EKS-DRM-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/VEGFR	438.3	2.4E-131	861	1220	360

Status

Unreviewed

Ensembl Protein

FBpp0290552

UniProt Accession

E1JHB7;

Protein Name

Protein Synonyms/Alias

PDGF-and VEGF-receptor related, isoform J;

Gene Name

Pvr

Gene Synonyms/Alias

Pvr; Dmel_CG8222;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0032006	FBpp0291357	FBtr0302147
FBgn0032006	FBpp0292228	FBtr0303109
FBgn0032006	FBpp0304689	FBtr0332416
FBgn0032006	FBpp0292227	FBtr0303108
FBgn0032006	FBpp0290553	FBtr0301339
FBgn0032006	FBpp0079245	FBtr0079626
FBgn0032006	FBpp0290552	FBtr0301338
FBgn0032006	FBpp0079244	FBtr0079625
FBgn0032006	FBpp0089341	FBtr0079628
FBgn0032006	FBpp0304691	FBtr0332418
FBgn0032006	FBpp0304690	FBtr0332417
FBgn0032006	FBpp0291358	FBtr0302148
FBgn0032006	FBpp0089342	FBtr0079629

Organism

Drosophila melanogaster

Functional Description

Protein Length

1468

Protein Sequence
(FASTA)

MAMLPRLILL PLLLILRISW SDAVPLQQFS PDPDDSIENC GGENGAPLMT PCKSAIILDA 60

QTSTTLKCED DEPMSWWTSQ SQYVHVKSFD NTEDPARPFG TSLHLIEVTA DYVAAYYCVK 120

TSKFSQIAKE EQSDEAMIEL VNQGYASSIY VYVNDPDTKL VDSHNVVTAR QYTDVVIPCK 180

PAMPDTEVLL ETSNGEMHSS KSVGRYDPQR GFTIEIRSIV DGGDYYCRPN PPFPHNEEEM 240

TSIEVRFIED GKPLPKPVIR SSVEHHVFTD TNFTLDCEQS AYVESVYGME WFTPSRDENR 300

IFASQSRTDP KTRNSTHQTG RSTLTVLNAQ PSDTGLYKCV TTDNSNQNVQ RATYRIKVLK 360

QNESYLNVGE PSGHYNVQEY ANRTIQMTAN FEGFPTPSFS WFKPDGTEVR QSENNFKILS 420

TELSTMLQVL NAQLQDSGTY VLRGSNSFGV VQREYNVSVM DAPALKMSDA YVQVGSVARL 480

ECTVRSYPPA IVTFFFRPCS LEPQWPTCSV LNQNFSLPSE QEKYQFQTRP RPGKLSVERI 540

YEVSFLPTEP GILTCIAQNI IDGKERRTLT KAHVLLGNIS ENMTIYGFDK DHKIAKEDNV 600

NFTCEALAYH FDGNLKWFIN GEDLKESDSV HIETSHTKYS YKSTVHITTI SDRDRGTYEC 660

RAYHNDKDAV YSSREIDLYV HDPSAPQWTN GGQEGHSKIK RKLSQTLELE CASTAVPVAI 720

VRWFKDDKEV TESKLRHIIE KESKLLITHL YPGDEGVYKC VVENRLDRIE RSFTVVISDL 780

PGISMAWVWF GVILFLILIG LCVFLAVRYQ KEHKRHLALK AAGLANFEEG AVGHINPDLT 840

LDEQAELLPY NREFEFPREN LKLGKQLGAG AFGVVLKGEA KGIRREEPTT TVAVKMVKAT 900

ADNEVVRALV SELKIMVHLG QHLNVVNLLG AVTKNIAKRE LMVIVEYCRF GNIQNFLLRN 960

RKCFINQINP DTDHIDPSIM TQRMSDNYEL HRNSDNDPRS GTRAGRTGSG TATYSYDRQM 1020

DTCATVMTTV PEDDQIMSNN SVQPAWRSNY KTDSTEAMTV TTVDLISWAF QVARGMDYLS 1080

SKKVLHGDLA ARNILLCEDN VVKICDFGLA RSMYRGDNYK KSENGKLPIK WLALESLSDH 1140

VFSTYSDVWS YGIVLWEMFS LAKVPYPGID PNQELFNKLN DGYRMEKPKF ANQELYEIML 1200

ECWRKNPESR PLFAELEKRF ANMLGEDVAS HYLDLNNPYM QSNIEYMKKQ STDYLALMGS 1260

PDELAPAAPR YVNGHIVPDI RIEELPDDYM EMSRDSDPDA CTAIFSPTRL EGESSDFPDF 1320

SSETTFNFPG ARQSPTLSNN LNSGSSKPLR KKNGMPTVDV ADQAPEEIPM LHRSSTGSDG 1380

SPEQGRRFNQ ALKQQYVTPT PSPRHHVETK LNGEPSENYV NMKPPRKNIP GKTTTGGGGA 1440

AAGASTEAFS NPSYQPLSTV NEKEQRRY 1468

Nucleotide Sequence
(FASTA)

ATGGCGATGC TTCCGCGGTT GATTCTGCTG CCACTGCTCC TGATTTTGCG GATCTCGTGG 60

AGCGATGCTG TGCCTTTGCA GCAGTTCTCA CCGGATCCCG ATGACAGCAT CGAGAACTGC 120

GGCGGCGAGA ATGGAGCTCC CCTGATGACG CCCTGCAAGA GCGCCATTAT CCTGGATGCC 180

CAGACGAGCA CCACGCTTAA GTGCGAGGAC GACGAGCCGA TGAGCTGGTG GACCAGTCAA 240

TCGCAATATG TGCATGTGAA GTCCTTCGAT AATACGGAGG ATCCGGCTCG ACCATTCGGA 300

ACTAGCCTGC ATCTCATCGA AGTGACGGCT GACTATGTGG CAGCCTACTA TTGCGTGAAG 360

ACTTCGAAAT TCAGTCAGAT CGCCAAGGAG GAGCAGTCGG ACGAGGCGAT GATCGAATTG 420

GTTAATCAAG GATACGCCAG CTCCATCTAC GTGTACGTGA ATGATCCGGA CACTAAGCTG 480

GTCGATAGTC ATAACGTGGT GACGGCACGC CAGTATACCG ACGTAGTCAT ACCCTGTAAA 540

CCAGCCATGC CGGACACAGA GGTGCTGCTA GAGACCAGTA ATGGAGAAAT GCATTCCAGC 600

AAATCTGTCG GTCGATACGA TCCGCAACGG GGATTCACCA TCGAAATCCG AAGCATCGTG 660

GATGGCGGAG ACTACTACTG CCGACCCAAT CCGCCATTCC CGCATAACGA AGAGGAGATG 720

ACCAGCATAG AAGTGCGCTT TATTGAAGAC GGCAAACCGC TGCCAAAGCC CGTGATCAGG 780

TCCTCCGTGG AGCATCACGT CTTCACGGAC ACCAACTTCA CCCTGGATTG CGAGCAGTCC 840

GCCTACGTTG AATCAGTATA CGGAATGGAA TGGTTCACTC CGTCCCGGGA TGAGAATCGC 900

ATATTTGCCT CCCAATCAAG AACCGATCCC AAGACCAGGA ACAGCACCCA TCAGACGGGC 960

AGGAGCACCT TGACAGTGCT AAATGCACAA CCCTCGGACA CTGGTCTATA CAAGTGTGTG 1020

ACAACAGATA ATTCTAACCA GAACGTACAA CGTGCCACCT ACAGGATTAA GGTGCTAAAG 1080

CAAAACGAAA GTTACCTGAA CGTGGGCGAA CCATCGGGTC ATTACAACGT TCAGGAATAT 1140

GCCAATCGCA CGATCCAAAT GACCGCGAAC TTTGAGGGAT TTCCGACGCC CTCCTTCAGT 1200

TGGTTCAAAC CCGATGGCAC CGAGGTGCGA CAATCGGAGA ATAACTTCAA GATTCTCTCC 1260

ACGGAATTGA GCACAATGCT CCAGGTGCTG AACGCCCAAT TGCAGGACAG CGGCACGTAT 1320

GTCCTCCGTG GATCCAATTC CTTCGGCGTC GTTCAGCGGG AGTACAACGT CAGTGTGATG 1380

GACGCACCGG CGCTGAAGAT GTCGGACGCC TATGTCCAGG TGGGATCCGT GGCGCGACTG 1440

GAGTGCACAG TACGCTCCTA TCCGCCGGCT ATCGTGACCT TCTTCTTCCG CCCCTGCAGC 1500

CTGGAACCAC AGTGGCCCAC TTGCTCTGTG CTCAATCAGA ACTTTAGCTT GCCGAGTGAA 1560

CAGGAGAAAT ATCAGTTCCA GACCCGGCCC AGACCCGGAA AGCTGAGTGT GGAACGCATA 1620

TACGAGGTAT CCTTCCTGCC CACGGAGCCG GGAATCCTCA CATGCATTGC CCAAAATATC 1680

ATTGATGGAA AGGAACGAAG AACCCTGACG AAGGCGCACG TTCTGCTGGG CAACATTTCC 1740

GAGAACATGA CCATATATGG CTTCGATAAG GATCACAAAA TCGCCAAGGA GGACAATGTG 1800

AACTTCACCT GCGAGGCGCT GGCCTATCAC TTCGATGGAA ATCTTAAATG GTTCATCAAT 1860

GGAGAGGATT TGAAGGAGTC GGATTCGGTT CACATTGAGA CCAGCCATAC CAAGTACTCC 1920

TACAAGAGCA CTGTACACAT CACAACGATA TCCGACAGGG ATCGTGGAAC CTATGAGTGC 1980

CGGGCCTACC ACAACGACAA GGATGCCGTT TACAGCAGCC GGGAGATAGA CTTGTACGTC 2040

CACGATCCCT CTGCTCCTCA GTGGACAAAC GGCGGACAGG AGGGTCACTC GAAAATAAAG 2100

CGCAAACTAA GCCAAACGCT GGAGCTGGAG TGTGCCTCCA CAGCGGTTCC CGTGGCAATT 2160

GTGCGTTGGT TTAAGGACGA CAAGGAAGTG ACCGAATCAA AGCTCAGGCA CATCATTGAA 2220

AAGGAATCCA AGCTGCTGAT CACTCACCTG TATCCCGGAG ATGAAGGCGT CTACAAGTGT 2280

GTGGTGGAGA ACCGATTGGA CAGAATCGAA CGCTCCTTCA CGGTAGTGAT ATCAGATCTG 2340

CCCGGCATTA GCATGGCCTG GGTGTGGTTC GGTGTGATAC TATTCCTCAT CCTGATCGGT 2400

CTGTGCGTCT TCCTCGCCGT GCGCTACCAG AAGGAGCACA AGCGGCATCT GGCCCTTAAG 2460

GCAGCCGGAT TGGCCAACTT CGAGGAGGGC GCCGTGGGAC ACATCAATCC CGATCTGACC 2520

CTGGACGAGC AGGCGGAACT GCTGCCCTAC AATCGGGAAT TCGAGTTCCC ACGGGAAAAC 2580

CTGAAACTGG GCAAGCAACT CGGAGCCGGA GCATTTGGCG TTGTGCTCAA GGGCGAGGCC 2640

AAGGGCATCC GGCGAGAGGA GCCCACCACC ACGGTGGCCG TCAAAATGGT CAAGGCGACG 2700

GCTGACAACG AGGTGGTGCG GGCACTGGTC TCCGAGCTCA AGATCATGGT ACATCTGGGA 2760

CAGCACTTGA ATGTGGTCAA TCTCCTGGGT GCAGTTACCA AAAATATTGC GAAGCGCGAA 2820

CTAATGGTCA TTGTGGAATA CTGTCGCTTT GGCAACATAC AGAACTTCCT TCTGAGGAAC 2880

AGAAAGTGCT TTATCAATCA AATCAATCCA GACACCGATC ACATTGACCC CAGCATCATG 2940

ACCCAGCGCA TGTCCGACAA CTACGAACTG CACCGAAATT CGGACAATGA TCCCCGATCG 3000

GGCACCCGAG CCGGACGAAC CGGATCCGGA ACAGCCACCT ACAGCTACGA CCGTCAGATG 3060

GATACCTGTG CCACCGTAAT GACCACCGTC CCAGAAGACG ATCAAATAAT GTCCAATAAC 3120

TCCGTACAAC CCGCCTGGCG TTCCAATTAC AAAACCGACT CCACGGAGGC GATGACAGTG 3180

ACCACTGTGG ATTTGATCAG TTGGGCATTC CAAGTGGCAA GGGGCATGGA TTACTTGTCC 3240

TCCAAGAAGG TGTTGCACGG CGATCTGGCC GCTAGAAATA TTCTCCTCTG CGAGGACAAT 3300

GTGGTAAAGA TTTGTGACTT TGGTCTGGCT CGATCCATGT ATCGAGGTGA TAACTACAAG 3360

AAGTCAGAGA ATGGCAAATT GCCCATCAAG TGGCTGGCGC TGGAATCGCT GAGCGATCAT 3420

GTGTTCAGCA CATACAGCGA TGTTTGGTCC TACGGAATTG TTCTATGGGA GATGTTCTCG 3480

CTGGCCAAGG TGCCGTATCC GGGCATCGAT CCCAACCAAG AGCTATTTAA CAAACTGAAC 3540

GATGGCTACC GCATGGAGAA GCCGAAATTT GCCAACCAGG AGCTCTACGA GATTATGCTA 3600

GAGTGCTGGC GAAAGAATCC CGAGAGCAGA CCTTTGTTTG CTGAGCTGGA GAAGCGATTT 3660

GCAAACATGC TGGGCGAGGA TGTAGCCAGC CACTACCTGG ACCTAAACAA TCCGTACATG 3720

CAGAGCAACA TTGAGTACAT GAAGAAGCAG TCTACGGATT ACCTGGCACT GATGGGATCA 3780

CCCGACGAGC TGGCGCCTGC AGCTCCGCGC TACGTGAACG GGCACATAGT GCCCGATATA 3840

CGCATCGAAG AGCTGCCGGA TGACTACATG GAGATGAGCC GGGATTCTGA TCCCGATGCC 3900

TGCACCGCCA TATTCTCACC CACACGCCTC GAGGGCGAGT CCTCAGACTT TCCGGATTTC 3960

TCTAGCGAAA CCACTTTCAA TTTCCCAGGG GCGCGACAGT CGCCTACGCT GAGTAACAAT 4020

CTCAACAGCG GATCGAGTAA GCCGCTCCGC AAGAAGAACG GCATGCCAAC TGTGGATGTG 4080

GCAGATCAGG CGCCGGAGGA GATACCTATG CTGCATCGCA GCTCCACTGG ATCGGATGGA 4140

AGTCCGGAAC AGGGAAGGCG CTTCAATCAG GCCCTTAAGC AGCAGTATGT CACGCCCACA 4200

CCGTCCCCTC GCCATCATGT GGAGACCAAA CTCAATGGGG AGCCATCCGA AAACTATGTG 4260

AATATGAAGC CACCCAGGAA GAATATACCC GGCAAAACCA CAACAGGTGG CGGGGGTGCT 4320

GCTGCTGGAG CCTCCACGGA GGCCTTCTCG AATCCCAGCT ACCAGCCACT GTCCACCGTC 4380

AACGAGAAGG AGCAACGAAG GTATTAG 4407

Domain Profile

S: 1     lklGkslGeGafGkvveasafgikkeetcktvavkmlkegatasevrallselkilihiG  60

         lklGk+lG+GafG v++++a+gi++ee+++tvavkm+k++a++++vral+selki++h+G

Q: 861   LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLG  920

         79**********************************************************

S: 61    khlnvvnllGactk..akgpllviveyckyGnlsnylrskrdefvlykek.aaelrk..k  115

         +hlnvvnllGa+tk  ak++l+viveyc++Gn++n+l  +r+ f+ + +  + +++

Q: 921   QHLNVVNLLGAVTKniAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPdTDHIDPsiM  980

         **************888********************999*9998654431222221001

S: 116   keale.alevdkkr........................svsssrslassg.....fkeek  145

          + ++ + e++++                         ++ +  +++++      +++++

Q: 981   TQRMSdNYELHRNSdndprsgtragrtgsgtatysydrQMDTCATVMTTVpeddqIMSNN  1040

         222221122111112233557777877766553332221111111222220000022223

S: 146   slsdvee.eeeaedlykepltledlisysfqvarGmeflasrkvihrdlaarnillsenn  204

         s++ + + + +++     ++t+ dlis++fqvarGm++l+s+kv+h+dlaarnill+e+n

Q: 1041  SVQPAWRsNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDN  1100

         333332202334445556799***************************************

S: 205   vvkicdfGlardiykdpdyvrkgdarlPlkWlalesifdkvystksdvWsyGvllWeifs  264

         vvkicdfGlar++y+ ++y+++++ +lP+kWlales++d+v+st+sdvWsyG++lWe+fs

Q: 1101  VVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFS  1160

         ************************************************************

S: 265   lgasPyPgvqineelikrlkeGtrlraPelatpeiyeimldcWkkdPeerPafaelvekl  324

         l+++PyPg++ n+el+++l++G+r+++P++a++e+yeiml+cW+k+Pe+rP fael++++

Q: 1161  LAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF  1220

         ********************************************************9975

Domain Sequence
(FASTA)

LKLGKQLGAG AFGVVLKGEA KGIRREEPTT TVAVKMVKAT ADNEVVRALV SELKIMVHLG 60

QHLNVVNLLG AVTKNIAKRE LMVIVEYCRF GNIQNFLLRN RKCFINQINP DTDHIDPSIM 120

TQRMSDNYEL HRNSDNDPRS GTRAGRTGSG TATYSYDRQM DTCATVMTTV PEDDQIMSNN 180

SVQPAWRSNY KTDSTEAMTV TTVDLISWAF QVARGMDYLS SKKVLHGDLA ARNILLCEDN 240

VVKICDFGLA RSMYRGDNYK KSENGKLPIK WLALESLSDH VFSTYSDVWS YGIVLWEMFS 300

LAKVPYPGID PNQELFNKLN DGYRMEKPKF ANQELYEIML ECWRKNPESR PLFAELEKRF 360

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007015	; P:actin filament organization
GO:0061327	; P:anterior Malpighian tubule development
GO:0019730	; P:antimicrobial humoral response
GO:0007298	; P:border follicle cell migration
GO:0030031	; P:cell projection assembly
GO:0035099	; P:hemocyte migration
GO:0035172	; P:hemocyte proliferation
GO:0048803	; P:imaginal disc-derived male genitalia morphogenesis
GO:0007443	; P:Malpighian tubule morphogenesis
GO:0000022	; P:mitotic spindle elongation
GO:0008360	; P:regulation of cell shape
GO:0045610	; P:regulation of hemocyte differentiation
GO:0006974	; P:response to DNA damage stimulus
GO:0007435	; P:salivary gland morphogenesis
GO:0007419	; P:ventral cord development

KEGG

dme:Dmel_CG8222

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR013106	; Ig_V-set.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.
PF07686	; V-set; 1.

SMARTs

SM00409	; IG; 3.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013