EKS-DRM-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	382.1	1.3E-114	22	263	242

Status

Unreviewed

Ensembl Protein

FBpp0290220

UniProt Accession

Q9W4F8; A9UNA4;

Protein Name

Protein Synonyms/Alias

CG4041; LD42868p;

Gene Name

CG4041

Gene Synonyms/Alias

CG4041, Dmel_CG4041;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0029736	FBpp0290220	FBtr0300998

Organism

Drosophila melanogaster

Functional Description

Protein Length

819

Protein Sequence
(FASTA)

MGTREREREC RLCAVTFFAK LHPGDVCGSN GLPLTPNSIA ILGRAQKLKE LQDEHLCQYL 60

DVIRGKHERT IVVSEYLGLS LEDYAMRHPP LAIAQILRIF YQVACGINVL SRHHLVAHNV 120

EPKHILLSSD GQRVKLFNYG LHHMTKGGAY VPFPIGNIRY MAPERLLGLN GNVKSDVWSL 180

ALVMVELILQ IELWPKLKLS NVVRKILAFG KSNGALEKIA REHQCHERYV QMDQRLRQLL 240

ESCLSVLPKR RPLPGELLEH PIFEEVLLDL KKQKMQPLSP ETEHLPLLLR CPLSQIYHLW 300

QLAGGDVQAE LKKEGLIRSE APILGLPQIV RLSGASVCPG RSQAQLMDDR VVPLRLKALL 360

QRLSGLPAAV YFPLLHSPRF PAHFARELQE LPLVIREKDI EYQFQRVRLF ARLLQGYPHT 420

AEQLQREAAV DVPPLLRGPI WAALLEVVPN GSYAKIDKFT STSTDRQIEV DIPRCHQYDE 480

LLSSPDGHRK LRRLLKAWVT AHPQYVYWQG LDSLTAPFLY LNFNNEELAF LSLFKFIPKY 540

LQWFFLKDNS AVIKEYLSKF SQLTAFHEPL LAQHLASISF IPELFAIPWF LTMFSHVFPL 600

HKILHLWDKL MLGDSSYPLF IGIAILRQLR STLLTSGFNE CILLFSDLPD IVMDGCVLES 660

QKMYEATPKS ITHRQHALRL QPPQALDIGV ADVELKHLQQ EQCPRISAKD VQFLLDNSPA 720

ELALIDLRSV VEFGRVHVPH SINIPFATVQ LGEQRLEALQ VPQLEAQLRG KIVVCVSNIH 780

QHSVEFSHFL VACGVQRTCI LHKGFNVLHS IEPNILISN 819

Nucleotide Sequence
(FASTA)

ATGGGCACGC GGGAGCGCGA AAGGGAGTGC CGCCTGTGCG CGGTCACCTT CTTCGCGAAA 60

CTGCATCCCG GCGACGTGTG CGGCAGCAAC GGCCTGCCCC TAACGCCCAA CTCGATTGCG 120

ATCCTGGGGC GTGCCCAGAA ACTGAAGGAG CTGCAGGACG AGCACCTGTG CCAGTACCTG 180

GATGTGATCC GCGGCAAACA CGAGCGCACC ATTGTGGTTT CGGAGTATCT GGGACTCTCA 240

CTGGAGGACT ACGCCATGCG TCATCCACCG CTGGCCATTG CCCAGATACT GAGAATCTTC 300

TACCAGGTGG CGTGCGGCAT CAATGTGCTG AGTCGACACC ATCTGGTGGC CCACAACGTG 360

GAGCCCAAGC ACATTCTACT CTCCAGCGAT GGGCAGCGGG TGAAGCTCTT CAACTACGGG 420

CTGCATCACA TGACCAAGGG CGGTGCCTAT GTGCCCTTTC CCATTGGCAA CATTCGCTAC 480

ATGGCACCCG AACGACTGCT CGGTCTGAAT GGCAATGTGA AGAGCGACGT TTGGTCGCTG 540

GCCCTGGTAA TGGTGGAGCT AATATTGCAG ATCGAGCTGT GGCCGAAGCT CAAGCTCTCG 600

AATGTGGTTA GAAAGATCCT GGCCTTTGGC AAGAGCAACG GGGCGTTGGA GAAGATTGCG 660

CGAGAGCACC AGTGTCACGA GCGCTATGTG CAGATGGATC AGCGCCTGCG ACAGCTGCTG 720

GAGAGCTGTT TAAGTGTACT GCCCAAGAGG AGACCACTGC CAGGTGAGCT CTTGGAACAT 780

CCCATTTTCG AGGAAGTCCT ATTGGATTTG AAGAAACAGA AGATGCAGCC ACTGAGCCCA 840

GAAACCGAAC ATTTACCGCT GCTGCTGCGA TGTCCCTTGT CGCAGATCTA CCACCTGTGG 900

CAACTGGCCG GCGGAGATGT GCAGGCGGAG CTGAAAAAGG AGGGCCTCAT CCGGAGTGAG 960

GCACCCATTT TGGGTCTGCC ACAAATCGTT CGCCTGAGCG GCGCCAGCGT TTGTCCCGGC 1020

CGAAGCCAGG CGCAGCTGAT GGACGATCGC GTGGTGCCGC TGCGCCTGAA GGCGCTGCTC 1080

CAGCGACTGA GTGGCCTGCC GGCCGCAGTC TACTTTCCCC TGCTCCACTC GCCGCGTTTT 1140

CCCGCCCACT TTGCCCGCGA ATTGCAGGAA CTGCCGCTGG TGATCCGCGA AAAGGACATC 1200

GAGTATCAGT TTCAGCGCGT GCGACTTTTT GCGCGCCTGC TCCAGGGCTA TCCGCATACG 1260

GCGGAGCAGC TGCAGCGCGA GGCAGCCGTG GATGTGCCGC CGCTACTGAG GGGTCCCATT 1320

TGGGCCGCCC TGCTGGAGGT TGTGCCCAAT GGCAGTTACG CGAAGATCGA CAAGTTTACG 1380

TCTACGAGCA CGGATCGGCA GATCGAGGTG GATATACCGC GCTGCCATCA GTACGATGAG 1440

CTGCTCTCCT CGCCGGATGG CCACCGCAAG CTGAGGCGGC TGCTCAAGGC CTGGGTCACC 1500

GCCCATCCGC AGTACGTCTA CTGGCAGGGA CTGGACTCAC TGACGGCACC GTTTCTCTAT 1560

CTCAACTTTA ACAATGAAGA GTTGGCCTTC CTCAGCTTGT TCAAGTTCAT TCCAAAGTAT 1620

CTGCAATGGT TCTTTCTCAA GGATAATTCG GCGGTGATCA AGGAGTACCT GAGCAAGTTC 1680

TCCCAGCTGA CTGCCTTCCA TGAGCCGCTT CTCGCTCAGC ATTTGGCCAG CATTAGCTTT 1740

ATACCCGAGT TGTTTGCCAT CCCGTGGTTC CTAACCATGT TCTCGCATGT ATTCCCGCTG 1800

CACAAGATCC TGCATTTGTG GGATAAACTC ATGCTGGGCG ATAGTTCGTA TCCGCTGTTC 1860

ATTGGCATCG CCATATTGCG CCAGCTGAGA AGCACGCTGC TCACCTCCGG TTTCAACGAG 1920

TGCATCCTGC TCTTCTCCGA CCTGCCCGAT ATCGTGATGG ATGGCTGTGT GCTGGAGTCA 1980

CAGAAGATGT ACGAAGCCAC ACCGAAGAGT ATTACTCATC GCCAGCACGC GTTGCGCCTC 2040

CAGCCGCCAC AGGCGTTGGA CATTGGCGTG GCGGATGTCG AGCTGAAGCA CCTGCAACAG 2100

GAGCAGTGCC CCCGGATCAG CGCCAAGGAT GTGCAATTCC TGTTGGACAA TTCGCCAGCG 2160

GAGCTGGCCC TCATCGATTT GCGCAGTGTA GTCGAGTTCG GACGCGTCCA TGTGCCGCAT 2220

AGCATCAACA TACCGTTCGC CACCGTCCAG TTGGGTGAAC AGCGATTGGA GGCCCTGCAG 2280

GTGCCCCAAT TGGAGGCGCA GCTCCGCGGC AAGATCGTCG TCTGCGTGAG CAATATCCAT 2340

CAGCACTCCG TGGAGTTCTC GCACTTTCTG GTGGCCTGCG GTGTCCAGCG CACCTGTATC 2400

CTTCACAAAG GATTCAACGT CCTGCACTCC ATCGAGCCAA ATATACTCAT CTCGAATTGA 2460

Domain Profile

S: 2     laqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlelsL  61

          + d++GsnGlpl++n++ ilGr+q+Lkelq+++LcqYld++rgkher+ivv+e+l+lsL

Q: 22    HPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGKHERTIVVSEYLGLSL  81

         5789********************************************************

S: 62    eDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyGL  121

         eD++++++p++++++lri+y+v++g+++l++h++v++++epk+ill+++gq+vkL++yGL

Q: 82    EDYAMRHPPLAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLFNYGL  141

         ************************************************************

S: 122   yhltayGkdvdfpigygsylaPerilqdedkllaatvksDvWsLglillelilgikLfae  181

         +h+t++G++v+fpig+++y+aPer+l+     l+++vksDvWsL+l+++elil+i+L+++

Q: 142   HHMTKGGAYVPFPIGNIRYMAPERLLG-----LNGNVKSDVWSLALVMVELILQIELWPK  196

         ***************************.....****************************

S: 182   ldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtllpskRpspde  241

         l+ls++++++l++++++++l+k+a+e++c+++++++d+rl++ll++CL++lp++Rp+p+e

Q: 197   LKLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPLPGE  256

         ************************************************************

S: 242   llkekvf  248

         ll++++f

Q: 257   LLEHPIF  263

         ****997

Domain Sequence
(FASTA)

HPGDVCGSNG LPLTPNSIAI LGRAQKLKEL QDEHLCQYLD VIRGKHERTI VVSEYLGLSL 60

EDYAMRHPPL AIAQILRIFY QVACGINVLS RHHLVAHNVE PKHILLSSDG QRVKLFNYGL 120

HHMTKGGAYV PFPIGNIRYM APERLLGLNG NVKSDVWSLA LVMVELILQI ELWPKLKLSN 180

VVRKILAFGK SNGALEKIAR EHQCHERYVQ MDQRLRQLLE SCLSVLPKRR PLPGELLEHP 240

IF 242

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0007030	; P:Golgi organization
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

dme:Dmel_CG4041

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013