EKS-DRM-00119
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00119
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MAPKAPK417.23.3E-12522281260
StatusReviewed
Ensembl ProteinFBpp0070802
UniProt AccessionP49071; Q9W480;
Protein NameMAP kinase-activated protein kinase 2
Protein Synonyms/Alias MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2;
Gene NameMAPk-Ak2
Gene Synonyms/Alias MAPk-Ak2; CG3086;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0013987FBpp0070802FBtr0070837
FBgn0013987FBpp0292066FBtr0302940
FBgn0013987FBpp0070803FBtr0070838
FBgn0013987FBpp0300801FBtr0308577
FBgn0013987FBpp0070804FBtr0070839
OrganismDrosophila melanogaster
Functional DescriptionIts physiological substrate seems to be the small heatshock protein (HSP27/HSP25) (By similarity).
Protein Length359
Protein Sequence
(FASTA)
MLSLQNQRQP KTTPLTDDYV TSNTVLGYGI NGKVVQCTHR RTQQNYALKV LLDSERARRE 60
VDLHWRVSGC RYIVNIIDVY ENTFKDRKCL LVVMECMEGG ELFQRIQDKA DGAFTEREAA 120
QIMHEICAAV DYLHSRDIAH RDLKPENLLY TTTQPNATLK LTDFGFAKET FTSYTLQTPC 180
YTPYYVAPEV LGPEKYDKSC DIWSLGVVMY IIMCGFPPFY SNHGLAISPG MKNRIRTGQY 240
DFPDPEWTNV SQAAKDLIKG MLNVDPSKRL RIQDVISNKW IAQYNAVPQT PLCTGRMLKE 300
AEETWPEVQE EMTRSLATMR VDYDQMQIKA LDKSNNPLLT KRRKKIEEME LYMANATRN 359
Nucleotide Sequence
(FASTA)
ATGCTTTCTC TGCAGAATCA ACGGCAACCG AAGACCACCC CACTGACGGA CGACTACGTG 60
ACCTCGAACA CGGTTCTGGG CTACGGGATC AACGGGAAGG TGGTGCAGTG CACCCATCGC 120
CGCACCCAAC AGAACTATGC CCTCAAGGTG CTGTTGGACA GTGAAAGGGC GCGTCGCGAA 180
GTGGACCTGC ATTGGCGGGT CAGCGGATGC CGGTACATTG TGAACATCAT TGATGTGTAC 240
GAGAACACGT TTAAGGACAG GAAGTGCCTC CTGGTGGTCA TGGAGTGCAT GGAGGGCGGC 300
GAGCTCTTCC AGAGAATTCA GGACAAGGCC GACGGTGCCT TTACGGAGCG GGAGGCGGCC 360
CAGATAATGC ACGAGATCTG CGCGGCCGTA GACTATCTGC ACAGTCGCGA CATAGCGCAT 420
CGCGATCTCA AGCCGGAGAA CTTGCTGTAC ACCACCACTC AGCCGAATGC GACCCTTAAA 480
TTGACGGACT TTGGCTTCGC CAAGGAGACA TTCACCAGTT ACACGCTGCA GACGCCCTGC 540
TACACTCCCT ATTACGTGGC TCCTGAGGTT CTGGGCCCGG AGAAGTACGA CAAGAGCTGC 600
GACATCTGGT CGCTGGGCGT GGTGATGTAC ATCATTATGT GCGGATTCCC GCCGTTCTAC 660
AGCAACCACG GCCTAGCCAT ATCGCCCGGC ATGAAAAATC GCATCCGCAC CGGCCAGTAT 720
GACTTTCCCG ATCCGGAGTG GACGAATGTG AGCCAGGCGG CAAAGGATCT GATCAAGGGC 780
ATGCTGAACG TGGACCCCAG CAAGCGTCTG CGCATCCAGG ACGTCATTAG CAACAAGTGG 840
ATTGCCCAGT ACAATGCTGT TCCACAGACA CCGCTCTGCA CGGGTCGCAT GCTAAAGGAG 900
GCCGAGGAAA CCTGGCCGGA AGTGCAGGAG GAGATGACGC GCTCACTGGC CACCATGCGC 960
GTAGACTACG ATCAGATGCA AATCAAGGCG CTGGACAAGT CGAACAACCC GCTGCTGACG 1020
AAGCGCAGGA AAAAGATCGA GGAGATGGAG TTATACATGG CCAATGCGAC GCGCAACTAG 1080
Domain Profile
S: 3     teevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidvfe  62
         +++vlG+Gi+gkv++c++++t+++yalk+l d++++rrev+lh+++sg+++iv++idv+e
Q: 22    SNTVLGYGINGKVVQCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYE  81
         6899********************************************************
S: 63    nsfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhskniahr  120
         n+f+d+k+ll+v+e++eGGel++riq++   afte+ea++++++i++a+++lhs++iahr
Q: 82    NTFKDRKCLLVVMECMEGGELFQRIQDKadGAFTEREAAQIMHEICAAVDYLHSRDIAHR  141
         ****************************889*****************************
S: 121   DlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeally  180
         DlkpenlLy++++ na++kl+Dfg+aket ++ +l+tpc+t++yvaPevl++ek     y
Q: 142   DLKPENLLYTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEK-----Y  196
         ******************************************************.....*
S: 181   dksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseeakd  240
         dksCD+WslGv++yi++cG+pPfys++g ais+++k+ri++g+y+fP++eW++vs++akd
Q: 197   DKSCDIWSLGVVMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKD  256
         ************************************************************
S: 241   lirklLkrdpkerltieevlnhpwv  265
         li+ +L++dp++rl+i++v++++w+
Q: 257   LIKGMLNVDPSKRLRIQDVISNKWI  281
         ************************8
Domain Sequence
(FASTA)
SNTVLGYGIN GKVVQCTHRR TQQNYALKVL LDSERARREV DLHWRVSGCR YIVNIIDVYE 60
NTFKDRKCLL VVMECMEGGE LFQRIQDKAD GAFTEREAAQ IMHEICAAVD YLHSRDIAHR 120
DLKPENLLYT TTQPNATLKL TDFGFAKETF TSYTLQTPCY TPYYVAPEVL GPEKYDKSCD 180
IWSLGVVMYI IMCGFPPFYS NHGLAISPGM KNRIRTGQYD FPDPEWTNVS QAAKDLIKGM 240
LNVDPSKRLR IQDVISNKWI 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00214
EKS-ANC-00222
EKS-BOT-00232
EKS-CAE-00211
EKS-CAJ-00238
EKS-CAF-00239
EKS-CAP-00258
EKS-CII-00138
EKS-CIS-00014
EKS-DAR-00545
EKS-ECT-00007
EKS-EQC-00224
EKS-FEC-00218
EKS-GAM-00136
EKS-GAG-00194
EKS-GAA-00284
EKS-GOG-00230
EKS-HOS-00239
EKS-ICT-00220
EKS-LAC-00244
EKS-LOA-00229
EKS-MAM-00235
EKS-MAE-00006
EKS-MEG-00180
EKS-MIM-00006
EKS-MOD-00232
EKS-MUM-00237
EKS-MUP-00231
EKS-MYL-00235
EKS-NOL-00216
EKS-OCP-00011
EKS-ORN-00300
EKS-ORA-00204
EKS-ORC-00208
EKS-ORL-00279
EKS-OTG-00238
EKS-PAT-00223
EKS-PES-00208
EKS-PEM-00121
EKS-POA-00225
EKS-PRC-00011
EKS-PTV-00009
EKS-RAN-00230
EKS-SAH-00217
EKS-SUS-00202
EKS-TAG-00248
EKS-TAR-00297
EKS-TAS-00007
EKS-TEN-00292
EKS-TUB-00010
EKS-TUT-00013
EKS-VIP-00005
EKS-XET-00307
EKS-XIM-00292
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007155; P:cell adhesion
GO:0045793; P:positive regulation of cell size
GO:0008360; P:regulation of cell shape
GO:0046328; P:regulation of JNK cascade
GO:0009651; P:response to salt stress
KEGG
dme:Dmel_CG3086;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013