EKS-DRM-00120

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00120

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	378.9	1.6E-113	67	351	285

Status

Unreviewed

Ensembl Protein

FBpp0082009

UniProt Accession

Q94548;

Protein Name

Protein Synonyms/Alias

LK6 protein kinase;

Gene Name

Lk6

Gene Synonyms/Alias

Lk6; LK6; CG17342;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0017581	FBpp0082008	FBtr0082534
FBgn0017581	FBpp0082009	FBtr0082535

Organism

Drosophila melanogaster

Functional Description

Protein Length

1090

Protein Sequence
(FASTA)

MLDGQNELTR YSSEDVSGNE SSEAPNMTEV ERQAELNRHK EEMQKKRRKK RISSSLHSST 60

FQELYKLTGE ILGEGAYASV QTCVNIYTDL EYAVKVIDKI PGHARARVFR EVETFHHCQG 120

HLGILQLIEF FEDDEKFYLV FEKINGGPLL SRIQEHICFS EHEASQIIKE IASGLDFLHK 180

KGIAHRDLKP ENILCVKTDS LCPIKICDFD LGSGIKFTTD ISSPAATPQL LTPVGSAEFM 240

APEVVDLFVG EAHYYDKRCD LWSLGVIAYI LLCGYPPFSG NCGEDCGWNR GENCRTCQEL 300

LFESIQEGHF SFPEAEWHDV SDEAKDLISN LLVKKASNRL SAEAVLNHPW IRMCEQEPPA 360

SKHGRRHKAL QTPSNIRRNH QSAREISQFA ESAMAVKRVV LQHFSMRYDY MKERPNIYQP 420

SQAYMDAYSD ENYNPKPPGH YTRNRSQRNP ASSLCGYGGR MSSMHGQRAN SRRSSRNASR 480

NASAIYPNSG GFKTLNVHEE DDDDEGLEAF GHIDDDDEWS RSRREYQQQC ETLGEDRFRR 540

QSGSEGDEVE DDEDGENEDY QHYKHYWREL DEEEGDDYLY EQQQRVDDKF GEEEFEDEPK 600

EETQADNLKL SKAYVEQVGE TNVEKSKPQD DNGGYIREDL IMDNMDMKKN TQQSEFAKLT 660

IMRNDAQTEE NKIMQQQDEE KKEEKQQDDV DGAKKQGPSS DISATTITDN NKLQTPVMTT 720

THINNWQTGD AIEDDDVKLL DSISDLNEKL PEIYETANIV VNSAAVPAAS TPAASATRPP 780

TDNPEEDDSN VTKPTTTAEG TTMQTTFGMS AEEEKPVALS HTAGHHSKTG RTVNFAPDAY 840

QNDEDADIDE DDDYDDEENL HEHSKQQLPS NAYTRKQRQQ HQRYIVPRYQ LADQVPQRQH 900

TENWRYRTHH SQEQQPTADY RKYRPPFSTG GGGGHHGNQQ RNYLGSFSHS GGAAGYKIAP 960

MPPPMQPPPR HNSAGSSGSG SGSGGSPPSD EQSAIRNWRQ DCVYARSCGM NQGPEQQRHN 1020

RSSGQRVQQQ PRIGSGRFAH LQAAQLMDEL PDMRIGLSPP SESVLLQRRL RQQQRANDLS 1080

EYCEPATASG 1090

Nucleotide Sequence
(FASTA)

ATGTTAGACG GACAGAATGA GCTGACGCGC TACAGCAGCG AGGATGTGTC GGGCAACGAG 60

TCCAGCGAGG CGCCCAACAT GACCGAGGTG GAACGCCAGG CGGAGCTTAA CAGGCACAAG 120

GAGGAGATGC AGAAGAAGCG GCGCAAGAAA CGCATCAGCT CCTCCCTTCA TTCCTCAACC 180

TTTCAGGAGC TGTACAAGCT GACTGGCGAG ATTCTTGGCG AGGGAGCCTA CGCATCGGTG 240

CAAACTTGCG TTAACATCTA CACCGATCTG GAGTATGCCG TGAAGGTGAT CGATAAGATA 300

CCGGGGCATG CGCGTGCACG TGTCTTTCGC GAAGTGGAGA CATTCCATCA CTGCCAGGGC 360

CATTTGGGCA TCTTGCAACT GATTGAATTC TTTGAGGATG ACGAGAAGTT CTACCTGGTA 420

TTCGAGAAGA TCAACGGTGG TCCATTGCTA TCGCGCATAC AGGAGCACAT TTGCTTCTCC 480

GAGCATGAGG CCTCGCAGAT AATCAAGGAG ATCGCCTCCG GACTTGATTT TCTGCACAAG 540

AAGGGCATTG CCCATCGTGA TCTCAAGCCG GAGAATATTC TGTGTGTCAA GACGGATTCG 600

CTGTGCCCAA TCAAGATTTG CGACTTTGAT TTGGGTTCGG GGATTAAGTT CACTACGGAC 660

ATCTCGTCGC CAGCAGCCAC TCCTCAGTTA TTGACACCAG TTGGCAGTGC CGAGTTTATG 720

GCTCCGGAAG TGGTCGATTT GTTTGTGGGT GAGGCACACT ATTACGATAA GAGGTGCGAT 780

TTGTGGTCCC TGGGAGTCAT TGCTTACATC CTGCTCTGCG GTTATCCGCC ATTTTCGGGC 840

AACTGTGGTG AGGATTGCGG CTGGAATCGC GGTGAAAACT GCCGCACGTG CCAGGAACTG 900

CTTTTCGAGT CCATTCAAGA AGGACACTTT TCTTTCCCGG AGGCCGAGTG GCACGATGTC 960

AGCGATGAGG CCAAGGACCT AATTTCTAAT CTGCTTGTCA AGAAGGCATC GAACCGCCTC 1020

AGTGCCGAGG CAGTGTTGAA TCACCCATGG ATTCGTATGT GCGAGCAGGA GCCACCGGCA 1080

AGCAAGCATG GCAGGCGCCA CAAGGCTTTG CAAACGCCCA GTAACATCCG ACGCAATCAC 1140

CAGTCGGCAA GGGAAATCTC GCAGTTTGCC GAATCTGCTA TGGCCGTCAA GCGTGTGGTC 1200

CTACAGCATT TCTCGATGCG CTACGATTAC ATGAAAGAGC GTCCCAACAT CTACCAGCCA 1260

TCGCAGGCCT ACATGGATGC CTATAGCGAT GAAAACTACA ATCCCAAGCC GCCGGGTCAT 1320

TACACTCGCA ATCGCTCGCA GCGCAATCCC GCTTCCTCCT TGTGCGGCTA CGGAGGGCGT 1380

ATGTCCTCGA TGCACGGCCA GCGGGCCAAT AGCCGTCGGT CTTCCCGAAA TGCGTCTCGC 1440

AATGCATCTG CAATTTATCC GAATAGCGGG GGCTTCAAGA CATTGAACGT CCACGAGGAA 1500

GATGACGACG ATGAAGGTCT GGAGGCTTTT GGCCACATCG ATGATGATGA TGAGTGGAGC 1560

AGGTCTAGGA GGGAATATCA GCAGCAGTGT GAGACGCTGG GCGAGGATCG CTTTAGGCGT 1620

CAGAGCGGAA GCGAAGGCGA CGAAGTGGAA GATGATGAGG ATGGAGAGAA TGAGGACTAT 1680

CAGCACTATA AGCATTACTG GCGCGAATTA GACGAGGAAG AGGGCGACGA CTATCTGTAT 1740

GAGCAGCAGC AGCGCGTCGA TGATAAATTC GGGGAAGAGG AGTTCGAGGA CGAACCAAAG 1800

GAGGAAACTC AAGCTGACAA TCTAAAGCTA TCGAAAGCTT ACGTGGAGCA AGTTGGCGAG 1860

ACCAATGTGG AGAAATCGAA GCCACAGGAC GATAACGGTG GGTATATAAG GGAGGACCTT 1920

ATTATGGATA ATATGGATAT GAAGAAAAAC ACTCAGCAAA GCGAATTTGC TAAGCTCACC 1980

ATAATGCGCA ACGATGCGCA GACGGAGGAG AATAAGATAA TGCAGCAGCA GGATGAGGAG 2040

AAGAAAGAGG AAAAACAGCA GGATGATGTT GATGGGGCTA AGAAGCAAGG ACCATCAAGT 2100

GATATTAGTG CTACTACCAT CACCGATAAT AACAAGCTGC AAACACCAGT TATGACTACA 2160

ACACACATTA ACAACTGGCA AACTGGCGAT GCAATTGAAG ATGATGATGT TAAACTATTG 2220

GATAGTATTA GTGATTTAAA TGAAAAGCTA CCTGAAATTT ATGAGACTGC AAATATTGTT 2280

GTCAACTCAG CGGCAGTGCC AGCAGCATCG ACACCAGCAG CATCAGCAAC ACGCCCACCA 2340

ACCGATAACC CAGAGGAAGA TGATTCGAAC GTGACCAAAC CGACGACTAC TGCTGAGGGG 2400

ACAACAATGC AAACGACTTT TGGCATGTCA GCGGAAGAGG AGAAGCCTGT AGCCCTATCC 2460

CACACCGCGG GTCACCACAG CAAGACCGGC CGCACTGTTA ACTTTGCCCC CGATGCATAT 2520

CAGAACGACG AGGATGCCGA TATCGACGAG GACGACGACT ACGATGACGA GGAGAATCTG 2580

CATGAGCACA GCAAGCAACA GCTGCCGTCC AATGCCTACA CTCGTAAGCA GCGACAGCAG 2640

CACCAGCGGT ACATTGTGCC ACGCTACCAG CTTGCGGATC AAGTTCCTCA GAGGCAGCAC 2700

ACCGAAAACT GGCGTTATCG CACCCATCAC TCGCAGGAAC AGCAGCCGAC AGCGGACTAT 2760

CGCAAGTATC GCCCGCCGTT TAGCACCGGA GGCGGCGGTG GCCACCATGG CAACCAGCAG 2820

CGCAATTACC TGGGGAGCTT CTCGCACAGC GGCGGTGCCG CTGGTTACAA GATTGCTCCA 2880

ATGCCGCCAC CAATGCAGCC GCCTCCGCGG CACAACAGCG CCGGAAGCAG TGGCAGTGGT 2940

AGCGGCAGCG GCGGATCTCC GCCATCTGAC GAGCAGTCGG CCATACGCAA CTGGCGTCAG 3000

GATTGTGTTT ACGCCCGCAG TTGCGGGATG AACCAGGGAC CGGAACAGCA GCGGCACAAC 3060

CGTTCGTCGG GTCAGCGTGT CCAGCAGCAG CCGCGGATTG GCAGTGGACG CTTCGCCCAC 3120

CTGCAGGCGG CCCAATTGAT GGACGAGTTG CCTGATATGA GGATCGGCCT TTCGCCGCCC 3180

AGCGAGAGTG TACTGCTCCA AAGGCGCCTG CGCCAGCAGC AGCGGGCCAA CGATCTGTCT 3240

GAGTACTGCG AGCCGGCCAC CGCCAGTGGT TAA 3273

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         lt e+lGeG++++v++cv++ t+ +ya+k++     ++r++v+reve++++++gh  i++

Q: 67    LTGEILGEGAYASVQTCVNIYTDLEYAVKVIdkipgHARARVFREVETFHHCQGHLGILQ  126

         7889********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         li++fe    d+++++lv+ek++GG+llsriqe+ +f+e+eas+++k+ias+l+flh+k+

Q: 127   LIEFFE----DDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKG  182

         ******....9*************************************************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaket..eee.......eelktpcltaeyvaP  167

         iahrDlkpen+L+ ++++ +p+k+cDf+l++++  +++       ++l tp+++ae++aP

Q: 183   IAHRDLKPENILCVKTDSLCPIKICDFDLGSGIkfTTDisspaatPQLLTPVGSAEFMAP  242

         *******************************99654448999999***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev++ +++ea++ydk+CDlWslGvi yillcGypPf++++g           r++++ l+

Q: 243   EVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGedcgwnrgencRTCQELLF  302

         ****************************************99******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         e+iqeg+++fPe+eW++vs+eakdli++lL++++++rl++e+vlnhpw+

Q: 303   ESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWI  351

         ************************************************8

Domain Sequence
(FASTA)

LTGEILGEGA YASVQTCVNI YTDLEYAVKV IDKIPGHARA RVFREVETFH HCQGHLGILQ 60

LIEFFEDDEK FYLVFEKING GPLLSRIQEH ICFSEHEASQ IIKEIASGLD FLHKKGIAHR 120

DLKPENILCV KTDSLCPIKI CDFDLGSGIK FTTDISSPAA TPQLLTPVGS AEFMAPEVVD 180

LFVGEAHYYD KRCDLWSLGV IAYILLCGYP PFSGNCGEDC GWNRGENCRT CQELLFESIQ 240

EGHFSFPEAE WHDVSDEAKD LISNLLVKKA SNRLSAEAVL NHPWI 285

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005874	; C:microtubule
GO:0005635	; C:nuclear envelope
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007017	; P:microtubule-based process
GO:0046580	; P:negative regulation of Ras protein signal transduction
GO:0040008	; P:regulation of growth

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013