EKS-DRM-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	433.6	5.4E-130	127	644	518

Status

Unreviewed

Ensembl Protein

FBpp0070911

UniProt Accession

Q9W3Y1;

Protein Name

Protein Synonyms/Alias

Lethal (1) G0148;

Gene Name

l(1)G0148

Gene Synonyms/Alias

l(1)G0148; Dmel_CG32742;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0028360	FBpp0070911	FBtr0070950

Organism

Drosophila melanogaster

Functional Description

Protein Length

700

Protein Sequence
(FASTA)

MADRVMCQEL ATPGSHYRRP KTGVPSTNVV YANGGGSWRA APRQTQRLPR QTVQQYATGT 60

PATGSAGRHS GRAFATAGAT EEQTVEFNGA AVMGLPATPR TTKQARNKSE EAINDLLTRI 120

PDIGKLFDVH SRIGNGTFST VLLGTLRRES HLPDSLRRKF AIKHHIPTSH PDRIMKELQC 180

MTKMGGKENV VGIHCCMRYD ASAAFVMPFM AHDRFQDFYT RMDVPEIRQY MRNLLVALRH 240

VHKFDVIHRD VKPSNFLYNR RRREFLLVDF GLAQHVNPPA ARSSGSAAAI AAANNKNNNN 300

NNNNNSKRPR ERESKGDVQQ IALDAGLGGA VKRMRLHEES NKMPLKPVND IAPSDAPEQS 360

VDGSNHVQPQ LVQQEQQQLQ PQQQQQQQQQ QQQSQQQQQP QQQSQQQHPQ RQPQLAQMDQ 420

TASTPSGSKY NTNRNVSAAA ANNAKCVCFA NPSVCLNCLM KKEVHASRAG TPGYRPPEVL 480

LKYPDQTTAV DVWAAGVIFL SIMSTVYPFF KAPNDFIALA EIVTIFGDQA IRKTALALDR 540

MITLSQRSRP LNLRKLCLRF RYRSVFSDAK LLKSYESVDG SCEVCRNCDQ YFFNCLCEDS 600

DYLTEPLDAY ECFPPSAYDL LDRLLEINPH KRITAEEALK HPFFTAAEEA EQTEQDQLAN 660

GTPRKMRRQR YQSHRTVAAS QEQVKQQVAL DLQQAAINKL 700

Nucleotide Sequence
(FASTA)

ATGGCCGATC GAGTTATGTG CCAGGAGTTG GCCACACCAG GCAGTCACTA TCGTCGCCCC 60

AAAACGGGAG TGCCCAGCAC CAATGTGGTG TACGCCAATG GTGGCGGATC CTGGCGTGCG 120

GCGCCAAGGC AAACCCAAAG GCTGCCGCGC CAGACCGTTC AGCAATATGC CACCGGCACT 180

CCGGCAACTG GAAGCGCGGG CAGGCATTCG GGCAGAGCAT TCGCCACTGC GGGCGCCACC 240

GAGGAGCAGA CAGTGGAATT CAATGGAGCT GCAGTCATGG GTCTGCCCGC CACGCCGCGT 300

ACAACCAAAC AGGCACGCAA CAAAAGCGAA GAAGCCATCA ATGATCTCCT CACACGAATC 360

CCGGACATTG GCAAGCTGTT CGATGTTCAC AGCCGGATTG GCAACGGAAC CTTTAGCACG 420

GTGCTGCTGG GCACACTGCG CCGGGAATCG CATCTGCCGG ACAGTCTGCG TCGCAAGTTC 480

GCCATCAAGC ATCACATACC AACCAGTCAT CCGGATAGGA TAATGAAGGA GTTGCAGTGC 540

ATGACCAAAA TGGGGGGAAA GGAGAACGTG GTGGGCATCC ACTGTTGCAT GCGTTATGAC 600

GCCTCCGCCG CTTTCGTGAT GCCCTTCATG GCACATGACC GATTCCAGGA CTTTTACACG 660

CGCATGGATG TGCCCGAGAT CCGGCAGTAT ATGCGCAATC TCCTGGTGGC ACTGCGTCAT 720

GTCCACAAGT TCGATGTCAT CCATCGCGAC GTGAAGCCGA GCAACTTTCT CTACAATCGA 780

CGTCGGCGAG AGTTTCTCCT CGTCGATTTC GGTCTGGCCC AGCATGTGAA TCCTCCGGCT 840

GCGCGATCTT CCGGAAGTGC CGCCGCCATC GCCGCAGCCA ACAACAAAAA CAACAACAAT 900

AATAACAATA ATAATAGCAA ACGGCCACGA GAGCGCGAAT CAAAGGGGGA TGTGCAGCAA 960

ATTGCGCTGG ATGCTGGTTT GGGTGGAGCA GTGAAGCGTA TGCGTTTGCA CGAGGAGTCC 1020

AACAAGATGC CCCTGAAACC GGTCAACGAT ATTGCGCCAA GCGATGCGCC GGAGCAGTCA 1080

GTAGATGGGT CCAATCACGT CCAGCCACAG CTAGTGCAGC AAGAGCAGCA ACAACTGCAG 1140

CCGCAACAGC AGCAGCAACA ACAGCAGCAG CAACAACAGT CGCAACAGCA GCAGCAGCCG 1200

CAGCAGCAGT CGCAACAGCA GCACCCACAA CGACAGCCAC AACTGGCGCA GATGGATCAA 1260

ACAGCATCGA CGCCATCTGG CAGCAAGTAC AATACGAATC GAAATGTCTC GGCAGCAGCG 1320

GCTAATAATG CCAAGTGCGT TTGCTTTGCA AATCCCTCAG TTTGCCTCAA CTGTCTGATG 1380

AAGAAGGAGG TGCACGCCTC CAGGGCAGGA ACACCTGGCT ATCGGCCGCC CGAGGTTCTG 1440

CTCAAGTACC CAGATCAGAC CACTGCCGTG GACGTTTGGG CGGCGGGTGT GATATTCCTT 1500

TCGATCATGT CAACGGTGTA TCCGTTTTTC AAAGCGCCCA ACGATTTTAT CGCGCTGGCC 1560

GAGATTGTAA CAATATTTGG AGATCAGGCG ATACGGAAGA CGGCCTTGGC TCTCGACCGT 1620

ATGATCACCC TGAGCCAGAG GTCCAGGCCA CTGAATCTGC GAAAGTTGTG CCTGCGCTTT 1680

CGCTATCGTT CCGTTTTTAG TGATGCCAAG CTCCTCAAGA GCTACGAATC TGTGGACGGA 1740

AGCTGCGAAG TGTGCCGGAA TTGTGATCAA TACTTCTTCA ACTGCCTATG CGAGGATAGC 1800

GATTACTTGA CAGAGCCACT GGACGCATAC GAATGTTTTC CACCCAGCGC CTATGACCTA 1860

CTGGATCGCC TGCTCGAGAT TAATCCCCAT AAACGAATTA CCGCCGAAGA GGCACTAAAG 1920

CATCCATTCT TTACGGCCGC CGAGGAGGCC GAGCAGACGG AGCAGGATCA GTTGGCCAAT 1980

GGAACGCCGC GCAAGATGCG TCGACAAAGA TATCAAAGTC ACAGAACGGT GGCCGCCTCA 2040

CAGGAGCAGG TCAAGCAGCA GGTTGCCCTT GATCTGCAGC AAGCGGCCAT TAACAAGCTG 2100

TGA 2103

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleeglee....kialkhliptshPeriaaeLelltvlgG  56

         f+++++iG+Gtfs+v+l+t+++e++l +    k+a+kh+iptshP+ri++eL+++t++gG

Q: 127   FDVHSRIGNGTFSTVLLGTLRRESHLPDslrrKFAIKHHIPTSHPDRIMKELQCMTKMGG  186

         89*************************99999****************************

S: 57    qenvvglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgi  116

         +envvg+++c+r+++s+++v+p+++h++f+d++++++++e+r+Y+rnLlval++vhkf++

Q: 187   KENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDV  246

         ************************************************************

S: 117   vhrDvkpsnfLynrrlkkfaLvDfGLaq...................seaqkeecsrnll  157

         +hrDvkpsnfLynrr+++f+LvDfGLaq                    ++++++  +n+

Q: 247   IHRDVKPSNFLYNRRRREFLLVDFGLAQhvnppaarssgsaaaiaaaNNKNNNNNNNNNS  306

         ****************************98888888877777776432333333333344

S: 158   saavekevd...................................................  166

         +++ e+e++

Q: 307   KRPRERESKgdvqqialdaglggavkrmrlheesnkmplkpvndiapsdapeqsvdgsnh  366

         4444444449999***********************************************

S: 167   ............................................................  166

Q: 367   vqpqlvqqeqqqlqpqqqqqqqqqqqqsqqqqqpqqqsqqqhpqrqpqlaqmdqtastps  426

         ************************************************************

S: 167   ..................tcdcygtdkvcsvclsrrqqvanraGtpGfraPevLlkipdq  208

                            c c++  +vc  cl +++ +a+raGtpG+r+PevLlk+pdq

Q: 427   gskyntnrnvsaaaannaKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQ  486

         ************************************************************

S: 209   ttaiDiwsaGvilLsllsgryPffkasddlealaeivtilGsreiikaakafgksvllsk  268

         tta+D+w+aGvi+Ls++s+ yPffka++d+ alaeivti+G+++i+k+a a  + ++ls+

Q: 487   TTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLSQ  546

         ***********************************************************9

S: 269   evp.........................................................  271

Q: 547   RSRplnlrklclrfryrsvfsdakllksyesvdgscevcrncdqyffnclcedsdyltep  606

         8766**************************************999999999999999998

S: 272   .dsdsyePdeaydlldkllelnPakritaeealkhpff  308

          d+ ++ P +aydlld+lle+nP+kritaeealkhpff

Q: 607   lDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFF  644

         8888888******************************8

Domain Sequence
(FASTA)

FDVHSRIGNG TFSTVLLGTL RRESHLPDSL RRKFAIKHHI PTSHPDRIMK ELQCMTKMGG 60

KENVVGIHCC MRYDASAAFV MPFMAHDRFQ DFYTRMDVPE IRQYMRNLLV ALRHVHKFDV 120

IHRDVKPSNF LYNRRRREFL LVDFGLAQHV NPPAARSSGS AAAIAAANNK NNNNNNNNNS 180

KRPRERESKG DVQQIALDAG LGGAVKRMRL HEESNKMPLK PVNDIAPSDA PEQSVDGSNH 240

VQPQLVQQEQ QQLQPQQQQQ QQQQQQQSQQ QQQPQQQSQQ QHPQRQPQLA QMDQTASTPS 300

GSKYNTNRNV SAAAANNAKC VCFANPSVCL NCLMKKEVHA SRAGTPGYRP PEVLLKYPDQ 360

TTAVDVWAAG VIFLSIMSTV YPFFKAPNDF IALAEIVTIF GDQAIRKTAL ALDRMITLSQ 420

RSRPLNLRKL CLRFRYRSVF SDAKLLKSYE SVDGSCEVCR NCDQYFFNCL CEDSDYLTEP 480

LDAYECFPPS AYDLLDRLLE INPHKRITAE EALKHPFF 518

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ciona intestinalis"; ?>Ciona savignyi"; ?>Xenopus tropicalis"; ?>

EKS-CII-00088

EKS-CIS-00178

EKS-XET-00132

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0035071	; P:salivary gland cell autophagic cell death

KEGG

dme:Dmel_CG32742

;

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013