EPS-DRM-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DRM-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	359.1	1.1E-107	168	387	220

Status

Unreviewed

Ensembl Protein

FBpp0071033

UniProt Accession

Q9W3Q1;

Protein Name

Protein Synonyms/Alias

GM14286p; Pyruvate dehydrogenase phosphatase;

Gene Name

Pdp

Gene Synonyms/Alias

Pdp; CG12151, Dmel_CG12151;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0029958	FBpp0298274	FBtr0307273
FBgn0029958	FBpp0071033	FBtr0071076

Organism

Drosophila melanogaster

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

MFKFVLNDAA SYVRSNVREF SLNALRLLPQ LPQLSPYDVN LVLRENEFVY NFPVDGVIRS 60

YETNQLGSNW PCEDSRTEAS FLHRNGFICG IFDGHAGAAC GQVVSKRLLR YVSAATLPRQ 120

VLREQMKQGA DSQSFLKCHN DNVDFVSMIK PMYEASFLKY VNQLLETPQR DVSSELVNAF 180

LQLDEEISQE ALTSNDVRTM NVALSGAVAC LVHIEGLQMH VASTGDCGAV LGVLDPQTQQ 240

WHSKKLNIEH NADNMSEVRR ILAEHPKEEH ETVIRNGRLL SQLAPLRAFG DFRYKWSQEI 300

MQQKVLPMFG VQAMAPNYYT PPYLTARPDV QQHELGPNDK FLVIASDGLW DFLPPSEVVS 360

LVGEHINSKK ILEPMRLPEG DTTLQEISQQ LAERKAGLTR KPVDQNAATH LIRHALGGTD 420

YGIEHSKISY YLTLPRDAVR LYRDDITITV IYFNSEHIAK LHSDVDQTEV TAPVA 475

Nucleotide Sequence
(FASTA)

ATGTTCAAGT TCGTGCTGAA CGACGCCGCC AGCTACGTGC GATCCAATGT GCGGGAGTTC 60

AGTTTGAATG CACTGCGTCT GCTGCCGCAA CTGCCTCAAT TGAGTCCATA CGATGTTAAC 120

CTTGTTCTGA GGGAGAACGA GTTCGTTTAC AACTTTCCCG TGGATGGAGT CATCCGCAGC 180

TATGAAACAA ATCAGCTGGG ATCAAACTGG CCCTGCGAGG ATTCCCGCAC GGAGGCCAGC 240

TTCCTGCACC GCAACGGCTT CATTTGTGGC ATTTTCGACG GGCATGCGGG AGCAGCATGT 300

GGCCAAGTGG TGTCCAAGCG ACTGCTTCGC TATGTTTCGG CGGCCACGCT GCCGCGCCAG 360

GTGCTCCGGG AGCAGATGAA GCAGGGTGCC GACAGCCAGT CGTTCCTCAA GTGCCACAAT 420

GACAACGTGG ACTTTGTTAG CATGATCAAG CCCATGTACG AGGCTAGTTT CCTCAAGTAT 480

GTCAATCAAT TGTTAGAGAC ACCGCAACGG GATGTATCCA GTGAACTGGT GAACGCCTTC 540

CTCCAGCTGG ATGAAGAGAT CTCGCAGGAG GCTCTGACCA GCAACGATGT ACGCACCATG 600

AACGTGGCCC TTTCTGGAGC CGTTGCCTGT TTGGTTCACA TTGAGGGACT GCAGATGCAC 660

GTGGCCAGCA CGGGTGATTG TGGCGCAGTG TTGGGCGTTC TTGATCCCCA GACGCAGCAG 720

TGGCACTCAA AGAAGCTTAA CATCGAACAC AATGCTGACA ATATGTCCGA GGTGCGTCGC 780

ATTCTGGCCG AGCATCCCAA GGAGGAGCAT GAGACGGTGA TCCGAAACGG CAGGCTGCTT 840

AGCCAGCTGG CGCCGTTGCG TGCCTTTGGG GACTTTCGCT ACAAGTGGTC CCAGGAAATA 900

ATGCAGCAGA AGGTGCTGCC GATGTTCGGC GTGCAGGCAA TGGCGCCGAA TTACTATACG 960

CCACCGTACC TAACCGCCCG CCCCGATGTC CAGCAGCACG AATTGGGGCC CAACGACAAG 1020

TTTCTAGTCA TCGCCAGCGA CGGCCTATGG GATTTCCTTC CGCCCAGCGA GGTGGTCAGC 1080

TTGGTGGGGG AGCACATCAA CTCCAAAAAG ATCCTCGAAC CGATGCGCCT GCCGGAAGGC 1140

GATACAACGC TGCAGGAAAT CTCTCAGCAG CTGGCCGAAA GAAAGGCTGG CCTCACTCGC 1200

AAACCCGTAG ACCAAAACGC GGCCACGCAT CTCATCCGGC ATGCTTTGGG CGGCACCGAC 1260

TATGGGATTG AGCACTCGAA GATCTCGTAC TATTTGACGC TGCCCAGGGA CGCGGTGCGT 1320

CTGTATCGCG ACGACATCAC AATCACTGTC ATCTACTTTA ACTCGGAGCA CATTGCCAAG 1380

CTGCACAGCG ATGTGGATCA AACGGAGGTC ACTGCGCCGG TAGCATGA 1428

Domain Profile

S: 1     tdidvkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhva  60

         +++dv+++lvnaf++lde+is+ea++s++++     +++valsGa+acl+h++G+++hva

Q: 168   PQRDVSSELVNAFLQLDEEISQEALTSNDVR-----TMNVALSGAVACLVHIEGLQMHVA  222

         699****************************.....************************

S: 61    ntGdsravlGvqe.edgswsavklsrdhnaqneselerlkaehpkseaktvikedrllgl  119

         +tGd++avlGv++ ++++w+++kl+++hna+n+se++r++aehpk+e++tvi+++rll++

Q: 223   STGDCGAVLGVLDpQTQQWHSKKLNIEHNADNMSEVRRILAEHPKEEHETVIRNGRLLSQ  282

         ************************************************************

S: 120   liplrafGdvkfkwskelqkrvvesgfdvladneykfiapnyytppyltaepevtyhrlr  179

         l+plrafGd+++kws+e+++++v+++f+v      +++apnyytppylta+p+v++h+l+

Q: 283   LAPLRAFGDFRYKWSQEIMQQKVLPMFGV------QAMAPNYYTPPYLTARPDVQQHELG  336

         *****************************......*************************

S: 180   pqdkflvlasdGlwdllsredvvrlvgey...........laeadttltel  219

         p+dkflv+asdGlwd+l++++vv+lvge+           l+e+dttl+e+

Q: 337   PNDKFLVIASDGLWDFLPPSEVVSLVGEHinskkilepmrLPEGDTTLQEI  387

         ************************************************996

Domain Sequence
(FASTA)

PQRDVSSELV NAFLQLDEEI SQEALTSNDV RTMNVALSGA VACLVHIEGL QMHVASTGDC 60

GAVLGVLDPQ TQQWHSKKLN IEHNADNMSE VRRILAEHPK EEHETVIRNG RLLSQLAPLR 120

AFGDFRYKWS QEIMQQKVLP MFGVQAMAPN YYTPPYLTAR PDVQQHELGP NDKFLVIASD 180

GLWDFLPPSE VVSLVGEHIN SKKILEPMRL PEGDTTLQEI 220

Keyword

Complete proteome; Hydrolase; Pyruvate; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0004741	; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

dme:Dmel_CG12151

;

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013