EKS-DRM-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	489.4	3.3E-147	1193	1461	269

Status

Unreviewed

Ensembl Protein

FBpp0086264

UniProt Accession

Q7KJ08;

Protein Name

Protein Synonyms/Alias

Alk; Receptor protein tyrosine kinase ALK splice variant A;

Gene Name

Alk

Gene Synonyms/Alias

Alk; CG8250, Dmel_CG8250;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0040505	FBpp0086264	FBtr0087118
FBgn0040505	FBpp0304259	FBtr0331926

Organism

Drosophila melanogaster

Functional Description

Protein Length

1701

Protein Sequence
(FASTA)

MPQLRQLVVV LAILSLLVDP SFAQRPLIMN HTFSSLPMSQ HPSFNSWPSA SGGKQLRNGR 60

LHEQPLPLPQ PTLPVATQYE DYEAAPPGSR RDNKRRLAQM AQRPGSGNGG RRGMESLRKE 120

LMNPSVGGPG GGISGGGSGY PSYSATSSIG RIDGLGQGLG SADRYGALYD QLRQPSGMAA 180

MTAGPLGGPY STRFPPLYAG VDDQPKRSNR KNSISELYKL KKALNQADEP AGGVTHGNFE 240

GDPQPSSADP LQEIKDRIRD TSPNANTYAP HTDATPSSEY EYELGVKCNF ETPCSWTWGN 300

YSDGFQVITG TELSKRNLTG LLPGPAADSI DDANGHFLYA RVNPSSRPLN LTSPEFSTTM 360

EKCFLEVYMH QSDMSHGLSR VVVELLHTAE SSWVPAEILG DNVRQWTRKV YRLGRVSRDF 420

RIVFEVVPDL RVGQKGHVAL DNLRMVNCFP EGTKSEKCST SQVKCTSSKV PVCIHLPRIC 480

DITRDCDEAE DEQQSCDKIP YGGRCDFEED WCGWRDSGKT TLTWSRHTGS SPTHDTGPDG 540

DHTMQHLQNN TSGYYMLVNM NQHMNNSEKN SIIGFASNAI MVSKTFNPPP SVHGNPDSPY 600

RNSCVVRFFI HQFGKNPGSI NLSVVEMKEK ENITTTLWWS TKNQGSDWMR AEYVLPNITS 660

KYYLQFEARM GMRIYSDVAV DDFSLSPECF GLNIPEDHLG GYNYWDVRQN LKSPTYKDFE 720

YTNYLELTTC DTRGMIGPSQ AQCEAAYREQ NKTHVLREVH VVEDQSSYKG MQKWKVPHEG 780

HYTIIAKGAS GGLGSGGVGS SRGSVAVAIL ELHKNEELYF LVGQQGENAC IKSMGVLKEA 840

GCGTDHDLDL AQYSFRSKQD MVKNIYIENG AGGGGGGSYV FLLNQAKNEA VPLLVAGGGG 900

GLGIGQYIDE DFQHGQKAKP LQAPESGQIN GEPLNKKTAG PGGGWRAKED QALSPTYGAA 960

LLQGGRGGHS CYVELADNGT SVHRHGQGGF GGGGGGCNTG GGGGGYAGGD VYLTESNGEG 1020

GSSYISPSRS LREISEIHAG ASSGPGAIII IPAIEGCGCD YRCVALDEFR SKVRCICPDG 1080

WSLKRDNHTA CEIREEAGKS SFQYLVSILM ISLAVLFICI AALIFMLYNR YQRKKQSKKR 1140

HKMLVEQDLQ LTRLRNNIDD SNLNNFNPNY GCDGILNGHI DVNSLPQVAR DSLQLVNALG 1200

KGAFGEVYMA LYRHRDGDAV EMGVAVKTLR EDPKREKEED FLKEAAIMAK FNHPNMVHLI 1260

GVCFDRQPYY IVLELLAGGD LQKFLRENRN TPERPSLLTM KDLLFCALDV AKGCRYMESK 1320

RFIHRDIAAR NCLLSSKGPG RVVKIADFGM SRDIYRSDYY RKGGKAMLPI KWMPPEAFLD 1380

GIFTSKTDVW SFGILLWEVF SLGRSPYPGQ HNTQVMELVV RGGRLGSPTE CPVSIYKVMA 1440

DCWNPTPEDR PTFITLLEHL TACTQDASIM NAPLPNILGP TASERDDTVI RPPNGEEFCL 1500

AVPDYLVPLP PGGSNNPSMA SGSGYVPELQ RQQMSSCTPP AVTSPAAPHP RPVENIAPTS 1560

GDCWETSFIL PNSKVEPPVV GSGHDVPLAG GEEAKLISLD TPQPTPTTIQ PPLSFASQLD 1620

GITLDPSALT KSLPNGNAKQ SYANVQVKNE AEAKVINGVV GNGTVMNGDV STGSGGADSP 1680

FTIQGYAERY KDNNNHSEIS C 1701

Nucleotide Sequence
(FASTA)

ATGCCACAGC TCAGGCAGCT GGTGGTGGTG CTGGCCATCC TATCCCTCCT TGTGGATCCC 60

TCGTTCGCCC AGCGACCGCT GATCATGAAC CACACCTTCA GCTCCCTGCC GATGTCCCAG 120

CATCCCAGTT TTAACAGCTG GCCAAGTGCA TCCGGGGGAA AGCAACTGCG CAATGGCAGG 180

CTCCATGAGC AGCCTTTGCC CCTGCCACAA CCCACTTTGC CGGTGGCCAC ACAATACGAG 240

GACTACGAGG CGGCACCGCC AGGGTCGCGA AGGGATAACA AGCGGCGACT GGCTCAGATG 300

GCCCAACGCC CAGGCAGTGG GAACGGCGGG CGGCGAGGCA TGGAATCCCT TCGAAAGGAG 360

CTTATGAATC CATCGGTTGG TGGTCCGGGC GGAGGTATTT CCGGCGGAGG ATCCGGCTAT 420

CCTTCGTACT CCGCCACCTC TTCCATTGGA CGTATAGATG GCCTGGGTCA GGGCCTAGGA 480

TCTGCGGATC GGTACGGAGC GTTATACGAC CAGCTGAGGC AGCCCAGTGG AATGGCAGCC 540

ATGACAGCCG GTCCCCTTGG CGGACCCTAC TCGACAAGGT TCCCTCCTCT GTACGCCGGT 600

GTAGACGACC AGCCCAAGCG CTCAAATCGA AAGAACTCCA TCAGCGAGCT CTATAAGCTG 660

AAGAAGGCCC TCAACCAGGC AGATGAACCT GCTGGCGGGG TGACGCACGG AAACTTTGAA 720

GGAGATCCAC AGCCCTCGTC GGCAGATCCA CTGCAAGAAA TCAAGGATCG TATACGAGAT 780

ACATCACCAA ATGCGAACAC CTATGCTCCT CACACGGATG CCACACCATC ATCAGAGTAC 840

GAGTACGAAC TTGGCGTGAA GTGCAACTTC GAGACCCCGT GCAGCTGGAC CTGGGGCAAC 900

TATTCGGATG GTTTTCAAGT TATAACTGGA ACGGAATTGT CGAAAAGGAA TCTCACAGGA 960

CTACTGCCAG GTCCTGCAGC CGATAGTATC GACGATGCGA ACGGTCACTT CCTGTACGCC 1020

CGCGTGAACC CCTCTTCAAG ACCCTTGAAT CTCACCTCAC CGGAATTTAG CACCACGATG 1080

GAGAAGTGCT TTTTAGAGGT CTACATGCAC CAGAGCGACA TGAGTCACGG ACTTTCGCGG 1140

GTGGTGGTTG AACTACTTCA CACGGCTGAG AGCAGTTGGG TTCCGGCCGA AATTCTGGGC 1200

GATAATGTGC GCCAATGGAC CAGGAAGGTA TATCGCCTGG GTCGCGTTTC CCGCGATTTC 1260

CGCATCGTTT TCGAGGTGGT TCCCGATCTG AGAGTGGGCC AGAAGGGTCA TGTGGCGTTG 1320

GACAACCTGC GCATGGTTAA CTGTTTTCCC GAGGGTACAA AGTCGGAGAA GTGCAGCACC 1380

TCGCAGGTGA AGTGCACCTC CAGCAAGGTG CCCGTGTGTA TCCATCTACC ACGAATCTGC 1440

GACATTACCA GGGACTGCGA TGAGGCGGAG GACGAGCAGC AGTCATGTGA TAAAATACCC 1500

TATGGCGGTC GTTGTGACTT CGAGGAGGAC TGGTGCGGTT GGCGGGACTC GGGAAAGACG 1560

ACGCTCACCT GGTCACGGCA CACGGGATCA TCTCCCACCC ACGATACGGG ACCGGATGGG 1620

GATCACACAA TGCAGCACCT GCAGAACAAC ACCAGTGGAT ACTATATGCT GGTCAATATG 1680

AATCAGCATA TGAACAACTC GGAAAAGAAT TCGATTATTG GATTTGCCAG CAATGCGATT 1740

ATGGTTAGCA AGACCTTCAA TCCGCCGCCA TCGGTACATG GAAACCCGGA CTCTCCCTAT 1800

CGTAACTCGT GTGTTGTGAG GTTTTTCATT CATCAATTCG GCAAGAATCC GGGCAGTATC 1860

AATCTCTCCG TGGTGGAGAT GAAGGAAAAG GAGAACATCA CCACTACACT GTGGTGGAGC 1920

ACCAAAAACC AGGGCAGCGA TTGGATGAGA GCGGAATATG TACTGCCTAA CATAACGTCC 1980

AAATACTATC TTCAGTTTGA AGCTCGCATG GGCATGAGAA TCTACTCAGA TGTGGCTGTG 2040

GATGACTTCT CACTGAGTCC CGAATGTTTT GGCCTCAATA TACCAGAAGA TCATCTAGGT 2100

GGCTACAACT ACTGGGATGT CCGACAGAAT CTAAAGAGTC CAACCTATAA AGACTTTGAA 2160

TATACCAACT ATCTTGAGTT AACCACCTGT GACACTCGTG GCATGATAGG ACCTTCCCAG 2220

GCGCAATGTG AAGCTGCCTA CAGGGAGCAA AATAAGACAC ATGTCCTGCG GGAAGTCCAT 2280

GTGGTGGAAG ATCAGAGCAG CTACAAGGGC ATGCAGAAGT GGAAGGTACC CCACGAAGGA 2340

CACTACACAA TCATTGCCAA AGGCGCCAGT GGAGGACTGG GTTCGGGTGG CGTAGGCAGC 2400

TCTCGAGGAT CCGTGGCTGT GGCCATTCTG GAACTTCACA AAAATGAGGA ACTGTATTTC 2460

CTCGTGGGAC AGCAGGGCGA GAACGCCTGC ATCAAGTCCA TGGGAGTTCT GAAGGAAGCT 2520

GGTTGCGGAA CCGATCACGA CTTGGACTTA GCCCAATATA GCTTCCGTTC CAAACAGGAT 2580

ATGGTCAAGA ATATCTATAT CGAAAATGGT GCCGGCGGCG GTGGTGGTGG CTCCTACGTG 2640

TTCCTTCTCA ATCAGGCCAA AAATGAGGCA GTCCCTCTTT TGGTAGCTGG CGGTGGAGGA 2700

GGTCTGGGAA TTGGCCAATA CATTGATGAG GACTTCCAGC ATGGTCAAAA GGCGAAGCCC 2760

CTTCAGGCTC CAGAAAGTGG ACAGATCAAT GGAGAGCCCT TGAATAAGAA GACAGCTGGT 2820

CCAGGTGGTG GATGGAGAGC CAAAGAGGAC CAGGCCCTGA GTCCCACCTA TGGAGCTGCC 2880

CTTCTCCAGG GCGGTCGAGG TGGACACTCC TGTTATGTGG AACTTGCGGA CAATGGAACT 2940

TCTGTTCACA GACATGGCCA AGGTGGATTT GGTGGTGGCG GTGGTGGCTG CAATACTGGA 3000

GGAGGCGGTG GCGGCTACGC TGGCGGAGAT GTCTACCTAA CCGAGTCGAA TGGCGAGGGC 3060

GGAAGTTCGT ACATCAGCCC CAGTCGAAGT CTTCGGGAAA TTAGTGAAAT ACATGCCGGC 3120

GCTAGCAGTG GACCAGGTGC CATCATCATT ATTCCGGCAA TCGAGGGCTG TGGATGCGAC 3180

TATAGGTGCG TGGCCTTGGA TGAGTTCCGA TCGAAGGTGC GGTGCATCTG CCCAGATGGC 3240

TGGAGCTTAA AACGGGACAA TCACACCGCC TGTGAGATCC GCGAGGAGGC GGGCAAGTCC 3300

TCCTTCCAGT ATCTGGTTTC CATCCTAATG ATCTCGCTTG CCGTGCTCTT CATCTGCATA 3360

GCTGCGCTCA TCTTTATGCT ATATAATCGC TATCAACGGA AGAAACAATC GAAGAAGCGC 3420

CACAAGATGC TCGTGGAGCA GGATCTTCAA CTTACCCGTT TGCGCAACAA TATCGACGAC 3480

TCCAATCTGA ATAACTTTAA CCCCAACTAT GGATGTGATG GTATTCTCAA TGGTCACATT 3540

GATGTCAATA GCTTGCCCCA GGTGGCACGC GATAGTCTGC AATTGGTCAA TGCTCTGGGC 3600

AAAGGTGCTT TTGGAGAGGT ATATATGGCA TTATATCGCC ATCGAGACGG AGATGCTGTG 3660

GAAATGGGCG TGGCAGTGAA AACCTTGCGG GAAGATCCCA AGCGGGAAAA GGAGGAGGAT 3720

TTCCTGAAGG AGGCGGCCAT AATGGCCAAG TTCAATCACC CGAATATGGT CCATTTAATA 3780

GGAGTCTGCT TTGACCGTCA GCCGTATTAT ATTGTCCTGG AACTTCTTGC TGGCGGGGAT 3840

CTACAGAAGT TTTTGCGCGA AAACAGGAAT ACTCCAGAGC GTCCCTCCCT CTTAACCATG 3900

AAGGATCTGC TTTTCTGCGC CCTCGACGTG GCCAAAGGAT GTCGCTACAT GGAGAGTAAA 3960

CGCTTCATCC ATCGGGATAT CGCCGCCAGG AACTGTCTGC TGAGCAGTAA GGGTCCTGGT 4020

CGCGTTGTGA AAATCGCCGA TTTTGGCATG TCCCGGGATA TCTACCGATC GGACTACTAT 4080

CGCAAGGGAG GCAAGGCGAT GCTACCCATC AAATGGATGC CGCCGGAAGC CTTCCTCGAT 4140

GGCATATTCA CCTCGAAAAC AGATGTCTGG TCCTTTGGCA TTCTCCTGTG GGAAGTCTTC 4200

AGTCTGGGCC GTTCACCATA TCCCGGCCAG CATAACACCC AGGTAATGGA GCTGGTTGTG 4260

CGTGGCGGTC GACTGGGATC GCCCACCGAG TGTCCCGTCT CCATATACAA GGTGATGGCC 4320

GACTGCTGGA ATCCCACGCC CGAGGATCGG CCCACATTTA TTACGTTGCT GGAGCATTTG 4380

ACCGCCTGCA CCCAGGATGC CAGCATAATG AACGCTCCTC TGCCCAATAT TCTGGGACCC 4440

ACAGCCTCCG AACGGGACGA CACAGTCATC CGGCCGCCCA ATGGCGAGGA GTTCTGTTTG 4500

GCGGTGCCGG ATTATCTGGT ACCTTTGCCA CCCGGCGGCA GCAACAATCC ATCGATGGCC 4560

AGTGGTTCGG GCTACGTGCC AGAATTGCAA CGCCAGCAGA TGAGCTCCTG CACTCCGCCG 4620

GCGGTCACAT CGCCCGCCGC ACCACATCCA AGGCCGGTGG AGAATATCGC ACCGACCAGC 4680

GGAGATTGCT GGGAGACGTC ATTTATACTA CCTAACTCGA AGGTGGAACC ACCAGTGGTT 4740

GGAAGTGGCC ACGATGTTCC ATTGGCCGGC GGTGAGGAGG CCAAACTGAT CAGTTTGGAC 4800

ACACCACAGC CCACACCAAC GACCATCCAA CCACCGCTGT CCTTCGCCTC GCAGCTTGAT 4860

GGCATCACAT TGGATCCCTC GGCACTGACC AAGAGTTTGC CCAACGGAAA TGCCAAGCAG 4920

TCGTATGCCA ATGTTCAGGT GAAAAACGAA GCCGAGGCCA AGGTCATCAA TGGTGTGGTT 4980

GGCAATGGAA CGGTGATGAA CGGGGACGTC TCGACGGGAT CGGGTGGTGC CGATTCACCT 5040

TTCACCATTC AGGGTTACGC GGAGCGATAC AAGGACAACA ACAATCATTC CGAAATCAGT 5100

TGTTAA 5106

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         ++lv+alGkGafGevy++l+++++gda+++ vavktl+e++++++e+dflkea+i++kfn

Q: 1193  LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFN  1252

         589*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+n+v+liGv+++++p++i+lellaGGdl++flre+r++pe++s l+mkdll++aldvak

Q: 1253  HPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAK  1312

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+y+e+++fihrdiaarn+llsskGp+rv+kiadfGm+rdiyr++yyrkgg+a+lp+kw

Q: 1313  GCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKW  1372

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeafl+GiftsktdvwsfG+llwevfslG++pypg++n++v+elvv+Ggrl+sp+e+p

Q: 1373  MPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECP  1432

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlq  269

         +s+y++m+dcw+++pedrp+f+++le+l+

Q: 1433  VSIYKVMADCWNPTPEDRPTFITLLEHLT  1461

         ***************************97

Domain Sequence
(FASTA)

LQLVNALGKG AFGEVYMALY RHRDGDAVEM GVAVKTLRED PKREKEEDFL KEAAIMAKFN 60

HPNMVHLIGV CFDRQPYYIV LELLAGGDLQ KFLRENRNTP ERPSLLTMKD LLFCALDVAK 120

GCRYMESKRF IHRDIAARNC LLSSKGPGRV VKIADFGMSR DIYRSDYYRK GGKAMLPIKW 180

MPPEAFLDGI FTSKTDVWSF GILLWEVFSL GRSPYPGQHN TQVMELVVRG GRLGSPTECP 240

VSIYKVMADC WNPTPEDRPT FITLLEHLT 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0007411	; P:axon guidance
GO:0042051	; P:compound eye photoreceptor development
GO:0048565	; P:digestive tract development
GO:0007498	; P:mesoderm development
GO:0045792	; P:negative regulation of cell size
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0040008	; P:regulation of growth
GO:0045610	; P:regulation of hemocyte differentiation
GO:0090328	; P:regulation of olfactory learning
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007522	; P:visceral muscle development

KEGG

dme:Dmel_CG8250

;

InterPros

IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50068	; LDLRA_2; 1.
PS50060	; MAM_2; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013