EPS-DRM-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DRM-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	194.9	2.7E-57	263	562	300

Status

Unreviewed

Ensembl Protein

FBpp0070653

UniProt Accession

O77023;

Protein Name

Protein Synonyms/Alias

DPP2C1;

Gene Name

Pp2C1

Gene Synonyms/Alias

Pp2C1; dpp2c1; CG2984;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0022768	FBpp0070653	FBtr0070685

Organism

Drosophila melanogaster

Functional Description

Protein Length

1427

Protein Sequence
(FASTA)

MLPANNRSST STHTNTNANT INATTNTTNR CLINTAIEKT VVRLRETAAN SGTFQDSDES 60

SVEFDIINYY GDDGGTTPAP APATASVTRH GGSSSGNNNN NSACHPALDA SSDVVVVEPA 120

AVGVAQEEEE EPEQRPERIS IPIPDLAFTE MEAYAEDIVV DMEGGSPAKP LNPKKQRLNS 180

ATTTTINRSR GGGAAQSRLR RSAAIVPPRS IPESCASSSN SNSSSSSNSN SSSSSATGSS 240

ASTGNPSPCS SLGVNMRVTG QCCQGGRKYM EDQFSVAYQE SPITHELEYA FFGIYDGHGG 300

PEAALFAKEH LMLEIVKQKQ FWSDQDEDVL RAIREGYIAT HFAMWREQEK WPRTANGHLS 360

TAGTTATVAF MRREKIYIGH VGDSGIVLGY QNKGERNWRA RPLTTDHKPE SLAEKTRIQR 420

SGGNVAIKSG VPRVVWNRPR DPMHRGPIRR RTLVDEIPFL AVARSLGDLW SYNSRFKEFV 480

VSPDPDVKVV KINPSTFRCL IFGTDGLWNV VTAQEAVDSV RKEHLIGEIL NEQDVMNPSK 540

ALVDQALKTW AAKKMRADNT SVVTVILTPA ARNNSPTTPT RSPSAMARDN DLEVELLLEE 600

DDEELPTLDV ENNYPDFLIE EHEYVLDQPY SALAKRHSPP EAFRNFDYFD VDEDELDEDE 660

ETVEEDEEEE EEEEETKSVG ILQQSLFNPR KTWRKSTINN SWSGVTEPEP EPDPEPDRID 720

VLTLDMYSHT SIDKGTNYGG SIAQSSIDPA ETAENRELSE LEQHLESSYS FAESYNSLLN 780

EQEEQEARSR SAAAAAAAAE AAAVEAQQTT AHSASVVLDR SMLEIIQEQQ HYQQQEGYSL 840

TQLETRRERE RLTESWPQQP AELLELDALL QQERAEEEQV ALEQQQQREQ QMEQMEVEAI 900

SSSGQHEFAY PVTTATASEW CATLQEDEEE LDSTVIDIVI QPEQELQDNE VSSTLPATPT 960

HVEPEQIVDK MEPLKVQEML TAVEKPPSKQ EKKLPKKQET KQVAVLDTVA EMPKEDAHAV 1020

HYIFQRIQKV QDSEATPVAV TNSTMADALP TESSGLGGSM TAPRIRRYRN VPNENHQHMQ 1080

TRRRQIFKHV KPKSFIQSSA AAIVAYGDST ETVGGTAGAS GTPAAGRVGG GGGGGGGRGS 1140

ASGGSSPAVA ANSRRSVNVV ANASGNSASK VVPSSSSMMM TRRSHTLTAS GGVNKRQLRS 1200

SLCTLGLGVG VGVGLGMDLD MTKRTLRTRN VPALSGGSAT PSSNSSPASG GSSPAGFTSP 1260

ASPVITSRGS GSRTTASPAR RLKRSHEDRE QRMSLRRSTL SGSASGSGLV GTGGSPSNVK 1320

SNRLQACNGA ISARPPPSPK KLNAAVPTLA IGTRAYTAAL AAAADHLNKR WSLRSSSGNS 1380

GNLITAISCY SDRSRAATAA GSPGSGGGAA GPPGASLAAS TVGTRRR 1427

Nucleotide Sequence
(FASTA)

ATGTTGCCCG CCAATAACAG GAGTAGCACC AGCACCCATA CCAACACAAA TGCCAACACA 60

ATCAACGCCA CTACCAATAC CACCAACAGA TGCCTCATCA ATACGGCCAT CGAAAAAACG 120

GTAGTCCGTT TGCGAGAGAC GGCAGCGAAT AGCGGTACTT TCCAGGACTC AGATGAGTCG 180

TCCGTGGAAT TTGATATTAT TAACTATTAT GGGGACGACG GCGGCACAAC TCCAGCACCA 240

GCTCCAGCCA CAGCCTCCGT TACTCGCCAC GGCGGCAGCA GCAGCGGCAA TAACAACAAT 300

AACAGTGCAT GCCATCCAGC ACTGGATGCC AGCAGTGATG TTGTTGTTGT TGAACCGGCA 360

GCGGTAGGAG TCGCACAGGA GGAAGAGGAA GAGCCGGAGC AAAGGCCAGA GAGGATCAGC 420

ATACCCATTC CCGACCTGGC GTTCACCGAG ATGGAAGCAT ATGCCGAGGA TATAGTCGTC 480

GATATGGAGG GGGGATCACC AGCCAAGCCT TTAAATCCAA AGAAACAACG TTTAAACTCA 540

GCAACAACCA CAACAATAAA TCGCTCGAGG GGCGGCGGAG CGGCACAGAG TCGATTACGC 600

CGGTCGGCGG CCATCGTTCC ACCGCGATCG ATTCCAGAGA GCTGTGCCAG CAGCAGCAAT 660

TCCAATTCGA GCAGCAGTTC CAACAGTAAT TCCAGTTCCA GCTCCGCTAC AGGAAGTAGC 720

GCATCCACCG GCAATCCGTC GCCGTGCTCC TCCCTGGGCG TCAATATGCG CGTAACTGGA 780

CAATGCTGCC AGGGAGGCCG GAAATACATG GAGGATCAGT TCTCGGTGGC CTACCAGGAA 840

TCACCGATCA CCCACGAACT GGAATACGCA TTTTTTGGCA TCTACGACGG ACACGGCGGT 900

CCCGAGGCCG CGCTCTTCGC CAAGGAGCAC CTTATGCTCG AGATCGTCAA GCAGAAGCAG 960

TTCTGGTCTG ATCAGGATGA GGATGTCCTG CGGGCAATAC GCGAGGGATA CATCGCCACA 1020

CATTTCGCCA TGTGGCGGGA ACAAGAGAAA TGGCCACGCA CTGCCAATGG GCATCTGAGC 1080

ACCGCCGGCA CCACCGCCAC AGTGGCCTTT ATGCGTCGCG AGAAGATCTA CATTGGTCAT 1140

GTGGGTGATT CTGGGATCGT TTTGGGTTAC CAGAACAAGG GCGAACGCAA CTGGCGTGCT 1200

CGTCCACTGA CCACGGACCA CAAGCCGGAG TCACTGGCAG AGAAGACGAG AATCCAGCGT 1260

TCCGGCGGCA ATGTTGCCAT CAAATCGGGA GTTCCGCGAG TGGTATGGAA CCGACCCAGG 1320

GACCCAATGC ATCGCGGTCC CATTCGCCGC AGAACTCTGG TAGATGAAAT ACCCTTTTTG 1380

GCGGTGGCTC GTTCCCTGGG CGATCTCTGG AGCTACAATT CCCGCTTCAA GGAATTCGTT 1440

GTGAGTCCCG ATCCGGATGT CAAAGTGGTT AAAATAAATC CCAGTACCTT TAGATGCTTA 1500

ATTTTCGGCA CCGATGGCCT GTGGAATGTG GTGACCGCCC AGGAGGCGGT GGACAGTGTG 1560

CGCAAGGAGC ATCTAATCGG CGAGATACTC AACGAGCAGG ACGTTATGAA TCCCAGCAAG 1620

GCGCTGGTGG ATCAGGCCCT CAAAACCTGG GCCGCCAAGA AGATGCGTGC GGACAACACG 1680

TCCGTTGTGA CTGTGATACT AACACCAGCG GCCCGCAATA ATTCGCCCAC AACGCCAACA 1740

CGTTCCCCAT CCGCGATGGC ACGCGACAAT GATCTGGAGG TGGAGCTACT GCTGGAGGAG 1800

GACGACGAGG AGCTGCCGAC ACTGGATGTG GAGAACAACT ACCCTGACTT TCTCATCGAG 1860

GAGCATGAGT ATGTGCTGGA CCAGCCGTAC AGTGCATTGG CCAAGCGACA TTCGCCTCCG 1920

GAAGCCTTCC GCAACTTCGA CTACTTCGAT GTGGACGAGG ACGAGTTGGA TGAAGATGAG 1980

GAAACAGTGG AAGAAGACGA GGAGGAGGAG GAGGAAGAGG AGGAAACCAA ATCGGTGGGA 2040

ATTCTACAGC AAAGTTTGTT CAACCCCAGA AAAACGTGGC GCAAGTCAAC CATCAACAAT 2100

TCCTGGAGTG GCGTCACCGA ACCGGAACCG GAACCCGATC CCGAACCAGA TCGAATAGAT 2160

GTCTTAACAC TGGACATGTA CTCCCACACC AGCATTGACA AGGGCACCAA TTATGGCGGC 2220

AGCATAGCCC AGTCCTCAAT AGATCCTGCG GAGACGGCTG AAAATCGTGA GCTGAGTGAG 2280

TTGGAGCAGC ATCTGGAGAG TAGCTACAGT TTCGCCGAGT CGTACAACTC CCTGTTAAAC 2340

GAGCAGGAGG AGCAGGAGGC ACGCTCACGT TCAGCAGCAG CAGCAGCCGC CGCCGCAGAA 2400

GCAGCAGCAG TAGAAGCACA ACAAACCACT GCCCATTCCG CATCCGTTGT GCTGGACCGC 2460

AGCATGTTGG AGATCATCCA GGAGCAGCAG CACTATCAGC AGCAAGAGGG CTATTCGCTA 2520

ACGCAACTAG AGACCAGACG TGAAAGGGAG CGGCTGACCG AATCGTGGCC ACAGCAGCCG 2580

GCTGAGCTGC TCGAGCTGGA TGCTCTACTG CAGCAGGAGC GTGCCGAGGA GGAGCAGGTA 2640

GCCCTGGAGC AGCAGCAGCA GCGCGAACAG CAAATGGAGC AAATGGAGGT GGAGGCCATT 2700

AGTAGTTCGG GACAGCACGA ATTTGCTTAC CCAGTGACCA CCGCCACAGC CAGCGAGTGG 2760

TGTGCTACAT TACAAGAAGA CGAGGAGGAG TTGGACTCCA CAGTAATAGA CATAGTAATT 2820

CAACCCGAAC AAGAGTTGCA GGACAATGAA GTGAGCTCCA CGTTGCCCGC CACACCCACT 2880

CATGTGGAGC CTGAGCAGAT TGTGGACAAG ATGGAGCCCC TGAAGGTTCA GGAGATGCTA 2940

ACCGCGGTCG AAAAACCTCC ATCCAAGCAG GAAAAGAAGC TGCCGAAGAA GCAAGAGACC 3000

AAACAGGTTG CTGTGCTAGA TACAGTGGCC GAGATGCCCA AAGAGGATGC CCATGCCGTG 3060

CACTATATAT TCCAGCGCAT TCAAAAGGTT CAGGACTCTG AGGCAACACC AGTGGCCGTG 3120

ACGAATTCCA CAATGGCTGA CGCCCTGCCC ACCGAATCTA GTGGACTGGG AGGATCTATG 3180

ACCGCGCCCC GAATCCGACG CTATCGCAAC GTGCCCAACG AGAACCATCA GCACATGCAG 3240

ACGCGTCGTC GTCAGATCTT CAAGCATGTC AAGCCAAAGT CCTTCATACA GTCCAGTGCT 3300

GCGGCGATTG TGGCCTATGG AGACAGCACC GAAACGGTCG GAGGAACAGC CGGAGCATCT 3360

GGCACACCTG CAGCTGGGCG TGTAGGCGGG GGCGGTGGCG GCGGCGGCGG CAGAGGATCG 3420

GCCAGTGGTG GGAGCAGTCC AGCGGTGGCA GCCAATAGTC GGCGGAGCGT CAATGTGGTG 3480

GCCAATGCGA GTGGAAACAG CGCTAGCAAA GTTGTGCCCA GCAGCAGTTC CATGATGATG 3540

ACCCGCCGCA GTCACACCTT GACGGCCAGC GGTGGTGTGA ACAAAAGGCA GCTGCGCAGC 3600

AGTCTCTGCA CCTTGGGCCT GGGTGTGGGT GTCGGTGTCG GTCTGGGCAT GGACCTGGAC 3660

ATGACCAAGC GCACGCTAAG GACAAGGAAT GTACCCGCTT TGTCGGGCGG TTCAGCCACG 3720

CCATCTAGCA ATTCGTCGCC AGCCAGCGGA GGCAGCAGTC CAGCCGGTTT CACAAGCCCA 3780

GCCAGTCCGG TCATCACGTC CAGGGGAAGC GGATCGCGTA CTACCGCCTC GCCAGCCAGG 3840

CGCCTAAAAC GCAGTCATGA GGATCGGGAG CAAAGAATGA GCTTGCGACG GAGCACTCTG 3900

AGTGGCAGTG CCAGCGGCAG TGGGCTGGTG GGCACTGGTG GGTCGCCCTC GAATGTGAAA 3960

TCAAATCGCC TGCAGGCCTG CAATGGAGCC ATCTCTGCGC GTCCGCCGCC CTCGCCGAAG 4020

AAACTGAATG CAGCCGTGCC CACATTGGCA ATTGGAACGC GTGCATATAC GGCGGCGTTG 4080

GCGGCGGCGG CGGATCACCT GAACAAGCGG TGGTCGTTGC GCAGCAGCAG TGGCAACTCT 4140

GGCAATCTGA TAACCGCCAT CAGTTGCTAC AGTGACAGGA GCAGGGCGGC GACTGCGGCG 4200

GGATCACCGG GATCTGGAGG CGGGGCAGCG GGACCACCAG GAGCATCTTT GGCCGCATCC 4260

ACAGTCGGCA CGCGAAGGCG CTAG 4284

Domain Profile

S: 8     vngrrnemedavtsspnflkspek.kdrlaffgvyDGhggsevakfcseklheilaeele  66

          +g r+ med+++++ +  +sp + + + affg+yDGhgg e+a f++e+l   + ++++

Q: 263   CQGGRKYMEDQFSVAYQ--ESPIThELEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQ  320

         689999*****987443..3443303449*******************************

S: 67    sseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvalikdsklyvan  121

         + ++++++v +a+++++++t+ ++     k++ +++   ++ G+ta+va ++ +k+y+ +

Q: 321   FWSDQDEDVLRAIREGYIATHFAMwreqeKWPRTANGHLSTAGTTATVAFMRREKIYIGH  380

         ************************************************************

S: 122   vGdSravLcrngk......avelssdHkpsredEleRieeaggsvilkdga.Rv......  168

         vGdS++vL+ ++k      a +l++dHkp++  E+ Ri++ gg+v+ k+g+ Rv

Q: 381   VGDSGIVLGYQNKgernwrARPLTTDHKPESLAEKTRIQRSGGNVAIKSGVpRVvwnrpr  440

         *********9776679********************************************

S: 169   ................lGvLavsRalGdlylk......pyvtpePevtshrltsede.fl  205

                         +++Lav+R+lGdl+++      ++v+p+P+v ++++++++  +l

Q: 441   dpmhrgpirrrtlvdeIPFLAVARSLGDLWSYnsrfkeFVVSPDPDVKVVKINPSTFrCL  500

         *****************************************************99988**

S: 206   iLasDGlwdvvsneeavslvrdvle.....kkeaeqeaakkLvklalargsk.....dnv  255

         i ++DGlw+vv+ +eav+ vr+ +      ++++  +++k Lv++al+ ++      dn+

Q: 501   IFGTDGLWNVVTAQEAVDSVRKEHLigeilNEQDVMNPSKALVDQALKTWAAkkmraDNT  560

         ********************99888999999******************99955555666

S: 256   sa  257

s+

Q: 561   SV  562

Domain Sequence
(FASTA)

CQGGRKYMED QFSVAYQESP ITHELEYAFF GIYDGHGGPE AALFAKEHLM LEIVKQKQFW 60

SDQDEDVLRA IREGYIATHF AMWREQEKWP RTANGHLSTA GTTATVAFMR REKIYIGHVG 120

DSGIVLGYQN KGERNWRARP LTTDHKPESL AEKTRIQRSG GNVAIKSGVP RVVWNRPRDP 180

MHRGPIRRRT LVDEIPFLAV ARSLGDLWSY NSRFKEFVVS PDPDVKVVKI NPSTFRCLIF 240

GTDGLWNVVT AQEAVDSVRK EHLIGEILNE QDVMNPSKAL VDQALKTWAA KKMRADNTSV 300

Keyword

Hydrolase; Magnesium; Metal-binding; Protein phosphatase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0016491	; F:oxidoreductase activity
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR003952	; FRD_SDH_FAD_BS.
IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS00504	; FRD_SDH_FAD_BINDING; 1.
PS01032	; PP2C; 1.

Prints

Created Date

20-Feb-2013