EKS-DRM-00058

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00058

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	327.2	1.0E-97	51	318	268

Status

Unreviewed

Ensembl Protein

FBpp0078604

UniProt Accession

Q9VMY8;

Protein Name

Protein Synonyms/Alias

Auxillin, isoform A; Auxillin, isoform B; SD05837p;

Gene Name

aux

Gene Synonyms/Alias

aux; auxillin; Dmel_CG1107;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0037218	FBpp0078605	FBtr0078966
FBgn0037218	FBpp0078604	FBtr0078965

Organism

Drosophila melanogaster

Functional Description

Protein Length

1165

Protein Sequence
(FASTA)

MGEFFKSLNL NYFSSSEVNG AAGNGAPEAL GGRLDNDFVG QVVEVAGHRL RIKCVIAEGG 60

YAFVYVAQDV QTGTEYALKR LIGADMQAST AIINEINIHK QLSGHENIVA FVGSSYTAPS 120

TQLGAQYLLL TELCKGGSLV DCFRTNNAPF NPTCVLRIFY QMARAVASLH SQSPPIAHRD 180

IKIENFLIGN DKQIKLCDFG SASTEVLSPT FEWSANQRSM LEDQLNTVTT PMYRSPEMLD 240

TWSNNPIGPK VDIWALGCIL YFLCYRKHPY EDGGKLRIIN ANYMLPPDPQ YQCFSDIIRG 300

CLKVNPFERL DITMVLEGLA ALAETHNWSL KGPLDLHIMP IESLPAESPL KSSAYSEVYT 360

EPLSAAIPSS YNGHGSLLSS LRGGAGTLLK NIKDTSTKVM QTMQQSLARN DLDISHITSR 420

ILVMPCPSDG FESTYKTNNI EDVRLSLESR FVPQKLSIYN FGQRTEPRLP PPVRTVEAGS 480

VYGCPQAHAP NLQGLFTVSA DMYNFLNADP KSVVIVQTGD SGGCTAATVI CALLMYADLL 540

REPEDAVQVF AVKRHTINLR PSEFRYLYYF GDILRPTPLL PHYKNTTLVS LSCQPVPRMT 600

KARDGCRIYM EVYCNGNLLL STLQDYEKMR LYQAGPGKIV LPINLTACGD VTVVLFHARK 660

GMVRPQGLKI CQFQFNTGFI PEPETLITFT NQDLDDLPDP EQVTPRFCVS LSLAVTDSES 720

PPSHKPPWMP AKPKRSPAAL FSSDLEYAEM LDNFVTKPST RSSPPPGARK SDRVSSPLVL 780

PDVTETAHEL PSPMPEPSPP IDLLNLNQQP SDVPAADPLT SAKPSTDASF DLLGAFGDDD 840

STGIGSAPIP DILPPPPLQQ PQPKINNDPF DIFGSVDQGG VPSMKPSGFP PFVGSLPTFV 900

AQPAATTNPS PTHPARASAD PFANIADLAT GLNLNFNRST LSGKSPVNTS PQPTQFSSPT 960

HKPSPSSQPQ ATFMHTPPTP QTLPSTSSIR TPTQPQAVPA QSRPDYSRLH FDSQKAAQQP 1020

GTGGSKNSDI FADILGQQGY SFGSKMNQCP RSINEMRKED LFKDMDPKKV RIMEWTDGKK 1080

NNIRALLCSM HTVLWDNAKW QRCEMSTMVT PTEVKKAYRR ACLAVHPDKH NGTENEEIAK 1140

LIFMELNNAW TDFENDATQQ NMFNA 1165

Nucleotide Sequence
(FASTA)

ATGGGCGAGT TCTTTAAGTC GCTCAACCTC AACTACTTCT CCTCTAGCGA GGTCAACGGA 60

GCTGCAGGAA ACGGAGCACC AGAGGCCCTC GGTGGCAGGC TGGACAATGA CTTCGTGGGC 120

CAGGTCGTTG AAGTCGCTGG ACACAGGCTG CGCATCAAGT GTGTCATCGC CGAAGGCGGA 180

TACGCCTTCG TGTATGTAGC CCAAGATGTG CAAACTGGCA CAGAATACGC CCTCAAGCGT 240

CTGATCGGGG CTGACATGCA AGCCTCCACC GCCATCATCA ACGAGATCAA CATCCACAAG 300

CAGCTGTCGG GGCACGAGAA CATTGTCGCC TTTGTGGGTT CCAGTTATAC CGCCCCATCA 360

ACTCAATTGG GAGCCCAGTA CTTGCTCCTC ACCGAGCTGT GTAAAGGCGG ATCTCTGGTG 420

GACTGCTTCA GAACAAACAA TGCTCCATTC AATCCGACTT GTGTTCTGCG CATCTTCTAC 480

CAAATGGCGC GGGCTGTGGC CAGCTTGCAC TCACAGTCAC CGCCGATAGC CCACCGAGAT 540

ATAAAGATTG AGAACTTTCT CATTGGCAAC GACAAACAGA TCAAGCTGTG CGACTTTGGG 600

TCCGCCAGCA CGGAGGTCCT GTCGCCCACG TTTGAGTGGA GCGCCAACCA GCGCAGCATG 660

CTGGAGGACC AGCTAAACAC TGTTACTACT CCGATGTACC GATCCCCTGA GATGCTCGAC 720

ACTTGGTCCA ACAACCCGAT TGGGCCCAAA GTGGACATAT GGGCTCTCGG ATGCATTCTC 780

TACTTCCTGT GCTACCGCAA GCATCCCTAC GAGGATGGCG GAAAGCTGCG GATCATTAAC 840

GCCAATTACA TGCTTCCGCC AGATCCTCAG TACCAGTGCT TCAGCGATAT AATCCGTGGC 900

TGTTTAAAAG TGAACCCGTT CGAGCGCCTG GATATTACTA TGGTGCTGGA GGGCCTTGCA 960

GCCCTCGCTG AGACACACAA TTGGTCGCTC AAAGGACCTC TAGACCTTCA TATAATGCCC 1020

ATCGAGTCCC TTCCGGCCGA AAGTCCTCTC AAAAGTTCTG CTTACTCTGA GGTTTACACC 1080

GAACCGCTTT CTGCCGCCAT ACCATCATCT TATAATGGAC ACGGCAGTCT TCTGTCGTCA 1140

CTGCGTGGTG GCGCTGGAAC GCTTTTAAAG AACATTAAAG ATACGTCCAC CAAAGTGATG 1200

CAAACAATGC AGCAATCTCT TGCTCGCAAC GATCTTGATA TAAGCCACAT TACCTCTCGC 1260

ATCCTGGTAA TGCCCTGCCC CTCTGACGGA TTCGAGTCGA CGTACAAGAC GAACAACATC 1320

GAAGACGTCC GACTATCTCT GGAGAGCCGA TTTGTCCCAC AAAAATTAAG CATTTACAAC 1380

TTTGGCCAAC GAACAGAGCC ACGGCTACCG CCACCCGTGC GAACAGTTGA GGCAGGTTCG 1440

GTTTATGGGT GCCCACAGGC ACATGCTCCT AATCTGCAGG GCCTTTTTAC CGTATCAGCC 1500

GACATGTACA ATTTTCTAAA TGCGGACCCC AAATCTGTCG TTATCGTGCA GACTGGAGAC 1560

TCGGGTGGAT GCACTGCTGC CACCGTTATA TGCGCGCTTC TTATGTATGC AGATTTGCTG 1620

CGGGAGCCGG AGGACGCGGT GCAAGTCTTC GCCGTTAAGC GGCATACCAT TAACCTCCGC 1680

CCCTCCGAGT TCCGTTACCT GTATTACTTC GGTGACATCC TGCGGCCCAC GCCCCTGCTG 1740

CCGCACTATA AGAACACAAC CCTTGTTTCA CTCAGCTGCC AGCCTGTGCC CAGAATGACC 1800

AAGGCACGCG ACGGCTGTAG GATCTATATG GAGGTTTATT GTAATGGAAA CTTGCTACTC 1860

AGCACTCTAC AGGACTATGA AAAAATGCGG TTGTATCAGG CCGGCCCCGG CAAAATAGTT 1920

CTGCCGATTA ACTTGACCGC ATGCGGTGAT GTGACAGTGG TATTATTTCA CGCCCGCAAA 1980

GGAATGGTGC GACCACAAGG CCTCAAGATA TGTCAGTTCC AATTCAACAC GGGATTCATC 2040

CCCGAACCAG AAACGTTGAT TACATTCACA AACCAGGACT TGGATGATCT GCCAGACCCT 2100

GAGCAGGTGA CACCTCGGTT CTGCGTTTCA CTTTCTCTGG CTGTTACTGA CTCGGAATCA 2160

CCTCCCAGCC ATAAGCCACC ATGGATGCCA GCCAAGCCCA AGCGGTCACC CGCCGCTTTG 2220

TTCAGCTCAG ATTTGGAGTA TGCAGAAATG CTCGACAATT TTGTAACCAA GCCTAGCACG 2280

CGTTCCTCAC CACCACCAGG TGCCCGCAAG AGTGATCGCG TCAGCTCTCC GCTCGTTTTG 2340

CCCGACGTCA CGGAGACCGC CCACGAACTG CCTTCGCCCA TGCCAGAGCC ATCTCCGCCC 2400

ATAGACTTGC TCAATTTAAA CCAGCAGCCC AGTGACGTAC CAGCAGCAGA TCCGTTAACC 2460

AGCGCTAAGC CCAGCACAGA TGCCAGCTTT GACTTGCTAG GGGCCTTCGG TGATGATGAC 2520

TCTACGGGCA TAGGATCTGC GCCAATTCCT GACATACTGC CACCACCGCC ACTGCAGCAG 2580

CCGCAACCAA AAATAAACAA TGACCCATTC GACATATTTG GATCTGTGGA CCAAGGTGGC 2640

GTGCCCAGCA TGAAGCCATC AGGCTTTCCA CCTTTCGTTG GCTCCTTACC AACTTTTGTT 2700

GCTCAGCCAG CGGCTACCAC CAATCCTTCA CCAACTCATC CGGCAAGGGC ATCTGCAGAT 2760

CCATTTGCGA ACATCGCCGA CCTGGCGACA GGGCTCAACT TAAACTTTAA CCGCAGCACG 2820

CTAAGTGGAA AGTCTCCCGT CAACACTAGT CCGCAGCCTA CTCAGTTCTC AAGCCCCACT 2880

CACAAGCCAT CGCCATCCTC GCAACCACAA GCAACGTTTA TGCATACACC GCCGACACCG 2940

CAGACTCTGC CCTCGACATC GTCTATCAGG ACGCCGACGC AGCCACAGGC GGTACCTGCT 3000

CAATCAAGAC CAGACTACAG TCGACTTCAC TTTGATTCTC AGAAAGCAGC CCAGCAACCG 3060

GGCACTGGCG GGTCCAAGAA CTCTGACATA TTTGCTGACA TTCTGGGCCA ACAAGGATAC 3120

TCCTTTGGCA GCAAAATGAA CCAGTGTCCA CGATCCATCA ATGAAATGCG CAAGGAAGAT 3180

TTGTTCAAGG ATATGGACCC GAAGAAAGTG CGGATTATGG AATGGACTGA TGGTAAGAAA 3240

AACAACATCC GTGCGCTTCT CTGCTCTATG CACACAGTGT TGTGGGACAA TGCCAAGTGG 3300

CAGCGCTGCG AGATGTCCAC CATGGTGACA CCGACCGAGG TTAAGAAAGC ATACCGTCGC 3360

GCCTGCCTAG CAGTGCATCC TGATAAGCAT AATGGAACAG AGAATGAAGA GATTGCCAAG 3420

CTTATATTTA TGGAACTAAA CAACGCATGG ACAGATTTTG AAAACGATGC CACGCAGCAA 3480

AATATGTTTA ATGCGTAA 3498

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         ri++v+aeGG+a+vy+a+d++tg++yalKr++  +++++++i++Ei+i+k+lsgh+niv

Q: 51    RIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVA  110

         89**********************************************************

S: 62    lvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtravaa  121

         +v ss ++ + +  +++lll+e+ck gslvd+++++++   ++ +++l+i+++++rava+

Q: 111   FVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCFRTNNAP--FNPTCVLRIFYQMARAVAS  168

         **99999999989********************999884..9******************

S: 122   lHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeiekn  178

         lH++s+p++HRD+k+eN+l+ ++++++lcD+GSa+t++l+++   s++++s+l++++++

Q: 169   LHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTfewSANQRSMLEDQLNTV  228

         *****************************************9999***************

S: 179   ttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPen  238

         tt++yrsPE++d++sn++i+ k+DiWaLGc+lY+lc++++P+e+++kl+i+n++y++P++

Q: 229   TTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPD  288

         ************************************************************

S: 239   sryseklkslikkmlevdpeeRptiaqvlel  269

         ++y ++++++i+ +l+v+p eR++i++vle

Q: 289   PQY-QCFSDIIRGCLKVNPFERLDITMVLEG  318

         *99.9**********************9985

Domain Sequence
(FASTA)

RIKCVIAEGG YAFVYVAQDV QTGTEYALKR LIGADMQAST AIINEINIHK QLSGHENIVA 60

FVGSSYTAPS TQLGAQYLLL TELCKGGSLV DCFRTNNAPF NPTCVLRIFY QMARAVASLH 120

SQSPPIAHRD IKIENFLIGN DKQIKLCDFG SASTEVLSPT FEWSANQRSM LEDQLNTVTT 180

PMYRSPEMLD TWSNNPIGPK VDIWALGCIL YFLCYRKHPY EDGGKLRIIN ANYMLPPDPQ 240

YQCFSDIIRG CLKVNPFERL DITMVLEG 268

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001745	; P:compound eye morphogenesis
GO:0007219	; P:Notch signaling pathway
GO:0007291	; P:sperm individualization
GO:0016191	; P:synaptic vesicle uncoating

KEGG

dme:Dmel_CG1107

;

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013