EKS-DRM-00041

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00041

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	385.1	3.8E-115	2077	2360	284

Status

Reviewed

Ensembl Protein

FBpp0080003

UniProt Accession

Q9VK45;

Protein Name

Target of rapamycin

Protein Synonyms/Alias

Gene Name

Tor

Gene Synonyms/Alias

Tor; CG5092;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0021796	FBpp0080003	FBtr0080422

Organism

Drosophila melanogaster

Functional Description

Promotes cell and tissue growth, maintains tissuehomeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiation. Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation. Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism. In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology. Rag GTPases act as activators of TORC1 in response to amino acid signals.

Protein Length

2470

Protein Sequence
(FASTA)

MSTTSVVQQF VNGLKSRNRN VQNKATQDLL FYVKTELREM SQEELAQFFD EFDHHIFTMV 60

NATDINEKKG GALAMKCLIN CEGSLTARKG ISPYLNRLRD LLLINDVSVM EIAARSLVKL 120

ANMPTSKGAD SFDFDIKKAF EVLRGERQEY RRHSAVFILR ELAIALPTYF YQHILTFFEV 180

IFNAIFDPKP AIRESAGEAL RAALIVTAQR ESTKQSSEPQ WYRICYDEAN GSFNADLGSS 240

KDQKGVTRDD RIHGGLVVFN ELFRCANATW ERRYTSLKTL FPKTQHNKFL EASSSSSMGS 300

QLNTLVPRLK VPFIDKLGST QTHLGEGEHH KGVAKFASHN VLESAYAQEI LQEHYTSICD 360

NVLEQRTSKS PYVQQALLQI LPRLAAFNRA VFVEKYLQTC VSHLMQILRG KEKDRTVAYI 420

TIGYMAVAVQ SAIEVHLSSI MTSVKVALPS KDLTSKRKVP VDPAVFACIT LLAHAVKSEI 480

ADDVKDILEQ MFYTGLSPAL TVCLRELSEN VPQLKSAITE GLIGILSQVL MNKAAILPYT 540

ALPTIAIDGS LMQNGDGATT VLALKTLGTF NFEEQNMLDF VQRCADYFIV HEQQEIRLEA 600

VQTCTRLLKL AVQSSESMEN SKTLSDTVSH VIERLLMVAI TDMDCNVRIR ILRSLDETFD 660

GKLAQPESLN SLFITLHDEI FEIRELAMVT IGRLSSINPA YVMPKLRTTM IELITDLKYS 720

GMSRNKEQSA KMLDHLVIST PRLISSYMNP ILKALVPKLH EPESNPGVIL NVLRTIGDLA 780

EVNGGSDEME LWADDLLSIL LEMLGDAGSP DKRGVALWTL GQLISATGRV VTPYHKYPVL 840

IDILINFLKT EQRRSIRRET IRVLGLLGAM DPYKHKMNKG LIDSQKDNVL IAYSDGKVDE 900

SQDISTAELL VNMGNALDEY YPAVAIAALM RILRDPTLST RHTSVVQAVT FIFQSLGIKC 960

VPYLAQVLPN LLDNVRTADN NLREFLFQQL AILVAFVKLH IISYMGDIFK LIKEFWTINT 1020

PLQNTLINLI EQIAVALGCE FRDYLAELIP QILRVLQHDN SKDRMVTRRL LQALQKFGST 1080

LGYYLPLILP PIVKLFDSPY VPQQVSMVAL ETINNLACQL DFTDFSSRII HPLVRVLDAE 1140

PELRDQAMTT LRSLAKQLGK KYLVFVPMVQ RTLNKHRIVD PEYEELLSKI KSCSTLADSY 1200

GAGESELRPS RFKNNEPFVT DRNSNNKNLQ VTTNELRTAW QVTRRVSKDD WVEWLKRLSI 1260

GLLKESPSHA LRACRSLAQE YDTLLRDLFN AAFISCWTEL SPDLKNELTQ SLIQALQVTD 1320

MPEITQTILN LAEFMEHCDR DPIPIETKLL GTRAMACRAY AKALRYKEEE FLLREDSQVF 1380

ESLILINNKL QQREAAEGLL TRYRNAANEL NVQGRWYEKL HNWDEALEHY ERNLKTDSSD 1440

LEARLGHMRC LEALGDWSEL SNVTKHEWEN FGTEAKSRAG PLAAVAAWGL QDWEAMREYV 1500

RCIPEDTQDG SYYRAVLAVH HDDFETAQRL IDETRDLLDT ELTSMAGESY ERAYGAMVCV 1560

QMLAELEEVI QYKLIPERRE PLKTMWWKRL QGGQRLVEDW RRIIQVHSLV VKPHEDIHTW 1620

LKYASLCRKS GSLHLSHKTL VMLLGTDPKL NPNQPLPCNQ PQVTYAYTKY MAANNQLQEA 1680

YEQLTHFVST YSQELSCLPP EALKQQDQRL MARCYLRMAT WQNKLQDSIR PDAIQGALEC 1740

FEKATSYDPN WYKAWHLWAY MNFKVVQAQK SALDKQQPPG ASMGMTMGSG LDSDLMIIQR 1800

YAVPAVQGFF RSISLIKGNS LQDTLRLLTL WFDYGNHAEV YEALLSGMKL IEINTWLQVI 1860

PQLIARIDTH RQLVGQLIHQ LLMDIGKNHP QALVYPLTVA SKSASLARRN AAFKILDSMR 1920

KHSPTLVEQA VMCSEELIRV AILWHEQWHE GLEEASRLYF GDRNVKGMFE ILEPLHAMLE 1980

RGPQTLKETS FSQAYGRELT EAYEWSQRYK TSAVVMDLDR AWDIYYHVFQ KISRQLPQLT 2040

SLELPYVSPK LMTCKDLELA VPGSYNPGQE LIRISIIKTN LQVITSKQRP RKLCIRGSNG 2100

KDYMYLLKGH EDLRQDERVM QLFSLVNTLL LDDPDTFRRN LAIQRYAVIP LSTNSGLIGW 2160

VPHCDTLHTL IRDYRDKKKV PLNQEHRTML NFAPDYDHLT LMQKVEVFEH ALGQTQGDDL 2220

AKLLWLKSPS SELWFERRNN YTRSLAVMSM VGYILGLGDR HPSNLMLDRM SGKILHIDFG 2280

DCFEVAMTRE KFPEKIPFRL TRMLIKAMEV TGIEGTYRRT CESVMLVLRR NKDSLMAVLE 2340

AFVYDPLLNW RLLDVDKKGN DAVAGAGAPG GRGGSGMQDS LSNSVEDSLP MAKSKPYDPT 2400

LQQGGLHNNV ADETNSKASQ VIKRVKCKLT GTDFQTEKSV NEQSQVELLI QQATNNENLC 2460

QCYIGWCPFW 2470

Nucleotide Sequence
(FASTA)

ATGTCGACGA CGTCGGTGGT GCAGCAGTTC GTCAACGGGC TTAAGTCCCG CAACCGGAAT 60

GTACAGAACA AGGCAACCCA GGATCTGCTC TTCTATGTGA AGACCGAGCT ACGCGAAATG 120

TCCCAGGAGG AGCTGGCCCA ATTTTTCGAC GAGTTCGACC ATCACATTTT CACGATGGTG 180

AATGCGACAG ATATCAACGA GAAAAAAGGC GGTGCCCTGG CCATGAAGTG CCTGATTAAC 240

TGCGAGGGCA GTCTTACTGC CAGGAAGGGC ATTTCGCCCT ATCTCAACCG CCTGCGCGAT 300

CTTCTGCTAA TCAACGATGT GTCCGTCATG GAGATTGCCG CCCGCTCCCT GGTCAAATTG 360

GCCAACATGC CCACCTCCAA GGGCGCCGAT TCCTTCGACT TTGATATTAA GAAGGCTTTT 420

GAGGTGCTCA GAGGCGAGAG ACAAGAGTAC CGCCGCCATT CAGCCGTCTT TATCCTCCGT 480

GAGCTGGCTA TCGCCTTGCC CACATACTTC TACCAGCACA TCCTGACCTT CTTCGAGGTT 540

ATCTTTAACG CCATCTTCGA TCCCAAACCT GCTATACGAG AGTCAGCTGG CGAGGCTTTG 600

AGGGCGGCTT TGATTGTCAC CGCTCAGCGA GAGAGCACCA AGCAGTCCAG TGAACCACAG 660

TGGTACAGAA TCTGCTATGA CGAGGCGAAT GGAAGCTTCA ATGCAGACTT GGGCTCTAGC 720

AAGGATCAGA AAGGCGTGAC CCGAGACGAT CGCATTCACG GTGGCCTCGT CGTCTTCAAC 780

GAGCTCTTTC GCTGTGCCAA TGCCACCTGG GAGCGGCGCT ACACGTCTCT GAAGACGCTG 840

TTCCCCAAGA CCCAACACAA TAAGTTCCTG GAGGCCAGCA GTTCGTCGAG TATGGGTTCC 900

CAGCTGAATA CTCTAGTGCC GCGGCTAAAG GTGCCCTTCA TTGACAAGCT CGGCAGCACC 960

CAAACGCATT TGGGTGAGGG AGAGCATCAC AAAGGAGTTG CCAAGTTCGC GAGCCACAAC 1020

GTACTGGAGT CCGCATATGC TCAGGAGATC CTTCAGGAGC ACTACACCTC CATTTGCGAC 1080

AATGTTTTGG AGCAGCGAAC TTCGAAGTCT CCGTATGTAC AGCAGGCACT CCTTCAAATA 1140

CTTCCTCGAT TGGCTGCCTT TAACCGCGCG GTGTTTGTGG AAAAATACCT GCAGACATGC 1200

GTGTCGCATT TAATGCAGAT CCTGCGAGGC AAGGAGAAGG ATCGCACGGT GGCGTACATA 1260

ACCATTGGTT ACATGGCTGT AGCGGTGCAG AGTGCGATCG AAGTTCATTT ATCCAGTATA 1320

ATGACTAGCG TGAAGGTCGC CTTGCCGTCA AAGGATTTGA CCAGCAAACG AAAGGTACCA 1380

GTGGATCCTG CGGTCTTTGC CTGCATAACG CTTCTTGCTC ATGCCGTTAA GTCGGAGATC 1440

GCCGACGATG TTAAGGATAT CCTTGAGCAG ATGTTCTACA CGGGTCTCTC GCCAGCTCTG 1500

ACTGTTTGCC TGAGGGAACT CTCCGAGAAT GTGCCGCAGC TTAAGTCGGC CATTACAGAA 1560

GGATTGATCG GAATCCTATC CCAGGTGCTG ATGAACAAGG CGGCAATTTT ACCATACACT 1620

GCTTTGCCAA CGATCGCCAT CGATGGCTCG CTAATGCAGA ATGGTGACGG AGCAACCACA 1680

GTGCTGGCAC TCAAAACGCT GGGTACCTTC AACTTTGAGG AGCAAAACAT GCTGGACTTT 1740

GTGCAACGAT GTGCTGACTA CTTCATCGTT CACGAGCAGC AGGAGATTCG TCTGGAGGCA 1800

GTGCAAACAT GCACACGACT CCTTAAACTG GCAGTGCAAT CCTCTGAAAG TATGGAGAAC 1860

TCCAAGACCC TCAGCGACAC CGTTTCCCAC GTGATTGAGC GCCTGCTTAT GGTAGCCATT 1920

ACTGATATGG ACTGTAATGT GCGAATACGA ATTCTACGTT CGCTGGACGA GACCTTTGAT 1980

GGGAAGCTTG CTCAGCCAGA GTCTCTAAAT TCGCTATTTA TTACGCTGCA CGATGAAATC 2040

TTTGAGATCC GGGAGCTGGC AATGGTTACC ATTGGAAGAT TGTCGTCCAT AAACCCGGCT 2100

TATGTGATGC CCAAGCTAAG AACCACCATG ATCGAATTGA TCACGGATCT AAAGTACTCG 2160

GGAATGAGTC GAAACAAGGA GCAGAGCGCA AAGATGCTTG ACCATTTGGT GATAAGCACG 2220

CCCAGGCTAA TATCCTCTTA CATGAATCCG ATCCTCAAAG CCTTAGTGCC CAAGTTGCAT 2280

GAGCCGGAAT CGAATCCAGG AGTTATTTTA AATGTGCTTC GCACAATTGG TGATTTAGCA 2340

GAGGTTAATG GAGGCTCCGA TGAAATGGAA TTGTGGGCAG ATGACCTTCT GTCCATTTTA 2400

CTCGAAATGC TGGGCGACGC TGGCAGTCCG GATAAGCGAG GAGTGGCTCT GTGGACGTTG 2460

GGACAGTTAA TCAGTGCAAC AGGCAGGGTG GTTACCCCAT ATCACAAGTA CCCCGTGCTC 2520

ATAGATATTT TGATTAATTT CCTTAAAACG GAACAACGTC GATCCATTCG AAGGGAAACG 2580

ATACGAGTGC TGGGCTTGTT GGGAGCCATG GATCCTTACA AGCACAAGAT GAACAAGGGC 2640

TTGATTGATA GCCAAAAGGA TAATGTTTTA ATAGCATACT CCGATGGCAA AGTCGATGAA 2700

AGTCAGGACA TCTCCACCGC TGAGTTGCTA GTTAACATGG GTAACGCATT GGATGAGTAT 2760

TATCCCGCTG TGGCCATAGC TGCATTGATG AGGATTCTAC GGGATCCCAC GTTAAGTACA 2820

CGTCACACCA GCGTGGTGCA GGCGGTTACT TTTATCTTCC AGAGCCTGGG CATCAAATGT 2880

GTGCCGTACT TGGCCCAAGT GCTTCCCAAT TTGCTGGACA ATGTACGCAC TGCAGATAAT 2940

AATCTAAGGG AGTTTCTCTT CCAGCAGCTC GCCATTCTGG TGGCTTTTGT CAAGCTGCAT 3000

ATCATCAGCT ACATGGGAGA TATTTTTAAG CTGATCAAAG AATTTTGGAC CATTAATACG 3060

CCTCTGCAAA ACACTCTAAT CAATTTGATT GAACAGATCG CCGTGGCTTT GGGATGCGAG 3120

TTTAGGGATT ATTTGGCGGA GCTGATCCCA CAAATTCTGC GAGTGTTGCA GCACGATAAC 3180

TCCAAGGATA GAATGGTCAC GAGAAGGTTG CTCCAAGCTC TTCAAAAGTT TGGCAGCACT 3240

TTGGGTTACT ATCTGCCGCT GATTTTGCCT CCGATCGTGA AACTCTTCGA TTCTCCGTAC 3300

GTACCACAAC AGGTGTCAAT GGTAGCCCTG GAAACGATCA ACAATCTAGC CTGTCAGCTG 3360

GACTTCACCG ACTTCTCCTC GCGCATCATA CATCCGTTGG TTCGAGTGCT GGACGCTGAG 3420

CCAGAGCTTC GGGACCAAGC TATGACAACC CTTCGCTCAC TGGCAAAGCA ACTGGGCAAG 3480

AAGTACCTCG TGTTCGTGCC TATGGTCCAG CGCACTCTCA ACAAACATCG CATTGTGGAT 3540

CCCGAGTACG AGGAGCTACT GAGTAAGATT AAGTCCTGCA GCACACTGGC GGATTCCTAT 3600

GGGGCCGGGG AGTCAGAACT GCGGCCGTCC AGGTTCAAAA ACAACGAGCC ATTTGTGACC 3660

GACAGAAATA GCAATAATAA AAATCTGCAG GTCACCACAA ACGAACTACG AACGGCGTGG 3720

CAGGTGACGC GGCGGGTGTC CAAGGACGAC TGGGTGGAGT GGCTAAAGCG GTTGTCCATT 3780

GGCCTGCTGA AGGAATCGCC TTCGCACGCA CTGAGAGCCT GTCGTTCGTT GGCCCAAGAG 3840

TACGATACGC TGTTGAGAGA TCTTTTTAAC GCCGCATTTA TCTCCTGTTG GACGGAACTA 3900

TCGCCGGATT TGAAAAACGA GCTAACACAG TCACTGATTC AAGCCCTGCA AGTTACCGAC 3960

ATGCCGGAAA TCACTCAGAC AATCCTCAAC TTGGCCGAGT TTATGGAGCA TTGCGATCGC 4020

GATCCAATAC CAATAGAAAC TAAGCTATTG GGTACTCGAG CGATGGCTTG CAGAGCGTAT 4080

GCCAAGGCAT TGCGCTACAA GGAGGAGGAG TTCCTTCTGC GAGAAGATTC CCAAGTTTTT 4140

GAGTCCTTGA TTCTAATCAA CAACAAGCTG CAGCAAAGAG AAGCAGCGGA AGGTCTGCTC 4200

ACAAGGTATC GTAATGCAGC CAACGAACTA AATGTTCAAG GAAGATGGTA TGAAAAACTT 4260

CACAATTGGG ATGAGGCGCT GGAACACTAT GAAAGGAATC TAAAGACGGA TTCCTCGGAC 4320

TTGGAGGCGC GACTCGGTCA CATGCGCTGC TTGGAGGCCC TCGGAGATTG GTCGGAGCTG 4380

AGCAACGTGA CCAAGCACGA GTGGGAAAAC TTCGGTACAG AGGCCAAATC AAGAGCAGGA 4440

CCCTTGGCCG CAGTGGCCGC CTGGGGTCTC CAGGATTGGG AGGCGATGCG GGAGTACGTA 4500

AGGTGTATAC CAGAGGATAC CCAAGATGGA AGCTACTATC GTGCTGTCCT CGCCGTGCAT 4560

CATGACGACT TTGAGACCGC ACAGCGCCTT ATTGACGAAA CAAGGGACCT CCTCGACACG 4620

GAGCTCACAT CAATGGCGGG CGAGTCCTAT GAAAGAGCCT ACGGAGCCAT GGTATGTGTA 4680

CAAATGCTGG CGGAGCTGGA GGAGGTCATC CAATACAAGC TCATTCCCGA GAGGCGAGAG 4740

CCGTTAAAGA CCATGTGGTG GAAGCGTCTT CAAGGAGGCC AGCGACTAGT AGAAGACTGG 4800

CGAAGGATCA TCCAGGTGCA CTCGCTGGTG GTAAAACCGC ACGAGGACAT ACATACCTGG 4860

CTGAAGTACG CTAGTCTGTG CAGGAAGAGC GGCTCCCTGC ACTTGTCCCA TAAAACTCTG 4920

GTGATGCTGC TAGGCACCGA TCCCAAGCTT AATCCGAACC AGCCACTGCC TTGTAATCAA 4980

CCACAGGTGA CCTATGCGTA CACCAAGTAC ATGGCTGCCA ATAATCAGCT GCAGGAAGCC 5040

TACGAGCAGT TGACGCACTT CGTCAGCACC TATAGTCAGG AGCTAAGCTG TTTACCTCCG 5100

GAAGCACTAA AGCAACAAGA TCAGCGACTC ATGGCCCGCT GCTATCTGCG CATGGCCACC 5160

TGGCAGAACA AGCTGCAGGA CAGCATCAGA CCGGATGCCA TTCAAGGCGC ACTCGAATGC 5220

TTTGAAAAGG CCACCAGCTA TGATCCCAAC TGGTACAAGG CCTGGCACCT GTGGGCGTAC 5280

ATGAACTTTA AGGTGGTGCA GGCCCAAAAA TCGGCGCTGG ACAAACAACA GCCTCCGGGA 5340

GCCAGCATGG GAATGACAAT GGGCTCTGGC CTCGACAGTG ATCTAATGAT CATACAGCGA 5400

TACGCCGTTC CGGCAGTTCA GGGATTCTTC CGTTCAATCA GCCTTATAAA AGGGAATTCG 5460

CTGCAGGATA CGCTACGTTT GTTAACTCTT TGGTTTGACT ATGGCAACCA TGCAGAGGTG 5520

TACGAGGCGC TGCTCTCTGG AATGAAGCTG ATCGAGATCA ACACCTGGCT TCAGGTTATC 5580

CCGCAGCTTA TTGCCCGCAT CGATACCCAC CGTCAGTTGG TGGGTCAATT AATCCACCAA 5640

CTCCTAATGG ACATAGGAAA GAATCACCCG CAGGCTCTGG TCTATCCTCT AACAGTCGCT 5700

TCCAAGTCAG CATCATTGGC GCGCAGGAAC GCCGCCTTTA AGATCCTCGA CTCGATGAGG 5760

AAACACTCGC CCACCTTGGT AGAGCAGGCG GTCATGTGTA GTGAGGAGCT CATCCGTGTG 5820

GCGATTCTGT GGCACGAACA GTGGCACGAA GGTTTGGAGG AAGCCTCGCG TCTTTACTTT 5880

GGAGATCGCA ACGTAAAGGG CATGTTTGAG ATCTTGGAGC CACTGCATGC TATGCTGGAG 5940

AGGGGACCAC AAACACTCAA GGAGACATCC TTCTCGCAGG CCTATGGACG CGAGCTGACA 6000

GAGGCGTACG AGTGGTCGCA ACGGTACAAG ACATCGGCGG TGGTGATGGA TCTGGATCGA 6060

GCGTGGGACA TTTACTATCA CGTCTTCCAA AAGATCTCGC GCCAGCTGCC ACAACTTACC 6120

TCGCTGGAGC TGCCGTATGT CTCGCCCAAA CTGATGACGT GCAAAGATCT CGAACTGGCA 6180

GTGCCCGGGT CCTACAATCC TGGCCAGGAG CTCATCCGGA TTAGTATCAT TAAAACCAAC 6240

CTTCAGGTGA TTACTTCCAA GCAGCGGCCG CGAAAACTGT GCATACGCGG CTCCAATGGC 6300

AAGGACTATA TGTACCTTCT AAAGGGACAC GAGGACCTTC GTCAGGACGA ACGCGTGATG 6360

CAGCTATTCT CCCTGGTGAA CACATTGCTG TTGGATGACC CCGACACTTT CCGTCGTAAC 6420

TTGGCCATCC AGCGGTATGC GGTTATCCCG CTCAGTACCA ACTCGGGTCT TATTGGTTGG 6480

GTGCCACATT GTGACACCCT TCATACGCTA ATCCGGGACT ACCGCGACAA GAAGAAGGTG 6540

CCACTGAATC AGGAGCATCG CACCATGCTC AATTTTGCGC CAGACTATGA TCACCTCACG 6600

CTGATGCAGA AGGTGGAAGT GTTCGAGCAT GCGTTGGGTC AGACGCAAGG CGACGACTTG 6660

GCCAAGTTGC TGTGGCTCAA GTCTCCGTCC TCTGAATTGT GGTTTGAACG GAGAAACAAC 6720

TATACCCGCT CACTGGCAGT CATGTCAATG GTTGGATATA TCCTAGGTCT GGGCGATCGT 6780

CATCCATCGA ACCTTATGCT GGATCGTATG AGCGGCAAGA TACTGCACAT AGACTTTGGC 6840

GACTGCTTCG AGGTGGCCAT GACCCGCGAA AAGTTTCCCG AAAAGATACC CTTCCGTCTC 6900

ACCCGGATGC TAATAAAGGC AATGGAGGTC ACTGGCATCG AGGGCACCTA CAGACGCACC 6960

TGCGAAAGCG TGATGCTGGT GCTTCGCCGC AACAAGGATT CCCTGATGGC GGTGCTGGAG 7020

GCCTTTGTCT ATGATCCGCT GCTCAACTGG AGACTGTTGG ATGTGGACAA GAAGGGTAAC 7080

GATGCGGTGG CTGGGGCGGG TGCTCCAGGT GGACGTGGCG GTTCCGGAAT GCAGGATAGC 7140

CTCAGTAACT CCGTAGAGGA CTCCCTGCCC ATGGCCAAGT CGAAGCCCTA CGATCCGACG 7200

CTACAGCAAG GCGGCCTGCA CAACAACGTG GCCGACGAGA CGAACAGCAA AGCCAGCCAG 7260

GTAATCAAGC GGGTCAAGTG CAAGCTAACA GGCACCGACT TCCAGACGGA AAAGAGCGTA 7320

AACGAGCAGT CGCAGGTGGA GCTGCTCATC CAGCAGGCGA CCAATAACGA GAACCTCTGC 7380

CAGTGCTACA TTGGCTGGTG TCCGTTTTGG TAG 7413

Domain Profile

S: 4     fderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdket  63

         ++ ++++++skq+p+kl++rGs+gk y+yL+kg+eDlrqderv+qlfslvNtlL  d+ t

Q: 2077  IKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDT  2136

         77899*******************************************************

S: 64    srrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstv  123

          rr+L i++y+V+plst+sgli+wv+++++L+ l++++++kk+v l+       ++++t+

Q: 2137  FRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLN-------QEHRTM  2189

         **********************************************9.......9*****

S: 124   qarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvi  181

            +p+++hl+l+  +evf+++l + +  d l+kll+ k+ps+e wfe+r++ytrslAv+

Q: 2190  LNFAPDYDHLTLMqkVEVFEHALGQ-TQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVM  2248

         *************************.5559******************************

S: 182   slvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnal  241

         s+vgyiLgLgdrh++nl++d+ +g+++hidfg +fe a+t++k+pek+PFRLTr++++a+

Q: 2249  SMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAM  2308

         ************************************************************

S: 242   gvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsket  293

         +vtg+eG +r++ce v+ vlr++k++l+++Le+f+ydpl++w+  + ++k++

Q: 2309  EVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGN  2360

         *******************************************966655555

Domain Sequence
(FASTA)

IKTNLQVITS KQRPRKLCIR GSNGKDYMYL LKGHEDLRQD ERVMQLFSLV NTLLLDDPDT 60

FRRNLAIQRY AVIPLSTNSG LIGWVPHCDT LHTLIRDYRD KKKVPLNQEH RTMLNFAPDY 120

DHLTLMQKVE VFEHALGQTQ GDDLAKLLWL KSPSSELWFE RRNNYTRSLA VMSMVGYILG 180

LGDRHPSNLM LDRMSGKILH IDFGDCFEVA MTREKFPEKI PFRLTRMLIK AMEVTGIEGT 240

YRRTCESVML VLRRNKDSLM AVLEAFVYDP LLNWRLLDVD KKGN 284

Keyword

ATP-binding; Cell cycle; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; TPR repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0004672	; F:protein kinase activity
GO:0043621	; F:protein self-association
GO:0007411	; P:axon guidance
GO:0007049	; P:cell cycle
GO:0048813	; P:dendrite morphogenesis
GO:0009594	; P:detection of nutrient
GO:0008340	; P:determination of adult lifespan
GO:0032456	; P:endocytic recycling
GO:0008406	; P:gonad development
GO:0035264	; P:multicellular organism growth
GO:0016242	; P:negative regulation of macroautophagy
GO:0042331	; P:phototaxis
GO:0030307	; P:positive regulation of cell growth
GO:0045793	; P:positive regulation of cell size
GO:0040018	; P:positive regulation of multicellular organism growth
GO:0046622	; P:positive regulation of organ growth
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0090070	; P:positive regulation of ribosome biogenesis
GO:2000377	; P:regulation of reactive oxygen species metabolic process
GO:0006974	; P:response to DNA damage stimulus
GO:0051124	; P:synaptic growth at neuromuscular junction

KEGG

dme:Dmel_CG5092

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR024585	; DUF3385_TOR.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.
IPR013026	; TPR-contain_dom.
IPR019734	; TPR_repeat.

Pfam

PF11865	; DUF3385; 1.
PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.
PS50005	; TPR; 2.
PS50293	; TPR_REGION; 1.

Prints

Created Date

20-Feb-2013