EKS-DRM-00097
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00097
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ryk442.09.2E-133317573257
StatusReviewed
Ensembl ProteinFBpp0080765
UniProt AccessionQ9V422; B9EQS2; O62533; Q5BII5; Q95TI0;
Protein NameTyrosine-protein kinase Dnt
Protein Synonyms/Alias Protein doughnut;
Gene Namednt
Gene Synonyms/Alias dnt; CG17559;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0024245FBpp0080765FBtr0081224
OrganismDrosophila melanogaster
Functional DescriptionMay play an essential role in neuronal pathwayrecognition and ventral muscle attachment site selection.
Protein Length584
Protein Sequence
(FASTA)
MESVNKCGKS ASTRNCTVKM SRKMWVLSLL ALAALQLHSG SEVAAHLNVF LNPVEVMRLL 60
GVSAEVYYVR EGHINNYALN FIVPVPANVK DISFTWQSLA GRGLPYSINV VSSDQEVLPR 120
PAINVSHSGE IPTTIQTWSI ALKCSGLKAA EVDVTVSLEV VLNRSLNNVT HLVFRRKKIC 180
LMNDSAEDLS EDVDDPQLLE TVMLPPTGLI TLVVGVSVAM GSVCLLLMIA YCVKGAANKR 240
QHHQHGGQPM RTSSFQRLNT HPPCQSSMGS AAYMTPSIIA PIHGSSLPRK VPVSVEQQHP 300
EELHRRISEL TVERCRVRLS SLLQEGTFGR VYRGTYNDTQ DVLVKTVAQH ASQMQVLLLL 360
QEGMLLYGAS HPGILSVLGV SIEDHTTPFV LYPALNNTRN LKQFLLDPAC ARTVTTIQIV 420
MMASQLSMAL DHLHSHGVVH KDIATRNCVI DDQLRVKLSD SSLSRDLFPS DYNCLGDSEN 480
RPVKWMSLEA LQHKQFSEAS DSWAFGVLMW ELCTSAKQPY AEVDPFEMEH YLKDGYRLAQ 540
PFNCPDELFT IMAYCWALLP AERPTFAQLQ SCLSEFYSQI TRYV 584
Nucleotide Sequence
(FASTA)
ATGGAATCTG TGAATAAATG CGGTAAAAGC GCATCCACAA GAAATTGTAC GGTGAAAATG 60
AGCCGGAAAA TGTGGGTGCT TTCGCTGCTG GCGCTGGCAG CGCTACAACT GCACTCGGGC 120
AGCGAAGTGG CTGCACATTT GAATGTTTTC CTAAATCCCG TGGAAGTAAT GCGTTTATTA 180
GGCGTCTCTG CTGAGGTTTA CTACGTTCGC GAAGGTCATA TAAATAACTA CGCTTTGAAC 240
TTCATTGTAC CAGTTCCGGC GAATGTCAAG GACATTAGTT TCACCTGGCA GTCGCTGGCG 300
GGGCGTGGCC TTCCCTACAG CATCAATGTG GTCAGCTCCG ATCAGGAAGT GCTTCCTCGA 360
CCGGCGATCA ATGTGTCACA CAGTGGGGAA ATCCCCACGA CCATACAAAC CTGGTCCATT 420
GCCCTCAAGT GCAGCGGATT GAAAGCGGCG GAGGTGGATG TGACTGTCAG CCTGGAAGTG 480
GTGCTCAACC GGTCACTGAA CAATGTAACT CATCTGGTGT TTCGGAGGAA GAAGATCTGT 540
CTTATGAATG ACAGTGCCGA GGATTTGTCG GAGGATGTGG ACGATCCCCA GTTGCTGGAG 600
ACCGTAATGT TACCACCCAC TGGATTGATC ACCCTGGTCG TTGGTGTTTC TGTGGCCATG 660
GGATCTGTGT GCCTGCTCCT CATGATTGCC TATTGCGTCA AGGGAGCAGC CAACAAGAGG 720
CAGCATCATC AACACGGAGG ACAGCCCATG AGGACTTCGA GCTTTCAGAG ACTAAATACC 780
CATCCGCCCT GCCAGTCTTC CATGGGATCG GCTGCTTATA TGACGCCTTC GATTATAGCT 840
CCAATTCATG GCTCCTCCTT GCCACGGAAA GTTCCAGTTT CCGTAGAGCA GCAACATCCG 900
GAGGAGCTTC ATCGCCGAAT TTCCGAGTTG ACCGTGGAGC GCTGCAGGGT ACGACTATCG 960
AGTCTCCTGC AGGAAGGAAC GTTTGGACGA GTTTATCGTG GCACCTACAA CGACACTCAG 1020
GATGTTCTGG TCAAAACGGT GGCCCAGCAT GCTAGCCAAA TGCAGGTGCT TCTCCTTCTC 1080
CAGGAAGGAA TGCTGCTCTA TGGCGCCTCT CACCCTGGAA TTCTCTCGGT TCTCGGCGTT 1140
TCCATTGAGG ATCACACCAC ACCGTTTGTC CTCTATCCCG CTCTGAACAA TACCCGCAAC 1200
TTAAAGCAAT TCCTGCTGGA TCCAGCTTGT GCTCGCACTG TGACCACCAT CCAAATTGTG 1260
ATGATGGCCT CGCAACTGTC CATGGCATTG GATCATCTGC ACAGCCATGG AGTGGTGCAT 1320
AAGGATATTG CCACAAGGAA CTGCGTTATT GACGATCAGC TGAGGGTGAA GCTCTCCGAT 1380
AGCTCCCTGT CCCGCGATCT CTTCCCCTCG GACTACAACT GCCTGGGGGA CAGCGAAAAC 1440
AGGCCAGTTA AGTGGATGTC CCTGGAGGCA CTGCAGCACA AACAGTTCTC CGAGGCCAGC 1500
GATTCGTGGG CCTTCGGAGT TCTGATGTGG GAGTTGTGCA CCTCCGCTAA GCAACCCTAC 1560
GCCGAGGTGG ATCCTTTCGA GATGGAGCAC TATCTCAAGG ACGGGTATCG TCTGGCCCAG 1620
CCCTTCAACT GCCCCGATGA GCTGTTTACG ATCATGGCCT ATTGTTGGGC CCTGTTACCT 1680
GCCGAGCGGC CGACCTTCGC CCAGCTGCAG TCTTGTCTCT CCGAATTCTA TTCACAAATC 1740
ACGCGCTATG TCTAG 1755
Domain Profile
S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60
         +rl++llqeGtfGr+yrG+++d++d      vlvktv+++as++qv lllqe++llyg+s
Q: 317   VRLSSLLQEGTFGRVYRGTYNDTQD------VLVKTVAQHASQMQVLLLLQEGMLLYGAS  370
         57899********************......*****************************
S: 61    hrnilsvllvsieeaekPlvvypalnk.gnlkkflricklkdkekaqalstkqlvelaiq  119
         h+ ilsvl+vsie++++P+v+ypaln+ +nlk+fl      d+++a++++t+q+v++a+q
Q: 371   HPGILSVLGVSIEDHTTPFVLYPALNNtRNLKQFL-----LDPACARTVTTIQIVMMASQ  425
         ************************9888*******.....9*******************
S: 120   iasalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkW  179
         +++al++lh+++vvhkdia+rncvidd+l+vkl+ds+lsrdlfP+dy+clGd+enrP+kW
Q: 426   LSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKW  485
         ************************************************************
S: 180   lslealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncP  239
         +slealq++++s+asd+Wa+Gvl+Wel+t++k+Pyae+dpfe+e+ylkdGyrlaqP+ncP
Q: 486   MSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCP  545
         ************************************************************
S: 240   delftvmaccWallpeerPsfeqlvscl  267
         delft+ma+cWallp+erP+f+ql+scl
Q: 546   DELFTIMAYCWALLPAERPTFAQLQSCL  573
         **************************98
Domain Sequence
(FASTA)
VRLSSLLQEG TFGRVYRGTY NDTQDVLVKT VAQHASQMQV LLLLQEGMLL YGASHPGILS 60
VLGVSIEDHT TPFVLYPALN NTRNLKQFLL DPACARTVTT IQIVMMASQL SMALDHLHSH 120
GVVHKDIATR NCVIDDQLRV KLSDSSLSRD LFPSDYNCLG DSENRPVKWM SLEALQHKQF 180
SEASDSWAFG VLMWELCTSA KQPYAEVDPF EMEHYLKDGY RLAQPFNCPD ELFTIMAYCW 240
ALLPAERPTF AQLQSCL 257
KeywordATP-binding; Cell membrane; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00178
EKS-ANC-00181
EKS-BOT-00187
EKS-CAE-00178
EKS-CAJ-00195
EKS-CAF-00194
EKS-CAP-00213
EKS-CII-00123
EKS-CIS-00226
EKS-DAR-00488
EKS-EQC-00183
EKS-FEC-00176
EKS-GAM-00107
EKS-GAG-00162
EKS-GAA-00231
EKS-HOS-00195
EKS-ICT-00181
EKS-LAC-00198
EKS-LOA-00186
EKS-MAM-00190
EKS-MEG-00145
EKS-MOD-00186
EKS-MUM-00192
EKS-MUP-00190
EKS-MYL-00193
EKS-OCP-00118
EKS-ORN-00239
EKS-ORA-00165
EKS-ORC-00171
EKS-ORL-00224
EKS-OTG-00194
EKS-PAT-00180
EKS-PES-00165
EKS-POA-00182
EKS-RAN-00183
EKS-SAH-00182
EKS-SUS-00163
EKS-TAG-00213
EKS-TAR-00245
EKS-TAS-00065
EKS-TEN-00239
EKS-TUT-00176
EKS-VIP-00086
EKS-XET-00220
EKS-XIM-00234
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007411; P:axon guidance
GO:0016204; P:determination of muscle attachment site
GO:0046331; P:lateral inhibition
GO:0007435; P:salivary gland morphogenesis
GO:0007165; P:signal transduction
KEGG
dme:Dmel_CG17559;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR003306; WIF.
Pfam
PF07714; Pkinase_Tyr; 1.
PF02019; WIF; 1.
SMARTs
SM00219; TyrKc; 1.
SM00469; WIF; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50814; WIF; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013