EKS-DRM-00098
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00098
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ryk435.87.2E-131343599257
StatusReviewed
Ensembl ProteinFBpp0080736
UniProt AccessionQ27324; Q9U9Y3; Q9VIY6;
Protein NameTyrosine-protein kinase Drl
Protein Synonyms/Alias Protein derailed;
Gene Namedrl
Gene Synonyms/Alias drl; lio; CG17348;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0015380FBpp0080736FBtr0081195
FBgn0015380FBpp0303242FBtr0330209
OrganismDrosophila melanogaster
Functional DescriptionProbable coreceptor of Wnt proteins. Involved inneuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.
Protein Length610
Protein Sequence
(FASTA)
MAPNLLTIGL LLTLIASGQA HLNIFLNLHE VLRLIGVSAE LYYVREGAIN DYALNFAVPV 60
PANISDVTFT WQSLVDHPLP YSINIATSDT EVLPRPILNI SRIGDVPVEP QTWGIALKCS 120
GTRNAEVTVT INVEVILDRA TNNNTNLIFK RKKICLREEQ DSAHEEYDDD DLDLLQTARK 180
GHGGDIHYVD RNDEHVVANG HQAPEKQRPV VTESPVGRGN SGGSKRDFDP MLRENLVPPA 240
SGLVTLIVGG ILALVLVSTL ILIAYCAKGP SKRHPSNGVH LIKTSSFQRL PTISSTAHNS 300
IYVCPSTITP TYATLTRPFR EYEHEPEEFN RRLQELTVQK CRVRLSCLVQ EGNFGRIYRG 360
TYNDCQEVLV KTVAQHASQL QVNLLLQESM MLYEASHPNV LSVLGISIED YATPFVLYAA 420
TGSVRNLKSF LQDPSYARSV TTIQTVLMGS QLAMAMEHLH NHGVIHKDIA ARNCVIDDQL 480
RVKLTDSALS RDLFPGDYNS LGDGEYRPIK WLSLEALQKS HYNEGSDVWS FGVLMWEMCT 540
LGKLPYAEID PYEMEHYLKD GYRLAQPFNC PDELFTIMAY CWASMPAERP SFSQLQICLS 600
EFHTQITRYV 610
Nucleotide Sequence
(FASTA)
ATGGCCCCCA ACTTGCTAAC AATCGGATTA CTTTTGACCC TGATCGCCAG CGGTCAGGCC 60
CATCTCAATA TTTTCCTCAA CTTGCACGAG GTGCTGCGCC TAATCGGAGT CTCGGCGGAG 120
CTTTACTACG TGCGGGAGGG CGCCATTAAC GACTACGCCT TGAACTTCGC CGTGCCCGTG 180
CCGGCGAACA TCAGTGACGT GACCTTTACG TGGCAATCCC TGGTGGACCA TCCGCTGCCC 240
TACAGCATCA ATATCGCCAC ATCGGACACG GAGGTGTTGC CGCGACCCAT TCTGAACATA 300
TCCCGGATCG GGGATGTGCC CGTGGAGCCA CAGACATGGG GCATTGCGCT CAAGTGCTCG 360
GGCACCAGGA ATGCCGAGGT TACGGTCACC ATAAATGTGG AGGTCATTCT GGATCGGGCT 420
ACCAATAACA ATACGAATCT GATCTTCAAA AGGAAGAAGA TCTGTTTGAG GGAGGAACAG 480
GACAGTGCGC ACGAGGAGTA CGACGACGAT GACTTGGACT TGCTGCAAAC GGCGCGTAAG 540
GGACATGGCG GAGATATTCA CTATGTGGAT CGAAACGATG AGCATGTGGT CGCCAATGGA 600
CACCAGGCGC CGGAGAAGCA ACGTCCGGTT GTCACAGAGT CGCCAGTGGG CCGTGGAAAC 660
TCCGGTGGAT CGAAGCGCGA CTTTGACCCG ATGCTGAGGG AGAACCTGGT GCCACCGGCC 720
AGTGGCCTGG TTACCCTAAT TGTGGGTGGC ATTCTGGCTC TGGTCCTTGT TTCCACCCTC 780
ATCCTGATAG CCTACTGTGC CAAGGGCCCG TCCAAGCGAC ATCCTTCGAA CGGAGTGCAT 840
CTCATCAAAA CCTCTAGCTT CCAGAGACTG CCCACCATAT CGTCGACGGC CCACAACTCG 900
ATCTACGTCT GCCCATCGAC CATCACTCCT ACATATGCCA CGCTGACGCG GCCCTTTCGC 960
GAATATGAGC ATGAGCCTGA GGAGTTCAAC CGCCGTCTCC AAGAGCTGAC AGTCCAAAAG 1020
TGCCGCGTCC GGCTCTCCTG CCTCGTCCAG GAGGGAAACT TTGGGCGAAT CTATCGCGGC 1080
ACTTATAACG ACTGCCAGGA GGTATTGGTC AAGACTGTGG CTCAGCACGC CAGCCAGCTG 1140
CAAGTGAATC TGCTGCTCCA GGAGTCCATG ATGCTGTACG AGGCCTCGCA TCCGAATGTC 1200
CTCTCCGTTC TGGGCATCTC CATCGAGGAC TATGCCACGC CCTTTGTGCT CTATGCCGCC 1260
ACCGGAAGTG TGAGGAACCT GAAGAGCTTC CTGCAGGATC CGTCGTACGC CAGGAGCGTC 1320
ACCACCATTC AGACGGTGCT TATGGGCTCA CAACTGGCCA TGGCCATGGA GCATCTGCAC 1380
AACCACGGCG TCATCCACAA GGACATTGCG GCCAGAAACT GTGTTATTGA TGATCAGCTT 1440
CGAGTTAAGC TCACTGATAG TGCTTTGAGT CGCGATCTCT TCCCGGGTGA CTACAATTCT 1500
CTGGGCGATG GCGAGTACCG ACCCATCAAG TGGCTGTCCT TGGAGGCCCT GCAGAAGTCC 1560
CATTACAACG AGGGCAGTGA TGTTTGGTCC TTCGGCGTTC TCATGTGGGA AATGTGCACT 1620
CTGGGTAAAC TGCCCTACGC CGAGATCGAT CCCTATGAGA TGGAGCACTA TCTCAAGGAT 1680
GGATACAGAT TGGCCCAGCC ATTCAACTGC CCCGATGAGC TCTTCACCAT TATGGCCTAT 1740
TGTTGGGCCT CCATGCCAGC TGAGCGACCT TCGTTCAGCC AGCTGCAGAT CTGCCTATCG 1800
GAGTTCCATA CCCAGATTAC CAGATATGTT TAA 1833
Domain Profile
S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60
         +rl++l+qeG+fGriyrG+++d+++      vlvktv+++as++qv+lllqe+++ly++s
Q: 343   VRLSCLVQEGNFGRIYRGTYNDCQE------VLVKTVAQHASQLQVNLLLQESMMLYEAS  396
         6899*********************......*****************************
S: 61    hrnilsvllvsieeaekPlvvypalnk.gnlkkflricklkdkekaqalstkqlvelaiq  119
         h+n+lsvl++sie++++P+v+y+a+++ +nlk+fl     +d+++a++++t+q+v +++q
Q: 397   HPNVLSVLGISIEDYATPFVLYAATGSvRNLKSFL-----QDPSYARSVTTIQTVLMGSQ  451
         *************************988*******.....9*******************
S: 120   iasalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkW  179
         +a+a+++lh+++v+hkdiaarncvidd+l+vkltdsalsrdlfP dy++lGd+e+rP+kW
Q: 452   LAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKW  511
         ************************************************************
S: 180   lslealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncP  239
         lslealqk++y++ sdvW++Gvl+We++tlgk Pyaeidp+e+e+ylkdGyrlaqP+ncP
Q: 512   LSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCP  571
         ************************************************************
S: 240   delftvmaccWallpeerPsfeqlvscl  267
         delft+ma+cWa++p+erPsf+ql++cl
Q: 572   DELFTIMAYCWASMPAERPSFSQLQICL  599
         **************************97
Domain Sequence
(FASTA)
VRLSCLVQEG NFGRIYRGTY NDCQEVLVKT VAQHASQLQV NLLLQESMML YEASHPNVLS 60
VLGISIEDYA TPFVLYAATG SVRNLKSFLQ DPSYARSVTT IQTVLMGSQL AMAMEHLHNH 120
GVIHKDIAAR NCVIDDQLRV KLTDSALSRD LFPGDYNSLG DGEYRPIKWL SLEALQKSHY 180
NEGSDVWSFG VLMWEMCTLG KLPYAEIDPY EMEHYLKDGY RLAQPFNCPD ELFTIMAYCW 240
ASMPAERPSF SQLQICL 257
KeywordATP-binding; Cell membrane; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Wnt signaling pathway.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0016199; P:axon midline choice point recognition
GO:0016204; P:determination of muscle attachment site
GO:0007482; P:haltere development
GO:0007613; P:memory
GO:0008355; P:olfactory learning
GO:0007435; P:salivary gland morphogenesis
GO:0016055; P:Wnt receptor signaling pathway
KEGG
dme:Dmel_CG17348;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR003306; WIF.
Pfam
PF07714; Pkinase_Tyr; 1.
PF02019; WIF; 1.
SMARTs
SM00219; TyrKc; 1.
SM00469; WIF; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50814; WIF; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013