EKS-DRM-00139
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00139
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK425.91.4E-127198494297
StatusReviewed
Ensembl ProteinFBpp0088344
UniProt AccessionQ9V3D5; A4V0P7; Q8T0L9;
Protein NameDual specificity tyrosine-phosphorylation-regulated kinase 2
Protein Synonyms/Alias Protein smell impaired at 35A; dDyrk2;
Gene Namesmi35A
Gene Synonyms/Alias smi35A; Dyrk2; CG4551;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0016930FBpp0088344FBtr0089288
FBgn0016930FBpp0099869FBtr0100447
FBgn0016930FBpp0089218FBtr0089289
FBgn0016930FBpp0089219FBtr0089290
FBgn0016930FBpp0099870FBtr0100448
FBgn0016930FBpp0302965FBtr0329933
OrganismDrosophila melanogaster
Functional DescriptionIn vitro; can phosphorylate exogenous substrates on Serand Thr residues. May have a physiological role in development being involved in cellular growth and differentiation.
Protein Length722
Protein Sequence
(FASTA)
MLDRCEMPIQ LDNEKLRRDV RLSGSRLDLP QLCNGSRRLD GHNNHVAANE NTVTTTSLNG 60
NGNGNGNSNS NNNNNIGSPV SSSTTNSSNG GNERGSSTKS NSSSGSGSSG NSASSTGSGE 120
LKCNTPMTPS ELVKKFRNYL TDLEFEELKV YKEVWYFGQH ASKNYNKPAP TANTTNLGYD 180
DDNGNYKIIE HDHIAFRYEI LEVIGKGSFG QVIRALDHKT NTHVAIKIIR NKKRFLNQAV 240
VELNILDELR EKDADGSHNV IHMLDYTYFR KHLCITFELM SLNLYELIKK NNYNGFSMSL 300
IRRFCNSIVK CLRLLYKENI IHCDLKPENI LLKQRGSSSI KVIDFGSSCY VDRKIYTYIQ 360
SRFYRSPEVI LGLQYGTAID MWSLGCILAE LYTGFPLFPG ENEVEQLACI MEVLGLPPKV 420
LISVARRRRL FFDSRDAPRC ITNTKGRKRS PGSKSLAHIL HCQDRYFIDF LQRCLEWDPA 480
ERMTPDEAAH HEFLQPSASS RHRSCRMSSS SSSSGLNSVS QKSSCYSFSE ISPGTNGPVV 540
ASITSTTAVH NAAIATTTKS RQQPPSQSHG HAQSNGHLPD IKLSASDKYN SMQKVAVRSK 600
ITSSVSDLES VQQYSLHRIY GGVGSGSTHH VSSAATRKHL PGTGSGIVGA MSSKYGSSTL 660
AHNHHNVTHH NASTATIATT THHHHHHGGQ QQQQSSSGAS TMAMSHSQST GDVSDRAIFG 720
RA 722
Nucleotide Sequence
(FASTA)
ATGTTGGATC GATGCGAAAT GCCGATCCAG CTGGACAACG AGAAGTTGCG GCGGGATGTT 60
CGATTGTCGG GCTCTCGACT TGATTTGCCA CAACTCTGTA ATGGATCCCG TCGGTTGGAT 120
GGCCACAACA ACCATGTGGC TGCCAATGAG AACACGGTTA CAACGACATC CCTGAATGGA 180
AATGGCAACG GCAATGGCAA TAGCAATAGC AACAACAACA ACAACATCGG ATCGCCCGTC 240
TCCTCATCGA CAACAAACAG CAGTAATGGC GGCAACGAGC GCGGCTCCTC CACAAAGTCC 300
AATAGCAGCA GTGGAAGTGG CAGCTCGGGA AACTCGGCCA GCAGCACGGG AAGTGGCGAG 360
CTCAAATGCA ATACGCCCAT GACGCCATCT GAGCTGGTGA AGAAGTTCCG CAACTACCTA 420
ACCGATCTTG AGTTCGAAGA GCTCAAGGTG TACAAGGAAG TGTGGTATTT TGGCCAGCAC 480
GCCAGCAAGA ACTACAACAA ACCCGCCCCC ACAGCCAATA CCACAAATCT GGGCTATGAC 540
GATGATAATG GCAACTACAA GATCATCGAA CACGATCACA TAGCTTTTCG TTACGAGATT 600
CTGGAGGTAA TTGGCAAGGG CAGTTTTGGC CAGGTCATCA GGGCGCTGGA TCACAAGACC 660
AACACACACG TGGCCATCAA GATCATAAGG AACAAGAAGC GCTTCCTCAA CCAGGCCGTC 720
GTCGAACTGA ATATCCTCGA TGAGCTGCGC GAAAAGGACG CGGATGGATC TCATAATGTC 780
ATACACATGC TCGACTATAC ATATTTCCGC AAGCATTTGT GTATTACTTT TGAGCTAATG 840
AGCTTGAACC TGTACGAATT GATAAAGAAG AACAACTACA ATGGATTCAG CATGAGTCTC 900
ATACGACGCT TCTGCAACTC GATTGTGAAG TGCCTGCGTT TGCTCTATAA GGAAAACATT 960
ATTCACTGTG ATCTCAAGCC GGAAAATATC TTGCTCAAAC AGCGTGGTAG CAGCTCCATT 1020
AAAGTTATCG ACTTTGGCAG CTCATGCTAC GTGGATCGCA AAATCTATAC GTACATCCAA 1080
TCGAGGTTCT ATCGCTCCCC GGAGGTGATT CTCGGCCTGC AATACGGCAC AGCCATCGAT 1140
ATGTGGAGCT TGGGCTGCAT TCTGGCCGAG CTGTACACAG GATTCCCGCT CTTCCCTGGC 1200
GAAAATGAAG TGGAGCAGTT AGCCTGCATC ATGGAGGTGC TCGGTTTGCC GCCTAAGGTG 1260
CTCATATCGG TTGCCAGGCG ACGTCGGCTG TTCTTTGATT CCCGTGATGC CCCGCGCTGC 1320
ATAACTAACA CCAAGGGACG CAAACGGTCG CCAGGCAGCA AGTCGCTGGC ACATATCTTG 1380
CACTGCCAGG ACCGCTATTT CATCGACTTC CTGCAGCGTT GCTTGGAGTG GGATCCTGCG 1440
GAGCGGATGA CGCCGGACGA GGCGGCCCAC CACGAGTTTC TGCAGCCATC TGCCTCCAGT 1500
CGCCATCGCA GCTGCCGCAT GTCGAGCAGT TCGTCCAGTT CCGGACTCAA CAGTGTTTCC 1560
CAGAAGTCTT CCTGCTACAG CTTTTCGGAG ATCTCGCCGG GCACCAACGG TCCCGTGGTG 1620
GCCTCGATCA CCAGCACCAC GGCGGTGCAC AATGCCGCGA TTGCTACCAC AACCAAGTCG 1680
AGACAGCAGC CGCCATCTCA GAGTCACGGC CATGCCCAAT CGAATGGACA CCTGCCCGAC 1740
ATCAAGTTAA GTGCCAGCGA TAAGTACAAT AGCATGCAGA AGGTGGCGGT GCGCTCGAAG 1800
ATCACGTCCA GCGTCTCGGA TCTGGAGTCC GTGCAGCAGT ACTCACTGCA CCGCATCTAC 1860
GGAGGAGTGG GTAGTGGCAG CACACACCAT GTCTCGTCAG CGGCCACCAG GAAACATTTG 1920
CCCGGTACAG GCAGTGGAAT TGTGGGTGCC ATGTCTTCCA AATACGGCAG CTCAACGTTG 1980
GCGCACAACC ATCACAATGT GACGCACCAC AATGCATCGA CTGCCACCAT TGCAACGACC 2040
ACGCACCACC ATCACCACCA TGGTGGGCAG CAGCAACAGC AGTCGTCGTC GGGAGCATCC 2100
ACCATGGCCA TGTCGCACTC ACAGTCCACT GGAGATGTTT CCGACAGGGC CATCTTTGGG 2160
AGAGCTTGA 2169
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         ye+levigkGsfgqV++ald+kt+++vaikii+nkkrf++qa  E++iL++l++kd + +
Q: 198   YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGS  257
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         +nv+++l++++fr+hlc++fel+s nLyel+kkn+ +g+s++l+r+++++i+k+L+lL++
Q: 258   HNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYK  317
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180
         ++iiH+DlKPeNill+++++s++kviDFGss++v++k iytyiqsrfYr+PE+ilgl+y 
Q: 318   ENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRK-IYTYIQSRFYRSPEVILGLQYG  376
         ************************************9.**********************
S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240
         +aiDmWSlGc+laEl+tG pLfpGenev+qla+i+evlglpp+ l++ a++++ ff+++ 
Q: 377   TAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRD  436
         ************************************************************
S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300
         ap++i++tk                 ++++p+sk+l+++l+ ++++ f+d+l+r+le+dp
Q: 437   APRCITNTK----------------GRKRSPGSKSLAHILHCQDRY-FIDFLQRCLEWDP  479
         ***988553................345679999999999987777.*************
S: 301   akRitpkealkhpfv  315
         a+R+tp+ea +h+f+
Q: 480   AERMTPDEAAHHEFL  494
         *************96
Domain Sequence
(FASTA)
YEILEVIGKG SFGQVIRALD HKTNTHVAIK IIRNKKRFLN QAVVELNILD ELREKDADGS 60
HNVIHMLDYT YFRKHLCITF ELMSLNLYEL IKKNNYNGFS MSLIRRFCNS IVKCLRLLYK 120
ENIIHCDLKP ENILLKQRGS SSIKVIDFGS SCYVDRKIYT YIQSRFYRSP EVILGLQYGT 180
AIDMWSLGCI LAELYTGFPL FPGENEVEQL ACIMEVLGLP PKVLISVARR RRLFFDSRDA 240
PRCITNTKGR KRSPGSKSLA HILHCQDRYF IDFLQRCLEW DPAERMTPDE AAHHEFL 297
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00253
EKS-BOT-00272
EKS-CAP-00307
EKS-CIS-00041
EKS-DAR-00609
EKS-ECT-00029
EKS-EQC-00263
EKS-FEC-00258
EKS-GAM-00165
EKS-GAA-00330
EKS-GOG-00270
EKS-HOS-00278
EKS-ICT-00255
EKS-LAC-00283
EKS-LOA-00281
EKS-MIM-00018
EKS-MOD-00269
EKS-MUM-00303
EKS-MUP-00268
EKS-MYL-00274
EKS-NOL-00248
EKS-ORN-00351
EKS-ORC-00256
EKS-ORL-00327
EKS-OTG-00278
EKS-PAT-00256
EKS-POA-00261
EKS-PTV-00036
EKS-RAN-00286
EKS-SAH-00255
EKS-SUS-00234
EKS-TAG-00286
EKS-TAR-00347
EKS-TUB-00021
EKS-XIM-00342
EKS-SCP-00048
Gene Ontology
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042048; P:olfactory behavior
KEGG
dme:Dmel_CG4551;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013