EKS-DRM-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	410.4	4.1E-123	157	424	268

Status

Reviewed

Ensembl Protein

FBpp0080861

UniProt Accession

O61267; O61268; P91876; Q8SZS3;

Protein Name

Ovarian-specific serine/threonine-protein kinase Lok

Protein Synonyms/Alias

Protein loki; dMNK;

Gene Name

lok

Gene Synonyms/Alias

lok; CG10895;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0019686	FBpp0080860	FBtr0081328
FBgn0019686	FBpp0080861	FBtr0081329
FBgn0019686	FBpp0297344	FBtr0306234
FBgn0019686	FBpp0080862	FBtr0081330

Organism

Drosophila melanogaster

Functional Description

May have a role in germline establishment.

Protein Length

459

Protein Sequence
(FASTA)

MARDTQGTQG TQSQASNIWT QVESQPMEKI VWGRLYGKNI KIKSLDLNND EFTAGRGEAN 60

DLILTLNDLP EKILTRISKV HFIIKRANCE LTNPVYIQDL SRNGTFVNNE KIGTNRMRIL 120

KNDDVISLSH PTYKAFVFKD LSPNESIGLP EEINKTYYVN RKLGSGAYGL VRLVYDTRTC 180

QQFAMKIVKK NMLSGARPST NFSDPDRVLN EAKIMKNLSH PCVVRMHDIV DKPDSVYMVL 240

EFMRGGDLLN RIISNKLLSE DISKLYFYQM CHAVKYLHDR GITHRDLKPD NVLLETNDEE 300

TLLKVSDFGL SKFVQKDSVM RTLCGTPLYV APEVLITGGR EAYTKKVDIW SLGVVLFTCL 360

SGTLPFSDEY GTPAAQQIKK GRFAYGHPSW KSVSQRAKLL INQMLIVDPE RRPSIDDVLQ 420

SSWLRDAPML QKAKRLMKLD GMEIEEENFL EPPTKRSRR 459

Nucleotide Sequence
(FASTA)

ATGGCACGCG ACACACAAGG AACGCAGGGA ACCCAGAGTC AGGCCTCCAA TATCTGGACG 60

CAGGTGGAGA GCCAGCCGAT GGAGAAGATA GTCTGGGGTC GATTGTACGG CAAGAACATT 120

AAGATCAAAT CGCTGGATCT CAACAACGAC GAGTTCACCG CAGGACGAGG GGAGGCCAAC 180

GACTTGATCC TCACGCTCAA CGATTTGCCC GAGAAAATCC TGACGCGCAT TTCCAAAGTG 240

CATTTTATCA TAAAGCGGGC AAACTGCGAA CTTACCAATC CAGTTTATAT TCAGGATCTC 300

TCACGCAACG GGACGTTTGT GAATAACGAG AAAATTGGCA CAAACAGGAT GCGAATCCTA 360

AAGAATGACG ACGTAATTTC CCTGTCCCAC CCAACGTACA AAGCCTTTGT ATTCAAGGAT 420

CTCAGCCCGA ATGAGTCGAT CGGGCTTCCC GAGGAGATTA ACAAGACGTA TTATGTAAAT 480

CGCAAGCTGG GATCTGGAGC GTACGGACTG GTGCGTTTGG TCTATGACAC CCGCACCTGC 540

CAGCAGTTTG CGATGAAAAT CGTTAAGAAG AATATGCTCT CTGGGGCGCG ACCCAGTACC 600

AATTTCAGTG ATCCCGACCG GGTGCTGAAC GAAGCCAAGA TTATGAAGAA TCTTTCACAT 660

CCGTGCGTGG TTCGCATGCA CGACATCGTG GACAAGCCGG ATTCTGTGTA TATGGTGCTG 720

GAGTTTATGC GCGGCGGCGA CCTGCTTAAC CGGATCATCA GCAACAAACT ACTTAGCGAG 780

GACATCTCGA AGCTTTACTT TTACCAAATG TGCCATGCCG TCAAGTACCT ACACGATCGG 840

GGCATCACCC ATCGTGACCT TAAGCCTGAC AATGTTTTGC TGGAGACCAA TGACGAGGAG 900

ACCCTACTGA AGGTCTCCGA TTTCGGGCTG AGTAAGTTTG TGCAGAAGGA CTCGGTTATG 960

CGCACGCTCT GTGGCACACC TCTCTACGTG GCCCCTGAGG TGCTGATTAC CGGCGGCCGA 1020

GAAGCCTACA CCAAGAAAGT GGACATTTGG AGCTTGGGAG TGGTGCTATT TACTTGCCTG 1080

AGTGGCACTC TGCCCTTTTC GGACGAGTAC GGCACCCCGG CGGCCCAGCA AATAAAGAAG 1140

GGCAGATTCG CGTATGGACA CCCTTCTTGG AAGAGTGTCT CGCAGCGCGC CAAGCTGCTG 1200

ATCAACCAAA TGCTCATTGT GGATCCCGAG AGGCGACCCT CAATCGACGA CGTTTTGCAG 1260

AGCAGCTGGC TGCGCGATGC GCCCATGCTG CAGAAGGCGA AGAGGCTGAT GAAGCTCGAT 1320

GGCATGGAAA TCGAGGAGGA GAACTTCCTT GAGCCACCCA CCAAGCGATC GCGACGCTAG 1380

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.s.irssreikkakeveeeveilk  58

         y+++++lG+Ga+g+v+l+y+++t++++a+ki++k++ s +r+s+++++ ++v +e++i+k

Q: 157   YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMlSgARPSTNFSDPDRVLNEAKIMK  216

         789*********************************8569********************

S: 59    klshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavky  118

         +lshP++v+++d++++++s+y+vle+++gG+ll++++++kll+ed+skl+f+q+++avky

Q: 217   NLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKY  276

         ************************************************************

S: 119   lhekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlv  178

         lh++gi+hrDlkP+n+Ll++++e++l+k++DfGl+k+++++s+m+tlCGtp yvaPevl+

Q: 277   LHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLI  336

         ************************************************************

S: 179   kkgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkise  238

         + gr++yt+kvDiWslGvvlf++lsG++Pfs+e+++++ ++qi+kg++a+++++wk++s+

Q: 337   TGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPA-AQQIKKGRFAYGHPSWKSVSQ  395

         *************************************9.9********************

S: 239   eakdlikklLvvdPeerlsieealnhpWl  267

         +ak li+++L+vdPe+r+si+++l+++Wl

Q: 396   RAKLLINQMLIVDPERRPSIDDVLQSSWL  424

         ****************************7

Domain Sequence
(FASTA)

YYVNRKLGSG AYGLVRLVYD TRTCQQFAMK IVKKNMLSGA RPSTNFSDPD RVLNEAKIMK 60

NLSHPCVVRM HDIVDKPDSV YMVLEFMRGG DLLNRIISNK LLSEDISKLY FYQMCHAVKY 120

LHDRGITHRD LKPDNVLLET NDEETLLKVS DFGLSKFVQK DSVMRTLCGT PLYVAPEVLI 180

TGGREAYTKK VDIWSLGVVL FTCLSGTLPF SDEYGTPAAQ QIKKGRFAYG HPSWKSVSQR 240

AKLLINQMLI VDPERRPSID DVLQSSWL 268

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0006919	; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071480	; P:cellular response to gamma radiation
GO:0000077	; P:DNA damage checkpoint
GO:0007281	; P:germ cell development
GO:0035234	; P:germ cell programmed cell death
GO:0072332	; P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0051091	; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

dme:Dmel_CG10895

;

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013