EKS-DRM-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	413.1	5.7E-124	1729	2023	295

Status

Unreviewed

Ensembl Protein

FBpp0111700

UniProt Accession

Q9VDJ9; Q0Q7G2;

Protein Name

Protein Synonyms/Alias

Leucine-rich repeat kinase;

Gene Name

Lrrk

Gene Synonyms/Alias

Lrrk; lrrk; Dmel_CG5483;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0038816	FBpp0111700	FBtr0112788

Organism

Drosophila melanogaster

Functional Description

Protein Length

2445

Protein Sequence
(FASTA)

MEHPKTGTET ALEACDYFVD EVIEASSIRD AREEVRQIKH GELRTAVISG DERTVRVLLA 60

ALGTERQIIV NMAPSGANTL LFLACQSGYE SITQRLLDAG ADGRSHAVTK YSPLYAAVHS 120

GHLGIARLML DHFPELIQQP TVERWLPLHA ACINGHIKLL ELLISYSYPD YLYQTYRDEE 180

GQWEWRLPFD ANAHDVTGQT SLYIASILGN KQLVGVLLKW QLHCRRTLGD SASSVSTPIT 240

PTRKRISFGI QAIMSKLHIS GESEGPDDLA SQESTECQRC PINVNLLCGA ARETALLAAV 300

RGGHLDVVQS LLQHGANPNI VAKPVEDHND PKCCEEIYGL SNVPIAEACK QRSLAMLDLL 360

LKHGARDDNG TAIGMAITCG DEAILSRLLA RRVHPDSDYK INKKGLPTPV EVNVFLPSTS 420

NISYSAMFPN NPTIIDWHSM GSSVQLSVVR VPWMVSGVLL LNPKLQSHPR LNEVALTAIT 480

RIDFSHNVLT SIPQELFHLV SLRYLNVAQN KITDLPAPIG QTYGCPVLDE LFLQDNQLTT 540

LPAAIFHLPA LSILDVSNNK LQQLPFDLWR APKLRELNVA FNLLRDLPVP PMQTSSSLLS 600

LDKLNLQSFE EPPSNKPRNV TQQRLTHRNL WSATLDITDN DMKWQHEQDL GDGKTAGVGS 660

SQLSSLNIAN NLFTSIPAAL PCLAVNLTRL NMSYNSLRSM GHVTSYPATL KQLDLSHNEI 720

SCWPSLPRIT ESDPHLLCYS CVQLPEGRDD DYKTASSKGS SSSATSFRAS VLKSVCRHRR 780

HLRLEALRTL ILADNLLTRI QLSTDDATTL FNESEDADWS VVGVNRSKVI FPNLSMLDMT 840

NNCLKEIPAS LHELSSLSVL NISGNVNITE LPPHLGLLSR LWNLNTRGCL LQEPLRSMIE 900

SKKHKTMDIV GYLKSIYEDA QPYARMKLMV VGVAGIGKST LLDLLRQGAG SGSSSSSHRS 960

RASENHWAKR MGHARSTSRS HRHSSASSAN ISTVGVDIGT WICEKRKRAP GSHGPVVFRT 1020

WDFGGQKEYY ATHQYFLSKR SLYLVLWRIS DGHKGLAELL QWLGNIQARA PNSPVIIVGT 1080

HFDAVGESIS PQKAEQLQQL IREKFIAIPD AEKIGLPRVI DSIEISCRTL HNIHLLANII 1140

YDTAMQLRSP GSKEPMLLQK IPASYIALED IVNVIACNLR AAGRDPVLDG EQYKRLVTEQ 1200

MRLHNYKSFR DAAELQQATT WCHENGVLLH YDDATLRDYY FLDPQWLCDM LAHVVTVREI 1260

NPFAPTGVMK LDDLQMLFRS VQVQGNGNRS YIVSLLNKFE VALTWDSRTL LIPSLLPSQE 1320

AATPNSGSTV KLSQRSRGRS LGCSVSQEVN LNNLIYEQRS APSSSSSSAS VSQGLRRILL 1380

MTYFPSGFWS RLITRILADE QIIEAIRGVY MASQDYADFD LRTSLEQDTQ WNLWQTGLAL 1440

YYGPILIFKI WEVPFQKTER TQPFRTDGNR FKLKQDGIWS DVNLSSSSIL EVYFPLYEVN 1500

ISQEVDDNER QLLAEIRPHM SQVAKLLALT VDHIDLLLED WYPSLGTRFV HTSEGRFLIT 1560

RLVLCPRCLW KLQLQQNNEP SDREVPPVGC NRPSRSSRRG AGAYFLHGVG DPGEDGALNV 1620

FSAYLNATAR RERRSEDSLG AGSDADSGVG PDSAGSSRNT SVDGHPGYHL PDNSNVCYAW 1680

MIEECILSVY NQSKISCPVH LEQSMAQLAP DVIFADIPDK HTIPSECIIK GSLLGRGAFG 1740

FVFKANCKVR GARSFKPVAM KMLQPVPPGA RAKESALMAF KVAVGKWDRD PLQHSCKAYC 1800

TARQELAVLL TLKHPNIVPL VGICIKPLAL VLELAPLGGL DALLRHYRRS GAHMGPHTFQ 1860

TLVLQAARAI EYLHRRRIIY RDLKSENVLV WELPQPHTED SPRNLVHIKI ADYGISRQTA 1920

PSGAKGFGGT EGFMAPEIIR YNGEEEYTEK VDCFSFGMFI YENISLRQPF EGHESIKECI 1980

LEGSRPALTQ RETQFPTCCL DLMVLCWHEQ PRRRPTASQI VSILSAPECI HLLDVVAMPH 2040

SEKIVCGVFQ SLVGMGDDER CGLELWLPSF GSRIDILDCS PSGSLLQCNS ISCSPQPQVA 2100

PPKTPENGAN SRARSAQRLP KMNMLCCCLV GEAIWMGDVS GNLHAYSTST YAHLFSYMLD 2160

PNIKSAVISL VYMEKIARVA VGTHNGRVFL VDATQMPSNC AFAEGSFVLT EICSGFVLHA 2220

ACSVVVDGIY ELWCGEIAGK INVFPLNENG VSGHQALCHS EEPNLIEDVK VARMCSNESH 2280

VFSCLYPGCM VYQWDVISKR IENKLDCSKL LPCSESLQSI AIDEHVNLIK CQISALAAHN 2340

SELYIGTTWG CLIVAELHTL RPISVFRPYE NEIKSIITLS KDNVPLIATI GRRYRSLISR 2400

YVDSAESSTK SSAVSTPTHG AAKSVPPADV DNHIHCLLWR AKHWT 2445

Nucleotide Sequence
(FASTA)

ATGGAACATC CCAAAACTGG AACTGAAACA GCTCTGGAAG CCTGTGACTA CTTCGTGGAT 60

GAGGTCATTG AGGCATCCTC AATACGGGAT GCCCGCGAGG AAGTGCGTCA GATCAAGCAC 120

GGGGAGCTGC GAACGGCAGT GATCTCTGGC GATGAGCGGA CTGTGCGGGT GCTGCTGGCA 180

GCTCTTGGAA CTGAGCGTCA GATTATAGTC AATATGGCTC CTTCAGGAGC AAACACCCTT 240

CTATTCCTAG CCTGCCAGTC TGGTTACGAG AGCATTACAC AGCGATTGCT GGATGCTGGA 300

GCGGATGGTC GCTCCCATGC CGTGACCAAG TACTCACCCT TGTACGCCGC CGTCCATAGC 360

GGTCACTTGG GCATTGCCCG ACTGATGCTA GACCATTTTC CAGAACTGAT CCAGCAGCCG 420

ACTGTAGAGC GCTGGCTGCC GCTGCACGCC GCCTGCATCA ATGGACACAT CAAGCTGCTG 480

GAACTCCTTA TCAGCTACAG TTATCCCGAC TACCTCTACC AGACATATCG CGACGAGGAG 540

GGCCAGTGGG AATGGCGGCT CCCCTTCGAC GCTAACGCTC ATGATGTGAC GGGTCAGACG 600

AGTCTGTATA TTGCCAGCAT CCTAGGAAAC AAGCAGCTGG TTGGTGTGCT TCTAAAGTGG 660

CAGCTCCATT GCCGGCGTAC GTTGGGCGAT TCCGCCAGCT CGGTGAGCAC TCCTATTACG 720

CCCACCAGGA AACGTATTTC ATTTGGCATT CAGGCTATCA TGTCCAAACT GCACATATCT 780

GGAGAGTCAG AAGGACCCGA CGACCTAGCT TCACAAGAGT CAACCGAGTG CCAACGGTGT 840

CCCATTAACG TGAATCTGCT ATGTGGAGCG GCGAGAGAAA CAGCTCTGCT TGCGGCCGTT 900

CGAGGCGGCC ACCTAGACGT GGTGCAGTCT CTGCTACAGC ACGGCGCAAA TCCGAATATT 960

GTAGCCAAGC CAGTTGAGGA TCACAACGAC CCGAAATGTT GCGAGGAAAT ATATGGGCTC 1020

AGTAATGTCC CCATTGCAGA GGCCTGCAAG CAAAGGTCGC TGGCTATGTT GGATCTCTTG 1080

CTTAAGCATG GAGCCCGCGA CGATAATGGC ACGGCCATTG GAATGGCTAT TACATGCGGC 1140

GACGAGGCCA TCCTGAGTCG TCTTTTGGCC CGACGAGTCC ATCCGGACTC AGACTACAAG 1200

ATCAACAAGA AGGGTCTTCC CACACCAGTG GAGGTGAACG TGTTTTTGCC GTCCACCAGC 1260

AACATATCTT ACAGTGCTAT GTTCCCCAAC AATCCAACCA TTATTGACTG GCACAGCATG 1320

GGCTCCAGTG TCCAGTTGTC TGTTGTAAGG GTTCCCTGGA TGGTCAGCGG TGTGTTGCTG 1380

CTGAATCCTA AGCTACAGTC GCATCCGCGA CTTAATGAGG TTGCTCTGAC AGCTATCACG 1440

CGAATAGATT TCTCGCACAA CGTTCTCACG TCAATTCCAC AGGAGCTTTT CCATTTGGTT 1500

AGCCTAAGGT ATTTAAATGT GGCGCAAAAC AAGATAACCG ATCTACCTGC ACCAATAGGC 1560

CAGACATATG GGTGTCCGGT ACTGGATGAA CTCTTTCTAC AAGACAACCA GTTAACTACG 1620

CTGCCAGCCG CCATCTTTCA CCTGCCCGCC CTATCTATAT TGGATGTTTC AAATAACAAA 1680

CTGCAACAGC TTCCCTTCGA CCTGTGGCGT GCACCCAAGT TGCGCGAACT TAATGTGGCC 1740

TTCAACCTAT TGCGGGATCT TCCTGTGCCG CCAATGCAAA CTAGCAGTTC GCTGCTGAGC 1800

CTAGACAAAT TGAATCTGCA ATCTTTTGAG GAGCCGCCAT CAAACAAACC GCGAAATGTG 1860

ACTCAGCAAC GTCTCACCCA TCGCAATCTA TGGTCGGCTA CTTTGGACAT AACCGATAAT 1920

GACATGAAGT GGCAGCATGA ACAAGATTTA GGCGATGGAA AGACAGCTGG TGTGGGCTCC 1980

TCCCAGCTAA GTAGCTTAAA TATAGCAAAT AACCTCTTCA CCAGTATCCC CGCTGCTTTG 2040

CCCTGTCTGG CTGTAAACCT AACACGGCTG AATATGTCAT ACAACAGTCT GCGTTCTATG 2100

GGACATGTAA CCAGTTACCC GGCAACACTT AAGCAGTTGG ATCTAAGTCA CAACGAGATA 2160

TCCTGCTGGC CAAGTTTACC GCGAATTACT GAATCGGATC CGCATCTACT GTGCTACAGT 2220

TGTGTCCAGC TACCAGAGGG TCGAGATGAC GACTACAAGA CGGCCTCCTC AAAGGGCAGT 2280

AGCTCGTCTG CCACATCGTT TCGCGCTTCG GTGTTAAAAA GTGTTTGTCG GCACAGGCGT 2340

CATCTGCGCC TGGAGGCTCT ACGCACATTG ATCTTGGCTG ACAATCTGCT TACGCGCATC 2400

CAACTATCAA CTGATGACGC CACAACCCTT TTCAATGAAA GTGAGGACGC CGATTGGAGT 2460

GTGGTAGGCG TGAACCGGTC TAAGGTGATA TTTCCCAACC TGTCTATGCT GGATATGACC 2520

AACAATTGCC TGAAGGAGAT TCCCGCCTCG TTGCACGAAC TGAGCAGTCT GTCAGTGCTG 2580

AATATTAGTG GCAACGTCAA CATCACGGAA CTGCCGCCGC ACTTGGGACT GCTGTCGAGA 2640

CTTTGGAATC TTAATACGCG CGGTTGCCTA CTGCAGGAGC CACTGCGCTC TATGATCGAG 2700

AGCAAGAAGC ACAAGACGAT GGACATTGTT GGATATCTTA AATCTATTTA CGAAGATGCT 2760

CAGCCCTACG CACGGATGAA ACTGATGGTG GTTGGTGTGG CTGGAATTGG CAAGAGCACT 2820

CTGCTGGACT TACTGCGCCA GGGGGCGGGC TCAGGGTCCA GCTCCAGCTC TCATCGATCG 2880

CGCGCCAGCG AAAATCATTG GGCCAAGCGA ATGGGACACG CACGCAGCAC ATCTCGATCT 2940

CATCGCCATT CGTCGGCTTC TAGCGCAAAC ATTTCTACAG TAGGAGTGGA CATTGGAACA 3000

TGGATATGTG AGAAACGAAA GCGAGCACCC GGCTCCCACG GCCCAGTGGT GTTTCGTACT 3060

TGGGATTTTG GTGGTCAGAA GGAGTACTAC GCCACACATC AGTACTTTTT GTCCAAACGG 3120

AGTCTGTATT TGGTGCTCTG GCGCATTAGC GACGGTCACA AGGGTCTGGC GGAGTTGCTG 3180

CAGTGGCTTG GCAACATTCA AGCGAGGGCT CCCAACTCCC CCGTAATCAT TGTGGGCACA 3240

CACTTTGATG CCGTTGGTGA ATCCATCTCG CCCCAAAAGG CAGAGCAACT GCAGCAATTG 3300

ATTCGGGAGA AGTTTATCGC CATTCCCGAT GCGGAAAAAA TTGGGCTGCC ACGGGTGATT 3360

GATTCCATCG AAATAAGTTG CCGGACCCTA CACAATATCC ACTTATTGGC CAACATTATT 3420

TACGACACCG CCATGCAACT GCGATCCCCT GGTTCCAAGG AGCCCATGCT ACTGCAAAAG 3480

ATCCCCGCCA GCTACATTGC CTTGGAGGAT ATTGTGAATG TGATTGCATG CAATCTGCGC 3540

GCTGCTGGGC GAGATCCCGT CCTGGATGGT GAACAATATA AGCGCTTGGT CACCGAACAG 3600

ATGAGATTGC ACAACTACAA GAGCTTCCGG GATGCCGCTG AGCTGCAGCA GGCCACTACA 3660

TGGTGCCACG AAAATGGAGT TTTATTGCAC TATGATGATG CTACGCTAAG GGACTACTAC 3720

TTTCTCGATC CACAGTGGCT TTGCGACATG CTGGCCCATG TGGTCACCGT GCGGGAGATC 3780

AACCCCTTTG CTCCTACGGG CGTGATGAAG CTGGATGATC TCCAGATGTT GTTCCGAAGT 3840

GTGCAGGTTC AAGGAAATGG AAACAGAAGC TACATTGTCA GTCTACTTAA CAAGTTTGAG 3900

GTTGCTTTAA CGTGGGATTC GAGAACTCTA CTCATACCCT CCTTACTGCC TTCGCAGGAG 3960

GCAGCTACAC CCAATTCAGG AAGCACGGTT AAGCTATCGC AACGATCTCG CGGCCGTAGT 4020

TTGGGTTGCT CTGTATCGCA AGAAGTAAAT CTAAATAATT TGATATACGA ACAGAGGTCA 4080

GCTCCTTCTT CATCATCTTC CTCTGCATCG GTTAGCCAAG GCTTGCGGCG CATCCTATTG 4140

ATGACTTATT TCCCGTCCGG GTTTTGGTCA AGATTAATCA CCCGGATTTT AGCTGATGAA 4200

CAAATAATCG AAGCAATTCG TGGCGTTTAT ATGGCTTCAC AAGATTACGC GGACTTTGAT 4260

CTACGCACAT CGTTGGAGCA GGACACCCAA TGGAATCTTT GGCAGACAGG CTTAGCACTG 4320

TACTATGGAC CTATCTTAAT ATTCAAGATC TGGGAAGTAC CCTTTCAGAA GACAGAGCGA 4380

ACGCAACCTT TCCGCACTGA TGGCAACCGA TTTAAGCTGA AACAAGATGG TATCTGGAGC 4440

GATGTAAATC TCAGCTCCTC TAGCATTTTG GAAGTTTACT TTCCACTCTA TGAAGTGAAC 4500

ATATCGCAAG AAGTGGATGA CAATGAACGT CAATTGCTGG CCGAGATTCG TCCGCACATG 4560

TCTCAGGTGG CCAAGCTTTT GGCCCTAACA GTGGATCATA TTGACTTGCT TTTGGAGGAT 4620

TGGTATCCTT CATTGGGAAC GCGGTTTGTG CACACTTCCG AGGGTCGATT CCTAATCACT 4680

CGATTGGTGT TGTGTCCGCG ATGTCTTTGG AAGTTGCAGC TGCAGCAGAA CAACGAACCG 4740

TCTGATCGGG AAGTGCCTCC AGTGGGTTGC AATCGACCAA GTCGAAGTAG TAGGCGTGGA 4800

GCGGGAGCAT ACTTTCTCCA CGGTGTAGGT GATCCCGGAG AGGATGGTGC TTTAAACGTG 4860

TTCTCGGCCT ATTTAAACGC CACAGCAAGG AGAGAACGCC GATCGGAGGA TTCTTTGGGT 4920

GCTGGATCCG ACGCGGACTC GGGCGTGGGT CCCGACTCAG CCGGTTCTTC GCGCAACACT 4980

TCAGTTGATG GTCATCCCGG ATATCACTTG CCTGATAACT CAAATGTGTG TTATGCTTGG 5040

ATGATTGAGG AGTGCATTTT GTCCGTTTAT AATCAAAGCA AGATTAGTTG CCCTGTTCAT 5100

CTTGAACAGT CTATGGCTCA GCTTGCGCCA GACGTAATCT TTGCCGATAT TCCTGATAAG 5160

CACACTATTC CAAGCGAGTG CATCATCAAG GGATCGTTGC TTGGTCGAGG TGCTTTTGGG 5220

TTCGTTTTTA AAGCAAATTG CAAGGTAAGG GGCGCCAGAT CCTTTAAGCC GGTGGCAATG 5280

AAAATGCTTC AGCCAGTGCC TCCCGGAGCT CGTGCAAAAG AGAGCGCTTT GATGGCTTTC 5340

AAGGTAGCTG TAGGCAAATG GGACCGGGAT CCACTGCAGC ACTCTTGCAA GGCCTACTGC 5400

ACTGCGCGTC AGGAATTGGC AGTACTTCTA ACTCTCAAGC ATCCAAACAT TGTACCCTTG 5460

GTCGGGATCT GCATTAAACC ATTAGCTCTG GTTCTGGAAC TAGCTCCTCT AGGCGGTTTG 5520

GACGCTTTGC TCCGGCATTA CCGACGCAGC GGAGCCCACA TGGGACCGCA TACTTTCCAG 5580

ACCCTTGTCC TGCAGGCGGC TCGAGCAATC GAGTATTTGC ATCGCAGAAG AATCATCTAC 5640

CGCGATCTAA AGTCTGAAAA TGTCTTGGTT TGGGAGCTTC CACAACCACA CACGGAAGAC 5700

AGTCCCCGCA ACCTTGTGCA CATAAAGATT GCCGACTACG GAATTAGCCG GCAAACTGCT 5760

CCAAGTGGAG CTAAAGGATT TGGTGGCACC GAGGGTTTTA TGGCTCCGGA GATCATACGC 5820

TACAATGGTG AGGAGGAATA TACTGAAAAG GTGGACTGCT TCTCATTTGG AATGTTCATA 5880

TATGAGAATA TCAGTTTACG ACAACCTTTC GAAGGCCACG AGTCTATTAA AGAGTGCATC 5940

TTGGAGGGTA GTCGCCCGGC TTTGACTCAA AGGGAAACCC AGTTTCCCAC CTGCTGTTTG 6000

GATCTTATGG TCTTGTGTTG GCACGAACAG CCTCGTCGCA GACCGACGGC AAGTCAGATT 6060

GTTTCCATAC TAAGTGCACC GGAGTGCATC CACCTCCTGG ATGTCGTTGC CATGCCGCAT 6120

AGCGAGAAGA TTGTCTGTGG GGTTTTTCAG TCGCTTGTTG GTATGGGCGA TGATGAACGA 6180

TGTGGTCTTG AACTGTGGCT ACCCTCCTTC GGCTCTCGCA TTGACATTCT AGACTGCTCA 6240

CCCTCGGGCA GCCTACTGCA GTGCAACAGC ATCAGTTGTT CTCCGCAGCC ACAGGTTGCT 6300

CCGCCCAAGA CACCCGAAAA CGGTGCAAAT TCACGTGCCC GCTCTGCCCA ACGTTTGCCC 6360

AAGATGAACA TGTTGTGCTG CTGCCTGGTG GGTGAAGCCA TCTGGATGGG CGACGTTTCC 6420

GGCAATCTGC ACGCCTATAG CACATCCACC TATGCCCACC TGTTTTCCTA CATGCTCGAT 6480

CCCAACATTA AGTCAGCTGT GATCAGTCTA GTCTACATGG AGAAAATAGC TCGCGTGGCT 6540

GTCGGAACGC ATAACGGTCG GGTGTTCCTT GTTGACGCCA CGCAGATGCC CAGCAATTGC 6600

GCATTTGCCG AGGGCTCTTT TGTGCTTACA GAGATCTGTT CTGGTTTTGT GTTGCACGCC 6660

GCTTGTTCCG TTGTTGTGGA TGGAATCTAT GAATTGTGGT GCGGCGAAAT TGCAGGAAAG 6720

ATAAATGTTT TTCCGTTGAA CGAGAATGGA GTTTCCGGAC ATCAGGCTTT ATGCCACAGC 6780

GAGGAACCCA ATCTCATCGA GGACGTCAAG GTGGCTCGAA TGTGCAGTAA TGAAAGCCAT 6840

GTGTTCAGTT GTCTATATCC CGGTTGTATG GTGTACCAGT GGGATGTTAT CTCCAAGCGG 6900

ATAGAAAATA AGCTGGACTG CTCAAAGCTG CTGCCCTGCT CCGAGTCTCT GCAAAGTATT 6960

GCGATTGATG AGCATGTGAA CCTTATAAAA TGCCAGATTT CGGCACTGGC GGCTCACAAT 7020

TCAGAACTGT ATATTGGGAC GACCTGGGGC TGCTTAATTG TGGCCGAACT GCACACCCTG 7080

CGCCCCATTA GTGTTTTCCG ACCCTATGAA AATGAGATCA AATCTATAAT AACCCTTTCT 7140

AAAGACAATG TTCCGCTGAT CGCCACGATC GGAAGACGAT ATCGCTCTCT GATCTCTCGA 7200

TATGTGGACT CCGCAGAGTC ATCCACCAAG AGCTCTGCCG TCAGCACACC CACCCATGGT 7260

GCAGCCAAAT CCGTGCCACC GGCGGATGTG GATAATCACA TTCATTGCCT GCTGTGGCGC 7320

GCCAAGCACT GGACCTAA 7338

Domain Profile

S: 2     kkgsllGrGafGsvyraavk.......................Geevavkafkiaadklk  38

         +kgsllGrGafG+v++a++k                        +e+a++afk+a++k++

Q: 1729  IKGSLLGRGAFGFVFKANCKvrgarsfkpvamkmlqpvppgarAKESALMAFKVAVGKWD  1788

         689**************************************999****************

S: 39    rdslelalkayselrqelsvLlalkhPsivsLvgisikPlalvleLaplgsLdrlLsedk  98

         rd+l++++kay+++rqel+vLl+lkhP+iv+Lvgi+ikPlalvleLaplg+Ld+lL++++

Q: 1789  RDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYR  1848

         ************************************************************

S: 99    ksssklgrtltkkialqvargleyLhkkkiiyrdLksenvLvwsl.......spkeaili  151

         +s++++g +++++++lq+ar++eyLh+++iiyrdLksenvLvw+l       sp++ ++i

Q: 1849  RSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELpqphtedSPRNLVHI  1908

         ************************************************************

S: 152   kladyGisrqslrsGakgveGteGfraPeivr..gevvydekvdvfsfGlllyellsgkr  209

         k+adyGisrq+++sGakg++GteGf+aPei+r  ge++y+ekvd+fsfG+++ye++s+++

Q: 1909  KIADYGISRQTAPSGAKGFGGTEGFMAPEIIRynGEEEYTEKVDCFSFGMFIYENISLRQ  1968

         ************************************************************

S: 210   pvegeeqlkivekllkGkrPvlvkeeevlptplldLlveCwkekPekrPtasqvvsi  266

         p+eg+e++k  e++l+G+rP+l+++e+++pt++ldL+v Cw+e+P++rPtasq+vsi

Q: 1969  PFEGHESIK--ECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSI  2023

         *********..********************************************97

Domain Sequence
(FASTA)

IKGSLLGRGA FGFVFKANCK VRGARSFKPV AMKMLQPVPP GARAKESALM AFKVAVGKWD 60

RDPLQHSCKA YCTARQELAV LLTLKHPNIV PLVGICIKPL ALVLELAPLG GLDALLRHYR 120

RSGAHMGPHT FQTLVLQAAR AIEYLHRRRI IYRDLKSENV LVWELPQPHT EDSPRNLVHI 180

KIADYGISRQ TAPSGAKGFG GTEGFMAPEI IRYNGEEEYT EKVDCFSFGM FIYENISLRQ 240

PFEGHESIKE CILEGSRPAL TQRETQFPTC CLDLMVLCWH EQPRRRPTAS QIVSI 295

Keyword

ANK repeat; ATP-binding; Complete proteome; Kinase; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0031594	; C:neuromuscular junction
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048312	; P:intracellular distribution of mitochondria
GO:0007528	; P:neuromuscular junction development
GO:0070507	; P:regulation of microtubule cytoskeleton organization
GO:0090128	; P:regulation of synapse maturation
GO:2000331	; P:regulation of terminal button organization
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

dme:Dmel_CG5483

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR001806	; Small_GTPase.
IPR017986	; WD40_repeat_dom.

Pfam

PF12796	; Ank_2; 2.
PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 5.
SM00369	; LRR_TYP; 1.

Prosites

PS50297	; ANK_REP_REGION; 2.
PS50088	; ANK_REPEAT; 1.
PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013