EKS-DRM-00169
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00169
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack434.02.3E-130123383261
StatusUnreviewed
Ensembl ProteinFBpp0073067
UniProt AccessionQ9VZI2; Q9U4G3;
Protein Name
Protein Synonyms/Alias Ack; BcDNA.GH10777;
Gene NameAck
Gene Synonyms/Alias Ack; BcDNA.GH10777; CG14992, Dmel_CG14992;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0028484FBpp0073067FBtr0073211
OrganismDrosophila melanogaster
Functional Description
Protein Length1073
Protein Sequence
(FASTA)
MTSTSAVDGG LGSETAWLED LLREVQLEQF LDRIRDDLQV TRLAHFDYVL PDDLERCGLG 60
KPAIRRLMEA VRKKKAHQWR KNILSKLIGG GKQPSSKKQS SAARESSQGN GTQLTCLIHE 120
KDITMGLKLG DGSFGVVRRG EWSASPAGKV IPVAVKVLKS DNLTQPGIID DFFREVQAMH 180
ALDHANLVRL YGVVLSQPMM MITELAERGS LLDTLRKQCR HTSLTIIWNW SVQIVTGMAY 240
LEQKRFLHRD LACRNVLLAA GNKIKIGDFG LMRALPQEDD CYVMSEHKKV PFPWCAPESL 300
RFRQFSHASD TWMFGVTLWE MFSFGEDPWV GLNGSQILRK IDREGERLHQ PDACPPDVYA 360
MMLQCWDKTP AERPTFAALK EYLASMSPPV MRASRSHHES KGLQIEPGDT IAIIDGRHEL 420
KLIKGQNQRT FDIGIFPRNL LEQRKVGAAG DVVMRSSVGN GSSSSPFGFC WGGAAAMANG 480
DDRQRKCASM TNQPHAKERK STSSKQFAYN KLVNDSATGL QRRNAVKHKG VVVGPQRPPP 540
PQFQQEGILI DISPDMRPIA EAGTGGAKGA GDSSSLQADS SFCILDAPID VPTYAGSSGS 600
GDLNVSPTYY NEQPQFDFDP AKMTASPGRL QPPPYQMPPT YSNTMEFVQK RDLHQQQLAT 660
PVRERDPFDT TNVETTVALY SNFNQSLEAA SPPAPIYNSP SVRKSLFGGS KSNKENIPAL 720
ESAAMQLNLS NLTLERHDAT CIQPVEPVPA PPGDGVLLDK SFIAELEKDM YSNGQNRAQE 780
EYQRNSTQMY ASKDMVYKQN LTPLKNGAAP GSVHSNHSSP SSTASPKQNN VEAAAAAAAT 840
TQSVVNRIWY EQVASTQSEY YAQPPTEQAE EQIYQNHRHQ QQQQQELNHS FVAISNRVVA 900
PKNNAYSSTA SLYDAVAAST AGSTYYGQVP NGSGAVLYDE VTQDDYLRPT RPAPLAPPPL 960
SAQQIQRRME KMRLQQQQQL DGAHQLYAPV PSDYGREQEK LQQLMQELGS SAVEQDVRNA 1020
LRAASGDVGL ATRHYKIDQL ARLGVAGRPQ CEQALQQTNW SLEVAAELLL NAG 1073
Nucleotide Sequence
(FASTA)
ATGACCTCCA CTTCGGCGGT GGATGGTGGG CTCGGGAGCG AGACGGCCTG GCTGGAGGAT 60
CTGCTGCGGG AGGTGCAGCT GGAGCAGTTT CTGGACAGGA TACGGGACGA CCTACAGGTG 120
ACCCGGCTGG CGCACTTCGA CTACGTGCTA CCTGACGATC TGGAGCGATG TGGTCTGGGG 180
AAACCGGCTA TTCGACGGCT GATGGAGGCA GTGCGGAAAA AGAAGGCCCA CCAGTGGCGC 240
AAGAACATCC TGTCCAAACT AATTGGCGGT GGCAAGCAAC CCTCGTCCAA GAAGCAGTCC 300
TCCGCCGCCC GGGAATCCAG TCAGGGCAAT GGCACCCAGC TTACCTGCCT TATCCACGAA 360
AAGGACATCA CAATGGGACT GAAACTGGGC GACGGATCAT TCGGTGTGGT GCGTCGCGGC 420
GAATGGAGTG CTTCGCCGGC GGGCAAGGTC ATCCCGGTGG CCGTCAAGGT GCTGAAGTCG 480
GACAACCTCA CCCAACCGGG CATCATCGAT GACTTCTTCC GCGAGGTTCA GGCTATGCAC 540
GCCCTGGATC ATGCGAATCT GGTGCGGCTT TACGGCGTCG TCTTATCCCA GCCGATGATG 600
ATGATTACAG AGCTGGCGGA GCGCGGGTCG CTGCTGGATA CGTTGCGAAA ACAATGCCGC 660
CACACCTCGC TGACCATCAT CTGGAACTGG TCGGTGCAGA TTGTGACTGG CATGGCCTAT 720
CTGGAACAGA AGCGCTTTCT ACATCGCGAT CTGGCATGTC GGAATGTCCT CCTGGCAGCT 780
GGAAACAAGA TCAAGATCGG AGATTTTGGC CTAATGCGTG CCTTGCCCCA AGAGGATGAT 840
TGCTATGTGA TGTCTGAGCA TAAGAAGGTG CCTTTTCCCT GGTGCGCTCC TGAATCGCTG 900
CGCTTCCGGC AGTTCTCGCA CGCCTCTGAC ACCTGGATGT TTGGCGTGAC GCTGTGGGAG 960
ATGTTTAGCT TTGGCGAAGA TCCATGGGTG GGACTCAATG GATCGCAGAT CCTGCGCAAA 1020
ATCGATCGCG AAGGCGAGCG ACTGCATCAG CCGGATGCCT GTCCACCGGA CGTTTATGCT 1080
ATGATGCTGC AATGCTGGGA TAAAACTCCA GCAGAGCGAC CCACTTTTGC TGCTCTCAAA 1140
GAATATTTGG CCAGTATGTC GCCTCCTGTG ATGCGTGCTT CCCGAAGTCA CCACGAGTCC 1200
AAGGGACTGC AGATCGAGCC TGGCGACACA ATCGCCATTA TCGATGGACG GCACGAGCTG 1260
AAATTGATAA AGGGCCAGAA CCAGCGAACA TTCGATATAG GAATCTTTCC CAGAAACCTA 1320
CTGGAGCAGC GCAAAGTGGG TGCTGCCGGA GATGTGGTAA TGCGAAGCAG CGTTGGAAAT 1380
GGTTCGTCGT CTTCGCCATT CGGCTTTTGT TGGGGCGGAG CAGCTGCAAT GGCCAACGGA 1440
GATGATCGAC AGCGAAAGTG TGCCTCGATG ACAAACCAGC CCCATGCCAA GGAGCGCAAG 1500
TCCACGTCCA GCAAGCAGTT TGCGTACAAC AAACTGGTTA ATGATTCCGC TACTGGTCTT 1560
CAGCGACGAA ATGCAGTGAA GCACAAAGGA GTGGTGGTGG GCCCGCAGCG TCCTCCGCCG 1620
CCACAATTTC AACAGGAGGG CATACTCATC GACATCTCGC CCGATATGCG ACCCATAGCC 1680
GAAGCTGGAA CAGGAGGAGC TAAGGGAGCA GGCGATAGTT CCTCACTGCA GGCGGACAGC 1740
TCGTTTTGCA TACTAGACGC TCCCATAGAT GTGCCCACTT ATGCCGGCTC CAGTGGATCG 1800
GGGGATCTTA ATGTCTCGCC CACGTACTAC AATGAGCAGC CGCAGTTCGA CTTTGATCCG 1860
GCCAAGATGA CAGCTTCACC AGGGCGCCTG CAACCGCCGC CGTACCAGAT GCCACCAACT 1920
TACTCGAATA CAATGGAGTT TGTCCAAAAA CGAGACCTTC ACCAACAGCA GCTAGCGACG 1980
CCTGTAAGGG AGCGAGATCC CTTCGACACC ACAAACGTTG AAACGACTGT GGCACTCTAC 2040
TCGAATTTCA ACCAGTCTCT GGAAGCAGCT TCTCCACCAG CACCGATTTA TAATAGTCCT 2100
TCGGTCAGGA AGAGCCTTTT CGGTGGCTCC AAGTCGAATA AAGAAAACAT ACCTGCCCTG 2160
GAATCAGCGG CTATGCAGCT AAATCTCAGT AATCTTACAT TGGAGCGACA CGACGCCACC 2220
TGCATTCAGC CAGTGGAGCC TGTACCTGCT CCTCCTGGTG ATGGAGTACT GCTGGACAAG 2280
TCCTTCATCG CCGAACTGGA GAAGGACATG TACAGCAACG GGCAAAACAG AGCGCAGGAG 2340
GAGTACCAGC GCAATTCTAC GCAGATGTAT GCCAGCAAGG ATATGGTGTA TAAGCAGAAT 2400
CTCACACCCT TAAAGAACGG TGCAGCACCC GGGTCAGTTC ACTCGAATCA TTCCAGTCCC 2460
TCTTCGACCG CGTCGCCCAA GCAGAACAAT GTGGAGGCAG CAGCTGCTGC GGCAGCTACC 2520
ACGCAAAGTG TGGTGAATCG TATTTGGTAT GAGCAAGTGG CGTCCACGCA GTCCGAGTAC 2580
TATGCCCAGC CGCCGACAGA GCAGGCAGAG GAGCAGATCT ACCAAAACCA TCGCCACCAG 2640
CAGCAGCAGC AGCAGGAGTT GAACCATTCG TTTGTTGCAA TATCCAATCG AGTGGTGGCA 2700
CCCAAAAACA ATGCGTACTC CTCAACCGCC TCGCTGTACG ATGCAGTGGC GGCCAGCACG 2760
GCGGGCTCCA CATACTACGG CCAAGTGCCG AATGGCAGTG GAGCTGTTCT GTACGATGAA 2820
GTGACTCAGG ATGACTACCT GCGGCCAACG CGACCAGCTC CATTGGCGCC ACCTCCTCTC 2880
TCCGCGCAGC AGATCCAACG AAGGATGGAG AAGATGCGGC TGCAGCAACA GCAGCAGCTG 2940
GACGGAGCCC ATCAGCTGTA TGCGCCAGTG CCCTCGGACT ACGGTCGCGA GCAGGAGAAG 3000
CTCCAGCAGC TAATGCAAGA GCTGGGCAGC TCCGCGGTGG AGCAGGATGT GCGCAATGCA 3060
CTGCGTGCGG CCAGCGGAGA TGTTGGACTA GCCACGCGGC ACTACAAAAT CGACCAACTG 3120
GCGAGGCTTG GGGTGGCTGG GCGACCACAG TGCGAACAGG CGCTGCAGCA GACCAACTGG 3180
AGCTTAGAGG TGGCAGCTGA ACTACTACTG AATGCCGGCT AA 3222
Domain Profile
S: 1     iklleklGeGsfgvvkrgeWsa.psgksvqvavkvlksdkllstel.ddflrevsvllkl  58
         i+++ klG+Gsfgvv+rgeWsa p+gk+++vavkvlksd+l+++ + ddf+rev+++++l
Q: 123   ITMGLKLGDGSFGVVRRGEWSAsPAGKVIPVAVKVLKSDNLTQPGIiDDFFREVQAMHAL  182
         68899****************999*********************99*************
S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118
         +h+nlvrlyGvvl+qp++++telae+gslld+lrk+++  +++++++++++vqi++g+ay
Q: 183   DHANLVRLYGVVLSQPMMMITELAERGSLLDTLRKQCR--HTSLTIIWNWSVQIVTGMAY  240
         *************************************9..8999****************
S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178
         le+kr++hrdla+rn+lla+ +++ki+dfGl+ral++e+d+yv++e+kkvPf+WcaPesl
Q: 241   LEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESL  300
         ************************************************************
S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238
         r+r+fs+asd+W+fGvtlWemfs+Ge+PWvgl+g+qil+kid+e+erl++P+acp d+y+
Q: 301   RFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYA  360
         ************************************************************
S: 239   lllkcWakkpadrpkfsalkekl  261
         ++l+cW+k+pa+rp+f+alke+l
Q: 361   MMLQCWDKTPAERPTFAALKEYL  383
         *******************9986
Domain Sequence
(FASTA)
ITMGLKLGDG SFGVVRRGEW SASPAGKVIP VAVKVLKSDN LTQPGIIDDF FREVQAMHAL 60
DHANLVRLYG VVLSQPMMMI TELAERGSLL DTLRKQCRHT SLTIIWNWSV QIVTGMAYLE 120
QKRFLHRDLA CRNVLLAAGN KIKIGDFGLM RALPQEDDCY VMSEHKKVPF PWCAPESLRF 180
RQFSHASDTW MFGVTLWEMF SFGEDPWVGL NGSQILRKID REGERLHQPD ACPPDVYAMM 240
LQCWDKTPAE RPTFAALKEY L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00323
EKS-BOT-00345
EKS-CAE-00280
EKS-CAJ-00351
EKS-CAF-00350
EKS-CAP-00379
EKS-CII-00192
EKS-CIS-00099
EKS-DAR-00713
EKS-ECT-00058
EKS-EQC-00337
EKS-ERE-00047
EKS-FEC-00333
EKS-GAA-00426
EKS-GOG-00342
EKS-HOS-00352
EKS-ICT-00326
EKS-LAC-00357
EKS-LOA-00354
EKS-MAM-00346
EKS-MEG-00282
EKS-MOD-00338
EKS-MUM-00377
EKS-MUP-00340
EKS-MYL-00346
EKS-NOL-00315
EKS-OCP-00064
EKS-ORN-00450
EKS-ORC-00324
EKS-ORL-00415
EKS-OTG-00350
EKS-PAT-00328
EKS-PES-00305
EKS-POA-00335
EKS-PRC-00058
EKS-PTV-00086
EKS-RAN-00360
EKS-SUS-00305
EKS-TAG-00421
EKS-TAR-00449
EKS-TEN-00446
EKS-XET-00440
EKS-XIM-00439
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042169; F:SH2 domain binding
GO:0007391; P:dorsal closure
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
dme:Dmel_CG14992;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
SM00165; UBA; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50030; UBA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013