EKS-DRM-00001

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00001

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	468.9	4.0E-141	708	966	259

Status

Unreviewed

Ensembl Protein

FBpp0290500

UniProt Accession

Q9V4E5;

Protein Name

Protein Synonyms/Alias

Eph receptor tyrosine kinase, isoform C;

Gene Name

Eph

Gene Synonyms/Alias

Eph; Dmel_CG1511;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0025936	FBpp0290500	FBtr0301285
FBgn0025936	FBpp0088155	FBtr0089086
FBgn0025936	FBpp0088154	FBtr0089085
FBgn0025936	FBpp0088153	FBtr0089084
FBgn0025936	FBpp0088152	FBtr0089083
FBgn0025936	FBpp0088151	FBtr0089082

Organism

Drosophila melanogaster

Functional Description

Protein Length

1005

Protein Sequence
(FASTA)

MTKSALKSAF YKNQAPISEQ NRSQIVSRMS LLRTILLIII SIHFKLAHAD QVVLLDTTRE 60

ATLEWTRYPY GPQAQTPGWV EESFTDFVKG INWRSYVVCD VAYHNVNNWL WSPFIDRGSA 120

NRLYIEIQFT IRDCSLFPGN ALSCKETFSL LFYEFDAATR EPPPWQTDSY RLIARIAAGE 180

GRFNQNSDVD INTEVKSIAV NKKGVYFAFR DQGACISVLA VKVYYITCPA VTENFAHFNE 240

TPTGREITII EKQNGTCVDN AEPYETPTYL CKGDGKWTIL TGGCRCKAGY EPNYTNKTCT 300

ECPLGTFKSP EVTKCTPCPP NSNASKTGSP FCKCASGFYR HPNDGRHMPC YSPPAAPTNL 360

TLLFVDQTSA IISWSAPAKN ESFSSETNSK IYHSDIVYKI KCNICSPNVV YNPSTDTFNE 420

TKITLTNLEP VTTYTVQIHA INSVSHINEF KRHSNESSLV AVSDIVFSNT SLLNIPLDLN 480

EVKTGQAEIV FTTESVLLST VFNLRILAIT NKDADLEWDK PVQSDFPLEF YEVRWFPKVE 540

LDAINKSALN TKETKAHIVG LLENTEYGFQ VRCKTNNGFG SYSNMIYAQT LQSVGSVYDD 600

SVQIRFIAGA IVTGVLFLVI FIIATVYFMR SKHQDDLDKK STNHLPLPLD YASNEVNSMD 660

TTPIVKKLHL NVTTPLFGNS RSYVDPHTYE DPNQAIREFA REIDANYITI EAIIGGGEFG 720

DVCRGRLKIP PNFVQDIDVA IKTLKPGSSE KARCDFLTEA SIMGQFDHPN VIYLQGVVTR 780

SNPVMIITEY MENGSLDTFL RVNDGKFQTL QLIVMLRGIA SGMSYLSDMN YVHRDLAARN 840

VLVNAQLICK IADFGLSREI ENASDAYTTR GGKIPVRWTA PEAIAFRKFT SASDVWSYGV 900

VLWEVMSYGE RPYWNWSNQD VIKSIEKGYR LPAPMDCPEA LYQLMLDCWQ KQRTHRPTFA 960

SIVSTLDNLA RQPQSLLTTR PSPESDGNHI LDGQRGQNIF ISTDL 1005

Nucleotide Sequence
(FASTA)

ATGACAAAAA GCGCCCTCAA GTCTGCGTTT TACAAAAATC AAGCTCCAAT TAGCGAGCAA 60

AACAGATCTC AAATTGTTTC GAGAATGTCA TTATTAAGGA CAATACTGCT TATTATAATT 120

TCAATTCACT TTAAATTGGC ACATGCAGAT CAGGTTGTTC TATTGGATAC AACTCGAGAA 180

GCTACATTAG AGTGGACCAG GTATCCATAT GGACCTCAAG CCCAAACACC AGGGTGGGTG 240

GAGGAGTCAT TTACCGACTT CGTTAAGGGC ATTAACTGGA GGAGCTATGT GGTTTGCGAT 300

GTGGCATATC ACAACGTCAA TAACTGGTTG TGGTCGCCGT TTATCGATCG TGGATCAGCA 360

AACCGACTTT ACATTGAAAT TCAGTTCACA ATACGCGATT GTTCTTTATT CCCAGGAAAC 420

GCCTTGTCAT GCAAGGAAAC ATTTAGCTTA CTTTTTTACG AGTTTGATGC GGCTACTAGA 480

GAACCTCCAC CATGGCAAAC AGACAGCTAC AGGCTGATTG CTCGCATCGC GGCTGGCGAG 540

GGGCGCTTCA ATCAGAACTC CGATGTAGAT ATTAACACAG AGGTGAAGAG TATAGCCGTC 600

AACAAAAAAG GCGTATATTT TGCTTTCAGA GATCAGGGCG CTTGTATTAG CGTTCTGGCA 660

GTAAAAGTAT ATTATATTAC GTGTCCTGCT GTTACCGAAA ACTTTGCACA CTTTAACGAA 720

ACACCTACGG GAAGAGAAAT TACTATAATT GAGAAACAAA ATGGAACATG TGTCGATAAC 780

GCAGAACCGT ATGAGACGCC AACTTACTTA TGTAAAGGTG ATGGAAAATG GACAATTCTT 840

ACTGGTGGGT GTCGTTGCAA GGCTGGCTAT GAGCCGAATT ACACAAATAA GACTTGTACA 900

GAATGTCCAC TTGGGACATT TAAATCCCCA GAGGTTACAA AATGTACTCC GTGTCCTCCC 960

AATTCAAATG CTTCAAAAAC TGGTTCACCT TTCTGTAAGT GTGCGTCTGG ATTCTATAGA 1020

CATCCAAATG ATGGTCGACA TATGCCGTGT TATAGTCCAC CAGCTGCGCC TACTAATCTC 1080

ACGTTGTTGT TTGTTGATCA AACAAGTGCA ATAATATCTT GGAGCGCACC GGCCAAAAAT 1140

GAATCGTTTT CATCTGAAAC TAATTCTAAA ATATATCACA GTGATATTGT GTACAAGATC 1200

AAGTGTAATA TATGCAGCCC AAATGTGGTT TACAATCCCT CAACTGACAC ATTTAACGAA 1260

ACAAAAATAA CACTTACAAA TCTGGAACCG GTAACGACAT ACACTGTGCA GATACACGCA 1320

ATAAATAGCG TGTCTCATAT TAACGAATTT AAAAGGCACT CCAACGAGTC TTCCCTGGTG 1380

GCAGTCAGTG ACATAGTATT TTCAAATACG TCTTTATTAA ATATACCTTT GGATTTAAAC 1440

GAAGTAAAGA CTGGTCAAGC TGAAATCGTT TTTACAACTG AGTCAGTTTT GCTCTCGACA 1500

GTTTTTAATT TGCGTATATT GGCTATAACT AATAAAGATG CCGATCTAGA ATGGGATAAA 1560

CCTGTTCAAA GTGATTTTCC ACTTGAATTT TATGAAGTGC GCTGGTTTCC AAAGGTCGAA 1620

TTAGATGCTA TAAATAAATC AGCTTTGAAC ACAAAAGAAA CGAAGGCACA TATAGTAGGA 1680

CTTCTAGAAA ATACGGAGTA TGGATTTCAA GTTCGTTGTA AAACGAATAA TGGATTTGGC 1740

TCTTATAGTA ACATGATTTA CGCCCAAACT CTTCAATCCG TTGGTTCAGT ATATGACGAT 1800

TCTGTGCAAA TACGATTTAT TGCTGGAGCC ATCGTGACGG GAGTATTATT TCTAGTCATT 1860

TTTATAATAG CTACAGTATA TTTCATGAGA TCGAAGCATC AGGATGATCT TGATAAAAAA 1920

TCGACAAATC ATTTGCCATT ACCACTTGAC TACGCCAGCA ACGAAGTTAA TTCTATGGAT 1980

ACTACTCCAA TTGTTAAAAA ACTTCATTTA AACGTGACGA CGCCTTTATT TGGAAATAGC 2040

AGAAGCTACG TAGATCCGCA TACCTATGAA GATCCTAATC AAGCTATAAG GGAATTCGCT 2100

CGAGAAATCG ATGCAAACTA CATTACAATA GAAGCTATTA TCGGAGGTGG AGAATTTGGC 2160

GATGTATGTC GTGGTCGATT AAAAATACCC CCAAACTTTG TACAGGACAT TGATGTGGCA 2220

ATAAAGACTT TAAAACCAGG GTCTTCGGAA AAAGCGCGCT GTGATTTCTT GACAGAGGCT 2280

TCTATTATGG GACAGTTTGA TCATCCAAAC GTTATTTATC TACAGGGAGT AGTTACTCGG 2340

TCTAATCCAG TTATGATTAT TACTGAGTAC ATGGAAAATG GCAGCTTAGA CACATTTCTT 2400

CGGGTGAATG ATGGAAAGTT TCAAACATTA CAGCTTATAG TTATGCTTCG GGGTATAGCC 2460

AGCGGGATGT CATATTTAAG TGATATGAAT TATGTACACA GAGACTTGGC GGCACGTAAT 2520

GTTCTTGTAA ATGCCCAATT AATATGCAAA ATCGCGGACT TCGGATTGTC ACGTGAAATT 2580

GAAAATGCAA GTGATGCATA CACAACTCGG GGCGGTAAAA TTCCTGTACG TTGGACTGCG 2640

CCGGAAGCCA TTGCTTTTAG AAAATTTACT TCAGCATCGG ATGTTTGGTC GTATGGAGTA 2700

GTTCTATGGG AGGTCATGTC CTATGGGGAA CGTCCATATT GGAACTGGTC AAATCAGGAC 2760

GTGATAAAGA GTATAGAAAA GGGCTACCGT TTACCAGCTC CGATGGATTG TCCAGAAGCC 2820

CTTTATCAGC TAATGTTGGA TTGCTGGCAA AAGCAACGTA CTCATCGCCC CACATTTGCA 2880

AGTATCGTTT CAACTCTTGA CAATTTGGCA CGACAACCAC AGTCATTATT GACAACACGA 2940

CCCTCGCCAG AATCAGACGG TAATCATATT TTGGATGGAC AGCGCGGTCA AAATATTTTC 3000

ATAAGCACTG ACCTTTGA 3018

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpg..kreiavaiktlkagstekqrrdflseasilGqfd  58

         ++ie +iG+GefG+vc+Grlk+p    ++i vaiktlk gs+ek+r+dfl+easi+Gqfd

Q: 708   ITIEAIIGGGEFGDVCRGRLKIPPnfVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFD  767

         789*******************653689********************************

S: 59    hpniirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkyls  118

         hpn+i l+Gvvt+s+pvmi+teymeng+ld+flr +dg+f+++ql+ mlrGiasgm yls

Q: 768   HPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLS  827

         ************************************************************

S: 119   dmgyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiay  178

         dm+yvhrdlaarn+lvn++l+ck++dfGlsr +e+ s +aytt+ggkip+rwtapeaia+

Q: 828   DMNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS-DAYTTRGGKIPVRWTAPEAIAF  886

         *********************************8877.57********************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyG+vlwev+syGerpyw++snqdvik+ie+gyrlp+pmdcp+alyqlml

Q: 887   RKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLML  946

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqk+r++rp+f++ivs+l

Q: 947   DCWQKQRTHRPTFASIVSTL  966

         *****************985

Domain Sequence
(FASTA)

ITIEAIIGGG EFGDVCRGRL KIPPNFVQDI DVAIKTLKPG SSEKARCDFL TEASIMGQFD 60

HPNVIYLQGV VTRSNPVMII TEYMENGSLD TFLRVNDGKF QTLQLIVMLR GIASGMSYLS 120

DMNYVHRDLA ARNVLVNAQL ICKIADFGLS REIENASDAY TTRGGKIPVR WTAPEAIAFR 180

KFTSASDVWS YGVVLWEVMS YGERPYWNWS NQDVIKSIEK GYRLPAPMDC PEALYQLMLD 240

CWQKQRTHRP TFASIVSTL 259

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0035011	; P:melanotic encapsulation of foreign target
GO:0016319	; P:mushroom body development
GO:0007422	; P:peripheral nervous system development

KEGG

dme:Dmel_CG1511

;

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013