EKS-DRM-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	382.1	1.6E-114	150	406	257

Status

Unreviewed

Ensembl Protein

FBpp0086414

UniProt Accession

A1ZA66;

Protein Name

Protein Synonyms/Alias

Stretchin-Mlck, isoform A;

Gene Name

Strn-Mlck

Gene Synonyms/Alias

Strn-Mlck; Dmel_CG18255;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0013988	FBpp0291928	FBtr0302788
FBgn0013988	FBpp0291929	FBtr0302789
FBgn0013988	FBpp0086409	FBtr0087271
FBgn0013988	FBpp0291936	FBtr0302796
FBgn0013988	FBpp0291935	FBtr0302795
FBgn0013988	FBpp0291934	FBtr0302794
FBgn0013988	FBpp0291933	FBtr0302793
FBgn0013988	FBpp0291932	FBtr0302792
FBgn0013988	FBpp0291931	FBtr0302791
FBgn0013988	FBpp0291930	FBtr0302790
FBgn0013988	FBpp0086412	FBtr0087274
FBgn0013988	FBpp0086414	FBtr0087276
FBgn0013988	FBpp0086413	FBtr0087275

Organism

Drosophila melanogaster

Functional Description

Protein Length

785

Protein Sequence
(FASTA)

MNDYGVEAAA ASVAVEGPPE PPSGQPSVSL GPDRVAVAWC GPPYDGGCMI TGFIIEMQTI 60

GDENCDEDSW QQVTRVVDSL AYTVKNLQPE RQYRFRVRAE NIHGRSAPGQ ASELVQITNT 120

PQRSTSSDAS DRFGQATVSV QSGGDFKSRF EIIEELGKGR FGIVYKVQER GQPEQLLAAK 180

VIKCIKSQDR QKVLEEISIM RALQHPKLLQ LAASFESPRE IVMVMEYITG GELFERVVAD 240

DFTLTEMDCI LFLRQVCDGV AYMHGQSVVH LDLKPENIMC HTRTSHQIKI IDFGLAQRLD 300

TKAPVRVLFG TPEFIPPEII SYEPIGFQSD MWSVGVICYV LLSGLSPFMG DTDVETFSNI 360

TRADYDYDDE AFDCVSQEAK DFISQLLVHR KEDRLTAQQC LASKWLSQRP DDSLSNNKIC 420

TDKLKKFIIR RKWQKTGNAI RALGRMANLS VSRRNSAIAM GVLSSPRPSI SGLGMLTTSA 480

IGSGTSSQMT SLHEEEDDFS GEMPPVEKRT VLKLRDKSQC SERSDSGYSE CSNCSGAQET 540

LLLSLAKSKL EAIAKASTLP TVVHDTEQPV SLELPTKGEA IMRSDFTNTI KMRKKSLEDS 600

AAREKPRSKP QVKPLLCESK LKVSQLKDRF QVSPAPASAS ASASAANKPP LAYGPFKIAK 660

VASVGRISRT EEPGRSGRGA PSVSGKGKSP QVRSMPSSPL PQRSATPTRL MSQRVREAAE 720

RLAQQHTVAS AQRHLGNGRG TGTGNGNGNS NSNGNGNGNT AETNRESRAR RLINRFNSET 780

QHITS 785

Nucleotide Sequence
(FASTA)

ATGAACGACT ATGGCGTGGA GGCAGCCGCT GCCTCGGTGG CAGTGGAAGG TCCTCCGGAG 60

CCACCAAGTG GCCAGCCCAG TGTATCGCTG GGTCCAGATC GCGTGGCAGT GGCCTGGTGT 120

GGTCCACCCT ACGACGGTGG CTGTATGATC ACAGGTTTTA TCATTGAGAT GCAGACCATT 180

GGCGATGAGA ACTGCGATGA GGACAGCTGG CAGCAGGTTA CCCGAGTGGT GGACAGCTTA 240

GCGTACACCG TCAAAAACCT CCAGCCGGAG AGGCAGTACC GATTCAGAGT GCGTGCCGAG 300

AATATCCATG GACGCAGTGC ACCCGGCCAG GCCAGCGAAC TGGTACAGAT TACCAATACG 360

CCACAGAGGA GCACATCATC GGATGCCAGC GATCGTTTCG GACAAGCGAC AGTGAGCGTG 420

CAGTCTGGTG GAGATTTCAA ATCCCGCTTC GAGATCATCG AGGAGCTGGG CAAGGGACGA 480

TTTGGCATTG TCTACAAGGT GCAGGAACGC GGTCAGCCGG AGCAGCTGCT GGCCGCCAAG 540

GTGATCAAGT GCATCAAGTC GCAGGATCGG CAGAAGGTGC TCGAGGAGAT CTCCATCATG 600

CGCGCACTGC AGCATCCCAA GCTCCTTCAG CTGGCTGCCT CCTTCGAAAG TCCCAGGGAG 660

ATTGTCATGG TGATGGAGTA CATCACTGGC GGAGAACTGT TCGAACGTGT GGTGGCTGAC 720

GACTTCACCT TGACCGAAAT GGACTGCATC CTGTTCCTGC GACAGGTTTG CGATGGCGTG 780

GCCTACATGC ACGGCCAGAG TGTGGTGCAT CTCGATCTGA AGCCGGAGAA CATAATGTGC 840

CATACGCGCA CTAGCCACCA GATCAAGATC ATTGACTTTG GTCTGGCCCA ACGACTGGAT 900

ACGAAAGCAC CCGTTCGGGT TCTCTTTGGT ACTCCCGAGT TTATACCACC AGAAATCATT 960

AGCTACGAAC CCATAGGTTT CCAGTCCGAC ATGTGGAGTG TGGGCGTCAT TTGCTACGTG 1020

CTACTCTCGG GTCTGTCGCC TTTCATGGGC GATACCGATG TGGAAACCTT CTCGAATATA 1080

ACTAGAGCGG ATTACGATTA CGATGACGAG GCCTTCGACT GCGTTTCGCA AGAGGCCAAG 1140

GATTTCATCT CGCAGCTATT GGTCCACCGA AAGGAGGACC GCCTGACCGC CCAGCAATGC 1200

CTGGCGTCCA AGTGGCTGAG CCAACGACCA GACGATAGTC TCAGCAACAA CAAGATCTGC 1260

ACGGATAAGC TGAAGAAGTT CATCATTCGA CGCAAGTGGC AGAAAACCGG AAACGCCATC 1320

CGTGCTCTTG GTCGCATGGC CAATCTTTCG GTGTCGCGAA GGAACTCAGC CATTGCCATG 1380

GGAGTACTGA GCAGTCCAAG GCCATCGATA TCGGGTCTGG GCATGCTGAC CACCAGTGCC 1440

ATTGGGAGTG GAACCAGCTC CCAGATGACA TCGCTCCACG AAGAGGAGGA CGACTTCAGC 1500

GGCGAGATGC CGCCAGTGGA GAAGCGCACC GTTCTCAAGC TGCGAGATAA ATCCCAGTGC 1560

AGTGAACGCA GTGATTCAGG CTACAGTGAG TGTTCCAATT GTAGTGGAGC CCAGGAGACG 1620

CTGCTACTCT CGCTGGCCAA ATCCAAACTG GAGGCTATAG CGAAGGCGAG CACCTTGCCC 1680

ACGGTGGTGC ACGATACGGA GCAACCCGTT AGCCTGGAGC TGCCCACCAA GGGCGAAGCC 1740

ATCATGCGCT CCGACTTTAC CAACACCATC AAGATGCGCA AGAAGTCACT GGAGGACAGT 1800

GCTGCACGGG AGAAACCCAG GTCCAAACCC CAGGTCAAGC CGCTCTTGTG TGAGTCCAAG 1860

CTGAAGGTGT CCCAGCTGAA GGACAGGTTC CAGGTGTCCC CTGCTCCTGC TTCTGCATCT 1920

GCATCCGCAT CCGCTGCTAA CAAACCTCCG CTTGCCTATG GGCCCTTCAA AATAGCCAAA 1980

GTGGCGAGTG TGGGACGCAT CAGTAGAACA GAGGAGCCGG GAAGGAGCGG TAGAGGCGCA 2040

CCCAGTGTAT CCGGCAAAGG CAAGTCACCC CAGGTGCGTT CCATGCCCAG CTCTCCGCTG 2100

CCTCAGCGAT CCGCTACGCC GACGCGGCTG ATGAGCCAAC GTGTCCGTGA GGCGGCCGAG 2160

CGTCTTGCCC AACAGCACAC GGTGGCCAGT GCTCAGCGGC ATTTGGGCAA TGGGAGAGGC 2220

ACTGGCACTG GCAATGGAAA TGGCAATAGC AATAGTAATG GCAATGGTAA TGGGAACACC 2280

GCGGAGACGA ATCGCGAATC ACGCGCGCGA CGTCTCATCA ACCGATTCAA TAGCGAAACG 2340

CAGCATATCA CGTCCTAG 2358

Domain Profile

S: 1     ysikeelgkGkfgvvvkavekst.gkklaakivkvrkekdkeevkkEieilnqlrHekli  59

         ++i+eelgkG+fg+v+k++e+ + ++ laak++k+ k++d+++v +Ei+i+++l+H+kl+

Q: 150   FEIIEELGKGRFGIVYKVQERGQpEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLL  209

         5799*****************9989999********************************

S: 60    qlydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgiv  119

         ql ++fes +eiv+v+E+++ggelfer+v++d++ltE++++lf+rqv+++++y+H +++v

Q: 210   QLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVV  269

         ************************************************************

S: 120   HldlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslat  179

         Hldlkpeni++++++s+qiK+idFGla++l++k+ ++vlfgtpef++PE++++ep+++++

Q: 270   HLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQS  329

         ************************************************************

S: 180   DmWsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvk  239

         DmWsvGvi+yvLlsGlsPF+gd+d et++n+++a+yd+d+eaf+ vs+eakdFis+llv+

Q: 330   DMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVH  389

         ************************************************************

S: 240   ekkkRmsaeeaLkhkwl  256

         +k++R++a+++L+ kwl

Q: 390   RKEDRLTAQQCLASKWL  406

         ****************8

Domain Sequence
(FASTA)

FEIIEELGKG RFGIVYKVQE RGQPEQLLAA KVIKCIKSQD RQKVLEEISI MRALQHPKLL 60

QLAASFESPR EIVMVMEYIT GGELFERVVA DDFTLTEMDC ILFLRQVCDG VAYMHGQSVV 120

HLDLKPENIM CHTRTSHQIK IIDFGLAQRL DTKAPVRVLF GTPEFIPPEI ISYEPIGFQS 180

DMWSVGVICY VLLSGLSPFM GDTDVETFSN ITRADYDYDD EAFDCVSQEA KDFISQLLVH 240

RKEDRLTAQQ CLASKWL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005875	; C:microtubule associated complex
GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity
GO:0004687	; F:myosin light chain kinase activity
GO:0005200	; F:structural constituent of cytoskeleton

KEGG

dme:Dmel_CG18255

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 26.
PF00069	; Pkinase; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 14.
SM00408	; IGc2; 12.
SM00220	; S_TKc; 1.

Prosites

PS50853	; FN3; 3.
PS50835	; IG_LIKE; 27.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013