EKS-DRM-00037
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00037
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk555.82.7E-167441711271
StatusReviewed
Ensembl ProteinFBpp0086841
UniProt AccessionQ9V6K3; B3LF77; O02001; O96391; Q9TYH9;
Protein NameTyrosine-protein kinase transmembrane receptor Ror2
Protein Synonyms/Alias dRor2; Neurospecific receptor tyrosine kinase;
Gene NameNrk
Gene Synonyms/Alias Nrk; ROR2; CG4007;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0020391FBpp0086841FBtr0087728
OrganismDrosophila melanogaster
Functional DescriptionTyrosine-protein kinase receptor that functions duringearly stages of neuronal development (By similarity).
Protein Length724
Protein Sequence
(FASTA)
MAAGQWVGVV ERVLRGMVLK WGANLAVLGL CVFLFASATH ANSLNAIEEP VTRRHHQRHH 60
EREREENGYC APYSGKVCKE YLTGQVWYSL EDPTGGWKNE QVTTALWDEL ISDLTGLCRE 120
AAEKMLCAYA FPNCHMEGGR AVKAPLCFED CQATHLQFCY NDWVLIEEKK ERNMFIKSRG 180
HFRLPNCSSL PHYNASMRRP NCSYIGLTEL KESEVSYDCR NGNGRFYMGT MNVSKSGIPC 240
QRWDTQYPHK HFQPPLVFHQ LLEGENYCRN AGGEEPHPWC YTVDESVRWQ HCDIPMCPDY 300
VDPNAVDLNT PIKMEKFFTP SMIFLLAGIG FVAIVTLHLM ILLVYKLSKH KDYSQPAGAA 360
TAECSVSMRG GGDCGGNLNT SRETLGGNGN TNTLAKWGTI RSTATIHSNC VALTTVTNVS 420
DAKGTKPNAR LEKLEYPRGD IVYVRSLGQG AFGRVFQARA PGLVPDQEDL LVAVKMLKDD 480
ASDQMQMDFE REACLLAEFD HPNIVRLLGV CALGRPMCLL FEYMAPGDLS EFLRACSPYA 540
THQAPTQDRL QLNELHLLQM AANIAAGMLY LSERKFVHRD LATRNCLINE HMAVKIADFG 600
LSHKIYLQDY YKGDENDFIP IRWMPLESIL YNKFSLESDV WAYGICLWEV FSFALQPYFG 660
LTHEEVIKYI KEGNVLGCPD NTPLSVYALM RRCWNRKPSE RPGFAEINHC IQHSIAESEC 720
KAML 724
Nucleotide Sequence
(FASTA)
ATGGCTGCCG GGCAATGGGT GGGGGTGGTT GAGCGGGTGC TCCGGGGAAT GGTGCTGAAA 60
TGGGGGGCCA ATTTGGCTGT CCTGGGGCTG TGCGTGTTTC TCTTTGCCAG CGCCACGCAC 120
GCGAACTCCC TGAACGCCAT CGAGGAGCCC GTCACCCGGC GACACCACCA GCGGCATCAC 180
GAGCGCGAGC GGGAGGAGAA CGGCTACTGC GCCCCGTACA GCGGCAAGGT GTGCAAGGAA 240
TACCTCACCG GCCAGGTGTG GTACAGTCTG GAGGATCCCA CTGGCGGGTG GAAGAACGAG 300
CAGGTGACCA CGGCGCTCTG GGACGAGCTT ATCTCCGATC TTACGGGTCT GTGTCGCGAA 360
GCAGCCGAGA AAATGCTCTG CGCCTATGCG TTTCCCAACT GCCACATGGA GGGCGGTCGA 420
GCGGTGAAGG CTCCTCTCTG CTTCGAGGAT TGCCAGGCCA CGCATCTCCA GTTCTGCTAC 480
AACGACTGGG TGCTCATCGA GGAGAAGAAG GAGCGAAATA TGTTCATCAA GAGCCGCGGC 540
CACTTCCGGC TACCCAACTG CTCCTCCTTG CCGCACTACA ACGCTTCCAT GCGGCGACCC 600
AACTGCTCCT ACATCGGTCT CACCGAACTC AAGGAGTCCG AAGTGAGCTA CGATTGCCGC 660
AATGGAAACG GACGCTTCTA CATGGGCACA ATGAACGTGT CCAAGTCGGG CATTCCCTGC 720
CAGCGCTGGG ACACTCAGTA CCCGCACAAG CACTTCCAGC CACCACTGGT CTTCCATCAG 780
CTCCTGGAGG GCGAAAACTA CTGCCGGAAT GCTGGCGGTG AGGAGCCGCA TCCCTGGTGC 840
TACACTGTGG ATGAATCAGT GCGCTGGCAG CACTGCGATA TACCCATGTG TCCGGATTAT 900
GTGGACCCCA ATGCTGTCGA TTTGAACACG CCCATCAAGA TGGAGAAGTT CTTCACGCCA 960
TCGATGATCT TTCTCTTGGC TGGAATAGGT TTCGTGGCCA TTGTGACCCT GCACTTGATG 1020
ATATTGCTAG TCTATAAGTT GTCCAAGCAC AAGGATTACT CTCAGCCTGC GGGAGCAGCC 1080
ACTGCCGAAT GCAGTGTTTC CATGCGTGGA GGAGGAGATT GTGGCGGCAA TCTGAACACC 1140
AGTAGAGAAA CCCTCGGAGG CAATGGAAAC ACGAACACCT TGGCAAAATG GGGCACCATC 1200
AGGAGCACGG CCACAATACA CAGCAATTGC GTGGCCCTTA CTACGGTGAC CAATGTGTCT 1260
GATGCGAAGG GCACGAAACC GAATGCACGC CTGGAGAAGT TGGAGTACCC ACGCGGGGAT 1320
ATAGTGTATG TGAGATCATT GGGTCAAGGA GCCTTCGGTC GCGTCTTCCA GGCCAGGGCT 1380
CCTGGACTTG TTCCCGATCA GGAAGATCTA CTAGTCGCTG TTAAGATGCT AAAGGACGAC 1440
GCCAGCGACC AGATGCAGAT GGATTTCGAG CGCGAGGCCT GTTTGCTGGC CGAGTTCGAT 1500
CATCCCAATA TCGTGAGGCT GCTGGGGGTG TGCGCCTTGG GCAGACCCAT GTGCCTGCTC 1560
TTCGAGTACA TGGCTCCTGG CGATCTAAGC GAGTTCTTGC GCGCCTGCTC CCCATATGCC 1620
ACACACCAGG CGCCGACACA GGATCGTCTG CAGTTGAACG AGCTACATCT GCTGCAGATG 1680
GCGGCCAACA TTGCAGCGGG CATGCTGTAT CTTTCGGAGA GAAAATTCGT CCACCGGGAT 1740
TTGGCCACCA GGAATTGCCT GATCAACGAG CACATGGCGG TAAAGATCGC CGACTTTGGG 1800
CTCTCGCACA AGATCTATTT GCAGGACTAT TACAAAGGCG ATGAGAACGA CTTCATCCCG 1860
ATCCGCTGGA TGCCACTTGA GAGCATACTG TACAACAAGT TCTCGCTTGA GTCGGATGTG 1920
TGGGCATACG GCATCTGTCT GTGGGAGGTC TTCTCCTTCG CCTTGCAGCC CTACTTTGGG 1980
TTAACCCACG AGGAGGTGAT CAAATACATC AAGGAGGGCA ACGTACTCGG CTGTCCGGAC 2040
AACACGCCGC TCTCCGTCTA CGCGCTGATG CGTCGCTGCT GGAACCGCAA GCCCAGTGAG 2100
CGACCTGGCT TCGCCGAGAT CAACCACTGC ATCCAGCACA GCATCGCCGA GAGCGAGTGC 2160
AAGGCAATGC TCTAG 2175
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         i+yvr+lg+gafgrvfqarapgl+p++e+llvavkmlk++as++mq+dferea+llaefd
Q: 441   IVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFD  500
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         +pniv+llgvca+g+pmcllfeyma+gdl+eflr++spy++           +q++++dr
Q: 501   HPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYAT-----------HQAPTQDR  549
         *****************************************...........9*******
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         l+l+e++ll++a+++aagm+ylserkfvhrdlatrncl++e+m+vkiadfgls+kiy++d
Q: 550   LQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQD  609
         ************************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyk+dend+ipirwmplesilyn+++lesdvwayg++lwe+fs+alqpy+gl+heeviky
Q: 610   YYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKY  669
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasi.hri  281
         +++gn+l+cp+ntpl++yalmr+cw+++p++rp+fa+i h+i
Q: 670   IKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEInHCI  711
         **************************************9997
Domain Sequence
(FASTA)
IVYVRSLGQG AFGRVFQARA PGLVPDQEDL LVAVKMLKDD ASDQMQMDFE REACLLAEFD 60
HPNIVRLLGV CALGRPMCLL FEYMAPGDLS EFLRACSPYA THQAPTQDRL QLNELHLLQM 120
AANIAAGMLY LSERKFVHRD LATRNCLINE HMAVKIADFG LSHKIYLQDY YKGDENDFIP 180
IRWMPLESIL YNKFSLESDV WAYGICLWEV FSFALQPYFG LTHEEVIKYI KEGNVLGCPD 240
NTPLSVYALM RRCWNRKPSE RPGFAEINHC I 271
KeywordATP-binding; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Kinase; Kringle; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-EQC-00077
EKS-FEC-00076
EKS-GAM-00105
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MEG-00059
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0046716; P:muscle cell homeostasis
GO:0072499; P:photoreceptor cell axon guidance
GO:0042052; P:rhabdomere development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
dme:Dmel_CG4007;
InterPros
IPR020067; Frizzled_dom.
IPR011009; Kinase-like_dom.
IPR000001; Kringle.
IPR013806; Kringle-like.
IPR018056; Kringle_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016247; Tyr_kinase_rcpt_ROR.
Pfam
PF01392; Fz; 1.
PF00051; Kringle; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00130; KR; 1.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013