EKS-DRM-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	351.5	4.7E-105	224	525	302

Status

Unreviewed

Ensembl Protein

FBpp0073135

UniProt Accession

Q95V83;

Protein Name

Protein Synonyms/Alias

Wishful thinking;

Gene Name

wit

Gene Synonyms/Alias

wit; CG10776;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0024179	FBpp0073135	FBtr0073279
FBgn0024179	FBpp0303105	FBtr0330072

Organism

Drosophila melanogaster

Functional Description

Protein Length

903

Protein Sequence
(FASTA)

MNWAIYLLLA LISLGRATPV PNRQYSCMSY QEDDNSFHDD DGDQDSSGEL QEQQVESTPI 60

PSEPHRRTCP DGYTFCFTIW NQTANGARVV KQGCWKDNTD RTSICSQSEC TSSAPTSKTS 120

SLYYCCCSGG VCNAQYSVVE PAPLELGSNE GRTSITNRAT EKQHQSFLAS TMLGLAGGLT 180

ALTIGIFLAV QYCRTAKEKP EPEESPLAPS GPGYSSNLRN VDNMNLIGML GSGKYGTVMK 240

GLLHDQEVAV KIYPEEHHQY YVNERNIYAL PLMECPALLS YFGYDERCTM DGRMEYQLVL 300

SLAPLGCLQD WLIANTLTFS ECCGMLRSIT RGISHLHTEL RLGDQHKPCV AHRDINTRNV 360

LVQADLSCCI ADFGFALKVF GSKYEYKGEV AMAETKSINE VGTLRYMAPE LLEGAVNLRD 420

CETSLKQMDV YALGLVLWEV ATRCSDFYAP GQATPPYKAP YEQEVGSHPS FDQMQALVVR 480

HKARPLFPTG WGGGAAAKVV RDTCEDCWDH DADARLTSLC AEERMQEMST LRPRAQAQPS 540

SPLLNTNNLV ASPTAEQGIN IIATTTTAAA VHHQMSSDTT GLIQPPPNQQ IPLAALEREK 600

NHLSYPQQQL QPYQGRNPCQ ERNLAPLTMR TPPVLVERSK KHSFQTQPQE NSLSCLEHDV 660

SVEELIASHQ HQQQKNTIVS TGGNGNSCLG QGFPKQQNTD QKLRGWHGVR ALIHKKLFRK 720

EHAEELCRQL QLGEEKSNLV TALRRPNNLD LNPRLDKPPP DQLRSAEQRM GTPAHIVPRS 780

LSSSLIKHIN GTTNNNSIQS HGSELQTLTR PASKRRPGHL RTNSLMATTG QGPPTEQQMR 840

RQHSLEVFRE VFSGRGSSER LRDPSERVKT PGDVPPSVRK ARASKTLSLY DDRMMDSSLL 900

NIL 903

Nucleotide Sequence
(FASTA)

ATGAATTGGG CTATCTATCT TTTGTTGGCC CTGATCTCGC TGGGCAGAGC AACACCTGTT 60

CCCAATCGCC AGTATAGCTG TATGAGCTAC CAGGAGGACG ACAACTCATT TCACGATGAT 120

GATGGCGATC AGGACTCTAG TGGCGAGCTG CAGGAGCAGC AGGTGGAGTC CACTCCGATT 180

CCGAGCGAGC CACATAGACG CACCTGCCCA GATGGCTACA CTTTCTGTTT CACCATCTGG 240

AACCAGACGG CCAATGGAGC GCGGGTTGTT AAACAGGGTT GCTGGAAGGA CAACACGGAT 300

CGCACTTCCA TTTGCAGCCA GTCGGAATGT ACCAGCTCGG CTCCCACCTC GAAGACCAGT 360

TCTTTGTACT ACTGTTGCTG TTCGGGAGGA GTGTGCAATG CCCAATATTC CGTGGTCGAA 420

CCGGCACCTC TGGAACTGGG CTCCAATGAG GGACGGACTT CGATCACAAA TCGGGCGACA 480

GAAAAACAGC ACCAGTCCTT TTTGGCCAGT ACAATGCTGG GCCTTGCCGG TGGACTCACA 540

GCCCTCACAA TCGGCATCTT TCTGGCTGTT CAATATTGCC GCACGGCCAA GGAGAAGCCG 600

GAACCGGAGG AGTCGCCTCT GGCACCATCG GGCCCTGGCT ACAGTTCTAA TCTCAGGAAT 660

GTCGACAACA TGAATTTGAT CGGCATGCTG GGGAGCGGCA AGTATGGAAC TGTGATGAAG 720

GGACTGCTCC ACGATCAGGA GGTGGCGGTT AAGATATATC CCGAAGAGCA TCATCAGTAC 780

TATGTGAACG AGAGGAACAT CTATGCCTTG CCTTTGATGG AGTGTCCTGC GCTGTTGAGC 840

TATTTCGGCT ACGATGAACG CTGTACCATG GACGGGCGAA TGGAGTATCA ACTGGTACTA 900

TCACTGGCTC CCCTCGGATG CCTCCAGGAT TGGTTGATAG CCAATACCCT AACTTTCAGC 960

GAATGCTGTG GAATGCTGCG GTCCATCACG CGTGGAATCT CGCACCTGCA CACGGAACTC 1020

CGACTGGGAG ATCAGCATAA GCCCTGTGTG GCTCATCGGG ATATCAACAC AAGGAATGTG 1080

TTGGTCCAAG CTGATCTCAG CTGTTGCATT GCGGACTTTG GTTTCGCTCT CAAGGTGTTT 1140

GGCTCCAAGT ACGAGTACAA GGGCGAGGTG GCCATGGCGG AAACGAAGAG CATCAATGAG 1200

GTGGGCACCC TTCGCTACAT GGCCCCAGAA TTACTGGAAG GAGCTGTAAA TCTGCGGGAT 1260

TGCGAAACCT CGCTGAAGCA AATGGATGTC TATGCCCTGG GCCTGGTGCT GTGGGAAGTG 1320

GCTACCCGCT GCTCGGATTT CTATGCCCCT GGTCAAGCAA CACCTCCCTA CAAAGCACCC 1380

TATGAGCAGG AGGTGGGCTC CCATCCCAGC TTTGATCAAA TGCAGGCGTT GGTGGTGCGG 1440

CACAAGGCGC GTCCCTTATT TCCCACCGGC TGGGGTGGAG GAGCAGCGGC TAAAGTGGTG 1500

CGGGATACTT GCGAGGACTG TTGGGATCAT GATGCGGATG CTAGGCTGAC CTCCCTGTGT 1560

GCCGAGGAGC GCATGCAGGA GATGTCGACT TTAAGGCCAC GAGCACAGGC TCAACCTTCC 1620

AGTCCACTGC TGAATACCAA CAATCTGGTG GCCAGTCCAA CTGCGGAACA GGGAATAAAT 1680

ATCATAGCCA CAACGACAAC GGCGGCTGCA GTCCATCACC AGATGAGCTC CGACACTACG 1740

GGACTTATAC AGCCACCTCC CAATCAGCAG ATACCTCTAG CTGCCTTGGA ACGGGAGAAG 1800

AATCATCTGA GCTACCCGCA ACAGCAATTG CAGCCGTATC AGGGCAGGAA TCCCTGCCAG 1860

GAGCGCAATC TGGCACCTCT GACAATGCGA ACTCCACCGG TTCTTGTGGA GCGGAGCAAG 1920

AAGCACAGTT TCCAGACACA GCCTCAGGAG AACTCACTGT CTTGCTTGGA GCATGATGTG 1980

AGTGTGGAGG AGCTGATAGC CAGCCATCAG CACCAGCAGC AAAAGAACAC GATTGTAAGC 2040

ACAGGTGGAA ATGGCAATTC CTGCTTGGGT CAGGGATTTC CCAAGCAGCA GAACACGGAT 2100

CAAAAACTCC GGGGATGGCA TGGAGTAAGA GCCCTGATCC ACAAGAAACT TTTTCGCAAA 2160

GAGCATGCCG AGGAGCTGTG TCGTCAGTTG CAGTTGGGCG AAGAGAAGTC CAATCTGGTG 2220

ACGGCTCTGC GTCGACCGAA CAACCTGGAT CTTAATCCTC GCCTCGATAA ACCTCCGCCG 2280

GATCAGCTGA GGAGTGCAGA GCAACGGATG GGAACTCCCG CTCACATTGT ACCCCGATCG 2340

CTGTCCAGCA GCCTGATCAA GCACATCAAC GGGACCACCA ACAATAACTC CATCCAGAGT 2400

CATGGTAGCG AATTGCAGAC CCTCACCCGT CCGGCTTCGA AGCGAAGACC AGGTCACCTG 2460

CGCACCAACT CCCTGATGGC CACCACGGGT CAGGGTCCGC CGACGGAGCA GCAAATGCGT 2520

CGTCAGCACA GTCTGGAGGT ATTCCGTGAG GTATTCAGCG GTCGGGGGAG CAGCGAGCGT 2580

TTGAGGGACC CCAGCGAGCG GGTCAAGACG CCGGGAGATG TGCCACCATC CGTACGGAAA 2640

GCCAGGGCCA GCAAGACACT GAGCTTGTAC GACGATCGGA TGATGGACTC CTCCCTGCTC 2700

AACATTCTCT AG 2712

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+ ++g+G+yg+V+k+ l+++evAvKi+++e+++ +++E++iy+++l++++++l++++

Q: 224   MNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFG  283

         57899*******************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

         +d+ +++d ++e++lv+++ + g+L+d+L ++tl+++e++ +++s+++G++hLH+e++

Q: 284   YDErCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLG  343

         ***99***************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee.......ldlaansqvG  172

          +++Kp++aHRD++++N+lv+ dl+cciaD+G+alk+  +k e       ++++++++vG

Q: 344   -DQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEykgevamAETKSINEVG  402

         .569*******************************9999998889999999999******

S: 173   tkRYmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee...vdeeveeyklpfe  228

         t RYmaPE+le+a+nl+d+e ++k++DvY+lgLvlWEva+Rc++   +++++++yk p+e

Q: 403   TLRYMAPELLEGAVNLRDCEtSLKQMDVYALGLVLWEVATRCSDfyaPGQATPPYKAPYE  462

         ********************9***********************9999************

S: 229   evvgsdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvk  288

         ++vgs+Ps+++m+++vv++k+rP +p+ w   +a k++++++e+cWd+d++aRlt+l+ +

Q: 463   QEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAE  522

         ***********************************************************9

S: 289   krl  291

+r+

Q: 523   ERM  525

Domain Sequence
(FASTA)

MNLIGMLGSG KYGTVMKGLL HDQEVAVKIY PEEHHQYYVN ERNIYALPLM ECPALLSYFG 60

YDERCTMDGR MEYQLVLSLA PLGCLQDWLI ANTLTFSECC GMLRSITRGI SHLHTELRLG 120

DQHKPCVAHR DINTRNVLVQ ADLSCCIADF GFALKVFGSK YEYKGEVAMA ETKSINEVGT 180

LRYMAPELLE GAVNLRDCET SLKQMDVYAL GLVLWEVATR CSDFYAPGQA TPPYKAPYEQ 240

EVGSHPSFDQ MQALVVRHKA RPLFPTGWGG GAAAKVVRDT CEDCWDHDAD ARLTSLCAEE 300

RM 302

Keyword

ATP-binding; Nucleotide-binding.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0048813	; P:dendrite morphogenesis
GO:0046331	; P:lateral inhibition
GO:0007528	; P:neuromuscular junction development
GO:0007274	; P:neuromuscular synaptic transmission

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013