EKS-DRM-00209

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00209

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	441.2	1.7E-132	87	349	263

Status

Unreviewed

Ensembl Protein

FBpp0074061

UniProt Accession

Q961D4;

Protein Name

Protein Synonyms/Alias

LD15203p;

Gene Name

rok

Gene Synonyms/Alias

rok; CG9774;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0026181	FBpp0074061	FBtr0074286

Organism

Drosophila melanogaster

Functional Description

Protein Length

1390

Protein Sequence
(FASTA)

MPAGRETVTK QRSMDVERRR RANTLEREMR DPTSICNVDC LLDTVSALVS DCDHESLRRL 60

KNIEQYAAKY KPLAMQINQL RMNVEDFHFI KLIGAGAFGE VQLVRHKSSS QVYAMKRLSK 120

FEMMKRPDSA FFWEERHIMA HANSEWIVQL HFAFQDAKYL YMVMDFMPGG DIVSLMGDYD 180

IPEKWAIFYT MEVVLALDTI HNMGFVHRDV KPDNMLLDSY GHLKLADFGT CMRMGANGQV 240

VSSNAVGTPD YISPEVLQSQ GVDNEYGREC DWWSVGIFLY EMLFGETPFY ADSLVGTYGK 300

IMDHKNSLSF PPEVEISEQA KALIRAFLTD RTQRLGRYGI EDIKAHPFFR NDTWSFDNIR 360

ESVPPVVPEL SSDDDTRNFE DIERDEKPEE VFPVPKGFDG NHLPFIGFTY TGDYQLLSSD 420

TVDAESKEAN VANSGAASNN HGHGHNHRHR PSNSNELKRL EALLERERGR SEALEQQDAG 480

LRQQIELITK REAELQRIAS EYEKDLALRQ HNYKVAMQKV EQEIELRKKT EALLVETQRN 540

LENEQKTRAR DLNINDKVVS LEKQLLEMEQ SYKTETENTQ KLKKHNAELD FTVKSQEEKV 600

RDMVDMIDTL QKHKEELGQE NAELQALVVQ EKNLRSQLKE MHKEAENKMQ TLINDIERTM 660

CREQKAQEDN RALLEKISDL EKAHAGLDFE LKAAQGRYQQ EVKAHQETEK SRLVSREEAN 720

LQEVKALQSK LNEEKSARIK ADQHSQEKER QLSMLSVDYR QIQLRLQKLE GECRQESEKV 780

AALQSQLDQE HSKRNALLSE LSLHSSEVAH LRSRENQLQK ELSTQREAKR RFEEDLTQLK 840

STHHEALANN RELQAQLEAE QCFSRLYKTQ ANENREESAE RLSKIEDLEE ERVSLKHQVQ 900

VAVARADSEA LARSIAEETV ADLEKEKTIK ELELKDFVMK HRNEINAKEA ALATLKEAEN 960

ELHKKLGQKA AEYEDLVQQH KKQQEELALM RSSKDEEITK LLDKCKNEVL LKQVAVNKLA 1020

EVMNRRDSDL PKQKNKARST AELRKKEKEM RRLQQELSQE RDKFNQLLLK HQDLQQLCAE 1080

EQQLKQKMVM EIDCKATEIE NLQSKLNETA SLSSADNDPE DSQHSSLLSL TQDSVFEGWL 1140

SVPNKQNRRR GHGWKRQYVI VSSRKIIFYN SDIDKHNTTD AVLILDLSKV YHVRSVTQGD 1200

VIRADAKEIP RIFQLLYAGE GASHRPDEQS QLDVSVLHGN CNEERPGTIV HKGHEFVHIT 1260

YHMPTACEVC PKPLWHMFKP PAAYECKRCR NKIHKEHVDK HDPLAPCKLN HDPRSARDML 1320

LLAATPEDQS LWVARLLKRI QKSGYKAASY NNNSTDGSKI SPSQSTRSSY KPYAVNVQRS 1380

ATLPANSSLK 1390

Nucleotide Sequence
(FASTA)

ATGCCAGCTG GACGAGAAAC TGTGACCAAG CAGCGCAGCA TGGATGTGGA ACGAAGGCGC 60

CGGGCGAATA CGCTCGAGCG CGAGATGCGC GATCCGACCA GCATCTGCAA TGTGGACTGC 120

CTGCTGGACA CGGTGTCGGC CTTGGTCAGC GATTGTGACC ACGAGTCCCT GAGGCGGCTT 180

AAGAACATCG AGCAGTATGC GGCCAAATAC AAACCATTGG CAATGCAGAT CAATCAGCTG 240

CGCATGAACG TCGAGGATTT CCATTTTATC AAACTCATCG GCGCCGGCGC CTTTGGAGAG 300

GTGCAGCTGG TGCGGCACAA GTCCTCCAGC CAGGTGTACG CCATGAAGCG GCTGTCCAAA 360

TTCGAGATGA TGAAGCGACC GGACTCCGCG TTCTTCTGGG AGGAGCGACA CATTATGGCG 420

CACGCCAACT CCGAATGGAT CGTTCAGCTG CACTTTGCAT TTCAGGATGC CAAATACCTA 480

TACATGGTGA TGGACTTTAT GCCCGGCGGC GATATAGTCT CGCTGATGGG TGACTACGAC 540

ATCCCGGAGA AGTGGGCCAT CTTTTACACA ATGGAGGTGG TTCTCGCGCT GGACACCATT 600

CACAATATGG GCTTCGTGCA TCGGGACGTT AAGCCGGATA ATATGCTCCT CGACAGCTAT 660

GGCCACCTGA AATTGGCCGA CTTTGGCACC TGTATGCGAA TGGGCGCCAA TGGCCAAGTG 720

GTGTCCAGCA ATGCCGTTGG CACGCCGGAC TACATCAGCC CGGAGGTGCT GCAGTCGCAG 780

GGCGTGGACA ACGAGTACGG GCGGGAATGC GACTGGTGGT CGGTGGGCAT TTTCCTCTAC 840

GAGATGCTGT TCGGCGAGAC ACCATTCTAC GCAGACTCGC TGGTGGGCAC CTACGGCAAG 900

ATCATGGACC ACAAGAACTC GCTTAGCTTT CCACCCGAGG TTGAGATCAG CGAACAGGCG 960

AAGGCACTGA TCCGCGCCTT TCTCACGGAC CGAACGCAAC GTTTGGGTCG CTACGGCATC 1020

GAGGACATTA AGGCGCATCC GTTTTTCCGA AATGATACCT GGTCGTTCGA CAACATTCGC 1080

GAGAGTGTGC CGCCTGTGGT GCCCGAACTC TCCTCCGACG ATGATACGCG AAATTTCGAG 1140

GACATTGAGC GCGATGAGAA GCCGGAGGAA GTGTTTCCCG TACCCAAGGG CTTCGATGGC 1200

AATCACTTGC CCTTCATCGG CTTTACGTAT ACGGGTGACT ATCAGCTGCT GTCTAGCGAC 1260

ACCGTGGATG CGGAGTCGAA GGAGGCCAAT GTGGCAAACA GCGGGGCGGC CAGCAATAAT 1320

CACGGCCACG GTCATAATCA CCGCCATCGG CCGTCGAATT CCAACGAGCT GAAGCGCCTG 1380

GAGGCGCTGC TCGAGCGGGA GCGTGGCAGG TCGGAAGCCT TGGAGCAGCA GGATGCTGGA 1440

CTGCGGCAGC AGATTGAGCT GATAACAAAA CGCGAAGCGG AGCTGCAGAG GATTGCCTCA 1500

GAGTACGAGA AGGATCTGGC TTTGCGTCAA CACAACTACA AGGTGGCCAT GCAGAAGGTG 1560

GAGCAGGAGA TCGAGCTGCG CAAGAAGACG GAGGCACTGC TCGTGGAAAC GCAGCGCAAT 1620

CTGGAAAACG AGCAAAAGAC GCGGGCACGC GACCTCAATA TCAACGACAA GGTGGTCTCA 1680

CTCGAAAAGC AGCTGCTTGA GATGGAGCAG AGCTACAAAA CGGAGACGGA GAACACTCAA 1740

AAGCTGAAAA AGCACAATGC CGAGCTGGAC TTCACGGTCA AGTCGCAGGA GGAGAAGGTG 1800

CGCGACATGG TCGACATGAT CGACACGCTA CAAAAGCATA AGGAGGAGCT CGGCCAGGAG 1860

AATGCCGAGC TGCAGGCGCT GGTGGTGCAG GAGAAGAATC TGCGATCGCA GCTCAAGGAG 1920

ATGCACAAGG AGGCCGAGAA TAAGATGCAG ACGCTGATCA ACGACATTGA ACGTACTATG 1980

TGTCGCGAAC AAAAGGCGCA AGAGGACAAC CGGGCGTTGC TTGAGAAGAT CAGCGACTTG 2040

GAGAAGGCGC ATGCCGGCCT CGACTTCGAA CTGAAGGCGG CCCAGGGCCG CTATCAGCAG 2100

GAGGTCAAGG CACACCAAGA GACGGAGAAG TCGCGGCTCG TCTCCCGCGA GGAGGCCAAT 2160

CTGCAGGAGG TAAAGGCGCT GCAGTCCAAG CTCAACGAGG AGAAGTCCGC TCGCATCAAG 2220

GCCGATCAGC ATTCTCAGGA AAAAGAGCGT CAGCTGAGCA TGCTGTCCGT GGACTATCGC 2280

CAAATCCAAC TACGTCTCCA GAAGCTCGAA GGCGAGTGCC GCCAGGAGTC GGAGAAGGTG 2340

GCCGCTCTGC AGTCACAGCT CGACCAGGAG CACAGCAAAC GCAATGCCTT GCTATCGGAA 2400

CTCAGCCTGC ACAGCTCGGA GGTGGCCCAC CTGCGATCCC GCGAAAACCA GCTACAGAAG 2460

GAACTGTCTA CCCAGCGCGA GGCGAAGCGA CGCTTCGAGG AGGACCTCAC CCAGCTAAAG 2520

AGCACACACC ACGAAGCGCT GGCCAATAAC CGTGAGCTTC AGGCCCAACT CGAGGCGGAG 2580

CAGTGCTTCT CGCGGCTGTA CAAGACACAG GCGAACGAGA ATCGCGAAGA GAGCGCTGAG 2640

CGGCTGTCGA AGATCGAGGA TCTTGAGGAG GAACGCGTCT CACTCAAGCA CCAGGTACAG 2700

GTGGCCGTTG CCCGTGCAGA CTCAGAGGCT TTGGCCCGAT CCATTGCCGA AGAGACGGTG 2760

GCGGATCTCG AAAAGGAGAA GACTATCAAG GAGCTAGAGC TGAAGGACTT CGTCATGAAG 2820

CATCGCAACG AGATCAACGC CAAGGAGGCG GCCCTAGCCA CGCTCAAGGA GGCCGAAAAC 2880

GAACTGCACA AGAAGCTGGG CCAGAAGGCA GCCGAGTACG AGGATCTTGT CCAGCAGCAC 2940

AAGAAGCAGC AGGAGGAGCT TGCGCTGATG AGAAGCAGCA AGGACGAAGA GATCACCAAG 3000

CTGCTGGATA AGTGCAAGAA CGAAGTGCTT CTCAAACAGG TGGCAGTGAA CAAGTTGGCC 3060

GAAGTGATGA ATCGTCGCGA CTCCGACCTG CCCAAACAAA AGAACAAGGC GCGCTCGACA 3120

GCCGAGCTGC GCAAAAAGGA GAAGGAGATG CGTCGGCTGC AGCAGGAGCT CTCGCAGGAG 3180

CGCGACAAGT TCAACCAGCT GCTGCTCAAG CACCAGGACC TGCAGCAGCT GTGCGCCGAG 3240

GAGCAGCAGC TCAAGCAGAA GATGGTCATG GAGATCGATT GCAAGGCCAC CGAGATCGAG 3300

AACCTGCAGA GCAAGCTCAA CGAGACGGCG TCGCTCTCCT CGGCGGACAA CGATCCCGAG 3360

GATAGCCAGC ACTCCTCTCT GCTCTCCCTC ACACAGGACT CGGTCTTCGA GGGCTGGCTA 3420

AGTGTGCCCA ATAAGCAGAA TCGGCGACGT GGCCACGGCT GGAAGCGGCA GTACGTCATT 3480

GTGTCGTCGC GCAAAATCAT CTTCTACAAT TCGGACATTG ACAAGCACAA TACCACGGAT 3540

GCCGTGCTCA TCCTGGACCT GAGCAAGGTG TACCACGTTC GTAGCGTCAC TCAGGGCGAT 3600

GTCATACGCG CCGATGCCAA AGAGATTCCA CGCATATTCC AGCTACTGTA CGCCGGCGAG 3660

GGCGCCTCCC ATCGTCCCGA CGAGCAGAGC CAGTTGGATG TGAGCGTGCT GCACGGTAAT 3720

TGCAACGAGG AGCGCCCGGG CACCATTGTC CACAAAGGTC ACGAGTTCGT TCACATTACC 3780

TACCACATGC CCACGGCTTG CGAGGTGTGC CCGAAGCCTT TGTGGCACAT GTTCAAGCCG 3840

CCGGCGGCTT ACGAATGCAA GAGATGCCGC AACAAGATAC ACAAGGAGCA TGTGGACAAA 3900

CACGACCCGC TGGCGCCCTG TAAGCTCAAT CACGATCCGC GCAGCGCCCG TGACATGCTG 3960

CTGCTGGCCG CCACGCCCGA GGATCAATCG CTGTGGGTGG CGCGCCTGCT GAAGCGTATC 4020

CAAAAGAGTG GATATAAGGC GGCTTCGTAC AACAACAACA GCACCGATGG CAGCAAGATA 4080

TCGCCCAGCC AATCGACGCG CTCCTCCTAC AAGCCGTATG CGGTTAATGT CCAACGCTCC 4140

GCCACGCTGC CAGCCAATTC ATCGCTGAAA TGA 4173

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+++k+iG Gafgev++vr+k++++vyamk l+k+e++kr +saff+eer+++++a+sew

Q: 87    FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEW  146

         7899********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         ivql++afqd kyly+vm++++GGd+++l+ +y+  +pe++a fy++e+vlald++h++g

Q: 147   IVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMG  204

         **********************************..************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         +vhrd+kpdn+lld+ Gh+kladfG+c+++ ++g+v ss+avGtpdyispevl++++  +

Q: 205   FVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQG-VD  263

         ********************************************************9.9*

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         +eyg+ecdwws+G++lye+l+getpfya+slv ty+ki++hk+sl+fp ++++se+ak l

Q: 264   NEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKAL  323

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+r++rlgr gied+k+hpff

Q: 324   IRAFLTDRTQRLGRYGIEDIKAHPFF  349

         *************************9

Domain Sequence
(FASTA)

FHFIKLIGAG AFGEVQLVRH KSSSQVYAMK RLSKFEMMKR PDSAFFWEER HIMAHANSEW 60

IVQLHFAFQD AKYLYMVMDF MPGGDIVSLM GDYDIPEKWA IFYTMEVVLA LDTIHNMGFV 120

HRDVKPDNML LDSYGHLKLA DFGTCMRMGA NGQVVSSNAV GTPDYISPEV LQSQGVDNEY 180

GRECDWWSVG IFLYEMLFGE TPFYADSLVG TYGKIMDHKN SLSFPPEVEI SEQAKALIRA 240

FLTDRTQRLG RYGIEDIKAH PFF 263

Keyword

ATP-binding; Kinase; Metal-binding; Nucleotide-binding; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032065	; P:cortical protein anchoring
GO:0000910	; P:cytokinesis
GO:0007391	; P:dorsal closure
GO:0001737	; P:establishment of imaginal disc-derived wing hair orientation
GO:0045184	; P:establishment of protein localization
GO:0008335	; P:female germline ring canal stabilization
GO:0000092	; P:mitotic anaphase B
GO:0000022	; P:mitotic spindle elongation
GO:0035191	; P:nuclear axial expansion
GO:0007302	; P:nurse cell nucleus anchoring
GO:0016318	; P:ommatidial rotation
GO:0007309	; P:oocyte axis specification
GO:0032231	; P:regulation of actin filament bundle assembly
GO:0050770	; P:regulation of axonogenesis
GO:0008360	; P:regulation of cell shape
GO:2000040	; P:regulation of planar cell polarity pathway involved in axis elongation
GO:0001932	; P:regulation of protein phosphorylation
GO:0007266	; P:Rho protein signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013