EKS-DRM-00183

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00183

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	337.6	7.9E-101	1189	1449	261

Status

Unreviewed

Ensembl Protein

FBpp0303771

UniProt Accession

Q8MSQ4;

Protein Name

Protein Synonyms/Alias

Mekk1, isoform B; SD09178p;

Gene Name

Mekk1

Gene Synonyms/Alias

Mekk1; CG7717, Dmel_CG7717;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0024329	FBpp0083099	FBtr0083684
FBgn0024329	FBpp0303771	FBtr0331353

Organism

Drosophila melanogaster

Functional Description

Protein Length

1478

Protein Sequence
(FASTA)

MTRNRIGALE EDMPPEDELA AHYEAFGTTP PRTRLKIKNR DWERKQKVVN VTASADLPAS 60

VGGTPKKTRT ARSRVLRRNT MDCALLNEMF VNDESKRTDK RLQSLLRDSE REMKNSLATT 120

AVAAPRGNSF HETAHPLESL DQIMPLNSEA MAPIPLRIAS KVVESCNRYR CVSSRPIGYR 180

SSAPPLAFAA QLPAGMLRSD GRATPGLGKR KDFHETFANL IKLGSVDRQD AKLSQEEHTW 240

QTELKDLIWL ELQAWQADRT VEQQDKYLFE ARQGVSDLLT HIINYKFQPR YRREPSLISL 300

DSGTHSDSNS NASSPLPSKM CQGCMSLYCK DCMDHQELAL REVEGMLTRL EAAEALYPSS 360

QAMGALHPIY KSQSFVGRIK SMCLWYNITK QNKLKLSILG KILARLQDEK FSWPVCTSSY 420

IATDSGSSSA SGVENDDSAV NSMDSSKPPS MAGSASRKGV TPCHKVQFML NDATHVPGET 480

SSSNESTSTE VSQWSSECSH SHMRKGSMHD INIFSVEPLG TCSSNGTGEQ STGLYRKFIE 540

NVLKSRGLAK SLAFLHKLHN VALYKAHIAL EKPGAEDFDY ESDAESIEED VPRLDPEISR 600

EQVVELRTYG YWSEEAQSIN LPSYIPTFVF LSGIPLQFMH EFLRMRLETR PVRPNPLSLE 660

QLMKELREGL TLALTHRERY QRHITTALVE NEAELGSYIS ILNHYDATVR KTFELYLEYI 720

DQLVLVAVPE GNQKSVLEKE WMFTKLISPM IKGMHTLASQ KFCGIISKLL RSISERLVKR 780

TVELDQQIDG TADTDDNEEV KWQLLTICRE TQSLLTVERE RSIKVLFFAK TFCRDVETTD 840

FHREHYEHDV ANQQHDFICS DVKAAFKLLQ QDVLQVRNKL TAIIEGVQKR CCLSNMRDLD 900

EQDKQAVLSR TREILHQGYK FGFEYHKDVI RLFEQKIMDQ KDSGAHTVDL ALGIIAYAKM 960

WMHFVMERCE RGRGMRPRWA SQGLEFLILA CDPQITQHLD DDEFEALKQQ MDRCISHVIG 1020

ITSEPEKVAK KKASPRTRKT SSPATSRSRT PTRTPMSAGM VLNPNTPPLQ SPPYNKLLHP 1080

QFSLKEDVSG TSYSPVDSSD YVDTPCQRSA NGELRLLVPQ TPPTPASPGK SSLESTPLAL 1140

RQERVRDAVN RLDMDLEDGL RERRLIGQVK SLNSSDKVHI RARSVHFRWH RGIKIGQGRF 1200

GKVYTAVNNN TGELMAMKEI AIQPGETRAL KNVAEELKIL EGIKHKNLVR YYGIEVHREE 1260

LLIFMELCSE GTLESLVELT GNLPEALTRR FTAQLLSGVS ELHKHGIVHR DIKTANIFLV 1320

DGSNSLKLGD FGSAVKIQAH TTVPGELQGY VGTQAYMAPE VFTKTNSDGH GRAADIWSVG 1380

CVVVEMASGK RPWAQFDSNF QIMFKVGMGE KPQAPESLSQ EGHDFIDHCL QHDPKRRLTA 1440

VELLEHNFCK YGRDECSSEQ LQMQVRGSFR RNVATSSS 1478

Nucleotide Sequence
(FASTA)

ATGACTCGAA ATCGGATTGG TGCTTTGGAG GAGGACATGC CTCCCGAAGA TGAGCTGGCG 60

GCGCACTATG AGGCCTTCGG CACTACTCCG CCACGTACCA GGCTCAAAAT CAAGAACCGC 120

GACTGGGAAC GCAAACAGAA GGTGGTCAAT GTGACAGCTT CCGCAGACTT ACCGGCCAGT 180

GTGGGTGGCA CCCCCAAAAA GACCAGGACG GCCAGATCCC GCGTCCTGCG GCGCAACACT 240

ATGGACTGCG CCCTGCTCAA CGAGATGTTT GTCAACGATG AGAGCAAGCG GACGGACAAG 300

CGGCTGCAGT CACTCCTTCG CGACTCGGAA CGTGAGATGA AGAACTCGTT GGCCACAACG 360

GCGGTGGCTG CTCCACGAGG TAACAGCTTC CACGAGACAG CTCATCCGCT GGAGTCTCTG 420

GACCAGATCA TGCCGCTCAA TTCGGAGGCA ATGGCGCCGA TTCCACTGCG AATTGCTTCC 480

AAGGTGGTGG AGAGCTGCAA TCGCTATCGC TGCGTGTCCT CACGTCCCAT TGGGTATCGC 540

TCCTCGGCGC CGCCGTTGGC TTTCGCTGCC CAACTTCCCG CTGGAATGCT AAGGAGTGAT 600

GGAAGAGCAA CACCTGGGTT GGGGAAAAGA AAGGACTTCC ACGAAACGTT TGCCAATCTA 660

ATTAAGCTCG GTAGCGTAGA TCGACAGGAC GCCAAACTAT CACAGGAGGA GCACACCTGG 720

CAGACTGAGC TGAAGGATCT CATCTGGCTA GAGCTACAGG CCTGGCAAGC AGACCGAACT 780

GTGGAGCAGC AGGACAAGTA CCTTTTCGAA GCGCGTCAGG GAGTCTCCGA TCTGCTCACC 840

CACATTATAA ACTACAAGTT CCAGCCGCGT TATCGCCGCG AGCCGAGTCT GATAAGCTTG 900

GATAGTGGCA CTCATTCCGA TAGCAATTCT AATGCCAGCT CTCCACTGCC CAGCAAGATG 960

TGCCAAGGAT GCATGTCGCT GTACTGCAAG GATTGCATGG ATCATCAGGA GTTGGCGCTG 1020

CGAGAAGTGG AGGGTATGCT GACGCGCCTG GAAGCTGCAG AGGCACTCTA CCCTTCCTCA 1080

CAGGCCATGG GCGCCCTGCA TCCCATTTAC AAATCACAGA GCTTTGTAGG GCGCATCAAG 1140

TCCATGTGCT TATGGTATAA CATTACCAAG CAGAACAAGT TGAAGCTCAG TATTTTAGGA 1200

AAAATTCTGG CAAGACTGCA GGATGAGAAG TTCTCTTGGC CCGTGTGCAC TTCCTCCTAC 1260

ATCGCCACCG ACAGCGGTAG TTCATCAGCA TCGGGTGTAG AGAACGATGA TTCGGCTGTT 1320

AACTCAATGG ATTCATCAAA GCCGCCCAGT ATGGCCGGAT CAGCCTCGCG AAAGGGTGTG 1380

ACACCGTGCC ACAAAGTGCA ATTCATGTTA AACGACGCCA CCCACGTGCC AGGCGAGACA 1440

TCAAGTAGCA ATGAATCCAC CTCCACGGAG GTAAGCCAGT GGTCCAGCGA GTGCTCTCAC 1500

AGCCATATGC GTAAGGGATC CATGCACGAC ATCAACATTT TCAGTGTCGA GCCATTGGGT 1560

ACGTGCAGCA GCAATGGGAC AGGAGAGCAA TCCACTGGGC TGTATCGCAA GTTCATTGAA 1620

AATGTGCTCA AAAGTCGAGG ACTGGCCAAG TCGCTGGCTT TTCTACACAA GCTGCACAAC 1680

GTGGCATTGT ACAAGGCGCA CATAGCTCTG GAAAAACCCG GAGCTGAAGA CTTCGATTAC 1740

GAGTCGGATG CAGAGTCCAT TGAAGAGGAC GTACCAAGGC TAGATCCTGA AATCAGCCGC 1800

GAACAGGTTG TGGAGCTGCG CACCTACGGC TACTGGAGCG AGGAGGCACA ATCCATAAAC 1860

CTGCCGTCGT ACATTCCCAC CTTTGTATTT CTGAGCGGAA TTCCGTTGCA GTTCATGCAT 1920

GAGTTCTTGC GCATGCGTCT CGAAACCAGA CCCGTTCGAC CCAATCCACT GAGCCTGGAA 1980

CAGTTGATGA AGGAGCTTAG GGAGGGCTTG ACCCTAGCCT TGACCCATCG GGAGCGATAC 2040

CAGCGGCACA TAACCACGGC GCTGGTGGAG AATGAGGCGG AACTGGGCAG TTATATTAGC 2100

ATTTTAAACC ACTACGATGC TACGGTGCGA AAGACTTTCG AGCTGTATTT GGAGTACATC 2160

GATCAACTAG TGCTGGTTGC CGTTCCGGAA GGCAACCAGA AGTCCGTCCT TGAGAAGGAA 2220

TGGATGTTTA CCAAGCTTAT CAGTCCCATG ATAAAGGGCA TGCACACGTT AGCATCTCAA 2280

AAATTCTGTG GCATAATCAG CAAACTTTTG CGGAGCATTT CCGAACGCCT GGTGAAGCGC 2340

ACCGTTGAGC TAGATCAACA GATCGATGGC ACCGCCGATA CCGACGACAA CGAGGAGGTT 2400

AAATGGCAGC TGCTAACCAT TTGCAGAGAG ACACAATCGC TGCTCACAGT CGAACGGGAG 2460

CGCTCCATTA AGGTGCTCTT CTTTGCCAAA ACCTTTTGTC GCGACGTCGA GACGACGGAT 2520

TTTCATCGCG AGCATTATGA ACATGACGTG GCCAACCAGC AGCATGACTT CATCTGTTCG 2580

GACGTAAAGG CGGCGTTCAA GCTCTTGCAG CAGGACGTTC TGCAAGTGCG CAACAAGTTG 2640

ACGGCAATAA TTGAAGGAGT GCAAAAACGG TGCTGTTTGA GCAACATGCG AGATTTGGAT 2700

GAGCAAGACA AACAGGCTGT GCTGTCGCGC ACTCGAGAGA TTTTGCATCA GGGATACAAA 2760

TTTGGATTTG AATATCACAA GGACGTCATT CGGTTGTTCG AGCAGAAGAT TATGGACCAA 2820

AAGGACAGCG GTGCTCACAC AGTAGATCTT GCCTTAGGAA TTATCGCTTA CGCTAAGATG 2880

TGGATGCATT TTGTAATGGA GCGTTGCGAA CGTGGACGAG GAATGCGTCC CCGTTGGGCC 2940

TCCCAGGGTC TGGAGTTTCT GATTCTTGCC TGTGATCCAC AAATCACCCA GCACTTGGAC 3000

GATGACGAGT TTGAGGCGCT AAAGCAGCAA ATGGATCGCT GTATTTCGCA CGTGATTGGC 3060

ATCACCTCGG AACCCGAAAA GGTCGCCAAG AAAAAGGCTT CGCCGCGCAC TCGCAAGACT 3120

TCATCGCCGG CCACCTCGCG TTCCCGGACA CCAACACGGA CTCCAATGTC CGCTGGCATG 3180

GTCCTTAATC CGAATACGCC GCCACTACAG TCGCCACCGT ACAACAAGTT ACTTCATCCG 3240

CAGTTCAGTT TAAAGGAGGA TGTGTCAGGA ACTTCGTACA GTCCCGTTGA CAGTTCAGAC 3300

TATGTTGACA CTCCGTGCCA AAGGAGTGCC AACGGCGAGC TGCGTCTGCT GGTGCCCCAG 3360

ACGCCGCCGA CTCCAGCATC TCCCGGAAAG AGCAGCCTCG AAAGTACACC GCTGGCCTTG 3420

CGGCAGGAAC GTGTTAGAGA TGCCGTCAAC CGTTTGGATA TGGATCTAGA GGACGGGCTA 3480

CGCGAACGAA GGTTGATTGG GCAGGTCAAG TCTCTTAATT CCAGCGACAA GGTGCATATA 3540

AGGGCGCGTA GCGTTCATTT CCGCTGGCAT CGTGGCATTA AGATCGGCCA GGGACGATTC 3600

GGCAAGGTAT ACACGGCGGT GAACAATAAC ACGGGAGAGC TGATGGCCAT GAAAGAGATC 3660

GCAATCCAGC CGGGAGAGAC GCGAGCACTC AAGAATGTGG CCGAAGAGCT AAAGATCTTG 3720

GAAGGAATAA AGCACAAAAA CCTGGTGCGT TACTATGGCA TCGAGGTGCA CCGCGAAGAG 3780

CTGCTTATTT TCATGGAGCT GTGCTCTGAG GGCACCCTCG AGTCACTGGT GGAGCTGACT 3840

GGTAATCTGC CGGAGGCGCT TACGCGACGT TTCACCGCCC AGCTGTTGTC GGGCGTGTCT 3900

GAGCTGCACA AGCATGGCAT TGTGCATCGC GACATCAAGA CTGCTAACAT ATTCCTCGTG 3960

GACGGCAGCA ACAGCCTAAA ACTGGGCGAT TTCGGATCAG CAGTGAAGAT CCAAGCGCAC 4020

ACCACTGTGC CCGGTGAGCT GCAGGGCTAT GTAGGCACGC AGGCCTATAT GGCGCCGGAG 4080

GTTTTCACAA AGACCAACAG CGATGGCCAT GGCAGGGCGG CCGATATCTG GTCGGTGGGC 4140

TGTGTGGTTG TCGAGATGGC CTCGGGCAAG CGTCCTTGGG CCCAGTTTGA TTCCAACTTC 4200

CAGATCATGT TCAAAGTGGG CATGGGCGAG AAGCCGCAGG CACCGGAGAG CCTATCCCAG 4260

GAGGGTCACG ACTTCATCGA TCATTGTCTG CAGCACGATC CCAAGAGGCG TTTAACGGCA 4320

GTGGAACTGT TGGAGCACAA TTTCTGCAAG TACGGTCGAG ACGAGTGCAG CAGTGAGCAG 4380

TTGCAGATGC AGGTGCGAGG CTCTTTCCGG CGAAATGTGG CGACCAGCAG CAGCTAG 4437

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+++  ig+G+fg+vy+a++ +tgel+a+Ke++i+p +++   ++k+++eE+k+l+ +kH

Q: 1189  WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETR---ALKNVAEELKILEGIKH  1245

         89999*****************************999776...79***************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+yyG+ev++eel if+E +++G+l+sl+e +g+l e +++++t q+l+g++ LH++

Q: 1246  KNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKH  1305

         ************************************************************

S: 121   kivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk.  178

         +ivHRDiK+aNi+l   s+ +kl+DFG + +++ ++t+ +el+ ++Gt+aymaPEv++k

Q: 1306  GIVHRDIKTANIFLVDgSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKt  1365

         ************98887*****************************************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +++g+gr+aDiWs+gcvv+em++gkrP+a++d++++imfkvg+ + kP+ pe+ls+eg+d

Q: 1366  NSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGE-KPQAPESLSQEGHD  1424

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+++cl++dpk+r +a eLL+h+f+

Q: 1425  FIDHCLQHDPKRRLTAVELLEHNFC  1449

         ***********************96

Domain Sequence
(FASTA)

WHRGIKIGQG RFGKVYTAVN NNTGELMAMK EIAIQPGETR ALKNVAEELK ILEGIKHKNL 60

VRYYGIEVHR EELLIFMELC SEGTLESLVE LTGNLPEALT RRFTAQLLSG VSELHKHGIV 120

HRDIKTANIF LVDGSNSLKL GDFGSAVKIQ AHTTVPGELQ GYVGTQAYMA PEVFTKTNSD 180

GHGRAADIWS VGCVVVEMAS GKRPWAQFDS NFQIMFKVGM GEKPQAPESL SQEGHDFIDH 240

CLQHDPKRRL TAVELLEHNF C 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0071475	; P:cellular hyperosmotic salinity response
GO:0071243	; P:cellular response to arsenic-containing substance
GO:0071276	; P:cellular response to cadmium ion
GO:0034605	; P:cellular response to heat
GO:0070059	; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0002385	; P:mucosal immune response
GO:0031452	; P:negative regulation of heterochromatin assembly
GO:0045793	; P:positive regulation of cell size
GO:0046330	; P:positive regulation of JNK cascade
GO:0006979	; P:response to oxidative stress

KEGG

dme:Dmel_CG7717

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013