EKS-DRM-00099
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00099
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ryk411.42.0E-123382637256
StatusUnreviewed
Ensembl ProteinFBpp0086907
UniProt AccessionQ7JQT0;
Protein Name
Protein Synonyms/Alias Derailed 2; GH27039p;
Gene NameDrl-2
Gene Synonyms/Alias Drl-2; CG3915, Dmel_CG3915;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0033791FBpp0086907FBtr0087794
OrganismDrosophila melanogaster
Functional Description
Protein Length648
Protein Sequence
(FASTA)
MELLPLKSPL PILLLCLTIS TSVSGYLNIF ISHHEVMKLM GLEADLFYVH EGAINTYAMH 60
FTVPVPADVH ELEFSWQSLI AYPLPYAISI EYNNDQEALG TPTLSIPHKG LVPQEIESFL 120
VYLPCTGNAS LQMPVNVNMV VRAPPRFNDT RLHFKRNKIC AKGISPEPNQ SPAPAHAPSQ 180
GPALLSAAAC ALGLVLAVGL VASMMYVRAR KQLRQDSLHT SFTTAAYGSH QNVFIRLDPL 240
GRPPSATGSY ATIASLNKYP ADSKKSCSIF DRFRSSPTPT PYATALLPMN LEQTAETIYS 300
KPESICPSRI SYYASSQLTQ PCSLSTPKSI RSNGNGNCTS GSGSLSLFGG IPTGSTITMA 360
SHGEKGNQRL RRITSVQPGA LSYEELVKEG TFGRIYAGKL GESCEALVKT VIDGASLTQV 420
ACLLQDASLL IGVSHQHILA PLLANTELPG PPEIAYPHPS KGNLKMYLQK SRESSTALST 480
RQLVEFGLHI TKGLAYLHSL GIVHKDIATR NCYLDEESYV KICDSALSRD LFPDDYDCLG 540
DNENRPLKWL SLESLQKRVY ATQGDVWALG VTYWELVTLA QMPHEEVDIF ELTNYLAAGF 600
RLEQPVNCPD EFFTVMNCCW HCEAKQRPTP SQLLSYLQDF HADLGMYI 648
Nucleotide Sequence
(FASTA)
ATGGAACTCC TTCCTCTGAA GTCGCCCCTC CCGATCCTGC TCCTATGCCT AACCATTTCC 60
ACTTCGGTCA GCGGCTATCT GAACATTTTC ATCAGCCACC ACGAGGTGAT GAAACTGATG 120
GGACTCGAGG CGGACCTGTT CTATGTGCAC GAGGGAGCCA TCAACACATA CGCAATGCAC 180
TTCACCGTCC CAGTGCCCGC GGATGTCCAT GAGCTGGAGT TTTCCTGGCA GAGTCTGATT 240
GCCTACCCAC TGCCATACGC CATTAGTATT GAGTATAACA ACGACCAGGA GGCACTGGGC 300
ACGCCCACGT TGAGCATTCC GCACAAGGGT CTGGTGCCAC AGGAGATCGA GTCCTTCCTG 360
GTTTACCTGC CCTGCACCGG AAATGCGAGC CTACAGATGC CCGTCAATGT CAACATGGTA 420
GTACGGGCTC CTCCTCGATT CAACGACACC CGGCTCCACT TTAAGCGCAA TAAGATCTGC 480
GCCAAAGGCA TCTCACCTGA GCCCAATCAA TCGCCGGCGC CAGCCCACGC ACCCTCCCAA 540
GGACCCGCCC TCCTCAGTGC CGCCGCCTGT GCTCTGGGTT TGGTTTTGGC CGTGGGACTA 600
GTGGCCAGCA TGATGTATGT GAGGGCGCGC AAACAGCTTC GCCAGGACTC GCTACACACC 660
AGTTTCACCA CCGCAGCTTA TGGCAGCCAC CAAAACGTGT TCATCCGACT GGATCCCCTG 720
GGAAGACCGC CGAGTGCCAC GGGATCCTAT GCGACCATTG CCAGCCTCAA CAAATACCCT 780
GCGGACAGCA AAAAGTCGTG CAGCATATTC GACCGTTTCC GGAGCTCACC CACCCCCACG 840
CCGTATGCCA CCGCCCTGCT GCCCATGAAC CTTGAACAGA CCGCAGAGAC GATTTACTCG 900
AAGCCAGAGT CGATCTGTCC CTCGAGGATT TCCTACTACG CCTCCTCGCA ACTGACCCAG 960
CCTTGCAGCC TATCGACGCC GAAGAGCATC CGAAGCAACG GCAATGGCAA CTGCACCAGC 1020
GGAAGTGGCA GCCTAAGCCT TTTTGGAGGC ATCCCCACCG GCAGCACCAT CACCATGGCC 1080
AGTCACGGGG AGAAGGGTAA CCAACGGCTG CGACGGATAA CCAGCGTCCA GCCCGGTGCC 1140
CTCAGCTACG AGGAGCTGGT CAAGGAGGGC ACCTTCGGCC GGATTTACGC CGGCAAGCTG 1200
GGCGAGTCAT GCGAGGCGCT CGTAAAGACC GTCATCGATG GCGCATCGCT CACCCAGGTG 1260
GCCTGCCTGC TGCAGGACGC CTCCCTGCTG ATCGGCGTCA GTCATCAGCA CATCCTGGCA 1320
CCGCTGTTGG CCAACACGGA GCTGCCGGGT CCACCGGAGA TTGCCTATCC CCATCCGTCC 1380
AAGGGCAATC TCAAGATGTA CTTGCAAAAG TCGCGGGAAT CGAGCACAGC ATTGAGTACG 1440
CGCCAACTGG TTGAGTTTGG GCTGCACATC ACCAAGGGAT TGGCCTATCT GCACTCACTG 1500
GGAATCGTTC ACAAGGACAT TGCTACACGC AATTGCTACC TTGACGAAGA GTCCTATGTG 1560
AAGATCTGCG ATAGCGCCCT CTCTCGCGAT CTCTTCCCAG ACGACTACGA CTGTCTGGGC 1620
GACAATGAGA ATCGCCCGCT GAAGTGGCTG TCGCTGGAAT CCCTCCAGAA GCGGGTCTAT 1680
GCCACCCAGG GCGACGTGTG GGCCTTGGGC GTGACCTACT GGGAGCTGGT CACTCTGGCG 1740
CAGATGCCGC ACGAGGAGGT GGATATATTC GAGCTTACCA ATTACTTGGC TGCCGGCTTC 1800
CGGCTGGAGC AGCCAGTCAA CTGCCCAGAT GAATTCTTTA CGGTTATGAA CTGCTGCTGG 1860
CACTGCGAGG CCAAACAGCG ACCTACGCCC TCACAGTTGC TATCGTATCT GCAGGACTTC 1920
CATGCGGATC TGGGCATGTA CATCTAA 1947
Domain Profile
S: 2     rlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvsh  61
         +++el++eGtfGriy+Gkl ++++      +lvktv+d as +qva+llq+a+ll+gvsh
Q: 382   SYEELVKEGTFGRIYAGKLGESCE------ALVKTVIDGASLTQVACLLQDASLLIGVSH  435
         789*********************......9*****************************
S: 62    rnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqia  121
         ++il+ ll+++e  + P ++yp+ +kgnlk++l    +k++e+++alst+qlve++++i+
Q: 436   QHILAPLLANTELPGPPEIAYPHPSKGNLKMYL----QKSRESSTALSTRQLVEFGLHIT  491
         *********************************....9999*******************
S: 122   salaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWls  181
         ++laylh+ ++vhkdia+rnc++d+e++vk++dsalsrdlfP+dydclGdnenrPlkWls
Q: 492   KGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDNENRPLKWLS  551
         ************************************************************
S: 182   lealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPde  241
         le+lqk++y++++dvWalGv++Welvtl+++P++e+d+fel++yl++G+rl+qPvncPde
Q: 552   LESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDE  611
         ************************************************************
S: 242   lftvmaccWallpeerPsfeqlvscl  267
         +ftvm+ccW++++++rP+++ql+s+l
Q: 612   FFTVMNCCWHCEAKQRPTPSQLLSYL  637
         ***********************987
Domain Sequence
(FASTA)
SYEELVKEGT FGRIYAGKLG ESCEALVKTV IDGASLTQVA CLLQDASLLI GVSHQHILAP 60
LLANTELPGP PEIAYPHPSK GNLKMYLQKS RESSTALSTR QLVEFGLHIT KGLAYLHSLG 120
IVHKDIATRN CYLDEESYVK ICDSALSRDL FPDDYDCLGD NENRPLKWLS LESLQKRVYA 180
TQGDVWALGV TYWELVTLAQ MPHEEVDIFE LTNYLAAGFR LEQPVNCPDE FFTVMNCCWH 240
CEAKQRPTPS QLLSYL 256
KeywordComplete proteome; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007435; P:salivary gland morphogenesis
GO:0016055; P:Wnt receptor signaling pathway
KEGG
dme:Dmel_CG3915;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR003306; WIF.
Pfam
PF07714; Pkinase_Tyr; 1.
PF02019; WIF; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50814; WIF; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013