EKS-DRM-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	473.1	3.1E-142	100	369	270

Status

Reviewed

Ensembl Protein

FBpp0072194

UniProt Accession

Q9W1B0; O44368;

Protein Name

Serine/threonine-protein kinase Genghis Khan

Protein Synonyms/Alias

Gene Name

gek

Gene Synonyms/Alias

gek; CG4012;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0023081	FBpp0072194	FBtr0072287

Organism

Drosophila melanogaster

Functional Description

Acts as a downstream effector for the regulation ofactin polymerization by Cdc42.

Protein Length

1637

Protein Sequence
(FASTA)

MEYESSEISD ITTGSCKKRL TFLKCILSDT TSDQKWAAEF GEDTEGHQFS LDYLLDTFIV 60

LYDECSNSSL RREKGVSDFL KLSKPFVHIV RKLRLSRDDF DILKIIGRGA FGEVCVVQMI 120

STEKVYAMKI LNKWEMLKRA ETACFREERD VLVFGDRQWI TNLHYAFQDN INLYLVMDYY 180

CGGDLLTLLS KFEDKLPEDM AKFYITEMIL AINSIHQIRY VHRDIKPDNV LLDKRGHVRL 240

ADFGSCLRLD KDGTVQSNVA VGTPDYISPE ILRAMEDGKG RYGTECDWWS LGVCMYEMLY 300

GETPFYAESL VETYGKIMNH QNCFNLPSQE TLNYKVSETS QDLLCKLICI PENRLGQNGI 360

QDFMDHPWFV GIDWKNIRQG PAPYVPEVSS PTDTSNFDVD DNDVRLTDSI PPSANPAFSG 420

FHLPFIGFTF SLTSSSTLDS KKNQSSGFGD DTLDTISSPQ LAILPSNNSE TPVDSVQLKA 480

LNDQLAALKQ EKAELSKQHN EVFERLKTQD SELQDAISQR NIAMMEYSEV TEKLSELRNQ 540

KQKLSRQVRD KEEELDGAMQ KNDSLRNELR KSDKTRRELE LHIEDAVIEA AKEKKLREHA 600

EDCCRQLQME LRKGSSSVET TMPLSISSEM SSYEIERLEL QFSEKLSHQQ TRHNMELEAL 660

REQFSELENA NLALTKELQQ TQERLKYTQM ESITDSAETL LELKKQHDLE KSSWFEEKQR 720

LSSEVNLKSK SLKELQAEDD EIFKELRMKR EAITLWERQM AEIIQWVSDE KDARGYLQAL 780

ATKMTEELEY LKHVGTFNNN GVDNKNWRNR RSQKLDKMEL LNLQSALQRE IQAKNMISDE 840

LSQTRSDLIS TQKEVRDYKK RYDSILHDFQ KKETELRDLQ KGGLEYSESF LNKSTHHGLS 900

SAFFRDMSKN SEIIDSAESF GNESGDNFTP NFFQSGNSGM LFNYEPKYAG KNNKDHSSMK 960

EASVSDLSRE ESDQLVKESQ KKVPGNTAIH QFLVRTFSSP TKCNHCTSLM VGLTRQGVVC 1020

EICGFACHTI CCQKVPTTCP VPMDQTKRPL GIDPTRGIGT AYEGYVKVPK SGVIKRGWIR 1080

QFVVVCDFKL FLYDISPDRC ALPSVSVSQV LDMRDPEFSV GSVRESDVIH AAKKDVPCIF 1140

KIKTALIDGG LSLNTLMLAD NESEKSKWVI ALGELHRILK RNSLPNTAIF KVNEILDNTL 1200

SLIRNALCSV IIYPNQILLG TEDGLFYINL DQYEIARIGE SKKILQLWYI EEEQILVILC 1260

GKQRNLRLLP IRALEASDVE WIKVVESKNC ISACTGIIRR FPNIVYSFII ALKRPNNHTQ 1320

IVVYEINRTR TRHQKTCEFT IGYMAQHLQI LSDMRLVVAH QSGFTAYFLR GEATAMSLVH 1380

PENQLCAFLN YSGVDAVRVI EILCPSGGNF GEYLLVFQTL AIYVDLQGRK SRDREIMYPA 1440

FPTYITFCDG HLLVFSDTHL DIFNTQTAEW VQSIGLKQSL PLNNLGNVVL SSVNDTPLIV 1500

YLSNIHTKGL LQYRDGNRKG LPSIKRRFSI REINKTIKSD RRSKMISAPT NFNHISHMGP 1560

GDGIQNQRLL DLPTTLETAD QACSPIIHSL SCIPQSRKSN FLEQVDANSD DYGNDNIISR 1620

TPSPMASSFM DGLSNND 1637

Nucleotide Sequence
(FASTA)

ATGGAATACG AATCTTCCGA AATCAGTGAT ATAACCACAG GAAGCTGCAA GAAAAGGCTC 60

ACATTTCTGA AATGTATTCT AAGCGACACC ACAAGCGATC AAAAATGGGC GGCCGAGTTC 120

GGCGAGGACA CGGAAGGACA TCAGTTTTCG TTGGACTATC TGCTGGACAC CTTCATCGTT 180

CTCTATGACG AGTGCAGCAA CTCCTCCCTG CGCAGGGAGA AGGGCGTCTC TGATTTCCTC 240

AAACTATCCA AACCCTTCGT GCACATAGTG CGAAAGCTTC GACTAAGCCG AGATGACTTT 300

GACATACTCA AGATCATCGG ACGCGGTGCC TTTGGAGAAG TGTGCGTGGT TCAGATGATA 360

TCCACCGAAA AGGTGTATGC CATGAAGATT CTGAACAAGT GGGAGATGCT GAAGAGGGCC 420

GAGACGGCCT GCTTCCGCGA GGAGCGGGAT GTGTTGGTTT TCGGCGACCG GCAGTGGATC 480

ACCAACCTTC ACTATGCCTT TCAAGACAAT ATTAACCTGT ATCTGGTGAT GGACTATTAC 540

TGCGGCGGAG ACCTGCTTAC ATTGCTCAGC AAATTCGAGG ACAAGCTGCC CGAGGACATG 600

GCCAAGTTCT ACATCACAGA GATGATCCTG GCAATCAATA GTATTCACCA GATTAGGTAC 660

GTTCACAGGG ACATCAAGCC GGATAATGTA CTGCTCGATA AGCGCGGTCA CGTGCGCCTG 720

GCTGACTTTG GATCCTGCCT GCGCCTGGAC AAGGATGGCA CCGTACAGTC CAACGTGGCC 780

GTGGGCACAC CCGACTACAT TTCCCCGGAA ATTTTGAGGG CCATGGAGGA CGGAAAGGGA 840

CGCTACGGCA CGGAGTGTGA TTGGTGGTCA CTCGGAGTGT GCATGTACGA GATGCTCTAC 900

GGAGAGACGC CCTTCTACGC AGAAAGTTTG GTGGAAACCT ATGGCAAGAT CATGAACCAC 960

CAAAACTGTT TCAACTTACC GTCACAAGAA ACCCTAAATT ACAAGGTATC GGAGACGTCT 1020

CAGGACTTGC TCTGCAAACT GATATGTATT CCCGAGAACC GACTTGGTCA GAACGGCATC 1080

CAAGACTTCA TGGACCACCC CTGGTTTGTG GGCATCGACT GGAAGAACAT AAGGCAGGGA 1140

CCAGCACCGT ATGTGCCGGA AGTGTCCAGT CCAACAGATA CCTCCAACTT CGATGTGGAC 1200

GACAATGACG TCCGGTTAAC GGACTCCATT CCGCCGTCAG CCAATCCTGC CTTCTCTGGA 1260

TTTCACTTGC CCTTCATCGG GTTTACCTTC TCGCTGACCA GCAGCTCCAC CTTGGACTCG 1320

AAGAAGAACC AGAGCTCGGG CTTCGGAGAT GATACCTTGG ACACCATAAG CAGTCCCCAG 1380

TTGGCCATTC TGCCGAGCAA CAACTCGGAG ACACCGGTGG ACTCCGTTCA GCTGAAGGCA 1440

CTAAACGATC AGCTTGCGGC TTTGAAGCAG GAAAAGGCAG AGTTGTCAAA GCAACACAAC 1500

GAGGTTTTCG AACGGCTCAA AACTCAAGAC TCTGAACTTC AGGACGCCAT CTCTCAACGA 1560

AACATCGCCA TGATGGAGTA CTCGGAGGTC ACTGAGAAAC TCTCGGAGCT GCGAAATCAG 1620

AAGCAGAAGC TCTCCCGCCA AGTCAGGGAC AAGGAGGAGG AGCTTGATGG TGCCATGCAG 1680

AAGAACGACA GCCTGCGGAA CGAACTGAGA AAGTCGGACA AAACGCGAAG GGAATTGGAG 1740

CTTCACATTG AGGATGCTGT CATCGAGGCT GCCAAAGAAA AGAAGCTGCG GGAGCATGCG 1800

GAGGACTGCT GCAGGCAGCT GCAGATGGAG CTGCGGAAGG GCTCCTCGAG TGTGGAGACA 1860

ACTATGCCAC TCAGCATTTC CTCCGAGATG TCGTCATACG AGATCGAACG CCTTGAACTC 1920

CAGTTCTCGG AAAAGCTAAG TCATCAGCAG ACGCGCCACA ATATGGAGTT GGAAGCACTG 1980

CGCGAGCAGT TCAGCGAGCT AGAGAACGCG AATTTGGCAC TCACCAAGGA GTTGCAACAA 2040

ACACAGGAAA GGCTGAAGTA CACTCAAATG GAGTCGATTA CCGATTCCGC CGAAACGCTT 2100

TTGGAATTGA AGAAGCAGCA TGATTTGGAG AAAAGCTCAT GGTTCGAGGA AAAGCAGAGA 2160

TTAAGCTCCG AGGTGAATCT CAAGTCAAAG AGTCTTAAAG AACTTCAAGC GGAGGACGAC 2220

GAGATCTTCA AGGAGTTGCG AATGAAACGG GAGGCCATCA CCTTGTGGGA GCGGCAAATG 2280

GCGGAGATTA TTCAATGGGT GTCCGATGAG AAAGACGCGC GAGGCTACTT GCAGGCCTTG 2340

GCCACCAAAA TGACGGAGGA GTTGGAGTAT CTGAAGCATG TGGGTACCTT CAACAACAAC 2400

GGTGTGGACA ATAAGAACTG GAGGAACCGG CGCTCTCAGA AGCTGGACAA GATGGAGCTG 2460

CTCAACCTGC AGAGCGCGCT GCAAAGGGAG ATTCAGGCCA AGAACATGAT ATCGGATGAG 2520

CTGAGTCAAA CCAGATCGGA CCTCATATCC ACACAGAAAG AGGTTCGAGA CTACAAAAAG 2580

CGGTACGACT CCATACTGCA CGATTTCCAG AAGAAGGAAA CCGAACTGCG GGACTTGCAG 2640

AAGGGAGGCT TGGAATACTC CGAGTCGTTC CTCAACAAAT CAACGCATCA TGGGCTAAGC 2700

AGCGCCTTCT TCCGCGACAT GTCAAAGAAC TCCGAGATTA TAGATTCTGC CGAGAGCTTT 2760

GGCAACGAAT CCGGCGACAA TTTCACTCCC AACTTCTTCC AGTCCGGCAA TTCGGGCATG 2820

CTCTTCAACT ACGAGCCAAA GTATGCGGGT AAGAACAACA AGGATCATTC GTCCATGAAA 2880

GAAGCCTCGG TCAGCGATTT GTCCCGCGAG GAGAGTGACC AGCTGGTCAA GGAATCTCAG 2940

AAGAAAGTGC CCGGCAACAC GGCGATCCAT CAGTTCCTGG TGCGCACATT CAGTAGTCCC 3000

ACAAAATGCA ATCACTGCAC ATCGCTGATG GTGGGGCTCA CACGACAAGG CGTTGTGTGC 3060

GAGATCTGCG GATTCGCCTG TCACACGATC TGCTGCCAAA AGGTGCCCAC CACGTGCCCC 3120

GTGCCCATGG ATCAGACGAA ACGGCCGCTG GGAATCGATC CCACCAGGGG AATCGGCACG 3180

GCATACGAGG GCTACGTAAA GGTCCCCAAG TCGGGGGTGA TTAAGCGAGG ATGGATTCGG 3240

CAGTTCGTAG TTGTTTGCGA CTTTAAGTTG TTCCTCTATG ACATTTCGCC GGATCGGTGT 3300

GCATTGCCCA GCGTGAGCGT GTCCCAAGTG CTGGATATGA GGGATCCCGA GTTCTCGGTG 3360

GGTAGTGTGC GCGAAAGCGA TGTCATCCAT GCCGCCAAGA AAGATGTGCC ATGTATTTTC 3420

AAGATAAAAA CCGCCCTTAT CGATGGCGGT CTTTCGCTGA ACACCCTTAT GCTCGCCGAC 3480

AACGAGTCGG AGAAGTCCAA GTGGGTCATT GCCCTGGGAG AACTACATCG AATATTGAAA 3540

CGAAACAGCT TACCAAATAC TGCTATATTT AAAGTTAACG AGATTCTGGA CAATACCCTG 3600

TCTTTAATAA GAAACGCATT GTGTTCTGTC ATCATATATC CAAATCAAAT ACTCTTGGGC 3660

ACCGAAGACG GCCTGTTCTA CATTAATCTG GACCAGTACG AGATCGCTCG TATTGGCGAA 3720

AGCAAGAAGA TTCTTCAGCT ATGGTACATT GAAGAGGAGC AGATCCTCGT CATTCTCTGC 3780

GGAAAGCAGC GCAACTTGCG TTTATTACCT ATAAGGGCAT TAGAGGCTAG TGATGTCGAG 3840

TGGATCAAGG TGGTCGAATC GAAGAACTGC ATATCTGCTT GCACTGGAAT AATCCGCCGC 3900

TTCCCCAATA TCGTTTACTC ATTTATCATC GCTCTAAAGC GGCCGAATAA CCACACACAA 3960

ATCGTAGTTT ACGAAATCAA TAGAACGCGC ACAAGACACC AGAAGACTTG CGAATTCACA 4020

ATTGGCTACA TGGCGCAGCA CCTGCAGATT CTGTCCGACA TGCGATTGGT TGTGGCTCAC 4080

CAAAGCGGAT TTACCGCATA CTTTCTGCGC GGAGAAGCAA CTGCAATGTC TTTGGTTCAT 4140

CCGGAGAACC AGTTATGTGC ATTTTTGAAC TACTCCGGAG TGGATGCGGT CAGGGTCATT 4200

GAAATTCTGT GCCCCAGCGG CGGCAATTTC GGGGAGTACT TACTGGTGTT CCAGACTCTG 4260

GCCATATACG TAGACCTGCA AGGGCGAAAG TCTCGGGATA GGGAAATTAT GTATCCAGCC 4320

TTCCCTACGT ATATAACCTT TTGTGATGGT CACTTGCTGG TGTTTTCGGA TACACATTTG 4380

GATATATTCA ATACGCAGAC TGCCGAATGG GTGCAGTCGA TTGGATTGAA GCAATCACTT 4440

CCCTTAAACA ATTTGGGAAA CGTGGTGCTG TCCTCAGTCA ATGACACTCC GCTGATTGTT 4500

TACCTATCCA ATATTCACAC AAAGGGCCTT TTGCAATACC GTGACGGAAA TCGAAAGGGA 4560

CTTCCGAGCA TAAAGCGGAG ATTCTCTATC AGGGAGATAA ACAAGACCAT CAAAAGTGAT 4620

CGTAGATCAA AGATGATATC AGCACCGACT AATTTCAACC ACATTTCTCA CATGGGGCCA 4680

GGGGATGGCA TTCAAAATCA ACGACTCCTA GACTTACCAA CCACGCTCGA AACAGCCGAT 4740

CAAGCCTGCA GTCCAATAAT ACATTCGCTG AGTTGCATAC CCCAGAGTAG AAAATCCAAT 4800

TTTCTAGAAC AAGTGGATGC AAACTCCGAT GACTATGGCA ATGACAACAT TATCTCCAGA 4860

ACGCCCAGTC CAATGGCATC GTCCTTCATG GACGGCTTAA GCAATAATGA TTAA 4914

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+ilk+iGrGafgev+vv++ +tekvyamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 100   FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQW  159

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd+ +lylvm+y++GGdlltllsk+edklpe++a+fy++e++la++s+h+++

Q: 160   ITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIR  219

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lldk+Gh++ladfGscl+l++dgtv+s+vavGtpdyispe+l+a+e+gk

Q: 220   YVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGK  279

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede....kvsee  236

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh++++++p++e    kvse+

Q: 280   GRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQEtlnyKVSET  339

         *************************************************9888889****

S: 237   akdlikklltsreerlgregiedlkkhpff  266

         ++dl++kl++ +e+rlg++gi+d+++hp+f

Q: 340   SQDLLCKLICIPENRLGQNGIQDFMDHPWF  369

         *****************************9

Domain Sequence
(FASTA)

FDILKIIGRG AFGEVCVVQM ISTEKVYAMK ILNKWEMLKR AETACFREER DVLVFGDRQW 60

ITNLHYAFQD NINLYLVMDY YCGGDLLTLL SKFEDKLPED MAKFYITEMI LAINSIHQIR 120

YVHRDIKPDN VLLDKRGHVR LADFGSCLRL DKDGTVQSNV AVGTPDYISP EILRAMEDGK 180

GRYGTECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HQNCFNLPSQ ETLNYKVSET 240

SQDLLCKLIC IPENRLGQNG IQDFMDHPWF 270

Keyword

ATP-binding; Coiled coil; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0030426	; C:growth cone
GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0008154	; P:actin polymerization or depolymerization
GO:0035556	; P:intracellular signal transduction
GO:0030833	; P:regulation of actin filament polymerization
GO:0008039	; P:synaptic target recognition

KEGG

dme:Dmel_CG4012

;

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013