| Tag | Content |
|---|
| EKPD ID | EKS-DRM-00212 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CK1/CK1 | 472.6 | 3.6E-142 | 20 | 280 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | FBpp0073513 |
| UniProt Accession | P54367; A4V4D3; Q0KHT2; Q9VYK2; |
| Protein Name | Casein kinase I isoform alpha |
| Protein Synonyms/Alias | CKI-alpha; DmCK1; |
| Gene Name | CkIalpha |
| Gene Synonyms/Alias | CkIalpha; CKI; CG2028; |
| Ensembl Information | |
| Organism | Drosophila melanogaster |
| Functional Description | Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May be required for mechanisms associated with DNA repair during early embryogenesis. |
| Protein Length | 337 |
Protein Sequence
(FASTA) | | MDKMRILKES RPEIIVGGKY RVIRKIGSGS FGDIYLGMSI QSGEEVAIKM ESAHARHPQL 60 | | LYEAKLYRIL SGGVGFPRIR HHGKEKNFNT LVMDLLGPSL EDLFNFCTRH FTIKTVLMLV 120 | | DQMIGRLEYI HLKCFIHRDI KPDNFLMGIG RHCNKLFLID FGLAKKFRDP HTRHHIVYRE 180 | | DKNLTGTARY ASINAHLGIE QSRRDDMESL GYVMMYFNRG VLPWQGMKAN TKQQKYEKIS 240 | | EKKMSTPIEV LCKGSPAEFS MYLNYCRSLR FEEQPDYMYL RQLFRILFRT LNHQYDYIYD 300 | | WTMLKQKTHQ GQPNPAILLE QLDKDKEKQN GKPLIAD 337 |
|
Nucleotide Sequence
(FASTA) | | ATGGACAAGA TGCGGATATT GAAGGAAAGT CGCCCCGAGA TAATCGTCGG TGGCAAATAT 60 | | CGGGTGATCA GGAAGATTGG AAGCGGATCG TTTGGCGACA TTTACCTGGG CATGAGCATC 120 | | CAGAGCGGCG AAGAAGTGGC CATCAAGATG GAGAGCGCCC ACGCCCGCCA TCCGCAGCTG 180 | | TTGTACGAGG CCAAGCTGTA CCGCATTCTG AGCGGCGGCG TTGGATTCCC TCGTATACGT 240 | | CACCATGGCA AGGAAAAGAA CTTCAACACC CTGGTCATGG ACCTGCTGGG ACCCTCGCTG 300 | | GAGGATCTGT TCAATTTCTG TACGCGCCAT TTCACAATCA AAACGGTTCT GATGCTCGTC 360 | | GACCAGATGA TCGGACGCTT GGAGTACATC CATCTCAAGT GCTTCATCCA TCGCGACATC 420 | | AAGCCGGATA ACTTCCTAAT GGGCATTGGT CGGCACTGCA ATAAGCTGTT CCTGATCGAT 480 | | TTCGGTCTGG CCAAGAAGTT CCGCGATCCG CACACGCGCC ATCACATCGT TTACCGCGAG 540 | | GACAAGAACC TCACCGGCAC TGCCCGCTAT GCCTCGATCA ATGCCCATCT GGGCATCGAG 600 | | CAGTCGCGGC GTGACGACAT GGAATCGCTT GGATACGTGA TGATGTACTT CAATCGCGGC 660 | | GTACTGCCAT GGCAAGGCAT GAAGGCCAAC ACCAAGCAGC AGAAATACGA GAAGATCTCC 720 | | GAAAAGAAGA TGTCCACGCC CATCGAGGTC CTCTGCAAGG GCTCGCCGGC CGAGTTCTCC 780 | | ATGTATCTGA ACTATTGTCG TAGCCTGCGC TTCGAGGAGC AGCCAGATTA CATGTACCTA 840 | | CGTCAATTGT TCCGCATACT GTTCAGAACG CTGAACCATC AGTATGACTA CATCTACGAC 900 | | TGGACAATGC TGAAGCAGAA GACCCATCAG GGTCAACCCA ATCCAGCTAT ACTCTTGGAG 960 | | CAATTGGACA AGGACAAGGA GAAGCAGAAC GGCAAGCCCC TGATCGCGGA CTAA 1014 |
|
| Domain Profile | S: 1 yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev 60 | yrv++kiGsGsfGdiylg++++sgeevaik+es+++++pql +e+++y+il+ggvg+P++ | Q: 20 YRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRI 79 | 89********************************************************** |
| S: 61 ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd 120 | r++gkek++n+lv+dllGpsledlf++c+r+f++ktvl+l+dq+i r+ey+h k++i+rd | Q: 80 RHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRD 139 | ************************************************************ |
| S: 121 ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk 180 | ikPdnfl+gigr+++k++lidfGlakk+rd++t++hi yre+k+ltGtaryasin+hlg+ | Q: 140 IKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGI 199 | ************************************************************ |
| S: 181 eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef 240 | eqsrrdd+eslgyv++yf+rg lPWqg+ka+tk+qkyekisekk+st+ievlc+g P+ef | Q: 200 EQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEF 259 | ************************************************************ |
| S: 241 atylkyvrklkfeekPdyeyl 261 | ++yl+y+r+l+fee+Pdy+yl | Q: 260 SMYLNYCRSLRFEEQPDYMYL 280 | *******************97 |
|
Domain Sequence
(FASTA) | | YRVIRKIGSG SFGDIYLGMS IQSGEEVAIK MESAHARHPQ LLYEAKLYRI LSGGVGFPRI 60 | | RHHGKEKNFN TLVMDLLGPS LEDLFNFCTR HFTIKTVLML VDQMIGRLEY IHLKCFIHRD 120 | | IKPDNFLMGI GRHCNKLFLI DFGLAKKFRD PHTRHHIVYR EDKNLTGTAR YASINAHLGI 180 | | EQSRRDDMES LGYVMMYFNR GVLPWQGMKA NTKQQKYEKI SEKKMSTPIE VLCKGSPAEF 240 | | SMYLNYCRSL RFEEQPDYMY L 261 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |