EKS-DRM-00202
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00202
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/Aur421.51.1E-12653305253
StatusReviewed
Ensembl ProteinFBpp0079769
UniProt AccessionQ9VKN7; Q9XTQ0;
Protein NameAurora kinase B
Protein Synonyms/Alias IPL1/Aurora-like protein kinase; Serine/threonine-protein kinase Ial; Serine/threonine-protein kinase aurora-B;
Gene Nameial
Gene Synonyms/Alias ial; CG6620;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0024227FBpp0079769FBtr0080180
OrganismDrosophila melanogaster
Functional DescriptionSerine/threonine-protein kinase which mediates bothmeiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates mei-S332 within residues 124-126 and stabilizes its association with centromeres during meiosis.
Protein Length329
Protein Sequence
(FASTA)
MTLSRAKHAN RNHLPHLLAK VPEEHQEPIK NMCLKMMSHD AYGQPYDWSP RDFEMGAHLG 60
RGKFGRVYLA RERHSHYLVA MKVMFKEELR KGCVQRQVLR EIEIQSRLKH PHILRLLTWF 120
HDESRIYLAL EIASEGELFK HLRGAPNHRF DEPRSAKYTY QVANALNYCH LNNVIHRDLK 180
PENILLTSTD DLKLADFGWS AHTPNNKRRT LCGTLDYLPP EMVDGNSYDD SVDQWCLGIL 240
CYEFVVGCPP FESNSTESTY SKIRRMEISY PSHLSKGCKE LIGGLLRKES KGRITLVDVM 300
THYWVKAGMA ERELQLQKRE RGKENTARN 329
Nucleotide Sequence
(FASTA)
ATGACGCTTT CCCGCGCGAA GCACGCCAAC CGCAACCACC TGCCGCACCT GCTGGCCAAG 60
GTGCCCGAGG AGCACCAGGA GCCGATCAAG AATATGTGCC TCAAGATGAT GTCCCACGAC 120
GCATACGGAC AGCCATACGA TTGGAGTCCC CGGGACTTTG AGATGGGCGC CCACTTGGGA 180
CGCGGCAAAT TTGGACGTGT CTACTTGGCG CGGGAGCGCC ACTCGCACTA TCTGGTGGCC 240
ATGAAGGTGA TGTTCAAAGA GGAGCTGCGC AAGGGCTGCG TGCAGCGTCA GGTTCTACGC 300
GAGATCGAGA TCCAGTCGCG ACTGAAGCAC CCGCACATCC TGCGCCTGCT CACTTGGTTC 360
CACGACGAGA GCCGCATCTA TCTGGCCCTG GAAATTGCGT CCGAGGGCGA GCTGTTCAAG 420
CACCTGCGTG GCGCACCCAA TCATCGATTC GATGAACCGC GGTCTGCGAA GTACACCTAC 480
CAAGTGGCGA ATGCCCTCAA CTACTGTCAC CTGAACAACG TGATCCATCG GGATCTGAAG 540
CCGGAGAACA TTCTGCTAAC CAGCACGGAC GACCTTAAGC TGGCCGACTT TGGTTGGTCG 600
GCGCACACGC CGAACAACAA GCGCAGGACT CTGTGCGGCA CCCTGGACTA TCTGCCGCCG 660
GAGATGGTGG ATGGGAACTC CTACGACGAC TCGGTGGACC AGTGGTGCCT GGGCATTCTG 720
TGCTACGAGT TCGTCGTCGG CTGTCCGCCC TTCGAGTCGA ACAGCACGGA GAGCACCTAC 780
AGCAAGATCC GGCGCATGGA GATCTCCTAC CCATCGCATT TGTCCAAGGG CTGCAAGGAA 840
TTGATTGGCG GGCTGCTTCG CAAGGAAAGC AAGGGCCGCA TCACCTTGGT GGATGTGATG 900
ACCCATTATT GGGTGAAGGC GGGAATGGCC GAAAGGGAGC TGCAGCTGCA GAAACGGGAG 960
CGCGGCAAGG AGAACACGGC CAGAAATTGA 990
Domain Profile
S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60
         fe+G +lG+GkfG+vylare++s+++va+kv+fke+l+k +v++q+ reieiqs+lkhp+
Q: 53    FEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPH  112
         9***********************************************************
S: 61    ilrlygyfhdekrvylileyaprGelykelqks..kkldeqraakyieeladalsylhkk  118
         ilrl+++fhde+r+yl le+a++Gel+k+l+ +  +++de r+aky++++a+al+y+h +
Q: 113   ILRLLTWFHDESRIYLALEIASEGELFKHLRGApnHRFDEPRSAKYTYQVANALNYCHLN  172
         *******************************9888*************************
S: 119   kvihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekv  178
         +vihrd+kpen+ll+s+++lkladfGws h+p++kr+tlcGtldylppemv+g++yd++v
Q: 173   NVIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSV  232
         ************************************************************
S: 179   dlwalGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepke  238
         d+w+lG+lcye++vG+ppfes+s+++ty++i+++++++ps++skg+k+li+ ll+ke+k 
Q: 233   DQWCLGILCYEFVVGCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKG  292
         ************************************************************
S: 239   rltladvlahpwi  251
         r+tl+dv++h+w+
Q: 293   RITLVDVMTHYWV  305
         ************8
Domain Sequence
(FASTA)
FEMGAHLGRG KFGRVYLARE RHSHYLVAMK VMFKEELRKG CVQRQVLREI EIQSRLKHPH 60
ILRLLTWFHD ESRIYLALEI ASEGELFKHL RGAPNHRFDE PRSAKYTYQV ANALNYCHLN 120
NVIHRDLKPE NILLTSTDDL KLADFGWSAH TPNNKRRTLC GTLDYLPPEM VDGNSYDDSV 180
DQWCLGILCY EFVVGCPPFE SNSTESTYSK IRRMEISYPS HLSKGCKELI GGLLRKESKG 240
RITLVDVMTH YWV 253
KeywordATP-binding; Cell cycle; Cell division; Chromatin regulator; Chromosome; Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Meiosis; Metal-binding; Mitosis; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Saccharomyces cerevisiae"; ?>
EKS-CAE-00363
EKS-SAC-00044
Gene Ontology
GO:0005737; C:cytoplasm
GO:0000776; C:kinetochore
GO:0030496; C:midbody
GO:0051233; C:spindle midzone
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008608; P:attachment of spindle microtubules to kinetochore
GO:0000910; P:cytokinesis
GO:0016572; P:histone phosphorylation
GO:0007126; P:meiosis
GO:0007076; P:mitotic chromosome condensation
GO:0007052; P:mitotic spindle organization
GO:0022008; P:neurogenesis
KEGG
dme:Dmel_CG6620;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013