTCG ACGATGTAGA GGGCAGTGTA 3300

CTTCTACGCC ATGTGCGCTC CATCACAGAC GATACCGATG CATTTTTCGA AAAGGACGAC 3360

GAAAATACCT ATAAAGACGA AGAAGACTTG TCCTCCAACA AACAATTCTA TGAGGTGTTT 3420

GCCAAGGAAT TGCCACCAAA TCAAACACAT TTTGTCTTTG AAAAACTGCG CCACTTCACC 3480

CGCTACGCTA TCTTCGTGGT AGCCTGTAGA GAAGAAATCC CCAGCGAAAA ATTAAGGGAC 3540

ACCAGTTTTA AGAAGTCGCT CTGCAGCGAT TATGACACCG TTTTCCAAAC TACAAAGAGA 3600

AAGAAATTTG CCGACATAGT CATGGACCTA AAAGTAGATT TAGAACACGC CAACAACACC 3660

GAGTCCCCAG TACGGGTTCG CTGGACGCCA CCAGTAGATC CCAACGGAGA AATTGTCACC 3720

TATGAAGTGG CCTACAAGTT GCAAAAACCC GATCAAGTGG AAGAAAAGAA GTGCATTCCG 3780

GCTGCTGACT TCAACCAGAC TGCCGGTTAT TTAATAAAGC TCAACGAGGG CCTTTACAGC 3840

TTCAGGGTGC GAGCCAATTC AATAGCGGGA TACGGCGATT TCACGGAAGT CGAACATATA 3900

AAAGTTGAGC CTCCGCCGAG CTATGCTAAG GTCTTTTTCT GGCTACTGGG AATCGGCCTA 3960

GCGTTCCTGA TCGTTTCCCT GTTCGGCTAT GTCTGTTACC TGCACAAGAG GAAGGTTCCC 4020

TCTAATGACC TTCATATGAA CACAGAGGTG AATCCGTTCT ATGCGAGCAT GCAATACATC 4080

CCAGACGATT GGGAGGTGCT GCGAGAGAAC ATCATTCAGT TGGCTCCACT AGGCCAGGGA 4140

TCCTTTGGCA TGGTGTATGA GGGTATCCTG AAGTCCTTTC CACCCAATGG CGTGGATCGC 4200

GAGTGTGCCA TTAAGACTGT CAACGAAAAT GCTACGGATC GCGAGCGAAC CAATTTCCTG 4260

AGCGAGGCGA GCGTCATGAA GGAGTTCGAT ACGTATCATG TCGTAAGATT GCTCGGTGTT 4320

TGCTCCAGGG GTCAGCCGGC TCTGGTGGTC ATGGAGCTAA TGAAGAAGGG TGATCTTAAG 4380

TCCTATTTGC GTGCCCATCG TCCCGAGGAG CGGGATGAGG CCATGATGAC GTATCTTAAT 4440

CGCATCGGAG TGACTGGTAA TGTGCAGCCT CCTACTTATG GAAGAATCTA CCAGATGGCC 4500

ATTGAGATTG CGGATGGCAT GGCATATTTG GCCGCCAAGA AGTTCGTCCA TCGTGATCTT 4560

GCAGCTCGAA ATTGCATGGT TGCTGATGAT TTGACGGTGA AAATTGGTGA CTTTGGAATG 4620

ACCCGTGACA TCTATGAGAC GGATTACTAT CGGAAGGGCA CTAAAGGGCT GCTGCCAGTT 4680

CGCTGGATGC CACCGGAGAG CTTGCGAGAT GGTGTCTACT CTAGTGCCAG TGATGTATTC 4740

AGCTTTGGAG TGGTTCTCTG GGAAATGGCC ACCTTAGCGG CTCAGCCATA CCAGGGACTT 4800

TCCAACGAGC AAGTCCTGCG TTACGTCATC GATGGCGGTG TTATGGAGAG GCCGGAAAAT 4860

TGTCCTGATT TTCTGCATAA ACTAATGCAA AGGTGCTGGC ATCATAGGTC TTCGGCGAGA 4920

CCCAGTTTTC TGGATATCAT TGCGTATCTC GAACCACAAT GCCCCAATTC ACAATTTAAG 4980

GAAGTATCCT TCTATCACTC AGAGGCAGGT CTGCAGCATC GGGAAAAGGA GCGCAAGGAA 5040

CGCAATCAGC TAGATGCATT CGCGGCAGTC CCCTTGGATC AAGATCTGCA GGATCGGGAA 5100

CAGCAGGAGG ATGCTACCAC ACCTTTACGA ATGGGCGATT ATCAGCAGAA CTCCTCGTTG 5160

GATCAACCGC CCGAAAGCCC CATCGCCATG GTTGATGATC AGGGTTCTCA CTTGCCATTT 5220

AGCCTGCCAT CCGGATTCAT TGCGAGCAGT ACTCCTGATG GGCAGACTGT AATGGCTACT 5280

GCTTTCCAGA ATATTCCAGC AGCGCAAGGT GATATTTCGG CGACTTACGT TGTGCCTGAT 5340

GCAGACGCTT TGGACGGCGA CAGGGGATAT GAGATCTACG ATCCCAGTCC GAAATGTGCA 5400

GAGCTGCCGA CGAGCAGAAG TGGCAGTACT GGCGGTGGAA AACTCAGCGG AGAACAACAT 5460

TTGCTGCCAA GAAAGGGTCG CCAGCCTACC ATCATGAGCA GCTCGATGCC AGATGATGTC 5520

ATCGGTGGGT CCTCACTGCA ACCCTCGACT GCGTCAGCAG GCAGTTCTAA TGCCAGTTCG 5580

CACACAGGAC GCCCAAGTCT GAAGAAAACA GTGGCGGATT CGGTTCGCAA TAAGGCAAAC 5640

TTCATTAATC GCCACCTATT TAACCACAAG CGAACGGGCA GCAATGCCAG CCACAAGAGC 5700

AATGCCTCCA ATGCTCCGAG TACCAGCAGT AACACCAACT TGACAAGTCA CCCAGTGGCT 5760

ATGGGCAATC TTGGAACTAT CGAGAGTGGT GGCAGTGGTT CGGCTGGTAG TTATACTGGA 5820

ACACCCCGCT TCTATACTCC ATCAGCGACG CCTGGAGGAG GCAGCGGTAT GGCCATTAGC 5880

GACAATCCTA ACTACAGACT ACTAGACGAG TCAATAGCCA GCGAACAGGC CACCATCCTA 5940

ACGACTAGCA GCCCCAATCC CAACTACGAG ATGATGCATC CACCAACCAG TCTGGTCAGT 6000

ACCAATCCGA ACTATATGCC CATGAATGAG ACTCCAGTGC AGATGGCGGG TGTGACCATT 6060

AGCCATAATC CGAATTACCA GCCCATGCAG GCGCCGTTGA ATGCACGCCA AAGCCAAAGT 6120

AGCTCCGACG AGGACAACGA GCAGGAGGAG GACGATGAGG ATGAGGACGA CGACGTGGAC 6180

GATGAGCATG TGGAGCACAT CAAGATGGAG CGCATGCCAT TGAGTCGGCC CAGGCAAAGA 6240

GCGTTGCCCA GCAAGACGCA GCCGCCTCGC AGTCGCAGCG TCAGCCAAAC GAGAAAATCT 6300

CCTACGAATC CCAACTCCGG AATCGGAGCG ACAGGAGCCG GAAACCGATC CAACTTGCTT 6360

AAAGAGAACT GGCTGCGACC GGCGAGTACG CCAAGGCCTC CACCACCCAA TGGATTCATC 6420

GGAAGGGAGG CGTAA 6435

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i++l+ lGqGsfGmvyeG+ k++  ++ ++++aiktvne+a++rer++fl+easvmkef+

Q: 1371  IIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFD  1430

         678899******************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaala............p  108

         t+hvvrllGv+s+gqpalvvmelmkkGdlksylr++rpee++ea+++            p

Q: 1431  TYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTylnrigvtgnvqP  1490

         ************************************************************

S: 109   paldkliqmaaeiadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyy  168

         p++++++qma+eiadGmayl+akkfvhrdlaarncmva+dltvkiGdfGmtrdiyetdyy

Q: 1491  PTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYY  1550

         ************************************************************

S: 169   rkggkgllpvrwmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvl  228

         rkg+kgllpvrwm+pesl+dGv++s+sdv+sfGvvlwe++tla+qpyqGlsneqvl++v+

Q: 1551  RKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVI  1610

         ************************************************************

S: 229   dggvlekpencpelltelmrlcwqynpklrpsfleivell  268

         dggv+e+pencp++l++lm++cw++++++rpsfl+i+++l

Q: 1611  DGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL  1650

         *************************************976

Domain Sequence
(FASTA)

IIQLAPLGQG SFGMVYEGIL KSFPPNGVDR ECAIKTVNEN ATDRERTNFL SEASVMKEFD 60

TYHVVRLLGV CSRGQPALVV MELMKKGDLK SYLRAHRPEE RDEAMMTYLN RIGVTGNVQP 120

PTYGRIYQMA IEIADGMAYL AAKKFVHRDL AARNCMVADD LTVKIGDFGM TRDIYETDYY 180

RKGTKGLLPV RWMPPESLRD GVYSSASDVF SFGVVLWEMA TLAAQPYQGL SNEQVLRYVI 240

DGGVMERPEN CPDFLHKLMQ RCWHHRSSAR PSFLDIIAYL 280

Keyword

ATP-binding; Cleavage on pair of basic residues; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Growth regulation; Kinase; Manganese; Membrane; Metal-binding; Neurogenesis; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; SH3-binding; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005899	; C:insulin receptor complex
GO:0005524	; F:ATP binding
GO:0043559	; F:insulin binding
GO:0043560	; F:insulin receptor substrate binding
GO:0005009	; F:insulin-activated receptor activity
GO:0046872	; F:metal ion binding
GO:0043548	; F:phosphatidylinositol 3-kinase binding
GO:0051425	; F:PTB domain binding
GO:0042169	; F:SH2 domain binding
GO:0007411	; P:axon guidance
GO:0007623	; P:circadian rhythm
GO:0008340	; P:determination of adult lifespan
GO:0007391	; P:dorsal closure
GO:0048132	; P:female germ-line stem cell division
GO:0060180	; P:female mating behavior
GO:0007390	; P:germ-band shortening
GO:0060250	; P:germ-line stem-cell niche homeostasis
GO:0007446	; P:imaginal disc growth
GO:0007626	; P:locomotory behavior
GO:0048133	; P:male germ-line stem cell division
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0045793	; P:positive regulation of cell size
GO:0040018	; P:positive regulation of multicellular organism growth
GO:0046622	; P:positive regulation of organ growth
GO:0007285	; P:primary spermatocyte growth
GO:0046777	; P:protein autophosphorylation
GO:0051290	; P:protein heterotetramerization
GO:2000377	; P:regulation of reactive oxygen species metabolic process
GO:0034059	; P:response to anoxia
GO:0042220	; P:response to cocaine
GO:0006974	; P:response to DNA damage stimulus
GO:0007584	; P:response to nutrient
GO:0006979	; P:response to oxidative stress
GO:0007296	; P:vitellogenesis

KEGG

dme:Dmel_CG18402

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS01352	; HEMATOPO_REC_L_F1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013