EKS-DRM-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	354.9	4.2E-106	419	676	258

Status

Unreviewed

Ensembl Protein

FBpp0089256

UniProt Accession

B9EQQ2;

Protein Name

Protein Synonyms/Alias

FI02066p;

Gene Name

Pk92B

Gene Synonyms/Alias

Pk92B; Pk92B-RC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0014006	FBpp0089256	FBtr0083819
FBgn0014006	FBpp0289484	FBtr0300256

Organism

Drosophila melanogaster

Functional Description

Protein Length

1196

Protein Sequence
(FASTA)

MREKFLSDMR TARDTYATNG AKLQSILHEM RKRLDDPHVL SGEVVHSFMC SLRDVQDYDA 60

MVRLVNDLKN IPNTRKYVET GNMSFLYAFA LNRRNRKGDR EKALESSLKA LEKKENHFPD 120

MLCLCGRIYK DIFVESDYTD ATSLAHAIKW YRQSFEVQPN EYAGINLATL LVIEGKEFTN 180

TEELQHIGMT LNNLIGKKGS LSSLSEYWDV ATFFEISVLA NDYAKAIQAA ECMFKLKPPN 240

WYLKSTIGNI SLIHRFRKKP EERQPPIEEQ VFQFWMDFFL EATNTEEVKN SIRFPILILE 300

PQKIYMPSYV TINMDADEKS IQIVNICLAH AKNACKKIHD FLFVASKIKS VSLYKRDDRC 360

AYLYVHHNSD DFQIYFPSTE RRQKFYDMIL EMTADQVVFV NLSNDDANIE YEYDYDEQNR 420

KMVLGKGTYG TVYAARDKQT QVRIAIKEVP EKNSQDVQPL HEEIKLHSQL RHRNIVRYLG 480

SCSENGFFKI FMEQVPGGSL SDLLETKWGP LKDNESTMAF YSKQILEGLK YLHEQDIVHR 540

DIKGDNVLVN TYSGVVKISD FGTSKRLARI NPMTETFTGT LQYMAPEVID QGVRGYGPAA 600

DIWSFGCTNV EMATGKPPFI ELGSAHAAMF KVGFYKKHPN IPEELSANAK NFILRCFAIS 660

VMDRPSASQL LEDPFLQDKP RKVRPALPIN TEFGRSISVP ADRFVHKTTP PLSYNTTCNT 720

PTTPELDITH SSSVDIDELP SNQFMLERRN SHGFLLSPEI EPSTPSLRTS ISETSETDGF 780

YRLKKDSQRR TTLSKVLALD ESKICDIWLK KVDADQNSIA IRKSDLEVLI RGLRDYIMNE 840

NEKHLEATIN ELKQKLNNDA VALDHLHLAL YSFQDAVVCV LRYHCIKPHW MFALDNLVKR 900

AVQAAVTIFS PELGANLADK DLSGNDDESL RTSLMQKGST ESQEKQSLEK VLPTSNTREG 960

VGLTPAESGG DALSSSMECA RILRDIRDNQ QKLQRQLLEQ QRQSMRALHN ISQELAHIYM 1020

GGRKRLRRTI NGFNKKCHRM STSVGGTSGV RPNIAGNPRR QLNKHHFGLH EVDEQLEQWL 1080

TQQEIDEFSK TLILNEGFTF DDFIYNMEKL DLMRLGLRVG IEVRLWKLII QERVCTSSDC 1140

VDSPPSTYHK PIGGNSSFAL IDNNNTLPSP TTTTPGTPGI KTKIKKSESE YDSCSE 1196

Nucleotide Sequence
(FASTA)

ATGCGTGAGA AATTTCTGAG TGACATGCGA ACGGCGCGGG ACACGTACGC CACCAACGGC 60

GCCAAGCTGC AGAGTATATT GCACGAGATG CGAAAGCGGC TGGACGATCC GCATGTCCTG 120

TCTGGCGAAG TGGTACACAG TTTCATGTGC TCGCTGAGGG ATGTGCAGGA CTACGATGCC 180

ATGGTGCGAC TGGTCAATGA CCTGAAGAAC ATACCCAACA CCCGGAAGTA CGTGGAGACG 240

GGCAACATGA GTTTCCTGTA CGCCTTCGCC CTGAACCGAA GAAATCGAAA GGGAGACCGT 300

GAAAAGGCTC TGGAATCTTC GCTGAAGGCG CTGGAAAAGA AGGAGAACCA CTTTCCGGAC 360

ATGCTCTGCC TGTGCGGCCG CATCTACAAG GACATCTTTG TGGAATCCGA CTACACGGAC 420

GCCACCAGTT TGGCGCACGC CATCAAGTGG TACCGCCAAA GCTTTGAGGT GCAGCCGAAT 480

GAGTATGCAG GCATCAATCT GGCTACTCTG CTGGTTATCG AGGGCAAGGA GTTTACCAAT 540

ACGGAGGAGT TGCAGCACAT CGGCATGACC TTAAACAATT TAATCGGTAA AAAGGGCAGC 600

CTATCCTCGC TGAGTGAGTA TTGGGATGTG GCCACCTTCT TTGAGATCTC CGTTTTGGCC 660

AACGACTACG CCAAGGCGAT TCAAGCTGCC GAGTGCATGT TCAAGCTAAA GCCACCCAAC 720

TGGTATCTGA AGTCGACCAT CGGAAATATC TCTCTTATAC ATCGATTTCG AAAGAAGCCC 780

GAGGAACGCC AGCCGCCCAT CGAGGAGCAG GTGTTCCAGT TCTGGATGGA CTTCTTTCTG 840

GAGGCCACCA ACACCGAGGA GGTTAAGAAC AGCATTCGCT TTCCGATTCT GATCCTCGAG 900

CCTCAGAAGA TTTATATGCC CAGTTATGTG ACTATAAACA TGGATGCGGA TGAGAAGTCC 960

ATTCAGATTG TGAACATCTG TTTGGCTCAC GCAAAGAATG CGTGTAAGAA AATCCACGAC 1020

TTCCTTTTCG TGGCATCGAA GATCAAGTCC GTCAGCCTTT ACAAGAGGGA TGATCGTTGT 1080

GCCTACTTGT ACGTCCATCA CAACTCAGAT GATTTTCAAA TATATTTTCC CTCCACTGAA 1140

CGACGACAAA AGTTCTACGA TATGATCCTG GAGATGACTG CAGATCAGGT GGTGTTTGTC 1200

AATCTCAGCA ATGATGACGC TAATATCGAG TACGAGTACG ACTACGATGA GCAGAATCGC 1260

AAAATGGTGC TGGGCAAAGG TACTTATGGC ACCGTGTACG CCGCCAGGGA CAAGCAGACG 1320

CAGGTGCGAA TCGCCATTAA GGAGGTGCCG GAAAAGAACT CGCAGGATGT GCAGCCACTG 1380

CACGAGGAGA TTAAGTTACA CTCTCAGCTG CGACATCGCA ACATAGTTCG CTATTTGGGA 1440

TCGTGCTCGG AGAACGGCTT CTTCAAGATC TTCATGGAGC AGGTGCCGGG AGGATCGCTT 1500

TCCGACCTCT TAGAGACCAA ATGGGGTCCG CTCAAGGACA ACGAGTCCAC CATGGCCTTC 1560

TACTCCAAGC AGATCCTCGA GGGGCTGAAG TACCTTCACG AGCAGGACAT TGTTCATCGC 1620

GATATAAAGG GTGACAACGT GCTGGTTAAC ACGTATAGCG GCGTGGTTAA GATCTCCGAT 1680

TTCGGCACCT CCAAGCGGCT GGCCCGCATC AACCCGATGA CGGAGACCTT TACGGGCACC 1740

TTGCAGTACA TGGCGCCGGA GGTGATTGAC CAGGGAGTAC GCGGCTATGG CCCGGCGGCT 1800

GACATCTGGT CCTTTGGATG CACAAACGTT GAGATGGCTA CGGGCAAACC ACCGTTTATC 1860

GAGCTGGGTA GCGCCCATGC GGCCATGTTC AAGGTGGGCT TTTACAAGAA GCATCCGAAC 1920

ATACCCGAGG AGCTGTCCGC CAACGCAAAG AACTTTATTT TGCGTTGCTT TGCCATCAGC 1980

GTGATGGACC GACCCTCCGC CTCGCAACTT CTGGAAGATC CCTTCCTACA AGATAAACCC 2040

CGCAAGGTGC GCCCAGCCCT GCCCATCAAT ACTGAGTTCG GACGCAGCAT TTCGGTGCCG 2100

GCTGATCGGT TTGTGCACAA AACCACACCG CCGCTGAGCT ACAACACAAC CTGCAATACG 2160

CCCACAACGC CGGAATTGGA CATAACGCAT TCATCCTCGG TGGACATTGA CGAGCTGCCC 2220

AGCAACCAGT TTATGCTTGA ACGGCGAAAT TCCCATGGAT TTTTGCTCTC GCCAGAGATT 2280

GAACCTTCCA CGCCGTCCTT GCGTACGAGC ATTAGTGAGA CGAGCGAGAC TGACGGTTTT 2340

TACAGGCTTA AAAAGGATTC GCAGAGGCGG ACAACGCTTT CCAAGGTGCT GGCACTAGAC 2400

GAATCCAAGA TCTGCGATAT TTGGCTGAAG AAGGTCGACG CTGATCAGAA CTCGATTGCG 2460

ATTAGGAAAA GCGATTTGGA GGTTCTAATC CGAGGACTGC GGGACTACAT TATGAACGAA 2520

AACGAAAAGC ATTTGGAAGC GACTATCAAC GAACTGAAAC AAAAGCTGAA CAACGACGCA 2580

GTTGCTCTGG ACCATCTTCA TTTGGCGCTG TACTCCTTTC AGGACGCCGT GGTCTGCGTA 2640

CTGCGGTACC ATTGCATCAA ACCCCATTGG ATGTTCGCAT TGGATAATCT GGTTAAGCGG 2700

GCCGTCCAGG CGGCGGTCAC TATTTTCTCT CCTGAACTGG GCGCCAATCT GGCGGACAAA 2760

GACCTGTCTG GAAATGATGA TGAGAGCTTG CGTACAAGTC TAATGCAGAA GGGTTCCACC 2820

GAGAGCCAGG AAAAGCAGAG CCTGGAAAAA GTTCTTCCCA CGAGCAACAC TCGCGAAGGT 2880

GTGGGATTAA CGCCTGCGGA ATCGGGCGGG GATGCTCTGT CCAGTTCGAT GGAGTGCGCG 2940

CGCATCCTGA GAGACATCCG TGACAATCAG CAGAAGCTGC AACGCCAGCT CCTTGAGCAG 3000

CAGCGGCAGA GCATGAGGGC CCTGCATAAT ATCAGTCAGG AGCTGGCTCA CATTTACATG 3060

GGCGGCAGAA AGAGATTAAG ACGCACAATA AACGGCTTTA ACAAAAAGTG CCATAGAATG 3120

AGTACCAGTG TGGGCGGAAC GTCCGGAGTC CGTCCGAATA TAGCGGGCAA TCCCCGGAGG 3180

CAGCTAAACA AGCATCACTT TGGTCTTCAC GAAGTAGACG AGCAGTTGGA GCAGTGGTTG 3240

ACCCAGCAGG AAATAGACGA GTTCTCAAAG ACGCTCATCC TGAATGAAGG TTTTACATTT 3300

GACGACTTTA TCTATAACAT GGAAAAGCTG GACCTCATGA GGCTGGGTCT GCGCGTTGGC 3360

ATCGAAGTGC GTTTGTGGAA ACTCATTATA CAAGAACGTG TGTGCACCTC GTCCGATTGT 3420

GTGGACAGTC CACCAAGCAC TTACCACAAA CCCATTGGAG GCAATAGCTC TTTTGCGCTT 3480

ATTGACAACA ACAATACGCT ACCATCACCC ACAACCACAA CTCCCGGAAC GCCGGGCATC 3540

AAAACGAAAA TCAAGAAAAG CGAAAGCGAG TACGATTCGT GCAGCGAGTG A 3591

Domain Profile

S: 2     qkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHe  61

         +++ v+gkG++g+vyaa+d++t+ ++a+Kev   pek+s+   v++l+eEikl+++l+H+

Q: 419   NRKMVLGKGTYGTVYAARDKQTQVRIAIKEV---PEKNSQ--DVQPLHEEIKLHSQLRHR  473

         57899**************************...777664..9*****************

S: 62    nivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLH  118

         niv+y+G+++e++ +kif+E+v+gGsls+lle k+g+l+  es++ +y+kqilegl+yLH

Q: 474   NIVRYLGSCSENGFFKIFMEQVPGGSLSDLLEtKWGPLKdnESTMAFYSKQILEGLKYLH  533

         ********************************9*****9999******************

S: 119   ekkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvik  177

         e++ivHRDiKg+N+l+++ sgvvk+sDFG+skrla++n++   +e++tGtl+ymaPEvi+

Q: 534   EQDIVHRDIKGDNVLVNTySGVVKISDFGTSKRLARINPM---TETFTGTLQYMAPEVID  590

         **************************************99...8****************

S: 178   kkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegk  237

         ++ +gyg +aDiWs+gc+ +em+tgk+Pf el++++a+mfkvg+ k++P+ipe+ls+++k

Q: 591   QGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAK  650

         ************************************************************

S: 238   dflekcleldpkkrpsaeeLLkhefl  263

         +f+ +c+ ++  +rpsa++LL+++fl

Q: 651   NFILRCFAISVMDRPSASQLLEDPFL  676

         ************************96

Domain Sequence
(FASTA)

NRKMVLGKGT YGTVYAARDK QTQVRIAIKE VPEKNSQDVQ PLHEEIKLHS QLRHRNIVRY 60

LGSCSENGFF KIFMEQVPGG SLSDLLETKW GPLKDNESTM AFYSKQILEG LKYLHEQDIV 120

HRDIKGDNVL VNTYSGVVKI SDFGTSKRLA RINPMTETFT GTLQYMAPEV IDQGVRGYGP 180

AADIWSFGCT NVEMATGKPP FIELGSAHAA MFKVGFYKKH PNIPEELSAN AKNFILRCFA 240

ISVMDRPSAS QLLEDPFL 258

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013