EKS-DRM-00032
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00032
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK332.03.5E-9926312287
StatusUnreviewed
Ensembl ProteinFBpp0086249
UniProt AccessionQ7K306;
Protein Name
Protein Synonyms/Alias Cyclin-dependent kinase 4, isoform A; Cyclin-dependent kinase 4, isoform B; Cyclin-dependent kinase 4, isoform C; LD31205p;
Gene NameCdk4
Gene Synonyms/Alias Cdk4; CG5072, Dmel_CG5072;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0016131FBpp0086250FBtr0087103
FBgn0016131FBpp0086251FBtr0087104
FBgn0016131FBpp0086249FBtr0087102
OrganismDrosophila melanogaster
Functional Description
Protein Length317
Protein Sequence
(FASTA)
MSYVRQLKRQ KMSQAKKFGD GDPFNYQELN IIGEGAYGTV YRARDVITGN IVALKKVRIS 60
LNENGVPMST LREISLLKQL NASNHANIVK LYEVCQFLER DGQLLILLVF EHVEQDLSDL 120
IDRLPKSGMS PPTIQRLSRE LLTGVDFLHS HRIIHRDLKP QNLLVSSQGH LKIADFGLAK 180
TYGSEMKLTS VVVTLWYRAP EVLLAQPYNS TVDIWSAACI IFEMFNRRAL FPGTSEKNQL 240
DRIFELTGRP TEQQWPQTIS VALEHFPQRH PKRPKDFCPH LCKYADDLLN KMLSYDLHLR 300
PSALACLEHD YFQQEPL 317
Nucleotide Sequence
(FASTA)
ATGTCATATG TACGCCAGCT GAAGCGGCAG AAAATGTCCC AGGCGAAGAA GTTCGGCGAT 60
GGCGATCCGT TCAACTACCA GGAGCTCAAC ATCATCGGCG AAGGTGCCTA TGGAACGGTT 120
TACAGAGCCC GCGATGTGAT CACCGGCAAC ATAGTGGCGC TGAAGAAGGT TAGGATATCG 180
CTGAACGAGA ACGGTGTGCC AATGTCCACG CTGCGGGAGA TTTCGCTGCT GAAGCAGCTG 240
AATGCCAGCA ATCATGCGAA TATTGTCAAA CTGTACGAAG TATGCCAGTT TCTGGAGCGC 300
GACGGCCAAT TGCTGATTCT GTTGGTTTTC GAACATGTGG AGCAGGATCT TTCGGATCTT 360
ATAGACAGAC TTCCCAAATC GGGCATGTCG CCGCCCACAA TTCAGCGCTT GTCAAGGGAA 420
CTACTGACCG GTGTGGACTT CTTACACTCA CACCGTATCA TCCATCGGGA TCTTAAGCCG 480
CAAAACCTGC TGGTCTCCTC GCAGGGCCAC CTCAAGATCG CCGACTTTGG CTTGGCCAAG 540
ACCTACGGTT CGGAGATGAA GCTCACCTCC GTGGTGGTCA CCTTGTGGTA CCGCGCACCC 600
GAGGTTCTGC TCGCCCAGCC CTACAACAGC ACCGTGGACA TCTGGAGTGC CGCCTGCATC 660
ATCTTCGAGA TGTTCAATCG GCGCGCCCTA TTCCCGGGCA CCTCCGAAAA GAATCAGCTG 720
GACCGCATCT TCGAACTGAC CGGTAGACCC ACCGAGCAAC AGTGGCCACA GACCATTTCC 780
GTGGCCCTGG AACACTTTCC CCAGCGGCAT CCAAAGAGAC CAAAAGACTT TTGCCCACAC 840
CTGTGCAAGT ACGCCGATGA TCTGTTGAAT AAAATGCTTT CCTACGACCT CCACCTGCGA 900
CCATCCGCCT TGGCCTGTTT GGAGCACGAT TACTTTCAGC AGGAACCCCT ATAG 954
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel...kh  57
         y++l+ igeG+yg+vy+a+d  tg++vAlKk+r++ +++gvp+++lrEisllk+l   +h
Q: 26    YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLnasNH  85
         899****************************************************9999*
S: 58    knivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113
         +nivkL+ev++      +  ++Lvfe++eqdL++l+++ +k+++s+ ++++l ++ll+g+
Q: 86    ANIVKLYEVCQflerDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGV  145
         ***********986333466789*************************************
S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLl  173
         ++lHs++i+HRDlKpqNlL+s++g+lk+aDfGla++++s++k +t++vvTlwYraPe+Ll
Q: 146   DFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLL  204
         *****************************************9.*****************
S: 174   gakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpe  233
          +  Y+++vDiWs+ ci+ e+++r++lf+g+se++ql+rif+l g p+e++wp++ ++  
Q: 205   AQ-PYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVAL  263
         65.7*****************************************************999
S: 234   ykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
            +fp++++k+ k+ +++l + a dll+k+l++d + R sa ++l+h+yf
Q: 264   E--HFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF  312
         4..6**********************************************9
Domain Sequence
(FASTA)
YQELNIIGEG AYGTVYRARD VITGNIVALK KVRISLNENG VPMSTLREIS LLKQLNASNH 60
ANIVKLYEVC QFLERDGQLL ILLVFEHVEQ DLSDLIDRLP KSGMSPPTIQ RLSRELLTGV 120
DFLHSHRIIH RDLKPQNLLV SSQGHLKIAD FGLAKTYGSE MKLTSVVVTL WYRAPEVLLA 180
QPYNSTVDIW SAACIIFEMF NRRALFPGTS EKNQLDRIFE LTGRPTEQQW PQTISVALEH 240
FPQRHPKRPK DFCPHLCKYA DDLLNKMLSY DLHLRPSALA CLEHDYF 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00064
EKS-ANC-00057
EKS-BOT-00069
EKS-CAE-00051
EKS-CAJ-00065
EKS-CAF-00070
EKS-CAP-00067
EKS-CII-00028
EKS-CIS-00069
EKS-DAR-00082
EKS-EQC-00067
EKS-ERE-00036
EKS-FEC-00067
EKS-GAM-00030
EKS-GAG-00055
EKS-GAA-00086
EKS-GOG-00068
EKS-HOS-00071
EKS-ICT-00064
EKS-LAC-00072
EKS-LOA-00067
EKS-MAM-00067
EKS-MAE-00028
EKS-MEG-00052
EKS-MIM-00032
EKS-MOD-00066
EKS-MUM-00071
EKS-MUP-00071
EKS-MYL-00072
EKS-NOL-00064
EKS-OCP-00043
EKS-ORN-00090
EKS-ORC-00065
EKS-ORL-00079
EKS-OTG-00072
EKS-PAT-00061
EKS-PES-00062
EKS-PEM-00037
EKS-POA-00064
EKS-PRC-00039
EKS-PTV-00061
EKS-RAN-00064
EKS-SAH-00064
EKS-SOA-00030
EKS-SUS-00062
EKS-TAG-00057
EKS-TAR-00088
EKS-TAS-00027
EKS-TEN-00090
EKS-TUT-00063
EKS-XET-00063
EKS-XIM-00088
Gene Ontology
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0007350; P:blastoderm segmentation
GO:0007049; P:cell cycle
GO:0016049; P:cell growth
GO:0008283; P:cell proliferation
GO:0007259; P:JAK-STAT cascade
GO:0007005; P:mitochondrion organization
GO:0007424; P:open tracheal system development
GO:0051726; P:regulation of cell cycle
GO:0001558; P:regulation of cell growth
KEGG
dme:Dmel_CG5072;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013