EKS-DRM-00200
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00200
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/WEE340.29.7E-102102351250
StatusReviewed
Ensembl ProteinFBpp0076824
UniProt AccessionQ9NI63; Q961T4; Q9VRP6;
Protein NameMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Protein Synonyms/Alias Myt1 kinase; dMyt1;
Gene NameMyt1
Gene Synonyms/Alias Myt1; CG32417;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0040298FBpp0076824FBtr0077118
OrganismDrosophila melanogaster
Functional DescriptionActs as a negative regulator of entry into mitosis (G2to M transition) by phosphorylation of the cdc2 kinase specifically when cdc2 is complexed to cyclins. Mediates phosphorylation of cdc2 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Protein Length533
Protein Sequence
(FASTA)
MEKHHRLPLP ELHDDKHRHK QCNGENSNRF RPPKYKTRGY VAVDNNNLNR SQSLGSCSTN 60
SSQIAHAISF RDAGCSDSST LPSSPVQAEL STLSLSHFEQ CFERLAKLGE GSFGEVFQVR 120
DRSDGQLYAV KISKQLFRGE QYRAERLEEV RRYEEFSGHE NCIRFIRAWE QYDRLYMQME 180
LCRESLEQYL LRCQRIPEER IWHILLDLLR GLKSLHDRNL IHLDIKLDNV LIGEDDETCK 240
LADFGLVIDV DRANSHHATE GDSRYMAPEI LQGHFSKAAD IFSLGIAMLE LACYMDLPSN 300
GPLWHELRHG ILPEEFINKI SLELQSVIKS MMKPDPAQRP TAEQLLSHPK LQYLQKKRKS 360
LMNFSMLSRS FRRSRRAVWG RMCNWKTAAF RYLLYFLEVL HLCKPITASQ PNINIVPSSP 420
SSKGVPLVPQ VEFQLVGSTP IANRDCYASD FLSGEDPLDL SNQGSPNVIN STPLNTNQGK 480
SRLDLLKNNV DSMGRYVHVH DFESPCSALS SAKVLDTSSF RRKKLFVLEY DDE 533
Nucleotide Sequence
(FASTA)
ATGGAAAAGC ATCATCGCCT GCCCCTCCCG GAATTGCACG ACGACAAACA CAGACACAAA 60
CAGTGCAATG GGGAGAACAG CAATCGCTTC CGGCCGCCCA AGTACAAGAC GCGTGGCTAC 120
GTCGCCGTGG ACAACAACAA TCTGAACCGA AGCCAATCGC TGGGCTCCTG TAGCACCAAC 180
AGTTCCCAGA TCGCGCACGC GATCTCCTTC CGGGACGCCG GATGTTCGGA TTCCAGTACG 240
CTGCCCTCGT CACCAGTCCA GGCCGAGCTG AGCACCCTCT CCCTGTCACA CTTCGAGCAG 300
TGCTTCGAAA GGCTGGCCAA ACTGGGCGAA GGATCCTTCG GCGAGGTATT CCAGGTGCGC 360
GATCGCTCCG ACGGCCAGTT ATATGCCGTC AAGATCTCCA AGCAACTGTT CCGCGGCGAA 420
CAGTACCGCG CAGAGCGGCT GGAAGAGGTG CGGCGCTACG AGGAGTTCTC CGGCCATGAG 480
AACTGCATCC GGTTCATCCG CGCCTGGGAG CAGTACGACC GACTGTACAT GCAAATGGAG 540
CTGTGCCGCG AAAGTCTGGA GCAGTACTTG CTGCGCTGCC AAAGGATACC GGAGGAGCGC 600
ATCTGGCACA TCCTGCTGGA TCTGCTGCGG GGTCTCAAGT CGCTGCACGA CCGGAATCTC 660
ATCCATCTGG ACATTAAACT GGACAACGTT CTGATCGGCG AGGACGACGA GACGTGCAAG 720
CTGGCAGACT TTGGACTGGT CATCGATGTG GACAGGGCCA ACAGCCATCA CGCCACGGAG 780
GGAGATTCGA GGTATATGGC TCCAGAGATC CTGCAGGGTC ACTTCTCCAA GGCTGCGGAC 840
ATCTTCAGTC TGGGCATTGC CATGCTAGAG CTGGCATGCT ACATGGATCT TCCTTCCAAC 900
GGCCCACTGT GGCACGAACT GAGGCACGGC ATTCTGCCCG AGGAGTTCAT AAACAAAATA 960
TCACTGGAGC TGCAGTCGGT AATTAAGTCC ATGATGAAGC CCGATCCTGC GCAGAGGCCG 1020
ACGGCCGAGC AGCTACTCTC ACATCCCAAG CTGCAGTACC TGCAAAAGAA GCGCAAGTCG 1080
CTGATGAACT TCAGCATGCT GTCGCGTAGT TTTAGGCGAT CTCGCCGCGC CGTTTGGGGA 1140
AGAATGTGCA ATTGGAAAAC AGCCGCCTTT CGTTACCTTC TATACTTCCT GGAGGTCCTG 1200
CATCTATGCA AGCCCATAAC GGCCTCACAG CCCAATATTA ACATAGTGCC CTCCTCGCCT 1260
TCGTCAAAGG GAGTGCCTCT GGTGCCTCAG GTGGAGTTCC AGCTGGTAGG ATCCACACCC 1320
ATTGCCAATC GTGACTGCTA TGCCTCCGAC TTCCTTTCCG GCGAGGACCC GCTGGACCTC 1380
TCCAATCAGG GTAGCCCCAA CGTAATAAAT TCCACGCCAT TGAACACAAA CCAAGGCAAA 1440
TCCCGTCTGG ATTTGCTAAA GAATAATGTT GATTCAATGG GCAGGTACGT TCATGTACAC 1500
GATTTCGAGA GTCCGTGTTC CGCCCTATCT TCCGCCAAGG TCCTGGACAC CTCATCGTTC 1560
CGACGCAAAA AGCTCTTCGT CCTGGAATAT GACGACGAGT GA 1602
Domain Profile
S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60
         Fe+++k+G+G+fgevf+v++r+dg+lyA+k sk+ ++g+++++++l+Ev+++++++ hen
Q: 102   FERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHEN  161
         899*********************************************************
S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120
         ++r+i+aWe+ d+ly+q+ElC ++sLe++l +c++    ++e+++++illdll+gl+ lH
Q: 162   CIRFIRAWEQYDRLYMQMELC-RESLEQYLLRCQR----IPEERIWHILLDLLRGLKSLH  216
         *********************.***********55....99*******************
S: 121   ssslvHlDikpenifi.tkevtlklgDlGlvtelnsedkskveEGDsrylakEilqeeys  179
         +++l+HlDik +n++i ++++t+kl+D+Glv++++++++++++EGDsry+a+Eilq+++s
Q: 217   DRNLIHLDIKLDNVLIgEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFS  276
         ****************66789***************************************
S: 180   klkaDiFslgltilevaanvelPsnGeaWhklRkgklpdeilkelsedlrellklmlepd  239
         k+ aDiFslg+++le+a++++lPsnG+ Wh+lR+g lp+e+++++s +l++++k+m++pd
Q: 277   KA-ADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPD  335
         **.*********************************************************
S: 240   perRptaeellkhevl  255
         p++Rptae+ll+h++l
Q: 336   PAQRPTAEQLLSHPKL  351
         ************9875
Domain Sequence
(FASTA)
FERLAKLGEG SFGEVFQVRD RSDGQLYAVK ISKQLFRGEQ YRAERLEEVR RYEEFSGHEN 60
CIRFIRAWEQ YDRLYMQMEL CRESLEQYLL RCQRIPEERI WHILLDLLRG LKSLHDRNLI 120
HLDIKLDNVL IGEDDETCKL ADFGLVIDVD RANSHHATEG DSRYMAPEIL QGHFSKAADI 180
FSLGIAMLEL ACYMDLPSNG PLWHELRHGI LPEEFINKIS LELQSVIKSM MKPDPAQRPT 240
AEQLLSHPKL 250
KeywordATP-binding; Cell cycle; Complete proteome; Golgi apparatus; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00398
EKS-ANC-00413
EKS-BOT-00428
EKS-CAE-00361
EKS-CAJ-00430
EKS-CAF-00425
EKS-CAP-00453
EKS-DAR-00819
EKS-DIO-00074
EKS-ECT-00015
EKS-EQC-00419
EKS-ERE-00016
EKS-FEC-00408
EKS-GAM-00248
EKS-GAA-00520
EKS-HOS-00432
EKS-ICT-00411
EKS-LAC-00440
EKS-LOA-00435
EKS-MAM-00426
EKS-MIM-00066
EKS-MOD-00416
EKS-MUM-00460
EKS-MUP-00422
EKS-MYL-00422
EKS-NOL-00389
EKS-ORN-00543
EKS-ORA-00375
EKS-ORC-00399
EKS-OTG-00432
EKS-PAT-00403
EKS-PES-00378
EKS-PEM-00236
EKS-POA-00415
EKS-RAN-00439
EKS-SAH-00398
EKS-SUS-00381
EKS-TAR-00540
EKS-TAS-00055
EKS-TEN-00537
EKS-TUT-00133
EKS-XET-00536
EKS-XIM-00534
EKS-SAC-00032
EKS-SCP-00030
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0000139; C:Golgi membrane
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0007143; P:female meiosis
GO:0048142; P:germarium-derived cystoblast division
GO:0007140; P:male meiosis
GO:0007095; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0045930; P:negative regulation of mitotic cell cycle
GO:0045793; P:positive regulation of cell size
GO:0048137; P:spermatocyte division
GO:0007284; P:spermatogonial cell division
KEGG
dme:Dmel_CG32417;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR016235; Tyr/Thr_kinase_Cdc2_inhib.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013